L’eliminació de mesures de subjecció al geriàtric de Ferreries gestionat per l’Intress

[cat] Als darrers anys, cada vegada, proliferen més intervencions destinades a cuidar de la persona gran sense necessitat de l’ús de subjeccions (físiques o químiques). Les investigacions apunten que l´ús de subjeccions no sempre assegura que la persona gran no caigui, i a més a més, impliquen un conjunt de repercussions negatives cap a la persona, com podria ser la pèrdua d’autonomia personal, sentiments negatius (ràbia, frustració, impotència, tristesa, etc.), afectació psicològica i/o cognitiva, deterioració funcional, entre altres. A la vegada, s’ha de plantejar fins a quin punt una subjecció no és una forma de vulneració dels drets fonamentals de la persona al limitar la seva llibertat. Per avaluar aquest aspecte, aquest estudi analitza el nombre de caigudes dels usuaris del centre residencial de Ferreries (gestionat per Intress), així com les condicions associades a les caigudes es puguin produir. Són usuaris que mai han estat subjectes, o bé, que s’han sotmès a un procés de retirada de subjeccions. A la vegada, l’avaluació és complementada amb una font d’informació externa: satisfacció i opinió dels familiars sobre la situació – usuaris lliures de subjeccions-. Entre els principals resultats de l’estudi s’indica que és reduït el nombre de caigudes per usuari, i que les repercussions associades són lleus (un 62,5% no tenen conseqüències i un 31,3% pateixen contusions lleus). També es constaten millores notables segons la valoració dels familiars: es converteixen en persones més actives (94,2%), incrementant les relacions socials, millorant l’estat d’ànim, realitzant més activitats d’autocura i participant més en les activitats del centre. Per tant, els resultants avalen aquesta iniciativa desenvolupada al centre residencial pel grup Intress i aposten per l’ús de mesures alternatives basades en plans individualitzats centrats en l’usuari, com podria ser: la reeducació de la marxa, l’ús d’ajudes dinàmiques i tècniques, la modificació ambiental o un augment de la supervisió de la persona.[spa] En los últimos años, cada vez, proliferan más intervenciones destinadas a cuidar de la persona mayor sin necesidad del uso de sujeciones (físicas o químicas). Las investigaciones apuntan que el uso de sujeciones no siempre asegura que la persona mayor no caiga, y además, implican un conjunto de repercusiones negativas hacia la persona, como podría ser la pérdida de la autonomía personal, sentimientos negativos (rabia, frustración, impotencia, tristeza, etc.), afectación psicológica y/o cognitiva, deterioro funcional, entre otras. Al mismo tiempo, se debe de plantear hasta qué punto una sujeción no es una forma de vulneración de los derechos fundamentales de la personal al limitar su libertad. Para evaluar este aspecto, este estudio analiza el número de caídas de los usuarios del centro residencia de Ferreries (gestionado por Intress), así como las condiciones asociadas a las caídas que se puedan producir. Son usuarios que nunca han estado sujetados, o bien, que se han sometido a una proceso de retirada de sujeciones. Al mismo tiempo, la evaluación es completada con una fuente de información externa: satisfacción y opinión de los familiares sobre la situación –usuarios libres de sujeciones-. Entre los principales resultados del estudio se indica que es reducido el número de caídas por usuario, y que las repercusiones asociadas son leves (un 62,5% no tienen consecuencias y un 31,3% sufren contusiones leves). También se contrastan mejoras notables según la valoración de los familiares: se convierten en personas más activas (94,2%), incrementando las relaciones sociales, mejorando el estado de ánimo, realizando más actividades de autocuidado y participando más en las actividades del centro. Por tanto, los resultados avalan esta iniciativa desarrollada en el centro residencial por el grupo Intress y apuestan por el uso de medidas alternativas basadas en planes individualizados centrados en el usuario, como podría ser: la reeducación de la marcha, el uso de ayudas dinámicas o técnicas, la modificación ambiental o un aumento de la supervisión de la persona

