I Seminario Hispano-Venezolano. Poder y mentalidad en España e Iberoamérica.

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La propiedad inmobiliaria de los conventos femeninos madrileños en el siglo XVIII.

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Fundación y dote del Convento de Nuestra Señora de los Ángeles de Madrid. Peculiaridades de un modelo diferente de patronato regio.

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V Seminario de Instituciones en la España Moderna. Dogmatismo e intolerancia, siglos XV - XVIII.

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La conciencia lingüística a través de un viajero árabe del siglo XIV: Ibn Bat túta.

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Photoresponsive Control of G-Quadruplex DNA Systems

[Image: see text] G-quadruplex (G4) oligonucleotide secondary structures have recently attracted significant attention as therapeutic targets owing to their occurrence in human oncogene promoter sequences and the genome of pathogenic organisms. G4s also demonstrate interesting catalytic activities in their own right, as well as the ability to act as scaffolds for the development of DNA-based materials and nanodevices. Owing to this diverse range of opportunities to exploit G4 in a variety of applications, several strategies to control G4 structure and function have emerged. Interrogating the role of G4s in biology requires the delivery of small-molecule ligands that promote its formation under physiological conditions, while exploiting G4 in the development of responsive nanodevices is normally achieved by the addition and sequestration of the metal ions required for the stabilization of the folded structure. Although these strategies prove successful, neither allows the system in question to be controlled externally. Meanwhile, light has proven to be an attractive means for the control of DNA-based systems as it is noninvasive, can be delivered with high spatiotemporal precision, and is orthogonal to many chemical and biological processes. A plethora of photoresponsive DNA systems have been reported to date; however, the vast majority deploy photoreactive moieties to control the stability and assembly of duplex DNA hybrids. Despite the unique opportunities afforded by the regulation of G-quadruplex formation in biology, catalysis, and nanotechnology, comparatively little attention has been devoted to the design of photoresponsive G4-based systems. In this Perspective, we consider the potential of photoresponsive G4 assemblies and examine the strategies that may be used to engineer these systems toward a variety of applications. Through an overview of the main developments in the field to date, we highlight recent progress made toward this exciting goal and the emerging opportunities that remain ripe for further exploration in the coming years

Carbon Dots as an Emergent Class of Antimicrobial Agents

Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.Peer reviewe

Drawing and construction. Applying normative chromatic codes to monumental restoration in Granada at the outset of the 20th century

[EN] The Ordenanzas municipales de la ciudad de Granada published in 1904 was a modern normative document specifying the mandatory chromatic directives for architectural plans submited when requesting a building license. This code stems from the separation in the mid-19 century of the Degree of Architecture from the Faculty of Fine Arts, which led to the normalization of graphic codes and the necessity of acquiring precise technical knowledge. The current study, based on searches in public archives for chromatic codes relative to architectural interventions, intends not only to explore their role in accurately depicting the reality of the images, but to shed light both on the economy of means deriving from Granada s 19th-century bourgeois transformation and the origins of monumetal restorartion, a young discipline that was to emerge in the first third of the 20th century.[ES] Las Ordenanzas municipales de Granada de 1904 constituyeron un avanzado documento normativo que recogía la obligatoriedad de emplear un código cromático en la representación gráfica de los planos para solicitar licencia de obras. Este criterio surge a mediados del XIX a raíz de la separación del título de Arquitectura de la rama de Bellas Artes, que exigía la síntesis documental de recursos gráficos y precisos conocimientos técnicos.Desde el acceso a archivos de la administración pública para el rastreo de la aplicación de códigos cromáticos en la representación de intervenciones arquitectónicas, se pretende poner en valor la trascendencia de estos criterios no solo para identificar con exactitud la realidad y su imagen representada, sino para explicar con economía de medios la transformación burguesa de la ciudad del novecientos y para constatar el nacimiento de la restauración monumental, una disciplina joven surgida en el primer tercio del siglo XX.Hernández Soriano, R.; Martínez-Quesada, MDC. (2022). Dibujo y construcción. Aplicación de códigos gráficos normativos a la restauración monumental en Granada. EGA Expresión Gráfica Arquitectónica. 27(46):88-99. https://doi.org/10.4995/ega.2022.160338899274

Trento y el marco institucional de las órdenes religiosas femeninas en la Edad Moderna

The Council of Trento establishes a general Reform of the organization of the Catholic Church, that affects especially to the feminine religious convents. These changes where making an evolution within these monasteries. The author studies its influence in the different religious orders.El Concilio de Trento establece una reforma general de la organización de la Iglesia Católica, que afecta de una manera especial a los conventos religiosos femeninos. Estos cambios depararon una evolución dentro de estos cenobios. La autora estudia su influencia en las diferentes órdenes religiosas