Benchmarking Diverse-Modal Entity Linking with Generative Models

Entities can be expressed in diverse formats, such as texts, images, or column names and cell values in tables. While existing entity linking (EL) models work well on per modality configuration, such as text-only EL, visual grounding, or schema linking, it is more challenging to design a unified model for diverse modality configurations. To bring various modality configurations together, we constructed a benchmark for diverse-modal EL (DMEL) from existing EL datasets, covering all three modalities including text, image, and table. To approach the DMEL task, we proposed a generative diverse-modal model (GDMM) following a multimodal-encoder-decoder paradigm. Pre-training \Model with rich corpora builds a solid foundation for DMEL without storing the entire KB for inference. Fine-tuning GDMM builds a stronger DMEL baseline, outperforming state-of-the-art task-specific EL models by 8.51 F1 score on average. Additionally, extensive error analyses are conducted to highlight the challenges of DMEL, facilitating future research on this task.Comment: 15 pages. ACL 202

Membership Determination of Open Cluster M48 Based on BATC Thirteen-Band Photometry

Beijing-Arizona-Taiwan-Connecticut (BATC) multi-band photometric data in the field of open cluster M48 are used to determine its membership. By comparing observed spectral energy distributions (SEDs) of stars with theoretical ones, membership probabilities of 750 stars with limiting magnitude of 15.0 in BATC $c$ band ($\lambda_{eff}=4194$ \AA) are determined. 323 stars with membership probabilities higher than 30% are considered as candidate members of M48. Comparing membership probabilities of 229 common stars obtained by the present method and the proper-motion based methods, a 80% agreement among these methods is obtained.Comment: 27 pages,7figures, accepted for publication in PAS

15 colour photometry of Landolt SA95 standard star field

In this paper, we present a set of photometric observations in 15 colors of stars in the Landolt covered by the system range from 300 nm to 1000 nm. Visual magnitudes of the stars being studied in the field are from 10th to 20th mag. The observational methodology and the data reduction procedures are described. The relationships between the BATC intermediate-band system and the Landolt UBVRI broad band system are obtained. A catalogue of the photometry has been produced which contains the SEDs of 3613 stars. The electronic form of this catalogue can be accessed at the CDS via anonymous ftp to cdsarc.u-strasbg.fr.Comment: 21 pages, accepted for publishing by A&

Heterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e-diary AllergyMonitor®

Background: Patient-generated symptom and medication scores are essential for diagnostic and therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different scores at population level in real-life data and trials. For clinicians, the evaluation of individual data quality over time is essential to decide whether to rely on these data in clinical decision-making. Objective: To analyze the consistency of different symptom (SS) and symptom medication scores (SMSs) at individual level in two study cohorts with different characteristics and explore individual patient trajectories over time. Methods: Within the pilot phase of the @IT.2020 project on diagnostic synergy of mobile health and molecular IgE assessment in patients with SAR, we analyzed data of 101 children and 93 adults with SAR and instructed them to record their symptoms and medication intake daily via the mobile app AllergyMonitor®. We then assessed the correlation between different SMS and a visual analogue scale (VAS) on the impact of allergy symptoms on daily life at population and individual level. Results: At population level, the Rhinoconjunctivitis total symptom score (RTSS) correlated better with VAS than the combined symptom and medication score (CSMS). At individual level, consistency among RTSS and VAS was highly heterogeneous and unrelated to disease severity or adherence to recording. Similar heterogeneity was observed for CSMS and VAS. Conclusions: The correlation of clinical information provided by different disease severity scores based on data collected via electronic diaries (e-diaries), is sufficient at population level, but broadly heterogeneous for individual patients. Consistency of the recorded data must be examined for each patient before remotely collected information is used for clinical decision making

Las representaciones sociales de los docentes, en relación con la incidencia de la enseñanza de idiomas extranjeros en la formación de grado universitario en el ámbito de la Facultad de Humanidades y Ciencias Sociales (FHyCS-UNaM). EIERS 2. 16H314

