Petrography, The Tar Sands Paradise, and the Medium of Modernity

This article engages with the artistic practice of petrography, the art of creating photographic images through the action of sunlight upon bitumen, the heavy-oil material that is the source of the petroleum in the Athabasca tar sands. It presents several examples of petrographs that document the process of industrial bitumen mining itself. Further, it theorizes the ways in which both the process of producing petrographs and the act of engaging with them as a viewer require a degree of collaboration normally absent from our consumption of petroleum as the medium of modernity. A key argument of the paper is the reconfiguration of bitumen as a medicine in Cree/Métis contexts, which leads to an alternative Indigenous idea of the petro-medium as an active, relational substance with its own potential agency

Tarhands: A Messy Manifesto

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Terristory: Land and Language in the Indigenous Short Story – Oral and Written

This paper examines the relationship between land and narrative in oral and written short stories by Indigenous artists of Turtle Island. It argues that certain Indigenous stories should be understood as inseparable from particular locations in the writer’s or teller’s traditional territory. The unity of story and place in these works is a powerful source of Indigenous sovereignty and an inspiration for contemporary Indigenous resurgence

Variable coordination of amine functionalised N-heterocyclic carbene ligands to Ru, Rh and Rr: C-H and N-H activation and catalytic transfer hydrogenation

Chelating amine and amido complexes of late transition metals are highly valuable bifunctional catalysts in organic synthesis, but complexes of bidentate amine–NHC and amido–NHC ligands are scarce. Hence, we report the reactions of a secondary-amine functionalised imidazolium salt 2a and a primary-amine functionalised imidazolium salt 2b with [( p -cymene)RuCl 2 ] 2 and [Cp*MCl 2 ] 2 (M = Rh, Ir). Treating 2a with [Cp*MCl 2 ] 2 and NaOAc gave the cyclometallated compounds Cp*M(C,C)I (M = Rh, 3 ;M = Ir, 4 ), resulting from aromatic C–H activation. In contrast, treating 2b with [( p -cymene)RuCl 2 ] 2 ,Ag 2 O and KI gave the amine–NHC complex [( p -cymene)Ru(C,NH 2 )I]I ( 5 ). The reaction of 2b with [Cp*MCl 2 ] 2 (M = Rh, Ir), NaO t Bu and KI gave the amine–NHC complex [Cp*Rh(NH 2 )I]I ( 6 ) or the amido–NHC complex Cp*Ir(C,NH)I ( 7 ); both protonation states of the Ir complex could be accessed: treating 7 with trifluoroacetic acid gave the amine–NHC complex [Cp*Ir(C,NH 2 )I][CF 3 CO 2 ]( 8 ). These are the first primary amine– or amido–NHC complexes of Rh and Ir. Solid-state structures of the complexes 3–8 have been determined by single crystal X-ray diffraction. Complexes 5 , 6 and 7 are pre-catalysts for the catalytic transfer hydrogenation of acetophenone to 1-phenylethanol, with ruthenium complex 5 demonstrating especially high reactivity

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

"How Come These Guns are so Tall": Anti-corporate Resistance in Marvin Francis’s City Treaty

With its clever examination of the effects of large corporations, logos, and unfair labour practices upon the lives of urban Native people, Marvin Francis’s City Treaty can be read as a streetwise anti-globalization manifesto for the indigenous world. Francis uses postmodern irony and verbal excess to show how the lives of contemporary Aboriginal people are implicated in complex patterns of symbol, contract, and stereotype that work to keep them in marginal positions. The author’s exploration of what might be called ‘post-corporate’ indigeneity is most readily contextualized in terms of recent currents in visual art, but is also part of a growing trend in Aboriginal literature, as evidenced by recent works by Thomas King and Jeannette Armstrong

Mixed media, intention and contrariety in Blake's art

grantor: University of TorontoThis dissertation examines William Blake's use of artistic media and his metaphorical representations of those media in his poetry, prose, and visual art. Blake's images of media have generally been considered to have rather monological meanings, but I argue that he destabilizes their moral associations so that they fluctuate between positive and negative possibilities. I contend that the ambiguity of these images allegorizes Blake's ambivalence about artistic intention itself. While his work often manifests a vehement desire to communicate vital intentions, it also reveals uncertainty about the potential of such intentions to reach beyond the artist's imagination. This uncertainty is also operative in larger ontological and metaphysical dimensions of Blake's art, because his idea of intention is implicated in the oppositional phenomenon of "contrariety," which is related to his theories of the "contraries" in his poems. For Blake, intention itself is contrary, which means that every intention necessarily invokes its opposite. Blake cultivates these contrary associations not in order to stymy interpretation, but rather to avoid Urizenic monologism and to create a kind of representation which is open to the imperatives of oppositional thinking. Contrariety generates semantic excess, which requires Blake's readers to undertake extraordinarily active forms of interpretation. Each of the four chapters examines a specific medium in Blake's work and tries to demonstrate how this medium embodies contrary intentional trajectories. Chapter One studies Blake's language, giving particular attention to his use of emphasis and his invocations of the prophetic voice. Chapter Two looks at Blake's theory and practice of linearism, showing how his lines embody the contrary functions of limitation and transgression. Chapter Three examines Blake's mirror metaphors and the mirror-effects of his graphic media, arguing that he alternates between a distortive Platonic mirror and a divine reflective surface which contains perfect representations. Chapter Four focuses on Blake's images of mechanism and his use of mechanical processes in his graphic media, arguing that he portrays technology as both an aid to human agency and a hindrance to it. Each of these chapters shows how Blake's contrariety of intention creates excess, which moves beyond the limits of system.Ph.D

Play Chthonics: New Canadian Readings

Warren Cariou is from Meadow Lake, Saskatchewan, where he grew up in a family of Métis, German, and French heritage. He has written a book of novellas, The Exalted Company of Roadside Martyrs, and a memoir/cultural history entitled Lake of the Prairies, and he has also edited several texts by Aboriginal writers including Marvin Francis's Bush Camp and the recent anthology from Kegedonce Press: W'daub Awae: Speaking True. He has recently produced a documentary film, Land of Oil and Water, and he is working on a documentary about storytelling. He is also working on a novel and a collection of poems. Cariou is a Canada Research Chair at the University of Manitoba, where he directs the Centre for Creative Writing and Oral Culture. Marie Clements is an award-winning performer, playwright, screenwriter, director, producer and founding artistic director of urban ink productions and fathom labs highway. Her ten plays including Copper Thunderbird, Burning Vision, The Unnatural and Accidental Women, and Urban Tattoo have been presented on some of the most prestigious stages for Canadian and international work including the Festival de Theatre des Ameriques (Urban Tattoo 2001, Burning Vision 2003) in Montreal, and The Magnetic North Festival (Burning Vision 2003 and Copper Thunderbird 2007) in Ottawa, and have garnered awards including 2004 Canada-Japan Award, short listed for the 2004 Governor General's Literary Award, Jessie Richardson Awards and a Jack Webster Journalism nomination. As writer and producer her full-length play Copper Thunderbird premiered as a co-production with The National Arts Centre in Ottawa, May 2007 and at The Magnetic North Festival 2007.Graduate and Postdoctoral StudiesOther UBCUnreviewedResearche