Dispositiu comunicació vídeo per IP

En un futur no molt llunyà desapareixerà la televisió analògica. Per a molts és un gran avantatge disposar de més canals per veure però per a uns altres és sinònim de pèrdua. Aquells que treballen a una televisió local, com ara la Televisió de Vallirana, es veuran obligats a compartir una llicència de TDT amb altres municipis dins la mateixa comarca. Per això s’ha establert l’estudi per a la formació d’una nova manera d’emetre televisió. La Televisió per IP. En aquest projecte formarem part de l’equip que estudiarà quin és el mètode més efectiu per poder portar a Vallirana la IPTV. Es treballarà per fer l’enllaç radioelèctric principal de la xarxa wireless que arribarà des de la TVV fins a la torre emissora. Es portarà a terme les configuracions dels diferents equips (punts d’accés, VLC, antenes, ...) Es tractarà d’afrontar els problemes durant les proves amb solucions reals. I s’estudiarà la manera de poder fer el desplegament de la xarxa en un futur pròxim. Tot això per poder assegurar que Vallirana continuï gaudint d’una de les seves senyals d’identitat: La Televisió

Electron-rich metal complexes for C02 and CS2 incorporation

The dihapto coordination of two molecules of carbon dioxide to a square-planar MoP2(P-P) fragment (P=monodentate-, P-P=bidentate phosphi- ne ligands) can occur in several ways giving rise to different conformers. Compounds of this type have been prepared and their spectroscopic proper- ties investigated by variable temperature 'H and 31P NMR studies. The for- mation of ethylene complexes related to Mo(C2H4)2(PMe3)4, 6, and the study of their reactivity towards carbon dioxide and carbon disulphide is also described. In particular, compound 6 induces a head-to-tail dimerization of carbon disulphide with formation of a Mo(II)-C$4 linkage, which, in the presence of carbon monoxide, undergoes a symmetric, oxidative rupture, which produces a Mo(0) complex and two molecules of carbon disulphide. The insertion reactions of carbon dioxide and other unsaturated molecules into the nickel-carbon bonds of the nickelacyclopentene complexes 9 have been investigated and different organic products isolated by means of simple or sequential insertion reactions.Ministerio de Educación y CienciaAgencia Nacional de Evaluación y Prospectiv

Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids

Biomarker; Individuals with severe asthma; Oral corticosteroidsBiomarcador; Persones amb asma greu; Corticosteroides oralsBiomarcador; Personas con asma grave; Corticosteroides oralesNowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. For this purpose, serum and lung tissue miRNAs of OCS and non-OCS asthmatic individuals were evaluated by miRNAs-Seq, and subsequently miRNA validation was performed using RT-qPCR. Additionally, pathway enrichment analysis of deregulated miRNAs was conducted. We observed altered expression by the next-generation sequencing (NGS) of 11 miRNAs in serum, of which five (hsa-miR-148b-3p, hsa-miR-221-5p, hsa-miR-618, hsa-miR-941, and hsa-miR-769-5p) were validated by RT-qPCR, and three miRNAs in lung tissue (hsa-miR-144-3p, hsa-miR-144-5p, and hsa-miR-451a). The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR-221-5p and hsa-miR-769-5p. Expression of hsa-miR-148b-3p and hsa-miR-221-5p correlated with FEV1/FVC (%) and these altered miRNAs act in key signaling pathways for asthma disease and the regulated expression of some genes (FOXO3, PTEN, and MAPK3) involved in these pathways. In conclusion, there are miRNA profiles differentially expressed in OCS-treated individuals with asthma and could be used as biomarkers of OCS treatment.This work was supported by ISCIII—Instituto de Salud Carlos III, FIS (Fondo de Investigación Sanitaria—Spanish Health Research Fund) grants PI18/00167, PI21/00896, and FI19/00067; Ciber de Enfermedades Respiratorias (CIBERES); RTC-2017-6501-1 (Ministerio de Ciencia, Innovación y Universidades), a Carlos III Institute of Health Initiative; and FEDER funds (Fondo Europeo de Desarrollo Regional)

