Algunos ejemplos de relación entre agregación, capacidad de infiltración y erosión en suelos mediterráneos

[Resumen] Este trabajo tiene por objeto evaluar la influencia de la agregación sobre la capacidad de infiltración y la tendencia a la erosión de suelos mediterráneos sobre litología caliza. Se identifican algunas variables de agregación que influyen de una manera importante en la infiltración y la erosión, aunque es en combinación con otras características del suelo cuando estas variables explican mejor dichos parámetros. Se consiguen una serie de modelos de ecuaciones de regresión múltiple basadas en variables indicadoras de la agregación de los suelos y otras características (cobertura vegetal, materia orgánica, pedregosidad y humedad del suelo) que explican bastante bien la capacidad de infiltración, la concentración de sedimentos y la erosión de los suelos en las zonas de estudio.[Abstract] The objective of this work is to evaluate the influence of soil aggregation on soil infiltration capacity and erosion in mediterranean soils developed on limestones. Sorne key-variables related to soil aggregation which play an important role on soil infiltration capacity and erosion are identified. Especially the combination of these variables with other soil characterisitics give the most satisfactory results explaining soil infiltration and erosiono Sorne models of multiple regression equations based in variables related to aggregation and other soil characteristics (vegetation cover, organic matter, stoniness and soil moisture) are obtained. They explain quite well the infiltration capacity, the sediment concentration and the erosion in the study zones

Influencia de la estructura y usos del suelo en las características de retención hídrica de suelos mediterráneos sobre litología caliza

[Resumen] Se investigan las diferencias entre la capacidad de retención hídrica de suelos mediterráneos sobre litología caliza sometidos a diferentes usos: incendiados y bajo pastoreo intensivo. En estos mismos suelos se valoran las relaciones entre estructura del suelo y capacidad de retención hídrica a diversos puntos de la curva de retención. Agregados de pequeño tamaño y materia orgánica influyen positivamente y de manera considerable en la capacidad de retención en casi todos los puntos de la curva de retención determinados. Agregados de gran tamaño y microagregados estables en agua influyen negativamente. La combinación de agregados de tamaño 1-0,105 mm y el contenido en materia orgánica predicen bastante bien la capacidad de retención a niveles bajos de succión (pF 0,4 YpF 1).[Abstract] The differences between the water holding capacity of Mediterranean soils developed on limestones and under different land uses (burnt and overgrazed soils) are investigated. The relationships between soil structure and soil moisture characteristic at different levels of the water retention curve in these same soils are evaluated. Organic matter and small sized aggregates are positively related to the water holding capacity. Large sized aggregates and waterstable microaggregates are negatively related to the water holding capacity of the soils. The combination of aggregates at 1-0,105 mm and organic matter content predict quite well the water retention capacity at lower suction levels (pF 0,4 and pF 1)

Morfología de vertientes y neotectónica en el Macizo de Javalambre (provincia de Teruel)

[Resumen] El modelado actual de las vertientes del macizo de Javalambre es consecuencia de tres tipos principales de procesos que actúan a partir de su elevación a comienzos del Plioceno -superior: (a) la dinámica periglaciar, (b) una etapa de activida~ tect6nica ocurrida hacia el Pleistoceno medio-superior, y (c) deslizamientos gravitacionales, translacionales y rotacionales producidos a favor de un sustrato plástico en las áreas de mayor incisión de la red -fluvial.Abstract] The present slope form in Javalambre area results from three principal types of processes which are active after its elevation in the early Upper Pliocene: (a) periglacial dynamics, (b) a tectonic phase in Middle-Upper Pleistocene, and (c) gravitational, translational and rotational landslides generated over plastic rocks in zones with a intensive fluvial incisio

Simulation Approach for Timing Analysis of Genetic Logic Circuits

Constructing genetic logic circuits is an application of synthetic biology in which parts of the DNA of a living cell are engineered to perform a dedicated Boolean function triggered by an appropriate concentration of certain proteins or by different genetic components. These logic circuits work in a manner similar to electronic logic circuits, but they are much more stochastic and hence much harder to characterize. In this article, we introduce an approach to analyze the threshold value and timing of genetic logic circuits. We show how this approach can be used to analyze the timing behavior of single and cascaded genetic logic circuits. We further analyze the timing sensitivity of circuits by varying the degradation rates and concentrations. Our approach can be used not only to characterize the timing behavior but also to analyze the timing constraints of cascaded genetic logic circuits, a capability that we believe will be important for design automation in synthetic biology

