CLARO-CMOS, a very low power ASIC for fast photon counting with pixellated photodetectors

The CLARO-CMOS is an application specific integrated circuit (ASIC) designed for fast photon counting with pixellated photodetectors such as multi-anode photomultiplier tubes (Ma-PMT), micro-channel plates (MCP), and silicon photomultipliers (SiPM). The first prototype has four channels, each with a charge sensitive amplifier with settable gain and a discriminator with settable threshold, providing fast hit information for each channel independently. The design was realized in a long-established, stable and inexpensive 0.35 um CMOS technology, and provides outstanding performance in terms of speed and power dissipation. The prototype consumes less than 1 mW per channel at low rate, and less than 2 mW at an event rate of 10 MHz per channel. The recovery time after each pulse is less than 25 ns for input signals within a factor of 10 above threshold. Input referred RMS noise is about 7.7 ke^- (1.2 fC) with an input capacitance of 3.3 pF. Thanks to the low noise and high speed, a timing resolution down to 10 ps RMS was measured for typical photomultiplier signals of a few million electrons, corresponding to the single photon response for these detectors

An Environmentally Friendly Nb–P–Si Solid Catalyst for Acid-Demanding Reactions

Here, we report the structural characteristics, the surface properties, and the catalytic performances of a Nb–P–Si ternary oxide material (2.5Nb2O5·2.5P2O5·95SiO2, 2.5NbP) in two reactions of importance for biomass valorisation and green industrial production: hydrolysis of inulin and esterification of oleic acid with polyalcohol for biolubricant production. High dispersion of the Nb centers, ascertained by UV–vis–DRS, 29Si, 31P, and 1H solid-state NMR spectroscopy, is the key point for the successful activity of 2.5NbP. Intrinsic and effective acidities of the sample were studied by FT-IR of adsorbed pyridine in the absence and presence of water and by volumetric titrations of the acid sites in cyclohexane and in water, to enlighten the nature and amount of acid sites in different environments. For both studied reactions, 2.5NbP catalyst exhibits water-tolerant acidic sites, mainly Brønsted ones, giving higher activity and better stability in the reaction medium than well-known niobium oxophosphate catalyst, which is considered one of the best water-tolerant acid catalysts

First array of enriched Zn82^{82}Se bolometers to search for double beta decay

The R&D activity performed during the last years proved the potential of ZnSe scintillating bolometers to the search for neutrino-less double beta decay, motivating the realization of the first large-mass experiment based on this technology: CUPID-0. The isotopic enrichment in $^{82}$Se, the Zn$^{82}$Se crystals growth, as well as the light detectors production have been accomplished, and the experiment is now in construction at Laboratori Nazionali del Gran Sasso (Italy). In this paper we present the results obtained testing the first three Zn$^{82}$Se crystals operated as scintillating bolometers, and we prove that their performance in terms of energy resolution, background rejection capability and intrinsic radio-purity complies with the requirements of CUPID-0

Study of the RET receptor dysfunctions caused by mutations associated with human neoplastic disorders and developmental diseases

The ret proto-oncogene encodes a membrane spanning glycoprotein which is a member of the receptor tyrosine kinase family (Hanks et al. 1988). RET is the signaling component of multi-subunit receptor complexes for the GDNF of family ligands, including GDNF, neurturin, artemin and persephin. The binding components of these receptor complexes are glycosyl-phosphatidylinositol (GPI)-membrane anchored molecules, known as GDNF family receptor α (GFRαs). Four different GFRαs (GFRα1–4) dictate ligand specificity. Germline point mutations of RET are responsible for the inheritance of MEN2 (Multiple Endocrine Neoplasia type 2) cancer syndromes which are usually divided into three different clinical subtypes: MEN2A, MEN2B and FMTC (familial medullary thyroid carcinoma), which are all autosomal dominant cancer syndromes. Inactivating mutations of RET cause an impaired development of the enteric nervous system which is responsible for the Congenital megacolon or Hirschprung's disease (HSCR). The aim of my work was to study the expression of different RET mutants in order to highlight their biological role in diverse cellular context. In particular, we focused on gain of function cysteine mutations that are responsible for medullary thyroid carcinoma (MTC) by causing covalent RET dimerisation, leading to ligand-independent activation of its tyrosine kinase. In this context, the association of Cys609 and Cys620 activating mutations with HSCR is still an unresolved paradox. To address this issue, we have developed a transgenic model for human diseases (specifically, Multiple Endocrine Neoplasia type 2 and Hirschsprung disease) through the insertion of a gain and loss of function RET mutation, the RETC620R in the mouse genome. We have also studied the in vitro effects of a tyrosine kinase inhibitor PP1, which we propose could represent a potential treatment strategy and merits further testing, using in vivo models such as the one we have generated

Analysis Techniques for the Evaluation of the Neutrinoless Double-Beta Decay Lifetime in 130^{130}Te with CUORE-0

We describe in detail the methods used to obtain the lower bound on the lifetime of neutrinoless double-beta ($0\nu\beta\beta$) decay in $^{130}$Te and the associated limit on the effective Majorana mass of the neutrino using the CUORE-0 detector. CUORE-0 is a bolometric detector array located at the Laboratori Nazionali del Gran Sasso that was designed to validate the background reduction techniques developed for CUORE, a next-generation experiment scheduled to come online in 2016. CUORE-0 is also a competitive $0\nu\beta\beta$ decay search in its own right and functions as a platform to further develop the analysis tools and procedures to be used in CUORE. These include data collection, event selection and processing, as well as an evaluation of signal efficiency. In particular, we describe the amplitude evaluation, thermal gain stabilization, energy calibration methods, and the analysis event selection used to create our final $0\nu\beta\beta$ decay search spectrum. We define our high level analysis procedures, with emphasis on the new insights gained and challenges encountered. We outline in detail our fitting methods near the hypothesized $0\nu\beta\beta$ decay peak and catalog the main sources of systematic uncertainty. Finally, we derive the $0\nu\beta\beta$ decay half-life limits previously reported for CUORE-0, $T^{0\nu}_{1/2}>2.7\times10^{24}$ yr, and in combination with the Cuoricino limit, $T^{0\nu}_{1/2}>4.0\times10^{24}$ yr.Comment: 18 pages, 18 figures. (Version 3 reflects only minor changes to the text. Few additional details, no major content changes.

A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

This paper describes a new annular reactor for continuous UV photochemistry, which uses easily interchangeable excimer lamps of different wavelengths. The reactor has narrow clearance to form thin films of material for efficient irradiation of molecules. Its use is demonstrated by investigating the effect of discrete wavelength lamps (222, 282 and 308 nm) on the reaction of potassium N-phthalimidobutanoate 1. The ability of the reactor to be integrated into multistep processes is illustrated by combining it with an Amberlyst scavenger and a solid acid catalyst, NbOPO4, to access a second product 3 that is obtained in a single telescoped process. The tricyclic scaffold in 3 is a motif found in several biologically active compounds and has possibilities as a synthon for new pharmaceutical products