Histological assessment of nanostructured fibrin-agarose skin substitutes grafted in burnt patients. A time-course study

A previously developed fibrin-agarose skin model—UGRSKIN—showed promising clinical results in severely burnt patients. To determine the histological parameters associated to the biocompatibility and therapeutic effects of this model, we carried out a comprehensive structural and ultrastructural study of UGRSKIN grafted in severely burnt patients after 3 months of follow-up. The grafted epidermis was analogue to native human skin from day 30th onward, revealing well-structured strata with well-differentiated keratinocytes expressing CK5, CK8, CK10, claudin, plakoglobin, filaggrin, and involucrin in a similar way to controls, suggesting that the epidermis was able to mature and differentiate very early. Melanocytes and Langerhans cells were found from day 30th onward, together with a basement membrane, abundant hemidesmosomes and lack of rete ridges. At the dermal layer, we found an interface between the grafted skin and the host tissue at day 30th, which tended to disappear with time. The grafted superficial dermis showed a progressive increase in properly-oriented collagen fibers, elastic fibers and proteoglycans, including decorin, similarly to control dermis at day 60-90th of in vivo follow-up. Blood vessels determined by CD31 and SMA expression were more abundant in grafted skin than controls, whereas lymphatic vessels were more abundant at day 90th. These results contribute to shed light on the histological parameters associated to biocompatibility and therapeutic effect of the UGRSKIN model grafted in patients and demonstrate that the bioengineered skin grafted in patients is able to mature and differentiate very early at the epithelial level and after 60–90 days at the dermal level.Consejería de Salud y Familias, Junta de AndalucíaGrant/Award Numbers: PE- 0395-2019, PI-0458-2016Consejería de Transformación Económica, Industria,Conocimiento y Universidades, Grant/Award Number: B-CTS-450-UGR20Instituto de Salud Carlos III, Grant/Award Number: AC17/0001

Nethserver, herramienta de control de acceso a estaciones de trabajo GNU Linux.

Ilustraciones de autoría propia.El mundo actual se ha definido por el uso marcado de diversas herramientas técnicas y tecnológicas que permiten la ejecución holística de las actividades humanas. Es así como en Linux se ofrece al mercado de software y en sí, al código abierto una herramienta de gestión y control como Nethserver; una distribución modular que busca administrar políticas de control de acceso a la red a través del uso de DHCP, VPN, Firewall, File Server entre otros paquetes. Partiendo de lo anterior, en este artículo se expone como trabajo final del diplomado en Sistemas Operativos Open Source con Certificación en Linux, el desarrollo de la instalación y configuración de la distribución basada en CentOS/RHEL, implementando servicios que ofrecen posibilidades infinitas a la organización contratante, tanto en el campo de ciberseguridad, como en la conexión de equipos, impresoras y servicios de red, accesos remotos y segmentación por áreas empresariales o personales.The current world has been defined by the marked use of various technical and technological tools that allow for the holistic execution of human activities. This is how Linux offers the software market and open source itself a management and control tool like Nethserver; a modular distribution that seeks to manage access control policies to the network using DHCP, VPN, Firewall, File Server, among other packages. Based on the above, this article presents as the final work of the Open-Source Operating Systems Diploma with Certification in Linux, the development of the installation and configuration of the distribution based on CentOS/RHEL, implementing services that offer infinite possibilities to the contracting organization, both in the field of cybersecurity, as well as in the connection of equipment, printers and network services, remote access and segmentation by business or personal areas

