3,478 research outputs found
High power coupled CO2 waveguide laser array
A hollow-bore ridge waveguide technique for phase locking arrays of coupled CO2 rf excited waveguide lasers was demonstrated. Stable phase-locked operation of two- and three-channel arrays has been demonstrated at the 50 W output level. Preliminary experiments with a five-element array generated an output power of 95 W but phase-locked operation was not conclusively demonstrated
Traumatic brain injury: future assessment tools and treatment prospects
Traumatic brain injury (TBI) is widespread and leads to death and disability in millions of individuals around the world each year. Overall incidence and prevalence of TBI are likely to increase in absolute terms in the future. Tackling the problem of treating TBI successfully will require improvements in the understanding of normal cerebral anatomy, physiology, and function throughout the lifespan, as well as the pathological and recuperative responses that result from trauma. New treatment approaches and combinations will need to be targeted to the heterogeneous needs of TBI populations. This article explores and evaluates the research evidence in areas that will likely lead to a reduction in TBI-related morbidity and improved outcomes. These include emerging assessment instruments and techniques in areas of structural/chemical and functional neuroimaging and neuropsychology, advances in the realms of cell-based therapies and genetics, promising cognitive rehabilitation techniques including cognitive remediation and the use of electronic technologies including assistive devices and virtual reality, and the emerging field of complementary and alternative medicine
Evaluation of positive G sub Z tolerance following simulated weightlessness (bedrest)
The magnitude of physiologic changes which are known to occur in human subjects exposed to varying levels of + G sub Z acceleration following bed rest simulation of weightlessness was studied. Bed rest effects were documented by fluid and electrolyte balance studies, maximal exercise capability, 70 deg passive tilt and lower body negative pressure tests and the ability to endure randomly prescribed acceleration profiles of +2G sub Z, +3G sub Z, and +4G sub Z. Six healthy male volunteers were studied during two weeks of bed rest after adequate control observations, followed by two weeks of recovery, followed by a second two-week period of bed rest at which time an Air Force cutaway anti-G suit was used to determine its effectiveness as a countermeasure for observed cardiovascular changes during acceleration. Results showed uniform and significant changes in all measured parameters as a consequence of bed rest including a reduced ability to tolerate +G sub Z acceleration. The use of anti-G suits significantly improved subject tolerance to all G exposures and returned measured parameters such as heart rate and blood pressure towards or to pre-bed-rest (control) values in four of the six cases
The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: A review
The acute and chronic effects of repeated intravitreal antivascular endothelial growth factor (VEGF) injections on intraocular pressure have not been fully characterized, and the development of sustained ocular hypertension could adversely affect patients who are at risk of glaucomatous optic neuropathy. As expected, volume-driven, acute ocular hypertension immediately follows intravitreal injection, but this pressure elevation is generally transient and well tolerated. Several medications have been investigated to limit acute ocular hypertension following anti-VEGF therapy, but the benefits of pretreatment are not conclusive. Chronic, sustained ocular hypertension, distinct from the short-term acute ocular hypertension after each injection, has also been associated with repeated intravitreal anti-VEGF injections. Risk factors for chronic ocular hypertension include the total number of injections, a greater frequency of injection, and preexisting glaucoma. Proposed mechanisms for chronic ocular hypertension include microparticle obstruction, toxic or inflammatory effects on trabecular meshwork, as well as alterations in outflow facility by anti-VEGF agents. Although limiting anti-VEGF therapy could minimize the risk of both acute and chronic ocular hypertension, foregoing anti-VEGF therapy risks progression of various macular diseases with resulting permanent central vision loss. While definitive evidence of damage to the retinal nerve fiber layer is lacking, patients receiving repeated injections should be monitored for ocular hypertension and patients in whom sustained ocular hypertension subsequently developed should be periodically monitored for glaucomatous changes with optic nerve optical coherence tomography and static visual fields
Gating-by-tilt of mechanosensitive membrane channels
We propose an alternative mechanism for the gating of biological membrane
channels in response to membrane tension that involves a change in the slope of
the membrane near the channel. Under biological membrane tensions we show that
the energy difference between the closed (tilted) and open (untilted) states
can far exceed kBT and is comparable to what is available under simple
ilational gating. Recent experiments demonstrate that membrane leaflet
asymmetries (spontaneous curvature) can strong effect the gating of some
channels. Such a phenomenon would be more easy to explain under gating-by-tilt,
given its novel intrinsic sensitivity to such asymmetry.Comment: 10 pages, 2 figure
On the existence of initial data containing isolated black holes
We present a general construction of initial data for Einstein's equations
containing an arbitrary number of black holes, each of which is instantaneously
in equilibrium. Each black hole is taken to be a marginally trapped surface and
plays the role of the inner boundary of the Cauchy surface. The black hole is
taken to be instantaneously isolated if its outgoing null rays are shear-free.
