4,139 research outputs found
Interactions mechanism of commonly used drugs for the treatment of Covid-19
In this study conformation analysis of seven drugs commonly used in the treatment of COVID-19 was performed. The most stable conformers of the drug molecules were used as initial data for docking analysis. Using the Cavityplus program, the probable most active binding sites of both apo and holo forms of COVID-19 main protease enzyme (Mpro) and spike glycoprotein of SARSCoV-2 receptors were determined. The interaction mechanisms of the 7 FDA approved drugs (arbidol, colchicine, dexamethasone, favipiravir, galidesivir, hydroxychloroquine, remdesivir) were examined using the AutoDock Vina program. The six of the seven drugs were found to be more stable in binding to apo form of COVID-19 Mpro and spike glycoprotein. Moreover, a set of molecular mechanics (MM) Poisson-Boltzmann (PB) surface area (SA) calculations on the investigated drugs-protein systems were performed and the estimated binding free energy of remdesivir and the apo form of Mpro system was found to be the best. The interaction results of FDA drugs with the apo form of COVID-19 Mpro and spike glycoprotein can play an important role for the treatment of COVID-19.
KEY WORDS: COVID-19, Drugs, Molecular modelling, Conformational analysis, Molecular docking
Bull. Chem. Soc. Ethiop. 2020, 34(3), 613-623.
DOI: https://dx.doi.org/10.4314/bcse.v34i3.1
Multicanonical Study of the 3D Ising Spin Glass
We simulated the Edwards-Anderson Ising spin glass model in three dimensions
via the recently proposed multicanonical ensemble. Physical quantities such as
energy density, specific heat and entropy are evaluated at all temperatures. We
studied their finite size scaling, as well as the zero temperature limit to
explore the ground state properties.Comment: FSU-SCRI-92-121; 7 pages; sorry, no figures include
A New Approach to Spin Glass Simulations
We present a recursive procedure to calculate the parameters of the recently
introduced multicanonical ensemble and explore the approach for spin glasses.
Temperature dependence of the energy, the entropy and other physical quantities
are easily calculable and we report results for the zero temperature limit. Our
data provide evidence that the large increase of the ergodicity time is
greatly improved. The multicanonical ensemble seems to open new horizons for
simulations of spin glasses and other systems which have to cope with
conflicting constraints
Radiation Testing of Electronics for the CMS Endcap Muon System
The electronics used in the data readout and triggering system for the
Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC)
particle accelerator at CERN are exposed to high radiation levels. This
radiation can cause permanent damage to the electronic circuitry, as well as
temporary effects such as data corruption induced by Single Event Upsets. Once
the High Luminosity LHC (HL-LHC) accelerator upgrades are completed it will
have five times higher instantaneous luminosity than LHC, allowing for
detection of rare physics processes, new particles and interactions. Tests have
been performed to determine the effects of radiation on the electronic
components to be used for the Endcap Muon electronics project currently being
designed for installation in the CMS experiment in 2013. During these tests the
digital components on the test boards were operating with active data readout
while being irradiated with 55 MeV protons. In reactor tests, components were
exposed to 30 years equivalent levels of neutron radiation expected at the
HL-LHC. The highest total ionizing dose (TID) for the muon system is expected
at the inner-most portion of the CMS detector, with 8900 rad over ten years.
Our results show that Commercial Off-The-Shelf (COTS) components selected for
the new electronics will operate reliably in the CMS radiation environment
Graph Mining for Object Tracking in Videos
International audienceThis paper shows a concrete example of the use of graph mining for tracking objects in videos with moving cameras and without any contextual information on the objects to track. To make the mining algorithm efficient, we benefit from a video representation based on dy- namic (evolving through time) planar graphs. We then define a number of constraints to efficiently find our so-called spatio-temporal graph pat- terns. Those patterns are linked through an occurrences graph to allow us to tackle occlusion or graph features instability problems in the video. Experiments on synthetic and real videos show that our method is effec- tive and allows us to find relevant patterns for our tracking application
Fluid Flows of Mixed Regimes in Porous Media
In porous media, there are three known regimes of fluid flows, namely,
pre-Darcy, Darcy and post-Darcy. Because of their different natures, these are
usually treated separately in literature. To study complex flows when all three
regimes may be present in different portions of a same domain, we use a single
equation of motion to unify them. Several scenarios and models are then
considered for slightly compressible fluids. A nonlinear parabolic equation for
the pressure is derived, which is degenerate when the pressure gradient is
either small or large. We estimate the pressure and its gradient for all time
in terms of initial and boundary data. We also obtain their particular bounds
for large time which depend on the asymptotic behavior of the boundary data but
not on the initial one. Moreover, the continuous dependence of the solutions on
initial and boundary data, and the structural stability for the equation are
established.Comment: 33 page
Grundstate Properties of the 3D Ising Spin Glass
We study zero--temperature properties of the 3d Edwards--Anderson Ising spin
glass on finite lattices up to size . Using multicanonical sampling we
generate large numbers of groundstate configurations in thermal equilibrium.
Finite size scaling with a zero--temperature scaling exponent describes the data well. Alternatively, a descriptions in terms of Parisi
mean field behaviour is still possible. The two scenarios give significantly
different predictions on lattices of size .Comment: LATEX 9pages,figures upon request ,SCRI-9
How large is "large " for Nuclear matter?
We argue that a so far neglected dimensionless scale, the number of neighbors
in a closely packed system, is relevant for the convergence of the large
expansion at high chemical potential. It is only when the number of colors is
large w.r.t. this new scale (\sim \order{10}) that a convergent large
limit is reached. This provides an explanation as to why the large
expansion, qualitatively successful in in vacuum QCD, fails to describe high
baryo-chemical potential systems, such as nuclear matter. It also means that
phenomenological claims about high density matter based on large
extrapolations should be treated with caution.Comment: Proceedings of CPOD2010 conference, in Dubna. Results based on
Phys.Rev.C82, 055202 (2010), http://arxiv.org/abs/1006.247
Three Millisecond Pulsars in FERMI LAT Unassociated Bright Sources
We searched for radio pulsars in 25 of the non-variable, unassociated sources
in the Fermi LAT Bright Source List with the Green Bank Telescope at 820 MHz.
We report the discovery of three radio and gamma-ray millisecond pulsars (MSPs)
from a high Galactic latitude subset of these sources. All of the pulsars are
in binary systems, which would have made them virtually impossible to detect in
blind gamma-ray pulsation searches. They seem to be relatively normal, nearby
(<=2 kpc) millisecond pulsars. These observations, in combination with the
Fermi detection of gamma-rays from other known radio MSPs, imply that most, if
not all, radio MSPs are efficient gamma-ray producers. The gamma-ray spectra of
the pulsars are power-law in nature with exponential cutoffs at a few GeV, as
has been found with most other pulsars. The MSPs have all been detected as
X-ray point sources. Their soft X-ray luminosities of ~10^{30-31} erg/s are
typical of the rare radio MSPs seen in X-rays.Comment: Accepted for publication in ApJ Letter
Measuring movement fluency during the sit-to-walk task
Restoring movement fluency is a key focus for physical rehabilitation; it's measurement, however, lacks objectivity. The purpose of this study was to find whether measurable movement fluency variables differed between groups of adults with different movement abilities whilst performing the sit-to-walk (STW) movement. The movement fluency variables were: (1) hesitation during movement (reduction in forward velocity of the centre of mass; CoM), (2) coordination (percentage of temporal overlap of joint rotations) and (3) smoothness (number of inflections in the CoM jerk signal)
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