11 research outputs found
Synergistic action of thermophilic pectinases for pectin bioconversion into D-galacturonic acid
- Publication venue
- 'Elsevier BV'
- Publication date
- 02/06/2022
- Field of study
Large amounts of pectin-rich biomass are generated worldwide yearly, which can be hydrolysed by pectinases to obtain bio-based chemical building blocks such as D-galacturonic acid (GalA). The aim of this work was to investigate thermophilic pectinases and explore their synergistic application in the bioconversion of pectic substrates into GalA. Two exo-polygalacturonases (exo-PGs) from Thermotoga maritima (TMA01) and Bacillus licheniformis (BLI04) and two pectin methylesterases (PMEs) from Bacillus licheniformis (BLI09) and Streptomyces ambofaciens (SAM10) were cloned and expressed in Escherichia coli BL21 (DE3), purified and fully characterised. These pectinases exhibited optimum activity at temperatures above 50 °C and good stability at high temperature (40-90 °C) for up to 24 h. Exo-PGs preferred non-methylated substrates, suggesting that previous pectin demethylation by PMEs was necessary to achieve an efficient pectin monomerisation into GalA. Synergistic activity between PMEs and exo-PGs was tested using pectin from apple, citrus and sugar beet. GalA was obtained from apple and citrus pectin in a concentration of up to 2.5 mM after 4 h reaction at 50 °C, through the combined action of BLI09 PME with either TMA01 or BLI04 exo-PGs. Overall, this work contributes to expand the knowledge of pectinases from thermophiles and provides further insights into their application in the initial valorisation of sustainable pectin-rich biomass feedstocks
Co-expression of thermophilic pectinases in a single host for cost-effective pectin bioconversion into D-galacturonic acid
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 16/02/2023
- Field of study
Co-expression of enzymes allow to produce multiple enzymes in a single host, representing a cost-effective alternative in biocatalytic processes which can be used for pectin bioconversion. Pectin-rich biomass is an abundant by-product from the fruit and sugar industries that is usually disposed in landfill or sold as a low value feedstock. The aim of this work was to co-express a thermophilic pectin methyl esterase (PME) and exo-polygalacturonases (exo-PGs) in a single host for pectin bioconversion into D-galacturonic acid (GalA) using different pectic substrates such as apple, citrus and sugar beet pectin. To achieve this, a PME from Bacillus licheniformis (BLI09) with either an exo-PG from Thermotoga maritima (TMA01) or from Bacillus licheniformis (BLI04) were cloned in pETDuet-1 and co-expressed in E. coli BL21 (DE3). Four co-expression plasmids containing both pectinases were constructed and factors such as the effect of the genesâ cloning order and their expression were evaluated. Co-expression constructs 3 and 4 (pETDuet-TMA01-BLI09 and pETDuet-BLI04-BLI09, respectively) showed better expression of both pectinases compared to co-expression constructs 1 and 2 (pETDuet-BLI09-TMA01 and pETDuet-BLI09-BLI04, respectively). Co-expression constructs 3 and 4 were the most efficient for pectin bioconversion into GalA reaching 3 and 2.5 mM GalA, respectively from apple and citrus pectin after 4 h reaction. In conclusion, this work demonstrates that the co-expression of pectinases can potentially contribute to reduce the cost associated to their production and purification as well as to increase their applicability for exploiting pectin-rich biomass to obtain bio-based chemicals
Characterization of a Type II L-Asparaginase from the Halotolerant <i>Bacillus subtilis</i> CH11
- Author
- Publication venue
- MDPI AG
- Publication date
- 01/10/2023
- Field of study
L-asparaginases from bacterial sources have been used in antineoplastic treatments and the food industry. A type II L-asparaginase encoded by the N-truncated gene ansZP21 of halotolerant Bacillus subtilis CH11 isolated from Chilca salterns in Peru was expressed using a heterologous system in Escherichia coli BL21 (DE3)pLysS. The recombinant protein was purified using one-step nickel affinity chromatography and exhibited an activity of 234.38 U mgâ1 and a maximum catalytic activity at pH 9.0 and 60 °C. The enzyme showed a homotetrameric form with an estimated molecular weight of 155 kDa through gel filtration chromatography. The enzyme half-life at 60 °C was 3 h 48 min, and L-asparaginase retained 50% of its initial activity for 24 h at 37 °C. The activity was considerably enhanced by KCl, CaCl2, MgCl2, mercaptoethanol, and DL-dithiothreitol (p-value Vmax and Km were 145.2 ”mol mLâ1 minâ1 and 4.75 mM, respectively. These findings evidence a promising novel type II L-asparaginase for future industrial applications
Novel extremophilic proteases from Pseudomonas aeruginosa M211 and their application in the hydrolysis of dried distiller's grain with solubles
- Author
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Proteases are the most important group of industrial enzymes and they can be used in several fields including biorefineries for the valorization of industrial byproducts. In this study, we purified and characterized novel extremophilic proteases produced by a Pseudomonas aeruginosa strain isolated from Mauritia flexuosa palm swamps soil samples in Peruvian Amazon. In addition, we tested their ability to hydrolyze distillers dried grains with solubles (DDGS) protein. Three alkaline and thermophilic serine proteases named EI, EII, and EIII with molecular weight of 35, 40, and 55âkDa, respectively, were purified. EI and EIII were strongly inhibited by EDTA and Pefabloc being classified as serineâmetalloproteases, while EII was completely inhibited only by Pefabloc being classified as a serine protease. In addition, EI and EII exhibited highest enzymatic activity at pH 8, while EIII at pHâ11 maintaining almost 100% of it at pHâ12. All the enzymes demonstrated optimum activity at 60°C. Enzymatic activity of EI was strongly stimulated in presence of Mn2+ (6.9âfold), EII was stimulated by Mn2+ (3.7âfold), while EIII was slightly stimulated by Zn2+, Ca2+, and Mg2+. DDGS protein hydrolysis using purified Pseudomonas aeruginosa M211 proteases demonstrated that, based on glycine released, EIII presented the highest proteolytic activity toward DDGS. This enzyme enabled the release 63% of the total glycine content in wheat DDGS protein, 2.2âfold higher that when using the commercial PronaseÂź. Overall, our results indicate that this novel extremopreoteases have a great potential to be applied in DDGS hydrolysis
Specimen collection is essential for modern science
- Author
- A Townsend Peterson
- Aaron M. Bauer
- Adam D. Leaché
- Adam P. Summers
- Alejandro Rico-Guevara
- Alison R. Davis Rabosky
- Allison J. Shultz
- Allison W. Bronson
- Amir Hamidy
- Anang Achmadi
- Angela D. Hornsby
- Awal Riyanto
- Bradford D. Hollingsworth
- Brian Sidlauskas
- Bruce D. Patterson
- Bryan L. Stuart
- Caleb D. McMahan
- Carla Cicero
- Carlos Daniel Cadena
- Carol L. Spencer
- Chan Kin Onn
- Chris J. Conroy
- Christopher C. Austin
- Christopher H. Martin
- Christopher J. Raxworthy
- Christopher Witt
- Cody W. Thompson
- Daniel L. Rabosky
- David C. Cannatella
- David M. Hillis
- David Salazar-Valenzuela
- Derek S. Sikes
- Drew R. Davis
- Eileen A. Lacey
- Eli Greenbaum
- Elizabeth A. Wommack
- Elizabeth J. Beckman
- Enrique P. Lessa
- F Keith Barker
- Frank T. Burbrink
- Gabriela Parra-Olea
- Gary Voelker
- George F. Barrowclough
- Gregory B. Pauly
- Guillermo DâElĂa
- Harry W. Greene
- HernĂĄn LĂłpez-FernĂĄndez
- Ian J. Wang
- Jacob A. Esselstyn
- Jairo Arroyave
- James Hanken
- James L. Patton
- Jeffrey M. Good
- Jeffrey W. Streicher
- Jeremy J. Kirchman
- Jimmy A. McGuire
- Jocelyn P. Colella
- Jodi Rowley
- Joel L. Cracraft
- John Bates
- John E. McCormack
- John P. Dumbacher
- Jon FjeldsÄ
- Jonathan L. Dunnum
- Jose Tavera
- Joseph A. Cook
- JuliĂĄn Faivovich
- JĂ©rĂŽme Fuchs
- Kassandra Ford
- Kayce C. Bell
- Kevin C. Rowe
- Kevin J. Burns
- Kevin Winker
- Lawrence R. Heaney
- Leo Joseph
- Link E. Olson
- Lisa N. Barrow
- Luiz A. Rocha
- Lynne R. Parenti
- Marvalee H. Wake
