Biomarcadores de sepse: uma revisão do valor diagnóstico da presepsina

A sepse é uma síndrome prevalente e com alta morbimortalidade, sendo necessário um método diagnóstico precoce e eficaz. Estudos recentes sugerem que a presepsina pode ser um potencial biomarcador para o diagnóstico de sepse e que tem um desempenho melhor do que outros biomarcadores mais consolidados, como procalcitonina e PCR. Esta revisão sistemática tem como objetivo avaliar a acurácia da presepsina para o diagnóstico de sepse e comparar com a procalcitonina e a proteína-C-reativa. Uma pesquisa sistemática abrangente foi conduzida no PubMed e na Biblioteca Virtual em Saúde para coletar estudos publicados nos últimos dois anos com foco na precisão diagnóstica da presepsina para sepse. Oito estudos foram selecionados. Todos eles sugeriram que a presepsina tem algum valor diagnóstico para sepse. Em quatro estudos, a presepsina teve um desempenho melhor do que a procalcitonina e em dois a presepsina teve um desempenho melhor do que a PCR. Dois estudos não mostraram diferenças significativas entre a presepsina e os outros biomarcadores. Esta revisão indica que a presepsina pode ter valor significativo para o diagnóstico precoce da sepse, corroborando para aumentar a eficiência de ferramentas existentes, como a PCR e a procalcitonina. No entanto, mais estudos são necessários para confirmar sua eficácia como um único marcador de diagnóstico.Sepsis is a prevalent syndrome with high morbimortality, so an efficient early diagnostic method is needed. Recent studies suggest that presepsin could be a potential biomarker to sepsis diagnosis and has a better performance than other more consolidated biomarkers, such as procalcitonin and CRP. This systematic review aims to develop assess the accuracy to sepsis diagnosis of the presepsin and compare with procalcitonin and C-reactive protein. A comprehensive systematic research was conducted in the PubMed and Virtual Health Library to collect studies published in the last two years that focused on presepsin diagnostic accuracy for sepsis. Eight studies were selected. All of them suggested that presepsin has some diagnostic value for sepsis. In four studies presepsin had a better performance than procalcitonin and in two studies presepsin performed better than CRP. Two studies did not show significant differences between presepsin and the other biomarkers. This review indicates that presepsin may have significant value for the early diagnosis of sepsis, corroborating to increase the efficiency of existing tools, such as CRP and procalcitonin. However, more studies are needed to confirm its efficiency as a single diagnosis’s marker

The normative aspects of the brazilian public debt

The purpose of this paper is to present the normative acts about the public debt, especially the Public Responsibility Law that was issued to institute a surveillance tool over the results, as well as to discipline public planning and expenditure, providing tools to penalize public managers. We aimed to interpret the current legislations about governmental budget and analyzing both regulations. We pointed that Brazil ended 2015 with a debt comprising 66.23% of its GDP. Thus, it requires attention of public managers, once there are legal limits for public indebtedness for Municipalities and States, but not for the Federal Government. The methodology known as indirect documentation was applied for theoretical fundamentation – bibliographic research (documental and bibliography research). For the general review were used secondary data available in books, specialized websites and laws and regulations.In Romania, the indebtedness level represented 39.6% of the GDP in 2014, in Brazil 57.19%. The Treaty of Maastricht in 1992, stipulated the limit of 60% of the GDP for the Euro Zone countries. Nevertheless the debt represented 91.9% of the GDP, especially due to Greece, Italy, Portugal, Spain and France. The Brazilian fiscal responsibility law has been developed from the experience of the tax laws of the United States and New Zealand . It is a reinterpretation of the applicable rules the Brazilian public debt compared with the limits set for the countries of the eurozone

The negative influences of the new brazilian forest code on the conservation of riparian forests

More than one million hectares of riparian forests were degraded or altered in Mato Grosso State (Brazil) up to 2009. The aim of the research is to set a comparative scenario to show differences in the quantification of environmental liabilities in riparian forest areas resulting from the change in native vegetation protection rules due to the transition between Laws 4771/65 and 12651/2012. Data collection took place in a marginal stretch of Vermelho River in Rondonópolis County, Mato Grosso State. The following data set was taken into consideration: aerial images derived from unmanned aerial vehicle, Rapid Eye satellite images and orbital images hosted at Google Earth. The spatial resolution of those images was compared. The aerial photos composed a mosaic that was photo-interpreted to generate land use and occupation classes. The riparian forest areas of a rural property were used as parameter, and their environmental situation was compared in 05 meter and 100 meter strips. Thus, by taking into consideration the current rules, 23,501 m2 of area ceased to be an environmental liability within the riparian forest and became a consolidated rural area. According to the previous Forest Code, in a different scenario, that is, in a set of rural properties, the public authority would receive USD 68,600.00 in fines. The new Brazilian Forestry Code of 2012, which replaces the previous one made in 1965, exempts those responsible for rural property from regenerating previously deforested native vegetation — an obligation established by older Forest Code. We have shown that the new Forest Code has diminished the legal responsibility of the rural owners in relation to the maintenance of forest fragments in their properties