Starting from the choice of a conformal metric and the freely specifiable part
of the extrinsic curvature in the bulk, we give a prescription for choosing the
shape of the inner boundaries and the boundary conditions that must be imposed
there. We show rigorously that with these choices, the resulting non-linear
elliptic system always admits solutions.Comment: 11 pages, 2 figures, RevTeX
Study of heterogeneous nucleation of eutectic Si in high-purity Al-Si alloys with Sr addition
The official published version can be accessed from the link below - Copyright @ 2010 The Minerals, Metals & Materials Society and ASM InternationalAl-5 wt pct Si master-alloys with controlled Sr and/or P addition/s were produced using super purity Al 99.99 wt pct and Si 99.999 wt pct materials in an arc melter. The master-alloy was melt-spun resulting in the production of thin ribbons. The Al matrix of the ribbons contained entrained Al-Si eutectic droplets that were subsequently investigated. Differential scanning calorimetry, thermodynamic calculations, and transmission electron microscopy techniques were employed to examine the effect of the Sr and P additions on eutectic undercoolings and nucleation phenomenon. Results indicate that, unlike P, Sr does not promote nucleation. Increasing Sr additions depressed the eutectic nucleation temperature. This may be a result of the formation of a Sr phase that could consume or detrimentally affect potent AlP nucleation sites.This work is financially supported by the
Higher Education Commission of Pakistan and managerially supported from the OAD
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Anatomic brain asymmetry in vervet monkeys.
Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance. Anatomic asymmetry has been observed in Old World monkeys, but the evidence for the direction and extent of asymmetry is equivocal and only one study has estimated the genetic contributions to inter-individual variance. In this study we characterize a range of qualitative and quantitative asymmetry measures in structural brain MRIs acquired from an extended pedigree of Old World vervet monkeys (nâ=â357), and implement variance component methods to estimate the proportion of trait variance attributable to genetic and environmental sources. Four of six asymmetry measures show pedigree-level bias and one of the traits has a significant heritability estimate of about 30%. We also found that environmental variables more significantly influence the width of the right compared to the left prefrontal lobe
The Einstein constraints: uniqueness and non-uniqueness in the conformal thin sandwich approach
We study the appearance of multiple solutions to certain decompositions of
Einstein's constraint equations. Pfeiffer and York recently reported the
existence of two branches of solutions for identical background data in the
extended conformal thin-sandwich decomposition. We show that the Hamiltonian
constraint alone, when expressed in a certain way, admits two branches of
solutions with properties very similar to those found by Pfeiffer and York. We
construct these two branches analytically for a constant-density star in
spherical symmetry, but argue that this behavior is more general. In the case
of the Hamiltonian constraint this non-uniqueness is well known to be related
to the sign of one particular term, and we argue that the extended conformal
thin-sandwich equations contain a similar term that causes the breakdown of
uniqueness.Comment: 9 pages, 1 figur
Reachability in Parametric Interval Markov Chains using Constraints
Parametric Interval Markov Chains (pIMCs) are a specification formalism that
extend Markov Chains (MCs) and Interval Markov Chains (IMCs) by taking into
account imprecision in the transition probability values: transitions in pIMCs
are labeled with parametric intervals of probabilities. In this work, we study
the difference between pIMCs and other Markov Chain abstractions models and
investigate the two usual semantics for IMCs: once-and-for-all and
at-every-step. In particular, we prove that both semantics agree on the
maximal/minimal reachability probabilities of a given IMC. We then investigate
solutions to several parameter synthesis problems in the context of pIMCs --
consistency, qualitative reachability and quantitative reachability -- that
rely on constraint encodings. Finally, we propose a prototype implementation of
our constraint encodings with promising results
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