- Matthew K. Fujita
- Melanie L. J. Stiassny
- Melissa TR Hawkins
- Michael J. Andersen
- Michael W. Nachman
- Michelle S. Koo
- Mohammad Irham
- Nancy B. Simmons
- Nicholas A. Mason
- Omar Torres-Carvajal
- Oscar A. Flores-Villela
- Pablo Teta
- Peter A. Hosner
- Prosanta Chakrabarty
- Rafe M. Brown
- Rauri CK Bowie
- Rayna C. Bell
- Rebecca D. Tarvin
- Ricardo A. Ojeda
- Robert Dudley
- Robert G. Moyle
- Robert M. Timm
- Robert M. Zink
- Robert S. Voss
- Rosa Alicia Jiménez
- Santiago R. Ron
- Sara Ruane
- Scott V. Edwards
- Sean M. Rovito
- Sergio Ticul Ălvarez-Castañeda
- Shannon Hackett
- Sharon Jansa
- Silvia E. Pavan
- Steven Poe
- Sushma Reddy
- Todd A. Castoe
- Travis J. LaDuc
- Tri Haryoko
- Tyrone B. Hayes
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/11/2023
- Field of study
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- AgĂŒero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Jaâafreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
- Albrecht W
- Aldridge J
- Alexander P
- Alfonso J
- Alhousani TN
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Aliberti S
- ALjalamdeh M
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allen U
- Allibone S
- Allison KS
- Allouzy SK
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almoguera B
- Alpuche-Aranda C
- AlRawashdeh TJ
- Alsafadi DB
- Alshaer W
- Alsoub FS
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alzuraiqi MR
- Amamio M
- Aman NF
- Amin V
- Amiya S
- Ampuero J
- Anan R
- Anastasescu E
- Andersen S
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andrade V
- Andreou P
- Andreu-Bernabeu Ă
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrews S
- Andrews SJ
- Angelini C
- Ansari AI
- Antcliffe D
- Antoine P
- Antony S
- Anumakonda V
- Anwer M
- Anzai T
- Apetri E
- Aquino M
- Aquino-GĂĄlvez A
- Arai D
- Arakelyan A
- Arana-Arri E
- Arana-Arri E
- Arango C
- Aravindan L
- Arbane G
- Archer K
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armistead J
- Armstrong D
- Armstrong J
- Armstrong L
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- Arning N
- Arnoldo S
- Arnott A
- Arora J
- Arora M
- Arranz MJ
- Arranz MJ
- Arribas-Rodriguez E
- Artiga M-J
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Asimakopoulos A
- Aslibekyan S
- Asselta R
- Astin-Chamberlain R
- Atayeva N
- Athanasiou L
- Atkinson EG
- Attwood B
- Atwal I
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Avetyan D
- Awano N
- Awasthi S
- Ayers A
- Ayo NI
- Ayuso C
- Aziz F
- Aziz N
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bacher P
- Badal B
- Badalamenti S
- Baddeley A
- Badia JR
- Badji RM
- Bafitis V
- Bahmer T
- Baikady RR
- Bailey L
- Baillie JK
- Baines D
- Baines K
- Baird T
- Baird Y
- Baker M
- Bakthavatsalam D
- Balaconis MK
- Baldini M
- Balla D
- Bals R
- Bamford A
- Bamford A
- Bamford P
- Banach D
- Banales JM
- Banasik K
- Banasik K
- Bancroft H
- Band G
- Bandera A
- Bandla N
- Bani younis FM
- Bano S
- Baptista D
- Baptista-Rosas RC
- Barber R
- Barberena-Jonas C
- Barberis L
- Barclay C
- Barclay L
- Barker J
- Barker M
- Barnes KC
- Barnes N
- Barnetche JM
- Barr J
- Barreda-SĂĄnchez M
- Barreira A
- Barretina J
- Barretina J
- Barrett F
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- Beadle J
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- Beger SD
- Begg C
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- Bellelli G
- Bellinghausen C
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- Below JE
- Bemand T
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- Blow S
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- Blunt M
- Boada M
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- Bocciolone M
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- Bourgeron T
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- Bouysran Y
- Bowes A
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- Busson A
- Bustos M
- Butcher D
- Buti M
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- Butler J
- Butler S
- Butler-Laporte G
- Butler-Laporte G
- Butt F
- Butte MJ
- Butte MJ
- Butterworth-Cowin N
- Button H
- Buttriss C
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- Cabral-Ortega L
- Cabrelli L
- Cabrero DG
- Cadenas IF
- Cadilla CL
- Cagova L
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- Carracedo Ă
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- Castaño-Vinyals G
- Castelao JE
- Castillejos-LĂłpez M
- Castoldi M
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- Caulfield MJ
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- Cavazza A
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- Ceballos FC
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- Cejudo TG
- Ceriotti F
- Cerpa LC
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- Chablani M
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- Cheung AM
- Cheyne C
- Chiba S
- Chihara Y
- Chikowore P
- Childs D
- Chiquete E
- Chirino-PĂ©rez A
- Chirouze C
- Chisholm C
- Chiu A
- Choe K-W
- Choudhr O
- Choudhury Y
- Chowdhary S
- Christaki E
- Christian MA
- Chubachi S
- Chueca N
- Chuhan NT
- Chukkambotla S
- Chung M
- Churchhouse C
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- ChwiaĆkowska K
- ChĂĄvez-Alderete J
- ChĂĄvez-Manzanera E
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- Cirulli ET
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- Claire D-R
- Clamp S
- Clapham M
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- Clausen M
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- Clement I
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- Cruz-Bautista I
- Cruz-Cruz AD
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- Cuerda VM
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- Daya M
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- De Cid R
- De Cid R
- De Felipe Mimbrera A
- De Gordoa LO-R
- De Heredia ML
- De JesĂșs Carrera GarcĂa K
- De JesĂșs SuĂĄrez LĂłpez J
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- Travers J
- Tregouet D-A
- Trembath RC
- Tremblay K
- Treus E
- Tridente A
- Trim F
- Trivedi B
- Trodd D
- Trotman S
- Trott S
- Trower H
- Truman N
- Trumper E
- Tse SM
- Tsechoeva T
- Tselios C
- Tsilidis K
- Tsinaslanidis G
- Tsourlos S
- Tsuchida T
- Tsuo K
- Tubiana S
- Tucci A
- Tucker P
- Tuckey V
- Tuleutayev M
- Tully R
- Turebayeva G
- Turki S
- Turley C
- Turley P
- Turnbull A
- Turner L
- Turner P
- Turner V
- Turner-Bone I
- Turney S
- Turtle L
- Turvey SE
- Tusié-Luna T
- Tutt G
- Tutton R
- Twiss S
- Tyl D
- Tyler A
- Tzoulaki I
- TĂ©llez L
- Uchimura Y
- Ueda S
- Ueda T
- Uellendahl-Werth F
- Uitterlinden AG
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- Umeda A
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- Upton J
- Urioste M
- Urrechaga E
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- Uwamino Y
- Vadgama N
- Vadla MS
- Vaida M
- Valdeavella K
- Valdés PA
- Valencia-Ramos J
- Valenti L
- Valenzuela-Jorquera H
- Vallerga CL
- Valsecchi MG
- Van den Berge M
- Van der Laan S
- Van Heel DA
- Van Heel DA
- Van Koutrick L
- Vandernoot I
- Varghese M
- Vasilevska-Ristovska J
- Vassell K
- Vedage D
- Veerapen K
- Vega J
- Vehreschild MJGT
- Velasco DG
- VelĂĄzquez-Cruz R
- Venkatesh H
- Verdugo RA
- Verdugo RA
- Vergasova E
- Verlander M
- Vertue M
- Verula J
- Vigueras-HernĂĄndez A
- Vigurs C
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- Villalonga JM
- Vincent R
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- Virginia M-RA
- Vitart V
- Vizcaychipi M
- Vlasschaert C
- Vochin A
- Volland S
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- Voza A
- Vuylsteke A
- VĂĄrnai R
- VĂĄzquez-PĂ©rez JA
- Wacker EM
- Wackett T
- Wadams B
- Waddell G
- Waddington N
- Wagner R
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wakefield P
- Wakinshaw F
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- Walker C
- Walker D
- Walker L
- Walker R
- Walker S
- Walker S
- Wall A
- Walsh T
- Walter J
- Walters RK
- Walton O
- Wang B
- Wang QS
- Wang X
- Wang X
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- Ward G
- Ward K
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- Ward M
- Ward S
- Warden S
- Warren D
- Warrington J
- Washington NL
- Wassall H
- Wasson C
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- Watanabe K
- Waters A
- Waters E
- Watkins C
- Watson E
- Watson G
- Watson J
- Watters M
- Watts S
- Waugh V
- Weaver J
- Webb N
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- Webster D
- Webster K
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- Wei Z
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- Weldon CH
- Welford A
- Wells C
- Welters I
- Wendorff M
- Wendtner CM
- Werge T
- Wesse T
- West J
- Westergaard D
- Weston H
- Whileman A
- Whitaker E
- Whitbread J
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- White I
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- White M
- White N
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- Whitelaw L
- Whiteley S
- Whiteside J
- Whitney J
- Whitton C
- Whyte C
- Wicks SJ
- Wiegrebe S
- Wienbrandt L
- Wignall A
- Wilby L
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- Wild H
- Wild L
- Wilding L
- Wiles M
- Wilfling S
- Wiliams A
- Wilkin F
- Wilkins J
- Wilkinson A
- Wilkinson B
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- Williams A
- Williams C
- Williams D
- Williams E
- Williams E
- Williams G
- Williams H
- Williams J
- Williams K
- Williams M
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- Wilson JF
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- Winchester J
- Winkler TW
- Winmill H
- Winnard S
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- Winter K
- Winter-Goodwin B
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford BN
- Wong I
- Wong J
- Wong J
- Wood D
- Wood H
- Wood S
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- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodward E
- Woodward J
- Woolcock M
- Woolley AE
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- Worsley L
- Wray G
- Wren L
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- Wyllie DH
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- Xue X
- Yagi K
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- Yamada Y
- Yamagata K
- Yamasaki M
- Yang J
- Yaspan B
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- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yåñez CE
- Yåñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- ZĂĄrate RN
- ZĂșñiga-Ramos J
- Ălvarez BG
- Ăvila-Arcos MA
- Ăvila-Arcos MC
- Ăzer O
- Ăberla K
- ĂorsteinsdĂłttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Recommended from our members
Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
- Author
- Aagaard  Bitten
- Accardi  Evan
- ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study Group
- Adam  Stacey J
- Adams  Amy
- Agarwal  Trisha
- Aggarwal  Neil R
- Akbari  Freshta
- Albert  Sara
- Alexander  Elizabeth
- Almasri  Eyad
- Alvarez  Michael S
- Ames  DeAnna
- Amos  Laura
- Amosu  Omowunmi
- Andreassen  Helle Frost
- Applegate  Darrin
- Armbruster  Brent P
- Arribas  Jose R
- Ashktorab  Kimia
- Ashok  Kiran
- Aston  Valerie T
- Audette  Matthew
- Babiker  Abdel G
- Badhwar  Vinay
- Badrock  Jonathan
- Baduashvili  Amiran
- Bagiella  Emilia
- Baio  Kim T
- Baker  Jason V
- Baker  Rebecca
- Bakowska  Elizieta
- Balde  Abby
- Banner-Goodspeed  Valerie
- Bansal  Aditya
- Baracco  Gio
- Baracz  Michelle
- Barkauskas  Christina E
- Barrett  Kevin
- Barros  Andrew
- Bartolo  Elizabeth Berry
- Baseler  Beth
- Baumgarten  Katherine
- Bayoumi  Emad
- Beakes  Caroline
- Becker  Nancy
- Bednarska  Agnieszka
- Bedoya  Gabriela
- Bender  William
- BergsÞe  Christina Marisa
- Berhe  Mezgebe
- Bettacchi  Christopher
- Beutler  Rebecca
- Bielica  Mona
- Bienstock  Karen
- Billouin-Frazier  Shere
- Bissel  Brittany
- Biswas  Kousick
- Bjork  Lauren
- Bledsoe  Joseph
- Bojesen  Ane
- Bokhart  Gordon
- Bouffler  Andrew
- Bowdish  Michael E
- Boyle  Katherine L
- Brait  Kelsey
- Brar  Indira
- Braun  Dominique L
- Broussard  Shane
- Brower  Roy G
- Brown  Craig
- Brown  Samuel
- Brown  Samuel M
- Bruun  Tina
- Buck  Theresa
- Bunner  Robin
- Burgos  Joaquin
- Burris  Sarah
- Buterbaugh  Sabrina
- Cabrera  Gesalit
- Caccia  Taylor
- Cahill  Kelly
- Cao  Huyen
- Carey  Catherine
- Carlsen  Amy
- Carter  Anita
- Casey  Jonathan D
- Cash  Jennifer
- Cassity  Evan P
- Caudill  Antonina
- Chang  Christina C
- Chang  Steven Y
- Chauhan  Lakshmi
- Chen  Peter
- Chi  Andrew
- Chia  Po Ying
- Chiu  Charlene
- Chiu  Joseph
- Choe  June
- Choudhary  Jay
- Clapham  Gregg J
- Clariday  Laura
- Clausen  Clara Lundetoft
- Co  Ivan N
- Coleman  Tanquinisha
- Cook  Sharri
- Cothran  Elizabeth
- Crew  Page
- Crovetto  Nicolle
- Currier  Judy
- Davey  Victoria J
- Davis  Allyson
- Davis  Bionca
- DellaValle  Natalie
- Delp  Alex
- Denning  Eileen
- Der  Tatyana
- Deshmukh  Rupali
- DeSouza  Leslie
- Dhar  Sanjay
- Dillon  Laura
- Ding  Xiao
- Dinh  Huan
- Diong  Shiau Hui
- Dishner  Emma
- Dixon  Mary
- Dolney  Suzanne
- Douglas  Ivor
- Douin  David J
- Dreyer  Grace R
- DuChateau  Nadine
- DuChene  Alain
- Duggal  Abhijit
- Duhaime  Erin
- Duque  Krizia
- Eichinger  Mareile L
- Eichman  Sharon M
- Enfield  Kyle B
- Engen  Nicole
- Escobar  Jose
- Esmann  Frederik V.L
- Estrada  Vicente
- Evans  Raquel
- Exposito  Maria
- Eyler  Carolyn
- Fabricius  Thilde
- Fayed  Mohamed
- Fenton  Kathleen
- Fergus  Melissa
- Fernåndez-Cruz  Eduardo
- Fielding  Michele
- Filbin  Michael R
- Files  D. Clark
- Finck  Lani L
- Fisher  Tammy
- Fitzgerald  Laura
- Fleischmann  Emily
- Flores  Lori S
- Flosi  Adam
- Fornaresio  Lisa
- Fox  Ashley
- Franzone  John
- Freasier  Heather
- Fresnedo  Michelle
- Frosch  Anne
- Frye  Leanna
- FÀtkenheuer  Gerd
- Galbraith  James
- Galcik  Michael
- Gammie  James S
- Garcia  Rebekah L
- Garcia-Myers  Kelly
- Gardner  Edward M
- Gee  Adrienne
- Gelijns  Annetine C
- Germann  Heather H
- Gerry  Norman P
- Gerstoft  Jan
- Gertz  Jensen
- Giangiacomo  Dana M
- Gibbs  Keven W
- Giebeig  Lisa
- Gillinov  Marc A
- Ginde  Adit A
- Gioukari  Vicky
- Girardet  Jean-Luc
- Glaze  Chad
- Golden  Kevin
- Goldsmith  Rachael
- Gong  Michelle N
- Gonzales  Sonia
- Goodman  Anna
- Gottlieb  Robert L
- Grandits  Greg
- Gray  Christopher
- Green  China J
- Gregory  Adam
- Grevsen  Anne Louise
- Grube  Christina
- Grund  Birgit
- GrĂŒttner-Durmaz  Manuela
- Gulati  Neelam
- Gupta  Lopa
- Gupta  Rajesh
- GĂŒnthard  Huldrych F
- Haley  Clinton
- Haley  Elizabeth
- Hand  Jonathan
- Hankinson  Liz
- Hanna  Sinan
- Hansen  Laura
- Hansen  Thomas Michael
- Harrington  Cristin
- Harris  Nicola
- Harrison  Merrie
- Haukoos  Jason
- HavmÞller  Signe Ravn
- Hayanga  J. Awori
- Hayes  Sharon
- Hays  Margaret
- Helleberg  Marie
- Hendershot  Jennifer
- Hendey  Gregory
- Hensley  Lisa
- Hernandez  Nilmo
- Herpin  Betsey R
- Herrera  Lisa
- Herring  Karen
- Hertz  Mathias A
- Hibbert  Kathryn A
- Higgs  Elizabeth S
- Hindoyan  Niree A
- Hines-Munson  Casey
- Hissey  Debbie
- Hite  R. Duncan
- Hogarty  Debi
- Hohn  Matt
- Holland  Thomas L
- Holley  H Preston
- Hollister  Beth A
- Hong  Zhi
- Hoopengardner  Lisa
- Hoover  Marie L
- Horban  Andrzej
- Horcajada  Juan P
- Hou  Peter
- Hough  Catherine L
- Hough  Sally
- Hovmand  Nichlas
- Howell  Michelle
- Hubel  Kinsley A
- Huber  Lynda
- Hudock  Kristin
- Hudson  Fleur
- Hughes  Alyssa R
- Hughes  Eric
- Hurutado-Rodriguez  Marian
- Hutcheon  Douglass
- Hyzy  Robert C
- HÞgsberg  Dorthe S
- Imel  Karah
- Iram  Nazia
- Iribarne  Alexander
- Isaac  Geralyn
- Jackman  Susan E
- Jain  Mamta K
- Jankelevich  Shirley
- Jauregui  Alejandra E
- Jensen  Jens-Ulrik
- Jensen  Tomas O
- Jensen  Tomas Ăstergaard
- Jerrow  Janet
- Jia  Shijing
- Jibrell  Hodan
- Joensen  Zillah Maria
- Johansen  Isik S
- Johnsen  Stine
- Johnson  Haley
- Johnson  Jakea
- Johnson  Les
- Jones  Alan E
- Jones  Felecia
- Jundgren  Jens D
- Jurek  Natalia
- Justino  Chris
- Kadl  Alexandra
- Kaiser  Payton
- Kalan  Shivam P
- Kamel  Dena
- Kamis  Kevin
- Kamstrup  Thobias
- Kan  Virginia
- Kangelaris  Kirsten N
- Kanne  Katja Lisa
- Kardos  Cynthia
- Kelleher  Anthony
- Kennedy  Sarah
- Khan  Akram
- Killian  Aaron
- King  Alexander H
- Kinjal  Mistry
- Kinzel  Emily
- Kiran  Simra
- Kirchoff  Matthew
- Kityo  Cissy M
- Kiweewa  Francis
- Klaphake  Jonathan
- Knowlton  Kirk U
- Knudsen  Lene Surland
- Knudtzen  Fredrikke C
- Ko  Emily R
- Koopmeiners  Joseph
- Kowalska  Justyna
- Kozikowski  Lori-Ann
- Krapp  Katharina
- Krauss  Gary
- Krol  Olivia F
- Krupica  Troy
- Kubernac  Amanda
- Kubernac  Robert
- Kumar  Naresh
- Kumar  Princy
- Lake  Eileen
- Landreth  Leigha D
- Lane  H. Clifford
- Lane  Kathleen
- Lanspa  Michael
- LaRose  Mary E
- Larsen  Lykke
- Lau  Christine
- Laudun  Sylvia
- Lee  Maia
- Lee  May M
- Lee  Myounghee
- Lee  Tau Hong
- Leither  Lindsey
- Leonard  Kiara
- Leong  Janet
- Leshnower  Bradley G
- Levine  Andrea
- Lewis  Meghan R
- Lichtenberger  Paola
- Lim  George W
- Lin  Leo
- Lin  Ray J
- Lindegaard  Birgitte
- Lindnér  Cecilia Ebba Clara Ellinor
- Linton  Jessica
- Lo  Melanie
- Lopez  Brenda
- Lorenzo  Josua
- Lozano  Edward
- Lucas  Claudia Sanchez
- Lusk  Erica
- Lutaakome  Joseph
- Lye  David
- LÞfberg  Sandra Valborg
- M'Rabeth-Bensalah  Khadija
- Ma  Ji
- MacDonald  Leah
- Mack  Michael
- Mackedanz  Shari
- Madathil  Ronson J
- Malinm  Jakob J
- Manandhar  Meryan
- Margolin  Justin D
- Margolis  David
- Markowitz  Norman
- Marks  Mary E
- Maroney  Karen
- Martinkovic  Jamie
- Mathewson  Sonya
- Maton  Missy
- Matthay  Michael A
- Matthews  Gail
- Matusov  Yuri
- Mayer  Kirby P
- McBride  Mary K
- McCarthy  Paul
- McDaniel  Hunter
- McDougal  Madeline
- McGowan  Lauren M
- McKernan  Kimberley
- McLean  Sherry
- McLendon-Arvik  Beth
- McNay  Laura A
- McSparron  Jake I
- Meger  Sue
- Mehdikhani  Shaunt
- Mehkri  Omar
- Menna  Maximiliano
- Metzler  Sara
- Mikail  Amani
- Miller  Chadwick
- Miller  Jeffrey
- Miller  Leslie
- Miller  Marissa A
- Mills  Emmanuel
- Mock  Rebecca
- Mogalian  Erik
- Montgomery  Quinn
- Montgomery-Yates  Ashley A
- Moore  Jessica
- Moquete  Ellen
- Morales-Rull  Jose Luis
- More  Harshada
- Morin  Haley D
- Morris  Peter E
- Morse  Richard
- Mosaly  Nilima
- Mosier  Jarrod M
- Moskowitz  Alan J
- Moss  Marc
- Motta  Marry
- Mourad  Ahmad
- Mugerwa  Henry
- Murphy  Joseph
- Murrary  Daniel D
- Murray  Thomas
- Muzikansky  Ariela
- Muñoz  José
- Nagy-Agren  Stephanie
- Nair  Rahul
- Nandi  Utsav
- Neaton  James D
- Nekach  Hafida
- Nelson  Kristine
- Newton  Crystallee
- Ngo  Linh
- Nguyen  Chinh
- Nguyen  Phuong Tran
- Nielsen  Ariella Denize
- Nielsen  Charlotte B
- Nielsen  Henrik
- Normand  Nick E
- North  Crystal
- Nossaman  Bobby
- Nyatsatsang  Sonam T
- NykjÊr  Bente Rosdahl
- Nytofte  Nikolaj Julian SkrÞder
- O'Mahony  D. Shane
- O'Sullivan  Karen
- Ochalek  Tracy
- Offor  Obiageli
- Ojukwu  Cristabelle
- Olbrich  Norman
- Oldmixon  Cathryn
- Olds  Anna P
- Oluremi  Charles
- Ong  Sean
- Ongko  Juwinda
- Osei  Suzette
- Osinusi  Anu
- Overbey  Jessica R
- Padillia  Maria L
- Palacious  Adriana
- Palmer  Ghazal
- Pandit  Lavannya
- Pantaz  Nikos
- Pappers  Brian
- Paredes  Roger
- Pariser  Alan
- Park  Pauline K
- Parmar  Mahesh KB
- Parr  Doug
- Parrino  Patrick E
- Parry  Blair Alden
- Pascual  Ethan
- Pasha  Sara N
- Pastor  Erika
- Patel  Bhakti
- Paul  Pam
- Peacock  Rebekah K
- Pedersen  Karen Brorup
- Pedersen  Lars
- Pedersen  Thomas Ingemann
- Peguero  Maya-Loren
- Peltan  Ithan D
- Peppercorn  Amanda
- Perez  Cynthia
- Petersen  Tianna
- Pett  Sarah
- Podlekareva  Daria
- Polizzotto  Mark N
- Ponder  Chari
- Popielski  Laura
- Porte  Kristina
- Possemato  Tammie
- Preamble  Katarina
- Proffitt  Calvin
- Puah  Ser Hon
- Quan  Kien
- Quan  Siu Fun
- Raben  Dorthe
- Rabin  Joseph
- Raim  Sharon Segal
- Ramesh  Mayur
- Ramierez  Noelia
- Ramos  Carol
- Ransom  Desirae
- Rashid  Marium
- Rastoder  Ema
- Read  Sarah
- Reece  Rebecca
- Reilly  Cavan S
- Reineck  Lora A
- Rice  Todd W
- Richardson  Lynne D
- Ringwood  Nancy
- Rivasplata  Heather
- Rivers  Emanuel
- Roads  Tammy
- Robert  Raven
- Robinson  Bryce H
- Robinson  Caitlin
- Robinson  Dianna
- Rodina  Valentina
- Rodriguez  Vicente
- Rogers  Angela J
- Rogers  Susan
- Roller  Brentin
- Romero  Chris
- Roque  Jonasel
- Roth  Megan
- Rothbaum  Howard R
- Rudzinski  Erin
- Ryan  Madison
- RÞge  Birgit Thorup
- Saharia  Kapil
- Salehi  Hanna
- Sandkovsky  Uriel
- Sandrus  Jen
- Santos  Milerva
- Sardana  Ratna
- Sarwari  Arif
- Schaffhauser  Marylu
- Schechner  Adam
- Schelle  Beth
- Scott  James
- Self  Wesley H
- Serezlic  Erna
- Shapiro  Nathan
- Sharifpour  Milad
- Sharma  Aniket
- Sharma  Shweta
- Sharma  Sunil
- Shaw-Saliba  Katy
- Sher  Linda
- Shipman  Samantha
- Simon  Rachel M
- Smith  Kenneth
- Smith  Peter K
- Smolskis  Mary C
- Solis  Edilia
- Solomon  Courtney
- Spainhour  Christine
- Spellberg  Brad
- Spindel  Stephen
- Spinelli-Nadzam  Mary
- Stallings  Ben
- Steingrub  Jay
- Stout  Gennifer
- Sturek  Jeffrey M
- Sturgill  Jamie L
- StÊrke  Nina Breinholt
- Suders  Connie
- Sueiro  Melyssa
- Sullins  Barbara
- Sutton  Lisa Giblin
- Sånchez  Adriana
- Tabatabai  Ali
- Taddei-Peters  Wendy C
- Talmor  Daniel
- Terndrup  Thomas E
- Thammavong  Jon
- Thiruchelvam  Nirosshan
- Thisted  Rikke Krog
- Thompson  B. Taylor
- Thompson  Greg
- Thorlacius-Ussing  Louise
- Thornton  Kara
- Thornton-Thompson  Sherell
- Tidswell  Mark A
- Tien  Phyllis
- Tierney  John
- Tinggaard  Michaela
- Tipple  Craig
- Tipton  Gregory
- Torbati  Sam S
- Touloumi  Giota
- Towfighi  Amytis
- Tran  Sonny
- Trautner  Barbara W
- Treagus  Amy
- Turner  Emma
- Turner  Melissa
- Tyler  Derrick
- Tzehaie  Hiwet
- Van  John
- Vargas  Julia
- Vasudeva  Shikha
- Vekstein  Andrew
- Villa  Samantha
- Vincent  Shelika
- Virachit  Sophie
- Vjecha  Michael
- Vock  David M
- Voge  Susan E
- Vojnik  Rosemary
- von Huth  Sebastian Leicht
- Vonderhaar  Derek
- Wald-Dickler  Noah
- Wallick  Julie A
- Walski  Jamie
- Wang  Bonnie R
- Want  Samantha
- Want  Yiqun
- Watson  Helen
- Watts  Matthew
- Webb  Brandon
- Weintrob  Amy C
- Weissman  Kevin
- Wenner  Christine
- Wentworth  Deborah
- West  Emily
- Whitacre  Heather
- Wiedemann  Herbert P
- Wiese  Lothar
- Williams  Roger
- Willis  Angela
- Wilson  David M
- Wilson  Jennifer G
- Witte  Marie
- Woldbye  Frederik
- Wyles  David
- Wynter  Timothy
- Yan  Li
- Yee  Kimberly J
- Yeo  Tsin Wen
- Young  Barnaby E
- Zheng  Yiling
- Zhong  Amy
- Zhu  Qing
- Zhuo  Hanjing
- Zink  Veronika
- Zuckerman  Judith
- Zuckerman  Richard A
- Ăstergaard  Lars
- Publication venue
- Elsevier Ltd
- Publication date
- 01/05/2022
- Field of study
We aimed to assess the efficacy and safety of two neutralising monoclonal antibody therapies (sotrovimab [Vir Biotechnology and GlaxoSmithKline] and BRII-196 plus BRII-198 [Brii Biosciences]) for adults admitted to hospital for COVID-19 (hereafter referred to as hospitalised) with COVID-19.
In this multinational, double-blind, randomised, placebo-controlled, clinical trial (Therapeutics for Inpatients with COVID-19 [TICO]), adults (aged â„18 years) hospitalised with COVID-19 at 43 hospitals in the USA, Denmark, Switzerland, and Poland were recruited. Patients were eligible if they had laboratory-confirmed SARS-CoV-2 infection and COVID-19 symptoms for up to 12 days. Using a web-based application, participants were randomly assigned (2:1:2:1), stratified by trial site pharmacy, to sotrovimab 500 mg, matching placebo for sotrovimab, BRII-196 1000 mg plus BRII-198 1000 mg, or matching placebo for BRII-196 plus BRII-198, in addition to standard of care. Each study product was administered as a single dose given intravenously over 60 min. The concurrent placebo groups were pooled for analyses. The primary outcome was time to sustained clinical recovery, defined as discharge from the hospital to home and remaining at home for 14 consecutive days, up to day 90 after randomisation. Interim futility analyses were based on two seven-category ordinal outcome scales on day 5 that measured pulmonary status and extrapulmonary complications of COVID-19. The safety outcome was a composite of death, serious adverse events, incident organ failure, and serious coinfection up to day 90 after randomisation. Efficacy and safety outcomes were assessed in the modified intention-to-treat population, defined as all patients randomly assigned to treatment who started the study infusion. This study is registered with ClinicalTrials.gov, NCT04501978.