Dossier "recent Perspectives Of Medieval History In Brazil"

3672131

Agrotóxicos como Tema Gerador para o Ensino-Aprendizagem das Propriedades Físico-Químicas de Compostos Orgânicos: Uma Proposta para o Ensino Médio

É notória a dificuldade dos alunos do Ensino Médio em reconhecer os fenômenos químicos em sua rotina. Um dos fatores geralmente apontados para isso é a falta ou a deficiência da associação do conteúdo de química com seus contextos sociais. A contextualização por meio de temas sociais – conhecidos como “Temas Geradores” ou “Temas Químicos Sociais” – é de grande importância, proporcionando uma aprendizagem com maior significado, pois permite a problematização e a análise de fenômenos da realidade com base nos conceitos químicos, podendo relacionar-se com outras disciplinas. Dessa forma, o objetivo deste trabalho é propor uma metodologia de ensino de propriedades físico-químicas de compostos orgânicos para o terceiro ano do Ensino Médio, com base na química dos agrotóxicos e, assim, estimular o pensamento crítico dos alunos em relação aos usos, riscos e benefícios desses produtos. A pesquisa foi realizada no segundo semestre de 2019, numa escola pública localizada em Seropédica/RJ, e utilizou como intervenções didáticas questionários, roda de conversa e aula teórica, todos voltados para a verificação dos conhecimentos prévios e/ou adquiridos ou reformulados a partir da metodologia aplicada. Os resultados obtidos na pesquisa apontam que os alunos têm dificuldade em reconhecer, na química, uma ferramenta para entender e explicar fenômenos do cotidiano. As intervenções se mostraram relevantes porque apresentaram informações até então desconhecidas ou incompletas para os alunos, como o uso urbano dos agrotóxicos, e possibilitaram a compreensão dos usos e riscos desses produtos a partir de um ponto de vista das propriedades dos compostos orgânicos

Germinación de semillas después del fuego: un estudio con una planta que habita áreas no propensas al fuego

After a fire event, germination of seeds with hard coats can be enhanced. In the present study, we investigated whether germination of Mimosa bimucronata (DC.) Kuntze (Fabaceae) seeds, which present hard coats, is increased after fire, even though these trees usually occur in damp areas, where fire is a transient event. Fire events were manipulated in trays filled with soil covered with different amounts of dry grasses, characterizing three treatments: a) 0g (control group); b) 300g, and c) 450g of dry grass. Burning treatments were applied to seeds positioned either on the soil surface or buried in the soil. Germination experiments were carried out at 0-h and 24-h after fire to obtain the germination percentage and the Germination Speed Index (GSI). For buried seeds, the control and the 300g treatments presented significantly higher germination percentages than the 450g treatment. On the other hand, the GSI was significantly higher in the 300g treatment. Significant differences were not found between 0-h and 24-h. Seeds on the soil surface did not survive after burning. Our study showed that temperatures around 100 degrees C significantly decrease the germinability of M. bimucronata seeds. However, when seeds were buried, the germination percentage did not differ between the control group and the 300g treatment. Results also suggest that temperatures around 60 degrees C may enhance the velocity of germination of M. bimucronata seeds.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ Uncsp, Dept Bot, IB, BR-18618000 Botucatu, SP, BrazilFed Univ Sao Paulo Unifesp, Dept Biol Sci, BR-09941510 Diadema, SP, BrazilFed Univ Sao Paulo Unifesp, Dept Biol Sci, BR-09941510 Diadema, SP, BrazilFAPESP: 05/57999-3FAPESP: 04/06737-6Web of Scienc

Idade Precoce De Início Da Atividade Sexual Está Associada A Elevada Prevalência De Lesão Intraepitelial Escamosa De Alto Grau

To evaluate the association of age at first sexual intercourse with the results of the cervicovaginal cytology. Study Design Observational analytical study about the prevalence of altered cervicovaginal cytology results in women aged between 18 and 34 years from a densely populated area in Brazil, during 10 years. The patients were stratified into 2 categories according to their age at first sexual intercourse (13-16 years and 17-24 years). Results From the total of 2,505,154 exams, 898,921 tests were in accordance with the inclusion criteria. Considering women with 4 years or less from the first sexual intercourse as a reference, those with 5 to 9 years and 10 years or more showed a higher prevalence of high-grade squamous intraepithelial lesions (HSILs). Women with an earlier onset of sexual intercourse (13-16 years) showed higher prevalence ratios for atypical squamous cells (ASC), low-grade squamous intraepithelial lesion (LSIL) and HSIL. The prevalence ratio for HSIL adjusted by age at diagnosis and by age at first sexual intercourse was higher only for women with an earlier onset of sexual intercourse. Conclusions The age of first sexual intercourse could be a variable that might qualify the selection among young women who are really at a higher risk for HSIL.3928085FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOAvaliar a associação entre idade de início da atividade sexual e os resultados de citologia cervico-vaginal. Métodos Estudo observacional sobre a prevalência dos resultados de citologia cervico-vaginal alterados em mulheres com idade entre 18 e 34 anos na região de Campinas – SP, Brasil, durante 10 anos. As pacientes foram estratificadas em dois grupos de acordo com a idade de início da atividade sexual (13 a 16 anos e 17 a 24 anos). Resultados Do total de 2.505.154 exames, 898.921 preencheram os critérios de inclusão. Considerando mulheres com tempo desde a primeira relação sexual menor ou igual a 4 anos como grupo de referência, mulheres com intervalos de 5 a 9 anos e 10 anos ou mais entre a data do exame e a primeira relação sexual mostraram maior prevalência de lesão intraepitelial escamosa de alto grau (LIEAG). Mulheres com início da atividade sexual mais precoce (13–16 anos) mostraram altas prevalências de atipia de células escamosas, lesão intraepitelial escamosa de baixo grau e LIEAG. A razão de prevalência de LIEAG ajustada pela idade na data do exame e pela idade do início da atividade sexual foi maior somente para mulheres que apresentaram início mais precoce da atividade sexual. Conclusão A idade de início da atividade sexual pode ser uma possível variável de seleção das mulheres com maior risco de LIEA

IRRIGATION WITH WATER DEFICIT APPLYING MAGNETIC WATER ON SCARLET EGGPLANT

The work aimed to evaluate the effect of irrigation with magnetically treated water on development, growth, and yield of the scarlet eggplant (Solanum gilo Raddi) cv. Morro Grande, in two growing seasons (autumn and spring). A completely randomized design in a 3x2 factorial scheme with three replications for the first growing season and 2x2 with five replications for the second growing season was used. Each experimental unit consisted of four plants spaced 0.75 m between plants and 1.00 m between rows. Factors consisted of irrigation using magnetically treated water, untreated water, three replacement of the crop evapotranspiration (50%, 75%, and 100% ETc) for the first growing season and two replacement of the crop evapotranspiration (75% and 100% ETc) for the second growing season. Stem diameter (millimeters), plant height (centimeters), shoot dry matter (grams), first flower and fruit (accumulated degree-days), number of fruits, fruit yield per plant (grams), and average fruit mass (grams) were evaluated. The water with magnetic treatment provided better results for the development variables, first flower, and first fruit in the second growing season. However, for the variables, stem diameter, plant height, shoot dry matter, fruit yield, and number of fruits, only the replacement irrigation depth factor obtained higher values for the 100% ETc than water-deficit treatments

Atendimentos não presenciais em fisioterapia durante a pandemia por COVID-19: uma reflexão sobre os desafios e oportunidades no contexto brasileiro

On March 11, 2020, Covid-19 was characterized by WHO as a pandemic. In this context, different councils from the health professional categories have adopted initiatives in the use of communication technologies as a means of providing services at a distance. Specifically for physiotherapy, the Federal Council of Physiotherapy and Occupational Therapy (COFFITO) made possible the modalities of teleconsultation, teleconsulting and telemonitoring. This work analyzes, in a preliminary way, guidelines to provide physiotherapists who provide teleconsultation, telemonitoring or teleconsulting, a structure that will help to guarantee the safety and quality of their practice in the context of emergency to the social withdrawal caused by the pandemic by COVID-19. The set of recommendations presented below aims to protect the health of professionals in the area and the population in general, establish conditions for remote care and safeguard the excellence of physical therapy assistance provided by the category to Brazilian society.Em 11 de março de 2020, a Covid-19 foi caracterizada pela OMS como uma pandemia. Nesse contexto, diferentes conselhos de classes das categorias profissionais de saúde adotaram iniciativas no uso das tecnologias de comunicação como modalidade de prestação de serviços à distância. Especificamente para a fisioterapia, o Conselho Federal de Fisioterapia e Terapia Ocupacional (COFFITO) possibilitou o teleatendimento nas modalidades de teleconsulta, teleconsultoria e telemonitoramento. O presente trabalho analisa, de forma preliminar, diretrizes para fornecer aos fisioterapeutas que prestam teleconsulta, telemonitoramento ou teleconsultoria, uma estrutura que ajudará a garantir a segurança e qualidade da sua prática no contexto de emergência ao afastamento social provocado pela pandemia por COVID-19. O conjunto de recomendações apresentadas a seguir tem como objetivos proteger a saúde dos profissionais da área e da população em geral, estabelecer condições para o atendimento não presencial e zelar pela excelência da assistência fisioterapêutica prestada pela categoria à sociedade brasileira