Usos y desusos del modelo GPT-3 entre estudiantes de grados de ingeniería

La herramienta ChatGPT, basada en el modelo GPT-3 desarrollado por OpenAI, ya se utiliza por estudiantes de grados de ingeniería como herramienta de apoyo en su proceso de aprendizaje. En este contexto, las implicaciones negativas que presenta el uso de esta herramienta son diversas: dependencia tecnológica, obstaculización del saber y conocer práctico, error en las respuestas, problemas éticos o incluso problemas legales. El uso de esta herramienta sin que los estudiantes hayan recibido formación se considera como problema a investigar. El objetivo es entender en profundidad el contexto tecnológico de la herramienta, cómo se utiliza actualmente entre los estudiantes de ingeniería de un conjunto de universidades privadas y públicas, y su impacto en la educación universitaria. Este artículo es un trabajo en desarrollo donde se presenta el contexto del estudio, la metodología de investigación y unos primeros resultados. Se conduce una encuesta cualitativa-exploratoria con una muestra de más de 360 estudiantes de grados de ingeniería matriculados en diferentes cursos. Se utiliza una estratificación aleatoria para asegurar que la muestra sea representativa de la población. Los resultados sugieren que el modelo GPT-3 puede ser utilizado como una herramienta beneficiosa para los estudiantes de grados de ingeniería.ChatGPT, the tool based on the GPT-3 model developed by OpenAI, is already being used by engineering students for support in their learning process. In this context, the negative implications of using this tool are diverse: technological dependency, hindrance of practical knowledge and understanding, errors in answers, ethical or even legal problems. The use of this tool by students without receiving proper training is considered a problem to be investigated. The goal is to deeply understand the technological context of the tool, how it is currently used among engineering students from a set of private and public universities, and its impact on university education. This paper is a work in progress that presents the context of the study, the research methodology and some preliminary results. A qualitative-exploratory survey is conducted with a sample of more than 360 engineering students enrolled in different courses. Random stratification is used to ensure that the sample is representative of the population. The results suggest that the GPT-3 model can be used as a valuable tool for engineering students.Peer ReviewedPostprint (published version

Usos y desusos del modelo GPT-3 entre estudiantes de grados de ingeniería

La herramienta ChatGPT, basada en el modelo GPT-3 desarrollado por OpenAI, ya se utiliza por estudiantes de grados de ingeniería como herramienta de apoyo en su proceso de aprendizaje. En este contexto, las implicaciones negativas que presenta el uso de esta herramienta son diversas: dependencia tecnológica, obstaculización del saber y conocer práctico, error en las respuestas, problemas éticos o incluso problemas legales. El uso de esta herramienta sin que los estudiantes hayan recibido formación se considera como problema a investigar. El objetivo es entender en profundidad el contexto tecnológico de la herramienta, cómo se utiliza actualmente entre los estudiantes de ingeniería de un conjunto de universidades privadas y públicas, y su impacto en la educación universitaria. Este artículo es un trabajo en desarrollo donde se presenta el contexto del estudio, la metodología de investigación y unos primeros resultados. Se conduce una encuesta cualitativa-exploratoria con una muestra de más de 360 estudiantes de grados de ingeniería matriculados en diferentes cursos. Se utiliza una estratificación aleatoria para asegurar que la muestra sea representativa de la población. Los resultados sugieren que el modelo GPT-3 puede ser utilizado como una herramienta beneficiosa para los estudiantes de grados de ingeniería.ChatGPT, the tool based on the GPT-3 model developed by OpenAI, is already being used by engineering students for support in their learning process. In this context, the negative implications of using this tool are diverse: technological dependency, hindrance of practical knowledge and understanding, errors in answers, ethical or even legal problems. The use of this tool by students without receiving proper training is considered a problem to be investigated. The goal is to deeply understand the technological context of the tool, how it is currently used among engineering students from a set of private and public universities, and its impact on university education. This paper is a work in progress that presents the context of the study, the research methodology and some preliminary results. A qualitative-exploratory survey is conducted with a sample of more than 360 engineering students enrolled in different courses. Random stratification is used to ensure that the sample is representative of the population. The results suggest that the GPT-3 model can be used as a valuable tool for engineering students