Leveraging Hardware QoS to Control Contention in the Xilinx Zynq UltraScale+ MPSoC

The interference co-running tasks generate on each other’s timing behavior continues to be one of the main challenges to be addressed before Multi-Processor System-on-Chip (MPSoCs) are fully embraced in critical systems like those deployed in avionics and automotive domains. Modern MPSoCs like the Xilinx Zynq UltraScale+ incorporate hardware Quality of Service (QoS) mechanisms that can help controlling contention among tasks. Given the distributed nature of modern MPSoCs, the route a request follows from its source (usually a compute element like a CPU) to its target (usually a memory) crosses several QoS points, each one potentially implementing a different QoS mechanism. Mastering QoS mechanisms individually, as well as their combined operation, is pivotal to obtain the expected benefits from the QoS support. In this work, we perform, to our knowledge, the first qualitative and quantitative analysis of the distributed QoS mechanisms in the Xilinx UltraScale+ MPSoC. We empirically derive QoS information not covered by the technical documentation, and show limitations and benefits of the available QoS support. To that end, we use a case study building on neural network kernels commonly used in autonomous systems in different real-time domains.This work has been partially supported by the Spanish Ministry of Science and Innovation under grant PID2019-107255GB; the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 878752 (MASTECS) and the European Research Council (ERC) grant agreement No. 772773 (SuPerCom).Peer ReviewedPostprint (published version

Evaluation of clinical and antidiabetic treatment characteristics of different sub-groups of patients with type 2 diabetes : Data from a Mediterranean population database

Altres ajuts: Institut Universitari d'Investigació en Atenció Primària Jordi GolAltres ajuts: MSD Spain 4R16/062-1Aims: To describe the characteristics and antidiabetic treatment among type 2 diabetes patients according to the clinical conditions prioritized in the Spanish 2020 RedGDPS (Primary Care Diabetes Study Groups Network) therapeutic algorithm: obesity, older than 75 years, chronic kidney disease, cardiovascular disease, and heart failure. Methods: Retrospective, cross-sectional study. Clinical characteristics, the use of antidiabetic drugs and the KDIGO renal risk categories at 31.12.2016 were retrieved from the SIDIAP (Information System for Research in Primary Care) database (Catalonia, Spain). Results: From a total of 373,185 type 2 diabetes patients, 37% were older than 75 years, 45% obese, 33% had chronic kidney disease, 23.2% cardiovascular disease and 6.9% heart failure. Insulin was more frequently prescribed in chronic kidney disease, cardiovascular disease and heart failure whereas Sodium-Glucose cotransporter 2 inhibitors and Glucagon Like Peptide 1 receptor agonists were scarcely prescribed (2.6% and 1.4%, respectively). Among patients with severe renal failure, contraindicated drugs like metformin (16%) and sulfonylureas (6.1%) were still in use. The 2012 KDIGO renal risk categories distribution was: Low: 60.9%, Moderate: 21.6%, High: 9.8% and Very high: 7.7%. Conclusions: Almost 80% of our T2DM patients meet one of the five clinical conditions that should be considered for treatment individualization. Importantly, a relevant number of patients with severe renal failure were found to use contraindicated drugs

Formation of Pyrazol-1,3,4-Thiadiazoles through 1,3-Dipolar Cycloadditions of 3-Thioxo-[1,2,4]-Triazepin-5-one with Nitrilimines: An Experimental and Computational study