Between Dec 16, 2020, and March 1, 2021, 546 patients were enrolled and randomly assigned to sotrovimab (n=184), BRII-196 plus BRII-198 (n=183), or placebo (n=179), of whom 536 received part or all of their assigned study drug (sotrovimab n=182, BRII-196 plus BRII-198 n=176, or placebo n=178; median age of 60 years [IQR 50â72], 228 [43%] patients were female and 308 [57%] were male). At this point, enrolment was halted on the basis of the interim futility analysis. At day 5, neither the sotrovimab group nor the BRII-196 plus BRII-198 group had significantly higher odds of more favourable outcomes than the placebo group on either the pulmonary scale (adjusted odds ratio sotrovimab 1·07 [95% CI 0·74â1·56]; BRII-196 plus BRII-198 0·98 [95% CI 0·67â1·43]) or the pulmonary-plus complications scale (sotrovimab 1·08 [0·74â1·58]; BRII-196 plus BRII-198 1·00 [0·68â1·46]). By day 90, sustained clinical recovery was seen in 151 (85%) patients in the placebo group compared with 160 (88%) in the sotrovimab group (adjusted rate ratio 1·12 [95% CI 0·91â1·37]) and 155 (88%) in the BRII-196 plus BRII-198 group (1·08 [0·88â1·32]). The composite safety outcome up to day 90 was met by 48 (27%) patients in the placebo group, 42 (23%) in the sotrovimab group, and 45 (26%) in the BRII-196 plus BRII-198 group. 13 (7%) patients in the placebo group, 14 (8%) in the sotrovimab group, and 15 (9%) in the BRII-196 plus BRII-198 group died up to day 90.
Neither sotrovimab nor BRII-196 plus BRII-198 showed efficacy for improving clinical outcomes among adults hospitalised with COVID-19.
US National Institutes of Health and Operation Warp Spee
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study
- Author
- Aalinezhad Fatemeh
- Abdulwahed Eman
- Abed-Maillard S.
- Abidi Khalid
- Abilama Fayez
- Abousnina Fathi A.
- Abu-Sayf Natalia
- Acevedo José Oscar
- Adeola Fowotade
- Agalar Canan
- Aguilar Candy Garcia
- Ahmadi Fatemeh
- Ahmed Abdullah Khudhur
- Ahmed Samiul
- Akbas TĂŒrkay
- Akdogan Ozlem O.
- Akova Murat
- Akova Murat
- Aksoy Firdevs
- Aktas Sabahat Cagan
- Akyol Ahmet
- Al-Jadaan Mohammad
- Aldhalia Amer
- Alfandari Serge
- Ali Fadi
- Ali Saedah
- AliAli Almajdoub Mohammed
- Aljabbary Ahmed
- Almekhlafi Ghaleb A.
- Almiqlash Bushray
- Almiroudi Mariota Panagiota
- Alonzo Microbiologa Irene
- Alsisi Adel
- Alsisi Adel
- Altin NilgĂŒn
- Altintas Neriman Defne
- Alves Madalena
- Amerigo Joaquin Amador
- Amiri Fereshteh
- Amro Sarah
- Anderzhanova Anastasia
- Angell Hollie
- Antcliffe David
- Antrolikar Supriya
- Aparicio Christelle
- Aparicio Dra Marta
- Apichatbutr Yutthana
- Aqeelah Ahmed
- Arbelot Charlotte
- Argaud Laurent
- Arias Sonia Sousa
- Armestar Fernando
- Arnillas Maria Pilar Gracia
- Arvaniti Kostoula
- Arvaniti Kostoula
- Asensio Dra Mj
- Asiyanbi Gabriel
- Aslan Abdullah Tarik
- Aslan Abdullah Tarik
- Athanasa Zoi
- Atobe Kaori
- Attokaran Antony George
- Attwood Ben
- Auchabie Johann
- Awad Ahmed K.
- Awad Maher
- Ayestaran J. Ignacio
- Azman Abd. Hamid
- Babashev Baurzhan
- Baby Sailaja K.
- Badre Gaëtan
- Baghbanian Reza
- Baig Nadia
- Baikady R. Rao
- Bajaj Manan
- Bakr Lubna
- Banach Dorota
- Barbier François
- Barbier François
- Baronia Arvind
- Barsoum Mina
- Bassetti Matteo
- Batirel Ayse
- Battaglini Denise
- Baudry Thomas
- Baumer Tom
- Bayindir Yasar
- Baykam Nurcan N.
- Bazhykayeva Yelena
- Belkhadir Z.
- Bellina Davide
- Belman Daniel
- Belskiy Vladislav
- Bermudez Rosana Munoz
- Beuzelin M.
- Bhadange Neeraj
- Bilir Yeliz
- Bilkhayr Hala
- Biradar Vishwanath
- Bisanti Alessandra
- Biston Patrick
- Black E.
- Blasco-Navalpotro Miguel Angel
- Bloos Frank
- Bojko Jozef
- Borsi Seyed Hamid
- Bortolotti Perrine
- Bose Payel
- Botelho Isabel
- Bouaziz Mounir
- Bouhuwaish Ahmad
- Boukatta Brahim
- Bourenne Jérémy
- Bourgeois Marc
- Bracht Hendrik
- Bracht Hendrik
- Brajkovic Ana Vujaklija
- Brewster David
- Broda Hanna
- Bruel CĂ©dric
- Bubenek-Turconi Serban
- Buetti NiccolĂČ
- Buimsaedah Ahmad
- Burma Yaroslava
- Cakmak Rumeysa
- Carelli Simone
- Cartoze Nuno
- Casares Vanessa
- Castanera Jérémy
- Castillo Roberto Alejandro
- Catalan Beatriz
- Centeno Pablo
- Cerman Jaroslav
- Ceyhun Solako?lu
- Chaaban Mohammad Karam
- Chandran Jagadish
- Chantziara Vasiliki
- Chatzis Marinos
- Chen Xiaomei
- Chiewroongroj Supattra
- Chikungwa Moses
- Chou Nai-Kuan
- Chukina Maria
- Cia Cong-Tat
- Cobb Katherine
- Cobilinschi Cristian
- Cole Stephen
- Conway Morris Andrew
- Cortegiani Andrea
- Costa Vasco
- Cotoia Antonella
- Coupez Elisabeth
- Covotta Marco
- Cowton Amanda
- Cunha Rui Pedro
- Custovic Aida
- da Costa Tito
- Dabiri Gholamreza
- Dahyot-Fizelier Claire
- Daroui Ivan
- Datta Avijatri
- Davalos-Alvarez Adrian
- De Bus Liesbet
- De Bus Liesbet
- de Figueiredo AntĂłnio Manuel Pereira
- De Geer Lina
- De La Rica Alejandro Suarez
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Elisabeth
- De Waele Jan
- De Waele Jan
- Demeret Sophie
- Demiray Emine Kubra Dindar
- Dendane Tarek
- Denys Wouter
- Desalu Ibironke
- Dessap Armand Mekonted
- Di Gravio Valentina
- Di Guardo Andrea
- Diab Adei
- Dimopoulos Georges
- Djanikian Flora
- Dolan Rachael
- Dominguez-Cherit Jose G.
- Dsilva Carol
- Duarte Tiago
- Dubler Simon
- Duburcq Thibault
- Dulac Thierry
- Duprey Matthieu
- Dwivedi Jyotsna
- Edin Alicia
- Efthymiou Anna
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbuzidi Abdurahaman
- Elhadi Muhammed
- Elhadidy Amr
- Elmandouh Omar
- Elrabi Omar
- Elsayed Ahmed
- Ercole Ari
- Erdo?an Cem
- Eremenko Aleksandr
- Eroglu Ahmet
- Eroglu Ege
- Erol Ăi?dem
- Ersoy Yasemin
- Ersoz Gulden
- Escudier Etienne
- Espina Lorena Forcelledo
- Evik Guliz
- Fares Aya
- Fartoukh Muriel
- Faulkner Maria
- Fernåndez Rubén
- Ferrer Ricard
- Fildisis Georgios
- Filipescu Daniela Carmen
- Filipovic-Grcic Ina
- Finnis Mackenzie
- Finnis Mackenzie
- Fiorelli Silvia
- Flores Matias
- Fong Kean Khang
- Foucrier Arnaud
- Fourie Cheryl
- Franke Uwe
- Fujitani Shigeki
- Furman Mikhail
- Gaigolnik Denis
- Gainnier Marc
- Gallego Alberto Orejas
- Gamra Marwa
- Garcon Pierre
- Geng Nan
- Georgopoulou Maria
- Ghannam A.
- Ghosh Pralay
- Giacobbe Daniele Roberto
- Goh Ken Junyang
- Goh Qing Yuan
- Goksu Senay
- GomĂ Gemma
- Gottschalk Antje
- Goyal Shraddha
- Graham Clive
- Gratarola Angelo
- Grigoras Ioana
- Grintescu Ioana Marina
- Gritsan Alexey
- Guesdon Charlotte
- GuimarĂŁes NĂĄdia
- Gundogan Kursat
- Gurjar Mohan
- Gurjar Mohan
- Guzeldag Seda
- GĂŒrbĂŒz Yunus
- Hachimi Abdelhamid
- Haentjens Lionel
- Haibo Qiu
- Hall Daniel
- Hamid Hytham K. S.
- Haney Michael
- Harara Belal
- Hasan Hayat Ben
- Hasan M. Shahnaz
- Hasan Rabab Shaban Ben
- Hasan Rajib
- Hashimoto Satoru
- Hayashi Yoshiro
- Hayashi Yoshiro
- Hdada Aisha Khaled
- Hemead Hanan M.
- Henin Pierre
- Hermosillo Mariana
- Herrera Mara Ocotlan Gonzalez
- Hewer Tayne
- Hoheisen Sandra
- Hollevoet Isabelle
- Homaidan Ahmed Gaber Sadik
- Hosokawa Koji
- Houfi Ashraf El
- Housni Brahim
- Hssain Ali Ait
- Hu Chungfang
- Hu Ting-Yu
- Huang Min
- Hugill Keith
- Humphreys Miss Sally K.
- Huq Shihan Mahmud Redwanul
- Husain A.