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

The MAX network transcriptional repressor (MNT) is an MXD family transcription factor of the basic helix-loop-helix (bHLH) family. MNT dimerizes with another transcriptional regulator, MYC-associated factor X (MAX), and down-regulates genes by binding to E-boxes. MAX also dimerizes with MYC, an oncogenic bHLH transcription factor. Upon E-box binding, the MYC-MAX dimer activates gene expression. MNT also binds to the MAX dimerization protein MLX (MLX), and MNT-MLX and MNT-MAX dimers co-exist. However, all MNT functions have been attributed to MNT-MAX dimers, and no functions of the MNT-MLX dimer have been described. MNT's biological role has been linked to its function as a MYC oncogene modulator, but little is known about its regulation. We show here that MNT localizes to the nucleus of MAX-expressing cells and that MNT-MAX dimers bind and repress the MNT promoter, an effect that depends on one of the two E-boxes on this promoter. In MAX-deficient cells, MNT was overexpressed and redistributed to the cytoplasm. Interestingly, MNT was required for cell proliferation even in the absence of MAX. We show that in MAX-deficient cells, MNT binds to MLX, but also forms homodimers. RNA-sequencing experiments revealed that MNT regulates the expression of several genes even in the absence of MAX, with many of these genes being involved in cell cycle regulation and DNA repair. Of note, MNT-MNT homodimers regulated the transcription of some genes involved in cell proliferation. The tight regulation of MNT and its functionality even without MAX suggest a major role for MNT in cell proliferation.This work was supported by Grant SAF2017-88026-R from Agencia Estatal de Investigación, Spanish Government (to J. L. and M. D. D.), funded in part by FEDER Program from the European Union, National Institutes of Health Grant CA57138/CA from NCI (to R. N. E.), and grants from Shriners Hospitals for Children (to P. J. H.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

A high concentration of TGF-β correlates with opportunistic infection in liver and kidney transplantation

Transforming growth factor-β (TGF-β) has been associated with numerous human infections, but its role in the occurrence of opportunistic infection (OI) after solid organ transplantation remains unexplored. This study aimed to assess the utility of the TGF-β following in vitro stimulation of whole peripheral blood (WPB) as a surrogate biomarker of post-transplant OI in a cohort of liver and kidney recipients. Thirty liver and thirty-one kidney transplant recipients were recruited to be prospectively monitored for one-year post-transplantation. Enzyme-linked immunosorbent assay (ELISA) was performed to calculate IFN-γ, IL-17, IL-10 and TGF-β concentration in the supernatant from the activated WPB. Recipients showed higher TGF-β concentrations compared to IFN-γ, IL-17, IL-10 at baseline, although these differences were not significant between INF and NoINF. However, recipients who developed an OI within the first sixth months had a higher concentration of TGF-β than those without OI. A concentration of TGF-β > 363.25 pg/ml in liver and TGF-β > 808.51 pg/ml in kidney recipients were able to stratify patients at high risk of OI with a sensitivity and specificity above 70% in both types of solid organ transplantations. TGF-β could provide valuable information for the management of liver and kidney recipients at risk of post-transplant infection.Our work was possible thanks to the support and funding obtained from the “Instituto de Salud Carlos III (ISCIII)”, Spanish Ministry of Health (Grant Number PI15/01370 and P19/01194); and co-funding by the European Union from the European Regional Development Fund (ERDF) with the principle of “A manner to build Europe”

Restauración del Patrimonio de la Universidad de Granada (I)

