Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer

Pancreatic cancer (PC) remains one of the most aggressive tumors with an increasing incidence rate and reduced survival. Although surgical resection is the only potentially curative treatment for PC, only 15-20% of patients are resectable at diagnosis. To select the most appropriate treatment and thus improve outcomes, the diagnostic and therapeutic strategy for each patient with PC should be discussed within a multidisciplinary expert team. Clinical decision-making should be evidence-based, considering the staging of the tumor, the performance status and preferences of the patient. The aim of this guideline is to provide practical and evidence-based recommendations for the management of PC

Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer

Pancreatic cancer (PC) remains one of the most aggressive tumors with an increasing incidence rate and reduced survival. Although surgical resection is the only potentially curative treatment for PC, only 15-20% of patients are resectable at diagnosis. To select the most appropriate treatment and thus improve outcomes, the diagnostic and therapeutic strategy for each patient with PC should be discussed within a multidisciplinary expert team. Clinical decision-making should be evidence-based, considering the staging of the tumor, the performance status and preferences of the patient. The aim of this guideline is to provide practical and evidence-based recommendations for the management of PC

Observations of the Cosmic Microwave Background and Galactic Foregrounds at 12-17 GHz with the COSMOSOMAS Experiment

(Abridged) We present the analysis of the first 18 months of data obtained with the COSMOSOMAS experiment at the Teide Observatory (Tenerife). Three maps have been obtained at 12.7, 14.7 and 16.3 GHz covering 9000 square degrees each with a resolution of ~1 degree and with sensitivities 49, 59 and 115 muK per beam respectively. These data in conjuction with the WMAP first year maps have revealed that the Cosmic Microwave Background (CMB) is the dominant astronomical signal at high galatic latitude in the three COSMOSOMAS channels with an average amplitude of 29.7+/- 1.0 \muK (68% c.l. not including calibration errors). This value is in agreement with the predicted CMB signal in the COSMOSOMAS maps using the best fit Lambda-CDM model to the WMAP power spectrum. Cross-correlation of COSMOSOMAS data with the DIRBE map at 100 \mu m shows the existence of a common signal with amplitude 7.4+/- 1.1, 7.5+/- 1.1, and 6.5+/-2.3 muK in the 12.7, 14.7 and 16.3 GHz COSMOSOMAS maps at |b|>30^\deg. Using the WMAP data we find this DIRBE correlated signal rises from high to low frequencies flattening below ~20 GHz. At higher galactic latitudes the average amplitude of the correlated signal with the DIRBE maps decreases slightly. The frequency behaviour of the COSMOSOMAS/WMAP correlated signal with DIRBE is not compatible with the expected tendency for thermal dust. A study of the H-alpha emission maps do not support free-free as a major contributor to that signal. Our results provide evidence of a new galactic foreground with properties compatible with those predicted by the spinning dust models.Comment: 11 pages, 21 figures. Submitted to MNRAS. For paper with figures at full resolution, see http://www.iac.es/project/cmb/cosmosomas

EFSUMB Statement on Medical Student Education in Ultrasound [long version]

Publisher Copyright: © 2016 Georg Thieme Verlag. All rights reserved.The European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) recommends that ultrasound should be used systematically as an easy accessible and instructive educational tool in the curriculum of modern medical schools. Medical students should acquire theoretical knowledge of the modality and hands-on training should be implemented and adhere to evidence-based principles. In this paper we report EFSUMB policy statements on medical student education in ultrasound that in a short version is already published in Ultraschall in der Medizin 1.publishersversionPeer reviewe

Prevalence of Symptomatic and Asymptomatic Peripheral Arterial Disease and the Value of the Ankle-brachial Index to Stratify Cardiovascular Risk