Es continuidad del Proyecto EIERS (16H-254); continuando con el diseño de investigación exploratoria, cuali-cuantitativo, que tiene por objeto relevar las representaciones sociales de los docentes de la FHyCS-UNaM sobre el valor otorgado a la inclusión del aprendizaje de idiomas extranjeros en la formación académica de grado y contrastarlos con las prácticas académicas (programas de cátedras, producciones didácticas e Informes de Investigación, de Avance y Finales, producidos por los docentes de las carreras de grado en estudio y con el Informe Final del proyecto EIERS). La finalidad será construir un corpus crítico entre lo relevado en los discursos y lo que se hace en la praxis en cuanto a la incorporación de la lengua extranjera en los procesos de enseñanzaaprendizaje en la formación de estudiantes universitarios de las carreras de grado de la FHyCSUNaM. Con este proceso de indagación se busca disponer de conocimiento, analizado a partir de datos primarios y fuentes secundarias, para construir criterios de análisis que posibiliten desarrollar acciones críticas sobre el quehacer en la formación universitaria de grado en relación a la adquisición de competencias lingüísticas que posibiliten el acceso a la producción científico académica que se realiza en otros idiomas. En esta segunda etapa el equipo de investigadores se propone explorar la percepción que tienen los docentes sobre los aprendizajes instrumentales de lenguas extranjeras y la valoración que realizan acerca del impacto de estos conocimientos en la habilitación académica de los estudiantes en su formación de grado universitario; como así también en la continuidad de las carreras de postgrado y / en su desarrollo profesional. El análisis de las RSd sobre la importancia de los IE en su formación de grado, brindará información acerca de los modos en que el docente construye el espacio disciplinar en que está inmerso a fin de trazar nuevas y más complejas redes conceptuales, redimensionando sus prácticas áulicas Resumen técnico: Es continuidad del Proyecto EIERS (16H-254); continuando con el diseño de investigación exploratoria, cuali-cuantitativo, que tiene por objeto relevar las representaciones sociales de los docentes de la FHyCS-UNaM sobre el valor otorgado a la inclusión del aprendizaje de idiomas extranjeros en la formación académica de grado y contrastarlos con las prácticas académicas (programas de cátedras, producciones didácticas e Informes de Investigación, de Avance y Finales, producidos por los docentes de las carreras de grado en estudio y con el Informe Final del proyecto EIERS). La finalidad será construir un corpus crítico entre lo relevado en los discursos y lo que se hace en la praxis en cuanto a la incorporación de la lengua extranjera en los procesos de enseñanzaaprendizaje en la formación de estudiantes universitarios de las carreras de grado de la FHyCSUNaM. Con este proceso de indagación se busca disponer de conocimiento, analizado a partir de datos primarios y fuentes secundarias, para construir criterios de análisis que posibiliten desarrollar acciones críticas sobre el quehacer en la formación universitaria de grado en relación a la UNaM – FHCS – SinvyP Gsinvyp03 adquisición de competencias lingüísticas que posibiliten el acceso a la producción científico académica que se realiza en otros idiomas

Very Low-Mass Stellar and Substellar Companions to Solar-Like Stars from MARVELS I: A Low Mass Ratio Stellar Companion to TYC 4110-01037-1 in a 79-day Orbit

TYC 4110-01037-1 has a low-mass stellar companion, whose small mass ratio and short orbital period are atypical amongst solar-like (Teff ~< 6000 K) binary systems. Our analysis of TYC 4110-01037-1 reveals it to be a moderately aged (~<5 Gyr) solar-like star having a mass of 1.07 +/- 0.08 MSun and radius of 0.99 +/- 0.18 RSun. We analyze 32 radial velocity measurements from the SDSS-III MARVELS survey as well as 6 supporting radial velocity measurements from the SARG spectrograph on the 3.6m TNG telescope obtained over a period of ~2 years. The best Keplerian orbital fit parameters were found to have a period of 78.994 +/- 0.012 days, an eccentricity of 0.1095 +/- 0.0023, and a semi-amplitude of 4199 +/- 11 m/s. We determine the minimum companion mass (if sin i = 1) to be 97.7 +/- 5.8 MJup. The system's companion to host star mass ratio, >0.087 +/- 0.003, places it at the lowest end of observed values for short period stellar companions to solar-like (Teff ~< 6000 K) stars. One possible way to create such a system would be if a triple-component stellar multiple broke up into a short period, low q binary during the cluster dispersal phase of its lifetime. A candidate tertiary body has been identified in the system via single-epoch, high contrast imagery. If this object is confirmed to be co-moving, we estimate it would be a dM4 star. We present these results in the context of our larger-scale effort to constrain the statistics of low mass stellar and brown dwarf companions to FGK-type stars via the MARVELS survey.Comment: 22 pages; accepted in A

Autism as a disorder of neural information processing: directions for research and targets for therapy

The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale

In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is however critical both for basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brain-wide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brain-wide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open access data repository; compatibility with existing resources, and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.Comment: 41 page

Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population

<p>Abstract</p> <p>Background</p> <p>It is known that steroid usage and alcohol abuse are major etiological factors in the development of avascular necrosis (AVN), a bone disease that produces osteonecrosis of the femoral head. The facilitation of fat biosynthesis by steroids and alcohol disrupts the blood supply into the femoral head. <it>SREBP-2 </it>plays a central role in the maintenance of lipid homeostasis through stimulating expression of genes associated with cholesterol biosynthetic pathways. The aim of this study was to examine the association between the polymorphisms of the <it>SREBP-2 </it>gene and AVN susceptibility in the Korean population.</p> <p>Methods</p> <p>Four single nucleotide polymorphisms (SNP) in the <it>SREBP-2 </it>gene, IVS1+8408 T>C (rs2267439), IVS3-342 G>T (rs2269657), IVS11+414 G>A (rs1052717) and IVS12-1667 G>A (rs2267443), were selected from public databases and genotyped in 443 AVN patients and 273 control subjects by using single-based extension (SBE) genotyping.</p> <p>Results</p> <p>The minor allele (C) frequency of rs2267439 showed a significant protective effect on AVN (P = 0.01, OR; 0.75, 95% CI; 0.604–0.935), and the genotype frequencies of this polymorphism were also different from the controls in all alternative analysis models (P range, 0.009–0.03, OR; 0.647–0.744). In contrast, rs1052717 and rs2267443 polymorphisms were significantly associated with AVN risk. Further analysis based on pathological etiology showed that the genotypes of rs2267439, rs1052717 and rs2267443 were also significantly associated with AVN susceptibility in each subgroup.</p> <p>Conclusion</p> <p>This study is the first report to evaluate the association between <it>SREBP-2 </it>gene polymorphisms and the susceptibility of AVN in the Korean population.</p