- Iasonidou Cristina
- Ibrahim Rebecca
- Idowu Olusola
- Imzi Nadia
- Ippolito Mariachiara
- Islam Mohammad Motiul
- Jackson Matthew
- Jain Nikhilesh
- Jakob Stephan
- Jamaluddin Muhamad Fadhil Hadi
- Janny Sylvie
- Jaramillo CFhavala
- Javaherforoosh Fatemeh
- Jayyab Mustafa Abu
- Jeon Kyeongman
- Jeon Kyeongman
- Jhanji S.
- Jianfeng Xie
- Jobran Rania
- Johnson Aimee
- Kagan Ilya
- Kaimakamis Evangelos
- Kalem Ay?e Kaya
- Kalfon Pierre
- Kaligozhin Zhannur
- Kampolis C.
- Kanjaa Nabil
- Kannan Santhana
- Karaali Ridvan
- Karaiskos Ilias
- Karar Ali Adil Ali
- Karic Edin
- Karmakar Saurabh
- Karumai Toshiyuki
- Kashipazha Davood
- Kato Hideaki
- Kayaaslan Bircan
- Keegan Allison
- Kent Melanie
- Khade Reena
- Kiani Arash
- Kipnis Eric
- Klouche Kada
- Kocagoz Sesin
- Kogkopoulos Evangelos
- Koksal Iftihar
- Komorowska Irmina Kaptur
- Kothari Nikhil
- Kotkowska Anna
- Kouroulas Vasilios
- Koutsoukou Vasiliki
- Kovacevic Pedja
- Krystopchuk Andriy
- Ku Shih-Chi
- Kuo Li-Kuo
- Kuriyama Akira
- Kurt Ibrahim
- Kusoglu Hulya
- Kutsogiannis Demetrios J.
- Kwa Andrea Lay Hoon
- Lance Marcus
- Larcher Romaric
- Lasic Hrvoje
- Laupland Kevin
- Layos Nathalie
- Le Guennec LoĂŻc
- Le Meur Anthony
- Le Souhaitier Mathieu
- Leal JesĂșs NicolĂĄs Pantoja
- Ledo Sara
- Ledtischke Anne
- Ledtischke Anne
- Lee Sang-Min
- Lefrant Jean-Yves
- Lennard James
- Leone Marc
- Leone Marc
- Lepper Philippe
- Leroy Olivier
- Levin Phillip
- Li Andrew Yunkai
- Lie Sui An
- Liew Mun Thing
- Lim Jia Yan
- Lim Sung Yoon
- Lipman Jeffrey
- Litton Edward
- Lodi Giovanni
- Loftus S.
- Lomeli-Teran Manuel
- Longbottom Rebecca
- Lopez Patricia Mabel
- Louis Guillaume
- Lungu Olguta
- Luo Jili
- Macfie Caroline
- Magomedov Marat
- Mahmoodpoor Ata
- Makino Jun
- Malliotakis Polychronis
- Marchalot A.
- Marcu Alexandra
- Margetts Ben
- Marmanidou Kyriaki
- Marouli Diamantina
- Marques Ana Josefina Pinheiro
- Marsden Nicholas
- Martin-Loeches Ignacio
- Martinez Maria
- Maseda Emilio
- Masjedi Mansoor
- Massri Alexandre
- Matei Mariana Kristina
- Mateu Philippe
- Matsuyoshi Takeo
- Mazlan Mohd Zulfakar
- Mc Cree Melanie
- McCoshen Lorena
- Mcguigan Peter
- Mckee Rachel
- Mehraban Zahra
- Mehtap Selcuk
- Meleshkina Yulia
- Mendes AntĂłnio Carvalho
- Merenkov Yevgeniy
- Mesland Jean-Baptiste
- Metz Carlos
- Meyer Jason
- Mikstacki Adam
- Mingmin Chen
- Mira Jean-Paul
- Mirabella Michele
- Mishima Yuka
- Misra Krushna Chandra
- Misset BenoĂźt
- Moldovan Leora
- Molinos Elena
- Mon Tomas
- Montefiore Pablo
- Montini Luca Maria
- Montravers P.
- Montrucchio Giorgia
- Moorthi P. Dhakshina
- Morris Andrew Conway
- Morris Andrew Conway
- Morvillo Lic Natalia
- Mostafa Tarek
- Mouhssine Doumiri
- Moura José Pedro
- Mugazov Miras
- Mukherjee Sudipta
- Mulhi Randeep
- Muzaffar Syed Nabeel
- Nadeem Rashid
- Nafees Khalid Mahmood Khan
- Nagashima Michio
- Ng Kangqi
- Ng Louis Xiang Long
- Ng Shin Yi
- Nica Alexandru
- Nikolaou Charikleia
- Nikolic Mario
- Nimbolkar Janardan
- Nissar Shaikh
- Noel Cindérella
- Noor Zuraini Md
- Novo Mariana
- Nowakowski Tomasz
- Nuccetelli Yanina
- Nunes Cristina
- Oikonomou Marina
- Oladimeji Motunrayo
- Olatosi John O.
- Omori Koichiro
- Ong Caroline Yu Ming
- Opdenacker Godelive
- Osman Nermin
- Ouhadian Maryam
- Ozair Ahmad
- Ozgen Cansu
- Ozturk Barcin
- Pagani Jl
- Pahuja Madhumati
- Paiva José-Artur
- Palermo Anna Maria
- Papageorgiou Eirini
- Papanikolaou M.
- Papathanakos Georgios
- Papoti Sofia
- Parcell Benjamin J.
- Park Seung Yong
- Park Sunghoon
- Pascoalinho Dulce
- Pasieka Bastian
- Paskalis Harry
- Patel Jamie
- Patel Mayur
- Patrier Juliette
- Paulet RĂ©mi
- Peichota Mariusz
- Peije Li
- Pelagalli Lorella
- Pelosi Paolo
- Pereira Tiago
- Pereira Ănio
- Perez-Nieto Orlando R.
- Perrigault Pierre-François
- Persec Jasminka
- Petros Sirak
- Pheng Lee See
- Philippart François
- Pietraszek-Grzywaczewska Iwona
- Pinto Ana Rios
- Pollock Hamish
- Popescu Mihai
- Porcile Elisa
- Povoa Pedro
- Prazak Josef
- Predoi Cornelia Elena
- Prieto Emilio Garcia
- Psallida Vasiliki
- Qian Chuanyun
- Qin Bingyu
- Qiu Haibo
- Quah Jessica Lishan
- QueirĂł Joana
- Quesada MarĂa Dolores
- Rabbani Raihan
- Radonic Radovan
- Raguer Laura
- Rahman Hamizah Bt Abdul
- Raj Ashok
- Ramanan Mahesh
- Rashid Nurhikmahtul Aqilah Haji Abd
- Rashidi Mahboobeh
- Rathod Darshana
- Razazi Keyvan
- Regli Adrian
- Renaud Paul Jean
- Renta Foteini
- Renuka M. K.
- Retselas Ioannis
- Reyes Luis Felipe
- Reyes Luis Felipe
- Rigler Merav
- Rinka Hiroshi
- Ritzema Jenny
- Rizzo Anna Chiara
- Rocca Ricard Ferrer
- Rocco Monica
- Rodriguez Dra M.
- Roger Claire
- Roig Regina
- Rojo Roceld
- Romanou Vasiliki
- Romero-Gonzalez Juan P.
- Roshdy Ashraf
- Rosman Jérémy
- Routledge Matthew
- Rubina Noor Ahmedi
- Ruckly Stéphane
- Saber Ahmed
- Sabetian Golnar
- Saidahmed Elfayadh
- Saito Hiroki
- Sakagianni Aikaterini
- Sakan Sanja
- Sakkalis Anastasios
- Sales Gabriele
- Salgado Dra Maria
- Sallam Hend
- Saltoglu Nese
- Samdani Pratit
- Sanderson Amanda
- Santos Emilio Diaz
- Saracoglu Kemal Tolga
- Sari Ali
- Sarode Vineet
- Sarshad Hakimeh
- Sarton Benjamine
- Savaie Mohsen
- Saxena Manoj
- Schlevenin Maria Grazia
- Schmidt Karsten
- Seddiki Rachid
- Segura MatĂas
- Sellami Walid
- Serck Nicolas
- Serghini Issam
- Sharma Ankur
- Sharma Priya
- Shekhar Saurav
- Sheshala Kaladhar
- Shigemitsu Hidenobu
- Siami Shidasp
- Siddiqui Suhail Sarwar
- Silva Stein
- Singer Pierre
- Singh Ritu
- Sjövall Fredrik
- Sligl Wendy
- Sligl Wendy
- Smith Tim
- Smonig Roland
- Smyrniotis Dimitrios
- Soar Natalie
- Sokhan Anton
- Soltan Marina
- Soltani Farhad
- Soulountsi Vasiliki
- Souweine Bertrand
- Spahic Dzana
- Sridharan Dhadappa Damodar
- Staiquly Quentin
- Sudhirchandra Shah
- Sungurtekin Hulya
- Svensson Carl Johan
- Szakmany Tamas
- Szczesniak Anna
- SĂĄnchez-Hurtado Luis
- Tabah Alexis
- Tabah Alexis
- Tabatabaei Seyed Mohammad Nasirodin
- Taher Ahmed Sa
- Tajvidi Ramin
- Takaki Shunsuke
- Talan Leyla
- Tamowicz Barbara
- Tatham Kate
- Tejeda-Huezo Brigitte
- Telli Murat
- Temirov Talgat
- Templeton Maie
- Teresa Ana
- Theodorou Vasiliki
- Thomas-Rueddel Daniel
- Thompson Patricia
- Thyrault Martial
- Tilley Rebecca E.
- Timsit Jean-François
- Timsit Jean-François
- Timuroglu Arif
- Tinaslanidis George
- Tizard Kate
- Tomas Ernesto Deloya
- Tomescu Dana
- Tong Lee Kok
- Torlinski Tomasz
- Torre Valentina Della
- Tran Marc
- Tribulev Maksim
- Tunay Burcu
- Turki Olfa
- Tyler Steven
- Ubeda Alejandro
- Ugwu Euphemia Mgbosoro
- Vaidyanathan R.