Database of spatial distribution of non indigenous species in Spanish marine waters

Research in marine Spanish waters are focused on several actions to achieve an effectively management on protected areas, with the active participation of the stakeholders and research as basic tools for decision-making. Among these actions, there is one about the knowledge and control on NIS. One of its objectives is the creation of NIS factsheets, which are going to be added to the National Marine Biodiversity Geographical System (GIS) providing complementary information about taxonomic classification, common names, taxonomic synonyms, species illustrations, identification morphological characters, habitat in the native and introduced regions, biological and ecological traits, GenBank DNA sequences, world distribution, first record and evolution in the introduced areas, likely pathways of introduction, effects in the habitats and interaction with native species, and potential management measures to apply. The database will also provide data for (1) the European online platforms, (2) the environmental assessment for the Descriptor 2 (D2-NIS) of the EU Marine Strategy Framework Directive (MSFD), as well as (3) supporting decisions made by stakeholders. It is the result of extensive collaboration among scientist, manager’s and citizen science in the Spanish North-Atlantic, South-Atlantic, Gibraltar Strait-Alboran, Levantine-Balearic and Canary Islands marine divisions, providing an updated overview of the spatial distribution of relevant extended and invasive NIS of recent and established NIS introduced by maritime transport and aquaculture pathways, as well as on cryptogenic or native species in expansion due to the climatic water warming trend

Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study

Limited data are available on the effectiveness and tolerability of direct-acting antivirals (DAAs) therapies in the real world for HCV-infected patients with comorbidities. This study aimed to describe the effectiveness of OBV/PTV/r ± DSV (3D/2D regimen) with or without ribavirin (RBV) in HCV or HCV/HIV co-infected patients with GT1/GT4 and CKD (IIIb-V stages), including those under hemodialysis and peritoneal dialysis in routine clinical practice in Spain in 2015.Non-interventional, retrospective, multicenter data collection study in 31 Spanish sites. Socio-demographic, clinical variables, study treatment characteristics, effectiveness and tolerability data were collected from medical records.Data from 135 patients with a mean age (SD) of 58.3 (11.4) years were analyzed: 92.6% GT1 (81.6% GT1b and 17.6% GT1a) and 7.4% GT4, 14 (10.4%) HIV/HCV co-infected, 19.0% with fibrosis F3 and 28.1% F4 by FibroScan®, 52.6% were previously treated with pegIFN and RBV. 11.1%, 14.8% and 74.1% of patients had CKD stage IIIb, IV and V respectively. 68.9% of patients were on hemodialysis; 8.9% on peritoneal dialysis and 38.5% had history of renal transplant. A total of 125 (96.2%) of 135 patients were treated with 3D, 10 (7.4%) with 2D and 30.4% received RBV. The overall intention-to-treat (ITT) sustained virologic response at week 12 (SVR12) was 92.6% (125/135) and the overall modified-ITT (mITT) SVR12 was 99.2% (125/126). The SVR12 rates (ITT) per sub-groups were: HCV mono-infected (91.7%), HCV/HIV co-infected (100%), GT1 (92.0%), GT4 (100%), CKD stage IIIb (86.7%), stage IV (95%) and stage V (93%). Among the 10 non-SVR there was only 1 virologic failure (0.7%); 4 patients had missing data due lost to follow up (3.0%) and 5 patients discontinued 3D/2D regimen (3.7%): 4 due to severe adverse events (including 3 deaths) and 1 patient´s decision.These results have shown that 3D/2D regimens are effective and tolerable in patients with advanced CKD including those in dialysis with GT 1 or 4 chronic HCV mono-infection and HIV/HCV coinfection in a real-life cohort. The overall SVR12 rates were 92.6% (ITT) and 99.2% (mITT) without clinically relevant changes in eGFR until 12 weeks post-treatment. These results are consistent with those reported in clinical trials