Utilización de los ingresos y su efecto en la liquidez de la empresa Conagas S.A.C., Santiago de Surco, Lima, 2017

RESUMEN El presente trabajo de investigación “Utilización de los ingresos y su efecto en la liquidez de la empresa Conagas S.A.C, Santiago de Surco, Lima, 2017”; está orientado a comprender que la variable liquidez es la capacidad de pago que tiene la empresa a corto plazo y tratar de generar dinero líquido en caja. El objetivo general busca determinar “El manejo de los ingresos y su efecto en la liquidez de la empresa Conagas S.A.C, Santiago de Surco, Lima, 2017”, un problema detectado que consideramos relevante para investigar la causa y efecto de las variables en estudio. Mediante la investigación se pretende aportar recomendaciones que permita contrarrestar el problema que se viene suscitando en forma mensual debido al inadecuado mecanismo del manejo de sus ingresos y que le permita mantener un nivel adecuado de liquidez mensual. Este proyecto se apoya en el marco teórico, logrando así una síntesis de cada una de las variables que ayuda a una mejor comprensión de la parte teórica de la investigación. Para la elaboración de este proyecto de investigación hemos aplicado el tipo de investigación aplicada, la población está constituida por la liquidez de la empresa, ya que esto nos ayudará a responder a las preguntas de investigación, el diseño es no experimental de corte transversal y con un enfoque cuantitativo. PALABRAS CLAVES: Liquidez, ingresos, indicadores financieros.ABSTRACT The present research paper "Use of income and its effect on the liquidity of the company Conagas S.A.C, Santiago de Surco, Lima, 2017"; is oriented to understand that the variable liquidity is the capacity of payment that the company has in the short term and try to generate liquid cash. The general objective is to determine "The management of income and its effect on the liquidity of the company Conagas S.A.C, Santiago de Surco, Lima, 2017", a detected problem that we consider relevant to investigate the cause and effect of the variables under study. The research is intended to provide recommendations to offset the problem that is arising on a monthly basis due to the inadequate mechanism of managing their income and to maintain an adequate level of monthly liquidity. This project is based on the theoretical framework, thus achieving a synthesis of each of the variables that helps a better understanding of the theoretical part of the research. For the elaboration of this research project we have applied the type of applied research, the population is constituted by the liquidity of the company, since this will help us to answer the research questions, the design is non-experimental of transversal cut and with a quantitative approach. KEYWORDS: Liquidity, revenues, financial indicators

Conservation program works as an alternative irrigation districts in sustainable water management of agricultural use

Water scarcity is an issue of worldwide concern since it is already having an impact on social development. Mexico is not an exception to this problem because in several regions of the country are great difficulties in supplying water, primarily for agricultural use. In Sinaloa, it had been mentioned repeatedly by the media that in the Irrigation District 063, located in the northern of the state, there are problems of water scarcity, and yet there still exist difficulties in conserving the resource. More than 49% of the water used for agriculture is wasted. To resolve this problem, producers and government agencies spend significant resources for investment in water conservation. However, the results have not been entirely satisfactory because the waste is high, a situation that motivates them to study more deeply the main weaknesses that affect sustainable resource use. Farmer’s participation in the administration of water infrastructure is important, as well as providing financial resources for the conservation of water system; and participation in activities of construction and repaired of water infrastructure. Farmer’s should also plan and design strategies for water conservation. This situation requires an appropriate level of technology and intellectual, rather than local producers and thus no complicated sustainable resource management. That is what local producers don’t have and therefore it complicates the sustainable management of the resource

Non-Hodgkin lymphomas of oral cavity

Non-Hodgkin lymphomas (NHL) often show up in an extranodal pattern, especially in the head and neck. Intraoral locations are much less frequent, particularly when they are single. This, in turn, can lead to a prolonged diagnosis and even to inadequate treatment. Different patients with initial extranodal location of NHL which were not previously diagnosed and in which it was manifested only intraoraly are presented in this paper. These cases are presented together with the additional examinations used for the early diagnosis and with the corresponding clinical pictures, as well as with the overview of other cases from the available literature

Spanish research on mathematics education

The writing of this text has been partly developed within several research projects: RTI2018-101153-B-C21 and RTI2018-101153-A-C22 (M. Bosch and B. Barquero); PID2019-105601GB-I00 (C. Batanero, M. M. Gea and J.D. Godino); ProID2021010018 (M. Camacho-Machín); EDU2016-75771-P and PID2020-113601GB-I00 (M. C. Cañadas and Enrique Castro); PGC2018-100758-B-I00 (J. M. Chamoso); RTI2018-096547-B-I00 (L. C. Contreras); EDU2017-84979-R (T. F. Blanco); 2021/FQM-226 and PPIIV.4/2021/005 (V. Martín-Molina); PID2020-116514GB-I00 (M. Moreno)

Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa: Implications for Irritable Bowel Syndrome

Estrés agudo; Barrera intestinal; SexoEstrès agut; Barrera intestinal; SexeCute stress; Intestinal barrier; SexIrritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder linked to intestinal barrier dysfunction and life stress. We have previously reported that female sex per se determines an increased susceptibility to intestinal barrier dysfunction after cold pain stress (CPS). We aimed to identify sex-related molecular differences in response to CPS in healthy subjects to understand the origin of sex bias predominance in IBS. In 13 healthy males and 21 females, two consecutive jejunal biopsies were obtained using Watson’s capsule, at baseline, and ninety minutes after CPS. Total mucosal RNA and protein were isolated from jejunal biopsies. Expression of genes related to epithelial barrier (CLDN1, CLDN2, OCLN, ZO-1, and ZO-3), mast cell (MC) activation (TPSAB1, SERPINA1), and the glucocorticoid receptor (NR3C1) were analyzed using RT-qPCR. NR3C1, ZO-1 and OCLN protein expression were evaluated through immunohistochemistry and western blot, and mucosal inflammation through MC, lymphocyte, and eosinophil numbering. Autonomic, hormonal, and psychological responses to CPS were monitored. We found an increase in jejunal MCs, a reduced CLDN1 and OCLN expression, and an increased CLDN2 and SERPINA1 expression 90 min after CPS. We also found a significant decrease in ZO-1, OCLN, and NR3C1 gene expression, and a decrease in OCLN protein expression only in females, when compared to males. CPS induced a significant increase in blood pressure, plasma cortisol and ACTH, and subjective stress perception in all participants. Specific and independent sex-related molecular responses in epithelial barrier regulation are unraveled by acute stress in the jejunum of healthy subjects and may partially explain female predominance in IBS.Supported in part by Fondo Europeo de Desarrollo Regional (FEDER), Fondo de Investigación Sanitaria and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Subdirección General de Investigación Sanitaria, Ministerio de Economiá y Competitividad: CM08/00229 (BL); CM10/00155 (MP); EII2011-0035, CD15/00010, and MV17-00043 (BKRJ.); FI12/00254 (ESR.), PI17/0190 (JS), PI12/00314 and PI15/00301 (CAC), CIBEREHD CB06/04/0021 (JS, CAC.); Vall d’Hebron Institut de Recerca, Programa de becas predoctorales Amics de Vall d’Hebron: PRED-VHIR-2014-018 (MF), PRED-VHIR-2016-53 34 (CPC.)

Cortical thinning over two years after first-episode psychosis depends on age of onset.

[EN] First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15-35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d=0.54; p=002). In a post-hoc-analysis, adolescent-onset (≤19y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe.We are extremely grateful to all subjects who took part in this study. This work was supported by CIBERSAM; Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (PI081203, PI08/0208; PI11/00325; PI1101686, PI14/00612, PI17/01997, PI20/01342), co‐financed by the ERDF from the European Commission “A way of making Europe”, European Union Seventh Framework Program (FP7- HEALTH-2013-2.2.1-2-603196 [Project PSYSCAN]), EU H2020 (IMI‐2 Joint Undertaking under grant agreements 115916 (project PRISM) and 777394 (project AIMS‐2‐TRIALS)), Madrid Regional Government (S2017/BMD‐3740, and AGES-CM-2-CM) and European Union Structural Funds; Fundación Familia Alonso, Fundacion Mutua Madrileña, and Fundación Alicia Koplowitz

Cortical thinning over two years after first-episode psychosis depends on age of onset

First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15-35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe

Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry

Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been greater. However, there are increasing number of recent publications addressing discordances between FISH and IHC. The controversy is further fuelled by the different regulatory approvals. This situation prompted us to investigate two ALK IHC antibodies (using a novel ultrasensitive detection-amplification kit) and an automated ALK FISH scanning system (FDA-cleared) in a series of non-small cell lung cancer tumor samples. Methods: Forty-seven ALK FISH-positive and 56 ALK FISH-negative NSCLC samples were studied. All specimens were screened for ALK expression by two IHC antibodies (clone 5A4 from Novocastra and clone D5F3 from Ventana) and for ALK rearrangement by FISH (Vysis ALK FISH break-apart kit), which was automatically captured and scored by using Bioview's automated scanning system. Results: All positive cases with the IHC antibodies were FISH-positive. There was only one IHC-negative case with both antibodies which showed a FISH-positive result. The overall sensitivity and specificity of the IHC in comparison with FISH were 98% and 100%, respectively. Conclusions: The specificity of these ultrasensitive IHC assays may obviate the need for FISH confirmation in positive IHC cases. However, the likelihood of false negative IHC results strengthens the case for FISH testing, at least in some situation

Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations

Intestinal barrier dysfunction; Intestinal glycocalyx; Mucosal nerve fibresDisfunción de la barrera intestinal; Glicocálix intestinal; Fibras nerviosas de la mucosaDisfunció de la barrera intestinal; Glicocàlix intestinal; Fibres nervioses de la mucosaIrritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plasma cells and epithelial integrity to gain understanding of IBS-D pathophysiology. One mucosal jejunal biopsy and one stool sample were obtained from healthy controls and IBS-D patients. Gastrointestinal symptoms, stress, and depression scores were recorded. In the jejunal mucosa, RNAseq and gene set enrichment analyses were performed. A morphometric analysis by electron microscopy quantified plasma cell activation and proximity to enteric nerves and glycocalyx thickness. Immunoglobulins concentration was assessed in the stool. IBS-D patients showed differential expression of humoral pathways compared to controls. Activation and proximity of plasma cells to nerves and IgG concentration were also higher in IBS-D. Glycocalyx thickness was lower in IBS-D compared to controls, and this reduction correlated with plasma cell activation, proximity to nerves, and clinical symptoms. These results support humoral activity and loss of epithelial integrity as important contributors to gut dysfunction and clinical manifestations in IBS-D. Additional studies are needed to identify the triggers of these alterations to better define IBS-D pathophysiology.This study was funded in part by Fondo Europeo de Desarrollo Regional (FEDER), Fondo de Investigación Sanitaria and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Subdirección General de Investigación Sanitaria, Ministerio de Economía y Competitividad: CP18/00116 (C.M.), PI19/01643 (B.L.); PI17/01443 (D.G.); PI15/00301 (C.A.-C.), PI17/0190 (J.S.), PI19/01643 & CPII16/00031, (M.V.); CIBEREHD CB06/04/0021 (F.A., C.A.-C., J.S., M.V.); Ministerio de Educación, Dirección General de Investigación: SAF 2016-76648-R (F.A.); Agència de Gestió d’Ajuts Universitaris i de Recerca, de la Generalitat de Catalunya: 2014 SGR 1285 (F.A.); Vall d’Hebron Institut de Recerca, Programa de becas predoctorales Amics de Vall d’Hebron: PRED-VHIR-2016-34 (C.P.-C.), PRED-VHIR-2014-018 (M.F.), the Swedish Research Council dnr 2019-00653 (J.-P.G.M.), and the European Union’s Horizon research and innovation programme 2020, grant no. 848228 (E.E., A.R.-U., B.L., C.A.-C., J.S.)

Tics as a pedagogical tool for the strengthening of interpersonal relationships and healthy coexistence

Las relaciones interpersonales son la esencia de la convivencia. Actualmente resulta uno de los objetos de mayor interés al interior de los colegios. Con base a lo anterior se desarrolla el presente estudio que tiene como objetivo fortalecer las relaciones interpersonales y la sana convivencia en los estudiantes de la Institución Educativa Departamental Santa Cruz DE Bálsamo apoyados en las TIC como herramienta pedagógica. La metodología empleada fue desde la investigación cualitativa, con un alcance descriptivo, se tomó como muestra (51) estudiantes de los grados quinto y sexto. Dentro de los hallazgos encontrados, se identifican diversos problemas de convivencia y falta de comunicación asertiva, basados principalmente en la poca aceptación a las formas de pensar y actuar delos estudiantes, así como también frecuentes problemas de bullying.Interpersonal relationships are the essence of coexistence. Currently it is one of the objects of greatest interest inside schools. Based on the above, the present study is developed to strengthen interpersonal relationships and healthy coexistence in the students of the Departmental Educational Institution Santa Cruz DE Bálsamo supported by ICT as a pedagogical tool. The methodology used was from qualitative research, with a descriptive scope, was taken as sample 51 students of the fifth and sixth grades. Within the found findings, diverse problems of coexistence and lack of assertive communication are identified, mainly based on the low acceptance to the ways of thinking and acting of the students, as well as frequent problems of bullying