- Valeanu Liana
- Vanderhaeghen Sofie F. M.
- Vargas Joel
- Vasileiou Maria
- Vera Paula
- Viderman Dmitriy
- Villafuerte Missael Vladimir Espinoza
- Vistovskaya Natala
- Visvalingam Sheshendrasurian
- Voiriot Guillaume
- Wajdi Maazouzi Ahmed
- Walczak-Wieteska Paulina
- Walid Haji Adi Muhamad Ibnu
- Walsham James
- Wang Hao
- Wang Jinfeng
- Wang Ruilan
- Wang Yan
- Wasowska Dominika
- Weeda Elizabeth
- Wei-Hua Lu
- Weifeng Xie
- Weiss Emmanuel
- Wempe Carola
- Wittebole Xavier
- Wong Siong Ling Danny
- Wongsurakiat Phunsup
- Wusi Qiu
- Xu Lei
- Yakubu Saidu Yusuf
- Yamasaki Masaki
- Yan Jing
- Yap Timothy
- Ye Jilu
- Ye Ling
- Yeh Yu Chang
- Yilmaz Mesut
- Yin Chengfen
- Yin Yongjie
- Ymbetzhanov Yerlan
- Yonan Aimee
- Yoshida Hideki
- Younes Oujidi
- Young Meredith
- Zaki Ahmed
- Zand Farid
- Zand Farid
- Zappela N.
- Zargar Mohammad Amin
- Zeggwagh Amine Ali
- Zhang Min
- Zhao Juan
- Zhao Peng
- Zhen Wang
- Zhou Suming
- Zlojutro Biljana
- Zormpa Artemis
- Zubareva Nadezhda
- Zuccaro Francesco
- Ă kerlund Joyce
- Ăolak Onur
- Ăolak Sait
- Ăamendys-Silva Silvio A.
- Ăamendys-Silva Silvio A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2023
- Field of study
Purpose
In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.
Methods
We carried out a prospective international cohort study of adult patients (â„â18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.
Results
2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28.
Conclusions
HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
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- Adekola Oyebola
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- Ademola Adeyinka
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- Barrett Stephen
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- Baxter Linden
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- Beavis Vanessa
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- Belda Margarita Tormo
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- Bell Stephanie
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- Bello Jibril
- Beloeil Helene
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- Beltran Anna Valle
- Ben-Menachem Erez
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- Bester Delia
- Bester Marlet
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- Bettinelli Alessandra
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- Bhatia Kailash
- Bhula Chettan
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- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
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- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
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- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
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- Botes Marisa
- Botis Ioannis
- Bottini Corrado
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- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
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- Boyd Christine
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- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
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- Brennan Andrew
- Brennan Emma
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- Brincat Maximilian
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- Bristogiannis Sotirios
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- Brookes Morag
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- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
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- Brown Robyn
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- Bryant Helen
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- Buerkle Christian
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- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- BĂŒhrer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabral Tiago do Nascimento
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo' Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
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- CarmenVaida Laura Aflori
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
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- Castaño Beatriz
- Castle Gail
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
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- Chaloulis Panagiotis
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- Chan Mathew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
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- Commey Thelma
- Comptaer Nicolas
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
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- Cooper Richard
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- Copaciu Elena
- Cope Jennifer
- Copetti Elisa
- Copley Edward
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- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Correia da Silva Rui Freitas Mendonça
- Corti Daniele
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
- Cozar Octavian Ionut
- Craig Jayne
- Craven Rachael
- Craw Nicholas
- Craw Sarah
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- Cripps Heather
- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
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- Cueva Andreu
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- Curley Gerard
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Hanying
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
- Daniel Gayatri Daniel
- Daniel Harvey
- Daniel Hull
- Daniel Sonya
- Dankl Daniel
- Darko Julia
- Darwish Sharif
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- Dasrath Ashish
- Datson Amanda
- Daubeny Thomas
- Daugaard Morten
- Davari Maria
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- Davies Helen
- Davies Keith
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- Davies Leigh
- Davies Zoe
- Davis Edward
- Davis Fiona
- Davis Simon
- Daya Bhavika
- De Andrés Ibanez José Antonio
- De Baerdemaeker Luc
- de Beer Johan
- de Boer Hans Donald
- De Bruyne Ann
- de Fretes Jennifer
- de Gasperi Julia
- de Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N.
- De Oliveira Mirella Cristine
- de Rudnicki Stéphane
- de Swardt Mathew
- de Vasconcellos Kim
- de Villiers Martin
- de Wet Jacques
- Deacon Matthew
- Deblaere Isabel
- Dedemadi Georgia
- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado GarcĂa David R.
- Della Rocca Giorgio
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
- Desbordes Jacques
- Despotidis Vasileios
- Diaconescu Ciresica
- Diago Lorena GĂłmez
- Dias Fernando
- Dias Sandra
- Dickson Jane
- Ditai James
- Divatia Jigeeshu
- Dixon Liane
- Dobson Gary
- Docherty Philip
- Dodiyi-Manuel Amabra
- Dodsworth Kerry
- Dolan Rachael
- Dominguez Saul Velaz
- Doncel Ma Sherezade Tovar
- Dong Beibei
- Donohue Roana
- Donovan Andrew
- Douglas Jeanene
- Doumos Rodamanthos
- Downes Charlotte
- Doyle Donna
- Dragnea Dragos
- Dragoescu Nicoleta Alice
- Drake Matthew
- Drimala Maria
- Drinkwater Zoe
- Drummond Leanne
- Du Fang
- Du Xindan
- Duarte CĂ©lia
- Dube Nokukhanya Z.
- Duca Alejandro
- Dudgeon Lucy
- Dudson Rosie
- Duenser Martin
- Dumitrascu Clementina Oana
- Dumitrescu Alexandra
- Dunay Artem
- Dunk Nigel
- Durant Emma
- Durodola Adekunle
- Dursin Ade Nurkacan
- Durst Alexander
- Duttchen Kaylene
- Dutu Madalina
- Dwyer Heather
- Dylst Dimitri
- Dzhamullaev Parvin
- Dzulkipli Norizawati
- Echem Richard
- Edmond Holly
- Edwards Jayne
- Edwards Marc
- Edwards Mark
- Efthymiadi Andromachi
- Egan Thomas
- Eggleston Christopher
- Eichwalder Andreas
- Eikman Johan
- Ekelund Kim
- El-Sayed Ahmed
- Elabib Ali
- Elena Gkonezou
- Elferink-Vonk Renske
- Elgasim Magdi
- Ellis Jessica
- Ellis Kate
- Elna Cifra
- Emma Temlett
- Endersby Simon
- Eneje Philip
- Eng Kristen
- English Duane
- English Rose
- Epodoi Joseph
- Ernesto Ernesto Pastor Martinez
- Eskildsen Katrine Zwicky
- Esteves Simao
- Ethgen Sabine
- Evans Adam
- Evans Chris
- Everingham Kirsty
- Ewe Renee
- Ezekiel Emmanuel
- Ezike Humphrey
- Fagerlund Malin Jonsson
- Faina Lais
- Falk Elke
- Fan Hao
- Fan Lihua
- Fan Yu
- Fanfani Lucia Caterina
- Fang Xiangming
- Faponle Folayemi
- Faria e Maia Dionisio
- Faria Filomena
- Farid Nahla
- Farina Zane
- Farrell Helen
- Farrow Mehreen
- Fasina Oluyemi
- Fatungase Oluwabunmi Motunrayo
- Faulds Matthew
- Fei Yue
- Fellinger Paul
- Feng Yunlin
- Fengas Lior
- Fergey Lauren
- Ferguson Marissa
- FernĂĄndez Salvador
- Ferrando Carlos
- Ferreira da Costa Fischer Bruna
- Filipescu Daniela
- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
- Fischbach Norbert
- Flatt Jim
- Fleischer Andreas
- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
- Flores Kathrina
- Flossos Andreas
- Foers William
- Foglia Julena
- Foley Julia
- Fonck Kristine
- Foord Denise
- Foot Helen
- Foot Jayne
- Ford David
- Forget Patrice
- Forsans Emma
- Forstner Karin
- Fosch de Campos Ferreira Mariana
- Foster Rebecca
- Foubert Luc
- Fouracres Anna
- Fowler A. J.
- Fowler Alexander
- Fowler Carolyn
- Fraga Julia Merladete
- Fragandreas George
- Francis Daren
- Franklin John
- Franks Romilla
- Frantzeskos Georgios
- Freeman David
- Freeman Victoria
- Freethy Alexander
- Freitas Katie
- Freschini Angela
- Freschini David
- Frewer Natasha
- Fritsch Gerhard
- Frost Victoria
- Fu Kaiwen
- Fu Shuying
- Fu Yunbin
- Fuad Akram
- Fuentes Isabel
- Fulton Graham
- Funk Bonita
- Funk Duane
- Furrer Markus
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N. Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T.
- Gao Hong
- Garcia Juliana
- Garcia-Saiz Irene
- GarcĂa-PĂ©rez Maria Luisa
- Gardikou Varvara Vanessa
- Gardiner Matthew
- Garg Atul
- Garg Sameer
- Garg Sanjeev
- Garrett Emily
- Gastaldi Christian
- Gatta Alessandro
- Gaudin Christophe
- Gavril Laura
- Gbolahan Olalere
- Ge Xiaodong
- Geddoa Burair
- Geddoa Emad
- Geisen Martin
- Geldenhuys Jacques
- Gemert Ankie Koopman-van
- Geng Wujun
- Georgakakis Georgios
- George Ronald
- Georgiou Georgios
- Georgopoulou Eleni
- Gercek Yuksel
- Germann Reinhard
- Geromarkaki Elisavet
- Ghignone Federico
- Ghosh Alison
- Ghushe Neil
- Giancarlo Luigi
- Giannaki Chrysavgi
- Gibson-Lapsley Hannah
- Giles Julian
- Gill James
- Gill Satwant
- Gill Talvinder
- Gille Jochen
- Gillespie David
- Gillies M.