In this work the results of experimental and computational study of the title compounds and some ancillary compounds are reported. Two bicyclic pyrazol-1,3,4-thiadiazole derivatives were synthesized by reaction between 6-dimethylaminomethylene-3-thioxo-[1,2,4]- triazepin-5-one 1 and several nitrilimines 2a-f to give corresponding spirocycloadducts 3a-f, which undergo a rapid rearrangement leading to the new bicyclic compounds, 4a-f and 5a-f. These obtained bicyclic products were characterized by 1H and 13C NMR spectroscopy and finally by X-ray crystallography. Theoretical calculations have been carried out using DFT methods to rationalize the formation of the two new bicyclic compounds. Two reaction types are involved in the formation of the compounds 4a-f and 5a-f. The first one is a 1,3-dipolar cycloaddition reaction between 1 acting as dipolarophile and 2a-f as dipoles. The results indicate that the cycloaddition between 1 and 2g, as model of 2a-c, takes place via a high asynchronous bond-formation process. The regioselectivity obtained from the calculations is in complete agreement with the formation of the unique spirocycloadducts 3a-f. The second reaction leading to the formation of the final products is a domino process that is initiated by the quick and irreversible cleavage in a catalytic acid environment of triazepenic ring

Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia

Objectives: To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes. Design: Prospective observational cohort study. Setting: General population from a semi-rural area. Participants: The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014. Results: The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to <6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931). Conclusions: Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass inde

Analysis of the Adherence and Safety of Second Oral Glucose-Lowering Therapy in Routine Practice From the Mediterranean Area : A Retrospective Cohort Study

Altres ajuts: AstraZeneca/ESR-16-12628Altres ajuts: Applied Research Collaboration East Midlands (ARC EM)Altres ajuts: National Institute for Health Research (NIHR)Altres ajuts: Imperial Biomedical Research Centre (NIHR)The aims of our study was compare adherence measured by the medical possession ratio (MPR), time until discontinuation and describe adverse events after adding a DPP-4i, SGLT-2i, or sulfonylureas (SU) to metformin in a primary care population with insufficient glycemic control. We used routinely-collected health data from the SIDIAP database. The included subjects were matched by propensity score. The follow-up period was up to 24 months or premature discontinuation. The primary outcomes were the percentage of subjects with good adherence, treatment discontinuation and adverse events among treatment groups. The proportion of patients with good adherence (MPR> 0.8) after the addition of DPP-4i, SGLT-2i or SU was 53.6%, 68.7%, and 43.0%, respectively. SGLT-2i users were 1.7 times more likely to achieve good adherence compared with DPP-4i users (odds ratio [OR]:1.72, 98% confidence interval [CI]:1.51, 1.96), and 2.8 times more likely compared with SU users (OR: 0.35, 98% CI: 0.07, 0.29). The discontinuation hazard ratios were 1.43 (98%CI: 1.26; 1.62) and 1.60 (98%CI: 1.42; 1.81) times higher among SGLT-2i and SU users than DPP-4i users during the follow-up period. No differences were observed for adverse events among the treatment groups. In conclusion, in our real-world setting, the combination of SGLT-2i with metformin was associated with better adherence. The mean time until discontinuation was longer in the SGLT-2i group in comparison with the DPP-4i or SU groups

Prevalence and risk factors of diabetic foot disease among the people with type 2 diabetes using real-world practice data from Catalonia during 2018

Altres ajuts: 8a Convocatòria d'Ajuts a projectes de Institut Català de la Salut with SIDIAP (financing code 4R18/187-1 and file number SIDIAP-18/7).Background: Our study aimed to assess the prevalence of diabetic foot disease (DFD) and its associated risk factors among subjects attending primary care centers in Catalonia (Spain). Methods: We undertook a cross-sectional analysis of data from the primary health care (SIDIAP) database. The presence of comorbidities and concomitant medication were analyzed for subjects with or without DFD. DFD prevalence was estimated from 1st January 2018 to 31st December 2018. Results: During the 12-month observational period, out of 394,266 people with type 2 diabetes, we identified 3,277 (0.83%) active episodes of DFD in the database. The majority of these episodes were foot ulcers (82%). The mean age of patients with DFD was 70.3 (± 12.5) years and 55% were male. In the multivariable descriptive models, male gender, diabetes duration, hypertension, macrovascular, microvascular complications, and insulin and antiplatelet agents were strongly associated with DFD. A previous history of DFD was the stronger risk factor for DFD occurrence in subjects with T2DM (OR: 13.19, 95%CI: 11.81; 14.72). Conclusions: In this real-world primary care practice database, we found a lower prevalence of DFD compared to similar previous studies. Risk factors such as male sex, duration of diabetes, diabetes complications and previous history of DFD were associated with the presence of DFD