Central-to-peripheral nuclear modification factors in Pb-Pb collisions at sqrt{s_NN} = 17.3 GeV

We present central-to-peripheral nuclear modification factors, R_CP, for the p_T distributions of K^0_S, Lambda, Anti-Lambda, and negatively charged particles, measured at central rapidity in Pb-Pb collisions at top SPS energy. The data cover the 55% most central fraction of the inelastic cross section. The K^0_S and Lambda R_CP(p_T) are similar in shape to those measured at sqrt{s_NN} = 200 GeV at RHIC, though they are larger in absolute value. We have compared our K^0_S R_CP data to a theoretical calculation. The prediction overestimates the data at p_T \approx 3-4 GeV/c, unless sizeable parton energy loss is included in the calculation.Comment: 13 pages, 5 figures, submitted to Physics Letters

Further description of the petrology of the Topopah Spring member of the paintbrush tuff in drill holes UE25A-1 and USW-G1 and of the lithic-rich tuff in USW-G1, Yucca Mountain, Nevada

The Topopah Spring Member of the Paintbrush Tuff and the Lithic-rich tuff and two Tertiary volcanic units that occur in cores from drill holes UE25a-1 and USW-G1 at Yucca Mountain, Nevada. Recently they have been suggested as possibly suitable for the permanent storage of high-level radioactive waste. Earlier petrologic characterization of these units is augmented here. The Topopah Spring Member (approximately 350 m thick) has two compound cooling units. The upper, thinner unit is densely welded to vitrophyric. The lower unit ranges from nonwelded to vitrophyric, and its nonwelded base is extensively zeolitized to clinoptilolite and mordenite. Heulandite occurs as fracture fill in the overlying vitrophyric part, but zeolites are absent above that vitrophyre. Here primary devitrification plus vapor-phase crystallization dominate the mineralogy. Vapor-phase effects are especially prominent between the two vitrophyres in both cores and include numerous large lithophysal cavities throughout most of this moderately to densely welded tuff. The Lithic-rich tuff extends from 1203 to 1506 m in the USW-G1 drill core. It is nonwelded to partly welded but is well indurated due to pervasive intergrowths of authigenic minerals. These phases are analcime, albite, alkali feldspar, sericite, chlorite and quartz. The transition from analcime to secondary albite corresponds to Iijima`s zeolite Zone IV boundary, and this boundary appears in USW-G1 at 1326 m. However, analcime remains as a prominent phase through most of the Lithic-rich tuff. Further work is necessary to assess the suitability of either of these horizons for a waste repository. In the Topopah Spring Member, both mechanical and hydrologic properties of thick lithophysal zone must be studied, as well as the complete sequence of fracture fill. For both units, zeolite and clay mineral stabilities need to be investigated

Retinal Structure and Function in Achromatopsia : Implications for Gene Therapy

Purpose: To characterize retinal structure and function in achromatopsia (ACHM) in preparation for clinical trials of gene therapy. Design: Cross-sectional study. Participants: Forty subjects with ACHM. Methods: All subjects underwent spectral domain optical coherence tomography (SD-OCT), microperimetry, and molecular genetic testing. Foveal structure on SD-OCT was graded into 5 distinct categories: (1) continuous inner segment ellipsoid (ISe), (2) ISe disruption, (3) ISe absence, (4) presence of a hyporeflective zone (HRZ), and (5) outer retinal atrophy including retinal pigment epithelial loss. Foveal and outer nuclear layer (ONL) thickness was measured and presence of hypoplasia determined. Main Outcome Measures: Photoreceptor appearance on SD-OCT imaging, foveal and ONL thickness, presence of foveal hypoplasia, retinal sensitivity and fixation stability, and association of these parameters with age and genotype. Results: Forty subjects with a mean age of 24.9 years (range, 6e52 years) were included. Disease-causing variants were found in CNGA3 (n [ 18), CNGB3 (n ¼ 15), GNAT2 (n ¼ 4), and PDE6C (n ¼ 1). No variants were found in 2 individuals. In all, 22.5% of subjects had a continuous ISe layer at the fovea, 27.5% had ISe disruption, 20% had an absent ISe layer, 22.5% had an HRZ, and 7.5% had outer retinal atrophy. No significant differences in age (P ¼ 0.77), mean retinal sensitivity (P ¼ 0.21), or fixation stability (P ¼ 0.34) across the 5 SD-OCT categories were evident. No correlation was found between age and foveal thickness (P ¼ 0.84) or between age and foveal ONL thickness (P ¼ 0.12). Conclusions: The lack of a clear association of disruption of retinal structure or function in ACHM with age suggests that the window of opportunity for intervention by gene therapy is wider in some individuals than previously indicated. Therefore, the potential benefit for a given subject is likely to be better predicted by specific measurement of photoreceptor structure rather than simply by age. The ability to directly assess cone photoreceptor preservation with SD-OCT and/or adaptive optics imaging is likely to prove invaluable in selecting subjects for future trials and measuring the trials’ impact