AbstractObjectivesTo determine the prevalence of ankle-brachial index (ABI)<0.9 and symptomatic peripheral arterial disease (PAD), association with cardiovascular risk factors (CVRF), and impact of adding ABI measurement to coronary heart disease (CHD) risk screening.DesignPopulation-based cross-sectional survey of 6262 participants aged 35–79 in Girona, Spain.MethodsStandardized measurements (CVRF, ABI, 10-year CHD risk) and history of intermittent claudication (IC), CHD, and stroke were recorded. ABI<0.9 was considered equivalent to moderate-to-high CHD risk (≥10%).ResultsABI<0.9 prevalence was 4.5%. Only 0.62% presented low ABI and IC. Age, current smoker, cardiovascular disease, and uncontrolled hypertension independently associated with ABI<0.9 in both sexes; IC was also associated in men and diabetes in women. Among participants 35–74 free of cardiovascular disease, 6.1% showed moderate-to-high 10-year CHD risk; adding ABI measurement yielded 8.7%. Conversely, the risk function identified 16.8% of these participants as having 10-year CHD risk>10%. In participants 75–79 free of cardiovascular disease, the prevalence of ABI<0.9 (i.e., CHD risk≥10%) was 11.9%.ConclusionsABI<0.9 is relatively frequent in those 35–79, particularly over 74. However, IC and CHD risk≥10% indicators are often missing. Adding ABI measurement to CHD-risk screening better identifies moderate-to-high cardiovascular risk patients

Sigma-phase in Fe-Cr and Fe-V alloy systems and its physical properties

A review is presented on physical properties of the sigma-phase in Fe-Cr and Fe-V alloy systems as revealed both with experimental -- mostly with the Mossbauer spectroscopy -- and theoretical methods. In particular, the following questions relevant to the issue have been addressed: identification of sigma and determination of its structural properties, kinetics of alpha-to-sigma and sigma-to-alpha phase transformations, Debye temperature and Fe-partial phonon density of states, Curie temperature and magnetization, hyperfine fields, isomer shifts and electric field gradients.Comment: 26 pages, 23 figures and 83 reference

La Cuevona de Avín (Avín, Asturias, North Spain): A new Late Pleistocene site in the lower valley of the River Güeña

The archaeological investigations carried out in the last twenty years in the Lower Valley of the River Güeña (Asturias, central part of northern Spain) have documented different prehistoric sites, particularly with Middle and Upper Palaeolithic occupations. This paper presents the first results of the archaeological excavation carried out in the cave of La Cuevona de Avín. From the systematic study of the biotic and abiotic remains, a total of three occupation phases (Phases 1 to 3) have been determined, dated in the Late Pleistocene. The lithic studies indicate the use of local raw materials (mainly quartzite), but also regional ones (different types of flint) in the whole sequence. Retouched implements are typologically representative only during the Upper Magdalenian (Phase II) and use-wear analysis indicates the manufacture and use of artefacts in situ during this phase. Archaeozoological studies reveal continuity in subsistence strategies throughout the sequence, noting specialization in red deer hunting during the Azilian (Phase I), and more diversified prey in the older phases of the sequence. © 2022 The Author(s

Sistema de comunicación de respaldo mediante tecnología LoRa con hardware y software abierto para aplicaciones de robótica de emergencias

Los sistemas de comunicación entre nodos sensores y los equipos de búsqueda y rescate presentan posibles vulnerabilidades ante emergencias o catástrofes, como el fallo de la infraestructura del sistema o la saturación de la red. Por ello, es necesario evaluar alternativas para garantizar la disponibilidad del sistema y los datos necesarios para la estrategia del equipo. Los requerimientos de una red de largo alcance y bajo consumo apuntan a evaluar las distintas tecnologías que engloban las redes LPWAN (Low Power, Wide Area Network). Entre ellas, destaca el protocolo LoRaWAN (Long Range, Wide Area Network) por ofrecer una flexibilidad operativa que no tienen los demás. De lado del hardware, se realizó una selección de componentes abiertos para los nodos sensores y el gateway. Para conseguir una red ad-hoc se ha usado el proyecto ChirpStack como servidor de red y de aplicación. Finalmente, se ha integrado el software de aplicación QGIS con la base de datos PostgreSQL que almacena los datos en la misma tarjeta host del gateway. El sistema fue probado en las XV Jornadas Internacionales de la Universidad de Málaga sobre Seguridad, Emergencias y Catástrofes. El código y la documentación del sistema presentado en este artículo está disponible en https://github.com/jjflozano/BackUpCommLoRa.Universidad de Málaga, Campus de Excelencia Internacional Andalucía Tech. Proyecto RTI2018-093421-B-I00, Ministerio de Ciencia, Innovación y Universidades, Programa Estatal de I+D+i 2018. Proyecto UMA18-FEDERJA-090, Programa operativo FEDER Andalucía 2014-2020, Convocatoria 2018, Junta de Andalucía