La serie editorial de Cuadernos Técnicos del Patrimonio surge debido a la necesidad de dotar al Vicerrectorado de Extensión Universitaria de publicaciones que aborden aspectos patrimoniales en relación con cuestiones de carácter transversal y que sirvan de vehículo de difusión y diálogo de las distintas colecciones que conforman el rico acervo universitario. El objetivo es convertir estos Cuadernos en un espacio de reflexión y debate sobre temas relacionados con la conservación, la restauración, la gestión, la difusión y la puesta en valor de los bienes muebles e inmuebles de la Universidad de Granada en toda su amplitud. No se plantean con un enfoque exclusivamente local pues su intención es abrirse a distintas problemáticas patrimoniales y convertirse en un instrumento que integre estudios de carácter nacional e internacional. Asimismo, entendemos que al Patrimonio hay que afrontarlo desde una perspectiva histórica pero también actual y en diálogo con la compleja realidad social

Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain

Background: Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households. Methods: A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated. Results: 1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01). Conclusions: Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility

Charming and bewitching : considering the Harry Potter series

Aquest document està relacionat amb: Addictive and wonderful : the experience of reading the Harry Potter serie

Multiple health behaviour change primary care intervention for smoking cessation, physical activity and healthy diet in adults 45 to 75 years old (EIRA study): a hybrid effectiveness-implementation cluster randomised trial

Methods: A cluster randomised effectiveness-implementation hybrid trial-type 2 with two parallel groups was conducted in 25 Spanish Primary Health Care (PHC) centres (3062 participants): 12 centres (1481 participants) were randomised to the intervention and 13 (1581 participants) to the control group (usual care). The intervention was based on the Transtheoretical Model and focused on all target behaviours using individual, group and community approaches. PHC professionals made it during routine care. The implementation strategy was based on the Consolidated Framework for Implementation Research (CFIR). Data were analysed using generalised linear mixed models, accounting for clustering. A mixed-methods data analysis was used to evaluate implementation outcomes (adoption, acceptability, appropriateness, feasibility and fidelity) and determinants of implementation success. Results: 14.5% of participants in the intervention group and 8.9% in the usual care group showed a positive change in two or all the target behaviours. Intervention was more effective in promoting dietary behaviour change (31.9% vs 21.4%). The overall adoption rate by professionals was 48.7%. Early and final appropriateness were perceived by professionals as moderate. Early acceptability was high, whereas final acceptability was only moderate. Initial and final acceptability as perceived by the participants was high, and appropriateness moderate. Consent and recruitment rates were 82.0% and 65.5%, respectively, intervention uptake was 89.5% and completion rate 74.7%. The global value of the percentage of approaches with fidelity ≥50% was 16.7%. Eight CFIR constructs distinguished between high and low implementation, five corresponding to the Inner Setting domain. Conclusions: Compared to usual care, the EIRA intervention was more effective in promoting MHBC and dietary behaviour change. Implementation outcomes were satisfactory except for the fidelity to the planned intervention, which was low. The organisational and structural contexts of the centres proved to be significant determinants of implementation effectiveness

Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study

Pantothenate kinase-associated neurodegeneration is a progressive neurological disorder occurring in both childhood and adulthood. The objective of this study was to design and pilot-test a disease-specific clinical rating scale for the assessment of patients with pantothenate kinase-associated neurodegeneration.info:eu-repo/semantics/publishedVersio

Micromón València (Universitat de València)

En Julio de 2017 se creó la red SWI@Spain, auspiciada por el grupo de Docencia y Difusión de la Microbiología (DDM) de la Sociedad Española de Microbiología (SEM), para desarrollar la iniciativa internacional Small World Initiative (SWI) en la península ibérica. En la Universitat de València (UV) se constituyó entonces el grupo de Innovación Docente en Microbiología (IDM) para implementar el proyecto a nivel local. Avalados por el Servei de Formació Permanent i Innovació Educativa (SFPIE) de la UV, el grupo ha llevado a cabo diferentes iniciativas relacionadas con el objetivo fundamental del proyecto: divulgar la problemática actual relacionada con el uso inadecuado de antibióticos, el incremento de bacterias resistentes a éstos y la necesidad de encontrar nuevas moléculas con actividad antibacteriana para combatir las infecciones que provocan