The Potential Effects of Hormonal Therapy and Stress on the Oral Health of the Transitioning Population

Problem: In terms of healthcare, the transgender population is underserved. Unfortunately, these individuals often experience stress related to seeking preventative care and fear discrimination. These factors preventing them from seeking care, in addition to hormone therapy taken during the transition process, could have severe impacts on their dental health. The purpose of this study is to establish a link between the hormone therapy used during gender transitioning and the effect on oral health. While there is a correlation between hormone replacement therapy and clinical evidence that sex hormones can impact on periodontal tissues, few studies have linked this knowledge to the healthcare needs of the transitioning population. Methods: Research was obtained from PubMed, the database of Dental and Oral Sciences Sources, Google Scholar, and LGBTQ+ databases. Recent studies and literature reviews were analyzed to determine if there was a correlation between hormone therapy and the health of the oral cavity. All sources found were published within five years. Major Findings: Many studies have revealed that there is an effect on sex hormones on the oral cavity. If it can happen to those that are taking sex hormone then there has to be a correlation to those who are transitioning taking the same hormone. Few studies have been conducted proving this correlation; this topic deserves more research and investigation. Conclusions: There is a clinical correlation between hormone replacement therapy and sex hormones and their effects on the oral cavity. Therefore, there is a possible correaltion to the transgender population that is taking hormones. As this population continues to grow, and more individuals identify as a part of the community, it is important to continue to research this topic.https://scholarscompass.vcu.edu/denh_student/1018/thumbnail.jp

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

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New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele