100 research outputs found

    Throwing away everything but the kitchen sink? Large assemblages, depositional practice and post-medieval households in Cambridge

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    Developer-funded archaeologists investigating post-1750 sites in Britain frequently recover large assemblages of material, which appear to have been rapidly deposited in features by particular households or other groups. Such assemblages possess considerable interpretive potential, but this is yet to be fully exploited. This paper proposes a nuanced approach to the analysis of such assemblages, one that is critically aware of stratigraphic sequencing and historical deposition factors.The work at Grand Arcade was jointly funded by Grosvenor Developments Ltd and the Universities Superannuation Scheme, as the Grand Arcade Partnership

    Tuberculosis before and after the Black Death (1346 – 1353 CE) in the Hospital of St John the Evangelist in Cambridge, England

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    This article was published with Open Access under the Elsevier/Jisc Open Access agreement The authors would like to thank all of the members of the ‘After the Plague’ project, and the Cambridge Archaeological Unit for their help and support. We would also like to thank György Pálfi for organising the ICEPT-3 conference, at which the initial findings of this research were presented and for inviting us to contribute to this special issue. This research was funded by the Wellcome Trust (Award no 2000368/Z/15/Z) and St John's College, Cambridge.Peer reviewedPublisher PD

    Caring for the injured : Exploring the immediate and long-term consequences of injury in medieval Cambridge, England

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    Open Access through the Elsevier Agreement Acknowledgments The authors would like to thank Trish Biers of the Duckworth Collection at the University of Cambridge as well as the anonymous reviewers and editors of this special issue (Ileana Mircarelli, Lorna Tilley, and Mary Ann Tafuri) for their comments on this manuscript. This research was generously funded by the Wellcome Trust (Award no 2000368/Z/15/Z) and St John’s College, Cambridge.Peer reviewedPublisher PD

    An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.

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    BACKGROUND: The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the occurrence of serotype b (Hib), the most virulent type of H. influenzae, has since decreased, reports of infections with other serotypes and non-typeable strains are on the rise. While non-typeable strains have been studied in-depth, very little is known of the pathogen's evolutionary history, and no genomes dating prior to 1940 were available. RESULTS: We describe a Hib genome isolated from a 6-year-old Anglo-Saxon plague victim, from approximately 540 to 550 CE, Edix Hill, England, showing signs of invasive infection on its skeleton. We find that the genome clusters in phylogenetic division II with Hib strain NCTC8468, which also caused invasive disease. While the virulence profile of our genome was distinct, its genomic similarity to NCTC8468 points to mostly clonal evolution of the clade since the 6th century. We also reconstruct a partial Yersinia pestis genome, which is likely identical to a published first plague pandemic genome of Edix Hill. CONCLUSIONS: Our study presents the earliest genomic evidence for H. influenzae, points to the potential presence of larger genomic diversity in the phylogenetic division II serotype b clade in the past, and allows the first insights into the evolutionary history of this major human pathogen. The identification of both plague and Hib opens questions on the effect of plague in immunocompromised individuals already affected by infectious diseases

    Genetic history of Cambridgeshire before and after the Black Death.

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    The extent of the devastation of the Black Death pandemic (1346-1353) on European populations is known from documentary sources and its bacterial source illuminated by studies of ancient pathogen DNA. What has remained less understood is the effect of the pandemic on human mobility and genetic diversity at the local scale. Here, we report 275 ancient genomes, including 109 with coverage >0.1×, from later medieval and postmedieval Cambridgeshire of individuals buried before and after the Black Death. Consistent with the function of the institutions, we found a lack of close relatives among the friars and the inmates of the hospital in contrast to their abundance in general urban and rural parish communities. While we detect long-term shifts in local genetic ancestry in Cambridgeshire, we find no evidence of major changes in genetic ancestry nor higher differentiation of immune loci between cohorts living before and after the Black Death

    Pathways to the medieval hospital : Collective osteobiographies of poverty and charity

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    Medieval hospitals were founded to provide charity, but poverty and infirmity were broad and socially determined categories and little is known about the residents of these institutions and the pathways that led them there. Combining skeletal, isotopic and genetic data, the authors weave a collective biography of individuals buried at the Hospital of St John the Evangelist, Cambridge. By starting with the physical remains, rather than historical expectations, they demonstrate the varied life courses of those who were ultimately buried in the hospital's cemetery, illustrating the diverse faces of medieval poverty and institutional notions of charity. The findings highlight the value of collective osteobiography when reconstructing the social landscapes of the past

    Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

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    The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541–750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events
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