Digital Transformation in Healthcare – the case of a Chinese Medicine Inquiring System

The unique philosophy, diagnosis, and treatment methods of Chinese Medicine (CM) suggest that Health Informatics developments in this domain could benefit by adopting a more suitable synthesis, specifically, incorporating Hegelian and Kantian inquiring systems with the support from Singerian, Lockean, and Leibnizian inquiring systems, and key concepts of Knowledge Management. Directed by qualitative methodology with Case Study and Design Science methods, the specific CM inquiring system, a Patient Management System (PMS) prototype, was constructed. It is anticipated that this experiment provides suggestions and reference to Health Informatics implementations in CM. This paper focuses on the design and building of the PMS

An Investigation on Integrating Eastern and Western Medicine with Informatics

Today, in many western countries, acceptance of alternate forms of healthcare such as Chinese medicine (CM) is increasing. In fact, countries such as Australia, Canada, and England are going so far as to set regulations, education, and standards regarding the practice of CM in these respective countries. Further, we can see the integration between western and Chinese medicine delivery of care and treatments in many instances. Information Systems and Information Technology (IS/IT) can be a key enabler in assisting this integration. The following study examines aspects of such integrations using IS/IT and identifies that CM IS/IT is more likely to succeed when there is synthesis between key aspects of the unique environment and user requirements. This perspective is supported theoretically by adapting Churchman’s Inquiring Systems to frame CM as a combination of Hegelian and Kantian inquiring systems with the support of Singerian, Lockean, and Leibnizian inquiring systems and Knowledge Management (KM) features. Based on this, the study then proposes a new design for a patient management system in clinics and hospitals

INVESTIGATING THE POSSIBILITY FOR IS/IT TO SUPPORT THE DELIVERY OF CHINESE MEDICINE

As Chinese medicine (CM) has increased in popularity globally it now becomes imperative to investigate ways in which safe, efficient, effective and evidence-based approaches might be adopted into CM practice. In the case of western or more traditional healthcare delivery practice, IS/IT is often adopted and employed to assist in this regard and thus this paper examines how IS/IT might be used to support the delivery of CM. In particular, the paper investigates how IS/IT tools and techniques might be used in supporting CM clinics daily processes and thereby bring greater value to a country’s healthcare. In doing so, this paper studies the current global CM situation and provides a solid foundation for how to design and develop an enterprise wide CM clinical management system

Using IS/IT to Support the Delivery of Chinese Medicine: The Design of a Chinese Medicine Clinic System

Using Information System/Information Technology (IS/IT) in Chinese Medicine (CM) has not been discussed much, if at all, in the literature. This is unlike the numerous references to the role for IS/IT to support various aspects of western medicine practice. Though the diagnosis and treatments between western medicine and CM are different, the clinical processes are similar. Thus, we believe that by implementing IS/IT system solutions, CM practice can also enjoy many benefits. CM practice relies on expert knowledge, hence applying knowledge management (KM) concepts to any proposed Chinese Medicine Clinic System (CMCS) is a necessary critical factor in the design of suitable IS/IT solutions in this context. This paper serves to identify a role for IS/IT in assisting CM clinic daily key processes as well as identify key system features and functions for a suitable CMCS

Genome maps across 26 human populations reveal population-specific patterns of structural variation.

Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in one experiment. Analyzing optical genome maps of 154 individuals from the 26 populations sequenced in the 1000 Genomes Project, we find that phylogenetic population patterns of large SVs are similar to those of single nucleotide variations in 86% of the human genome, while ~2% of the genome has high structural complexity. We are able to characterize SVs in many intractable regions of the genome, including segmental duplications and subtelomeric, pericentromeric, and acrocentric areas. In addition, we discover ~60 Mb of non-redundant genome content missing in the reference genome sequence assembly. Our results highlight the need for a comprehensive set of alternate haplotypes from different populations to represent SV patterns in the genome

Size effect on properties of varistors made from zinc oxide nanoparticles through low temperature spark plasma sintering

Conditions for the elaboration of nanostructured varistors by spark plasma sintering (SPS) are investigated, using 8-nm zinc oxide nanoparticles synthesized following an organometallic approach. A binary system constituted of zinc oxide and bismuth oxide nanoparticles is used for this purpose. It is synthesized at roomtemperature in an organic solution through the hydrolysis of dicyclohexylzinc and bismuth acetate precursors. Sintering of this material is performed by SPS at various temperatures and dwell times. The determination of the microstructure and the chemical composition of the as-prepared ceramics are based on scanning electron microscopy and X-ray diffraction analysis. The nonlinear electrical characteristics are evidenced by current–voltage measurements. The breakdown voltage of these nanostructured varistors strongly depends on grain sizes. The results show that nanostructured varistors are obtained by SPS at sintering temperatures ranging from 550 to 600 8C

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

Correction: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 96 Issue: 5 Pages: 852-852 DOI: 10.1016/j.ajhg.2015.04.001 Published:MAY 7 2015Peer reviewe

Author Correction: Discovery of 42 genome-wide significant loci associated with dyslexia

Correction to: Nature Genetics https://doi.org/10.1038/s41588-022-01192-y. Published online 20 October 2022. In the version of this article originally published, a paragraph was omitted in the Methods section, reading “Genomic control. Top SNPs are reported from the more conservative GWAS results adjusted for genomic control (Fig. 1, Extended Data Figs. 1–4, and Supplementary Tables 1, 2, 9 and 10), whereas downstream analyses (including gene-set analysis, enrichment and heritability partitioning, genetic correlations, polygenic prediction, candidate gene replication) are based on GWAS results without genomic control.” The paragraph has now been included in the HTML and PDF versions of the article