- Gillies Michael
- Gilmore Jemma
- Gilmour Fiona
- Gkini Konstantia-Paraskevi
- Gkiokas Georgios
- Gkioni Panagiota
- Glasbey James
- Glasgow Emma
- Glister Georgina
- Glover Lyn
- Goebel Ulrich
- Goga Ismail E.
- Goga Riaz
- Goldberg Olivia
- Golder Kim
- Gondo Prisca
- Gong Haixia
- Gonzalez Alba Perez
- Gordon Paul
- Goss Harry
- Gouws Hanni
- Govender Komalan
- Govindasamy Vishendran
- Grace Anuforo
- Gracia Estefania
- Gradwohl-Matis Ilse
- Granum Simon NĂžrgaard
- Graterol Juan
- Gratrix Karen
- Graves Lynne
- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves Rosanna
- Green Garyth M.
- Green-Thompson Randolph
- Greene Michael
- Gregory Peter
- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
- Grigoryev Evgeny
- Grintescu Ioana
- Grishkowez Elena
- Grocott Mike
- Grosu Ramona - Mihaela
- Grubmueller Karl Gernot
- Gudaca Mariethel
- GuimarĂŁes Mario
- Guizeline Jaqueline
- Gunn Jacqueline
- Guo Baolei
- Guo Fengying
- Guo Huinan
- Guo Yongqing
- Guo Zheng
- Guok Eng Ching
- Gupta Ajay
- Gupta Janesh Kumar
- Guttenthaler Vera
- Guy Kramer
- GĂ€tke Mona Ring
- Haberl Claudia
- Habicher Marit
- Hack Yvonne
- Haddow James
- Hadebe Bernard
- Hadfield Daniel
- Hagau Natalia
- Haigh Kathryn
- Haisjackl Markus
- Hales Dawn
- Hall Andrew Macalister
- Hall Kathryn
- Hall Richard
- Hall Roger
- Halliwell Richard
- Hambidge Oliver
- Hamdan Alhafidz
- Hamilton Caroline
- Hamzah Zulkarnain
- Han Kunyuan
- Han Yangyang
- Handayani Dini
- Hanna George
- Harden Catherine
- Hare Gregory
- Hariharan Vimal
- Harper Mark
- Harrichandparsad R.
- Harries Rhiannon
- Harris Benjamin
- Harris Clair
- Harris James
- Harris Meredyth
- Harris Rudy
- Harris Sarah
- Harrison Jonathan
- Harsan Cristian Remus
- Hartmann Andreas
- Hartmann Cristina
- Haselberger Simone
- Hatton Jonathan
- Haunch Kirsty
- Hawes Elizabeth
- Hawkins Lesley
- Hay David
- Hayes Katia
- Hayes Morgan Philip
- He Changlin
- He Jie
- He Long
- He Miao
- He Xin
- Heather Blaylock
- Hedin Annika
- Heintzelmann Simon Bisgaard
- Helen Bryant
- Hellewell Alistair
- Helliwell Laurence
- Hellstrom Johanna
- Helmy Naeder
- Hennings Charles
- Hering Jens Peter
- Hernandez Carlos B.
- Hernandez Miguel
- Hesketh Sue
- Hewson R.
- Hewson Russ
- Hewson Russell
- Heymans Chan Hey Man
- Heyse Bjorn
- Hicks Catherine
- Hidayatullah Rahmat
- Hiesmayr Michael
- Higgie Kushlin
- Hill Gillian
- Hill Simon
- Hillermann Thomas
- Hills Vicky
- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E.
- Hodzovic Emil
- Hoedt Marielle den
- Hoeft Andreas
- Hoelzenbein Thomas
- Hofer Christoph
- Hoffer Franz
- Hoffmann JoĂŁo
- Holaubek Caroline
- Holden Douglas
- Hollands Heidi
- Holliger Stephan
- Hollmann Markus
- Holmes Kerry
- Holmström Sandra
- Holt Peter
- Hong Bosun
- Hood Marion
- Hopkins Brian
- Hopkins Luke
- Hopkins Phil
- Hopkins Thomas
- Horn Rachel
- Hosdurga Gurunath
- Hou Benchao
- Hou Jiabao
- Houston Kendra
- Houweling Peter
- Hove Mazvangu Onie
- Hovendal Claus
- Hu Chun hua
- Hu Liu
- Hu Na
- Hu Nianqiang
- Hu Rong
- Hu Shuangfei
- Hu Tingju
- Hu Xianwen
- Hu Xiaolan
- Hu Xuming
- Huang Changshun
- Huang Haijin
- Huang Jian
- Huang Ledan
- Huang Lixia
- Huang Luping
- Huang Song
- Huang Wenhui
- Huang Yang
- Huang Yanming
- Hubert Ribeiro Gustavo Luis
- Hubner Martin
- Hughes Thomas
- Hugill Keith
- Hulme Jonathan
- Hulst Abraham
- Humphreys Sally
- Humphries Ryan
- Hung Ching Yue Janice
- Hunt Jane
- Husain Tauqeer
- Hussain Ayyaz
- Hussain Nabilah
- Hutchings Melanie
- Hutchins David
- Hutton Monica
- Huygens Christel
- Huynh Wilson Binh Quan
- Hwan Haifang
- HĂ€rtl Christine
- HĂŒppe Michael
- Iasonidou Christina
- Idowu Olusola
- Ijuo Eke
- Iloabachie Ikechukwu
- Ilyina Yana
- Incertis Raul Raul
- Indra Imai
- Ioannidis Orestis
- Ionescu Daniela
- Ionita Victor
- Iosep Gabriel Florin
- Ip Peter
- Irshad Mariam
- Ischaki Eleni
- Ishimaru Alexander
- Iurin Aleksandr
- Jack James
- Jacobs Tom
- Jaeger Tarkan
- Jaffray David
- Jain Megha
- James Kathryn
- James Lynne
- James Sarah
- Jammer Ib
- Jansen van Vuuren Amanda
- Jansen Tracy-Lee
- Janssen Bruno
- Januszewska Marta
- Jaquet Yves
- Jardim Jaquelline
- Jawad Monir
- Jee Chiun Chen
- Jeeraz Mohammud A.
- Jeffery Holly
- Jeffs Carol
- Jehosua Brillyan
- Jelschen Florian
- Jemmett Kim
- Jemna Ramona
- Jenkins Nia
- Jenkins Nicole
- Jensen-Gadegaard Peter
- Jesus Joana Sofia Teixeira
- Jeyanthan Somasundaram
- Ji Binbin
- Ji Zhenrong
- Jia Danyun
- Jiang Linghui
- Jiang Ning
- Jiang Xinmei
- Jiang Zhangjie
- Jin Lin
- Jin Shenhui
- Jing Liang
- Jing Yan
- Johnson Emily
- Johnson Joanne
- Johnson Lyndsay
- Johnson Robert
- Jonas Attila
- Jones Craig
- Jones Dawn
- Jones Eleanor
- Jones Philip
- Jones Stephanie
- Jones Timothy
- Joory Kavita
- Jordaan J.
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- Yagnik Anmol
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- Yao Yurui
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- Yeh Erlinda
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- Yuan Jing
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- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeidan Lisa
- Zeng Qiuting
- Zerman Luiza
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Hongyan
- Zhang Huaigen
- Zhang Huan
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- Zhang Min
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- Zhang Qin
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- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Xuekang
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Ă kring Irene
- Ăgren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained â„1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32â0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88â1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62â0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61â0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo FĂĄbia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia GonzĂĄlez
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa HermĂnia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto SĂ©rgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
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- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
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- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boer Hans Donald
- Boereboom Catherine
- Boggiano Victoria
- Bokkel-Andela Janneke
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
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- Bouwman Arthur
- Bouwman Arthur
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- Bradburn Mike
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- Buise Marc
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- Burns Karen
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- Burrows Tom
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- Burton Megan
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- Cang Jing
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- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
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- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
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- Castle Gail
- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
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- Chan Yik Lam
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- Chandler Ben
- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conceição Soares Maria
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
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- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
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- Cornell Jonathan
- Cornish Julie
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- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
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- Cotterell Sharon
- Cotterill Donna
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- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
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- Craven Rachael
- Craw Nicholas
- Craw Sarah
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- Cruikshanks Andrew
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- Cunha Pedro
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- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- Cådiz Maria José Hernåndez
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Qingqing
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- De Bruyne Ann
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
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- Deepak Shantal
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- Deja Maria
- Del Valle Santiago Garcia
- Delgado GarcĂa David R
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- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
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- Green Garyth M
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- Xiong Xiapei
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- Xu Guan-Jie
- Xu Lin
- Xu Liyuan
- Xu Qiong
- Xu Shixia
- Xue Rui
- Yagnik Anmol
- Yan Yixiu
- Yang Jian
- Yang Lu
- Yang Qiuhong
- Yang Shuangjia
- Yang Tianqin
- Yang Yang
- Yao Shanglong
- Yao Yurui
- Yap Huey Ling
- Yarwood Jamie
- Yassaee Arrash
- Ye Haiwang
- Ye Hui
- Yegnaram Shashikant
- Yeh Erlinda
- Yin Ning
- Yip Chi Pang
- Yong Johnny
- Yu Hai Chuan
- Yu Shuchun
- Yu Tian
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- Yuan Fang
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- Yuan Jing
- Yuan Yazhuo
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- Yun Bai
- Zaane Bas
- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeggeren Laura
- Zeidan Lisa
- Zeng Qiuting
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Huaigen
- Zhang Huan
- Zhang Jie
- Zhang Kai
- Zhang Lina
- Zhang Min
- Zhang Mingxiao
- Zhang Qin
- Zhang Ruilin
- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- Ă„kring Irene
- Ăgren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The ClavienâDindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the ClavienâDindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using ClavienâDindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using ClavienâDindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally