Desarrollo de nanopartículas mesoporosas de sílice para el tratamiento de cancer de mama

[EN] The aim of this project is to develop nanodispositives based on silica mesoporous nanoparticles for triple negative breast cancer treatment. Those will be directed against the cancer stem cell subpopulation for controlled delivery of a cytotoxic drug and microRNAs involved in drug resistance.[ES] El objetivo es el desarrollo de nanodispositivos basados en nanopartículas de sílice mesoporosa para el tratamiento de cancer de mama triple negativo, pretendiéndose dirigir estos dispositivos a la subpoblación de células madre tumorales. Su aplicación permitirá la liberación controlada de un fármaco citotóxico y microRNAs implicados en resistencias a fármacos.Garrido Cano, I. (2016). Desarrollo de nanopartículas mesoporosas de sílice para el tratamiento de cancer de mama. http://hdl.handle.net/10251/68572TFG

Lactic acid bacteria : reviewing the potential of a promising delivery live vector for biomedical purposes

Lactic acid bacteria (LAB) have a long history of safe exploitation by humans, being used for centuries in food production and preservation and as probiotic agents to promote human health. Interestingly, some species of these Gram-positive bacteria, which are generally recognized as safe organisms by the US Food and Drug Administration (FDA), are able to survive through the gastrointestinal tract (GIT), being capable to reach and colonize the intestine, where they play an important role. Besides, during the last decades, an important effort has been done for the development of tools to use LAB as microbial cell factories for the production of proteins of interest. Given the need to develop effective strategies for the delivery of prophylactic and therapeutic molecules, LAB have appeared as an appealing option for the oral, intranasal and vaginal delivery of such molecules. So far, these genetically modified organisms have been successfully used as vehicles for delivering functional proteins to mucosal tissues in the treatment of many different pathologies including GIT related pathologies, diabetes, cancer and viral infections, among others. Interestingly, the administration of such microorganisms would suppose a significant decrease in the production cost of the treatments agents since being live organisms, such vectors would be able to autonomously amplify and produce and deliver the protein of interest. In this context, this review aims to provide an overview of the use of LAB engineered as a promising alternative as well as a safety delivery platform of recombinant proteins for the treatment of a wide range of diseases

Simulations of Melting of Encapsulated CaCl2·6H2O for Thermal Energy Storage Technologies

We present in this work simulations using the finite difference approximation in 2D for the melting of an encapsulated phase-change material suitable for heat storage applications; in particular, we study CaCl2·6H2O in a cylindrical encapsulation of internal radius 8 mm. We choose this particular salt hydrate due to its availability and economic feasibility in high thermal mass building walls or storage. Considering only heat conduction, a thermostat is placed far from the capsule, providing heat for the melting of the phase-change material (PCM), which is initially frozen in a water bath. The difference in density between the solid and liquid phases is taken into account by considering a void in the solid PCM. A simple theoretical model is also presented, based on solving the heat equation in the steady state. The kinetics of melting is monitored by the total solid fraction and temperatures in the inner and outer surfaces of the capsule. The effect of different parameters is presented (thermostat temperature, capsule thickness, capsule conductivity and natural convection in the bath), showing the potential application of the method to select materials or geometries of the capsule

Evaluation of Obesity Management Recorded in Electronic Clinical History: A Cohort Study

Background: The prevalence of obesity is increasing worldwide. Because of their close proximity to the population, primary care physicians and nurses are in a unique position to motivate and advise patients with obesity on a healthy diet and increased physical activity. Drawing from information recorded in electronic clinical records, we evaluated how the general recommendations included in obesity guidelines are being implemented in routine clinical practice. Methods: This study drew from the following data from a cohort of 209 patients with obesity that attended primary care consultations: electronic clinical records, body mass index (BMI), waist circumference (WC), cardiovascular risk factors, comorbidities and whether their health professional documented compliance with the recommendations of the evidence-based obesity guidelines in their electronic history. Results: Only 25.4% of the clinical records met all the criteria established in the therapeutic guidelines regarding diet prescription, 1.4% for physical activity and 1.5% for behavioral change activities. The patients whose records mentioned diet prescription and physical activity and who received follow-up consultations for both factors had lower average BMI and WC, although this relationship was not significant after adjusting for baseline. Conclusions: We found that only a small number of records in the electronic clinical histories followed the evidence-based obesity guidelines. Recording dietetic prescription and physical exercise in the patient's clinical record is associated with better control of obesity.Universidad de Cádi

Development of Bioglass/PEEK Composite Coating by Cold Gas Spray for Orthopedic Implants

Cold gas spray (CGS) technology has allowed the development of biofunctional coatings composed of 45S5 and polyetheretherketone (PEEK). The combination of a bioactive glass material embedded in a polymeric matrix makes this composite an interesting material for orthopedic applications since this composite meets the biomechanical and biological requirements of an implant. In the present study, blends of bioactive glass 45S5 and PEEK powder with different granulometry and 45S5/PEEK ratio have been prepared. These mixtures of powders have been deposited onto PEEK substrates by CGS with the goal of incorporating a bioactive additive to the biocompatible polymer, which can improve the bone-implant interaction of PEEK. The deposition efficiency (DE) of the coatings has been evaluated, and from the results obtained, it was possible to conclude that DE is significantly affected by the granulometry and by the 45S5/PEEK ratio of the blends. By scanning electron microscopy (SEM) inspection, it was observed that the use of blends with high 45S5/PEEK ratio lead to the deposition of coatings with high content of 45S5. Finally, the friction behavior of the coatings was analyzed performing ball-on-disk tests and these experiments showed that the presence of glass particles has a beneficial role in the wear resistance

Documentación sobre el trastorno por déficit de atención con hiperactividad.

El Trastorno por déficit de atención con hiperactividad (TDAHe)s una de las alteraciones psicopatológicas de inicio en la infancia que cuenta con el mayor número de estudios publicados (más de 5.000)' en la última década. Debido a la gran cantidad de información existente, se ha acotado la búsqueda bibliográfica al periodo comprendido entre 10s años 1995 y el mes de setiembre de 2001. La búsqueda se ha realizado en !as bases de datos PsycINFo y Medline. Para realizar esta búsqueda se han combinado 10s siguientes términos en ambas bases de datos: hyperactivity, children, adults, diagnostic, assessment, cognitive processes, neurology, physiology, etiology, treatment y epidemiology

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis

Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equivalent material produced in E. coli. Results: Protein nanoparticles have been efficiently produced in L. lactis, showing the desired size, internalization properties and biodistribution. Conclusion: In vitro and in vivo data confirm the potential and robustness of the production platform, pointing out L. lactis as a fascinating cell factory for the biofabrication of protein materials intended for therapeutic applications.Award-winningPostprint (published version

Sostenibilidad en áreas metropolitanas intermedias. El caso del acceso a los servicios públicos en el área metropolitana de Valencia

El análisis de la sostenibilidad en espacios complejos, como las áreas metropolitanas presenta un enorme potencial de aplicación en términos de políticas públicas. La prestación de los servicios públicos locales es uno de los aspectos más destacables y menos estudiados de la llamada sostenibilidad social, aunque es un aspecto clave de la acción política en las zonas urbanas. En la presente comunicación se propone una aproximación al tema basada en el acceso de la población a los servicios públicos esenciales (educación, salud y servicios sociales) en el Área Metropolitana de Valencia (AMV). Los Sistemas de Información Geográfica (SIG) han permitido trabajar con enormes cantidades de información espacial y estadística. A partir de la ubicación de las instalaciones de servicios públicos (con sus características en cuanto a número de plazas ofertadas) y de la capacidad de la población para desplazarse en transporte público y/o a pie, se analizan diferentes escenarios con el objetivo de señalar los espacios metropolitanos más problemáticos en términos de prestación de servicios y sugerir respuestas que podrían ayudar a mejorar la sostenibilidad social y espacial del AMV. Las simulaciones sobre nuevas localizaciones de la oferta y el ajuste de la misma a la demanda ofrecen diferentes opciones para la toma de decisiones y refuerzan el papel de los gobiernos locales en un territorio complejo como son las áreas metropolitanas

Innovación y tecnología, motor de éxito a largo plazo. El caso de Podoactiva.

Con el presente Trabajo de Fin de Grado se pretende analizar la trayectoria de la empresa Podoactiva, así como, las decisiones estratégicas y modelo de negocio que le han permitido posicionarse como líder en el sector de la podología y la biomecánica en el mercado nacional. Asimismo, se analizarán cuáles son los factores tanto externos como internos que determinan cual es el entorno en el que se desarrollará la empresa y, aplicando los conocimientos adquiridos durante el Grado de Administración y Dirección de Empresas, obtendremos las características clave de su modelo basado en la tecnología e innovación y que posibles decisiones podrían llevarse a cabo de cara al futuro