Survival after Laparoscopic versus Abdominal Radical Hysterectomy in Early Cervical Cancer: A Randomized Controlled Trial

Previous studies have reported the safety of laparoscopic radical hysterectomy for treatment of early cervical cancer, as option to laparotomy. This study aims to compare overall survival between laparoscopic versus abdominal radical hysterectomy for early cervical cancer. Methods: A single-center randomized controlled trial enrolled 30 patients with clinically staged IA2 cervical cancer and lymphovascular invasion, IB and IIA, who underwent laparoscopic radical hysterectomy (16) or abdominal radical hysterectomy (14). Result: The mean overall survival time was 74.74 months (CI 95%: 54.15-95.33) for LRH 91.67 months (CI 95%: 74.97-108.37) for ARH (logrank test = 0.30). The mean disease-free survival time was 81.07 months (CI 95%: 60.95-101.19) for LRH and 95.82 months (CI 95%: 80.18-111.47) for ARH (log-rank test = 0.371). The overall survival hazard ratio was 2.05 (CI 95%: 0.51-8.24), and the disease-free hazard ratio was 2.13 (CI 95%: 0.39-11.7). Conclusion: Our study suggests a nonsignificant trend of worse outcomes for LRH. In light of recent controversy and need for prospective studies, further studies in different populations are required for definite conclusions and until then, patients should be aware of risks and benefits, survival data and quality of life outcomes related to both surgical techniques.info:eu-repo/semantics/publishedVersio

Chia protein hydrolysates: characterisation and emulsifying properties

The evaluation of functional properties of different chia protein hydrolysates (CPH) and their application in O/W emulsions were studied. Enzymatic treatments with pepsin, pancreatin or the sequential action of pepsin–pancreatin were applied to hydrolyse a chia protein concentrate (CPC). Oil-in-water emulsions stabilised with CPC or these CPHs, with or without chia mucilage, were prepared at pH 7 or 10. Particle size, global stability, ζ-potential and rheological measurement of emulsions were determined. CPH presented higher (P ≤ 0.05) solubility and surface hydrophobicity levels, exhibiting better emulsifying properties than CPC. Emulsions with CPH presented smaller (P ≤ 0.05) droplet sizes than those with CPC. Regarding to physicochemical stability, emulsions at pH 7 were less stable than those at pH 10, showing destabilisation by creaming and coalescence. The addition of chia mucilage increased the apparent viscosity of emulsions and led to modifications in their fluid behaviour, exhibiting an interesting role as a thickening agent.Fil: Salazar Vega, Ine M.. Universidad Autónoma de Yucatán; MéxicoFil: Julio, Luciana Magdalena. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Segura Campos, Maira Rubi. Universidad Autónoma de Yucatán; MéxicoFil: Tomás, Mabel Cristina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentin

Graphene-Based Coating to Mitigate Biofilm Development in Marine Environments

Due to its several economic and ecological consequences, biofouling is a widely recognized concern in the marine sector. The search for non-biocide-release antifouling coatings has been on the rise, with carbon-nanocoated surfaces showing promising activity. This work aimed to study the impact of pristine graphene nanoplatelets (GNP) on biofilm development through the representative marine bacteria Cobetia marina and to investigate the antibacterial mechanisms of action of this material. For this purpose, a flow cytometric analysis was performed and a GNP/polydimethylsiloxane (PDMS) surface containing 5 wt% GNP (G5/PDMS) was produced, characterized, and assessed regarding its biofilm mitigation potential over 42 days in controlled hydrodynamic conditions that mimic marine environments. Flow cytometry revealed membrane damage, greater metabolic activity, and endogenous reactive oxygen species (ROS) production by C. marina when exposed to GNP 5% (w/v) for 24 h. In addition, C. marina biofilms formed on G5/PDMS showed consistently lower cell count and thickness (up to 43% reductions) than PDMS. Biofilm architecture analysis indicated that mature biofilms developed on the graphene-based surface had fewer empty spaces (34% reduction) and reduced biovolume (25% reduction) compared to PDMS. Overall, the GNP-based surface inhibited C. marina biofilm development, showing promising potential as a marine antifouling coating

Cell block sensitivity for immunohistochemical detection of cytokeratin 5, oestrogen and progesterone receptors in canine primary mammary carcinoma

Mammary carcinomas are relatively common ailments among female canines aged around 10 years old, presentingan important morbidity with an average survival of five years. The cytoinclusion technique is frequently employed in human medicine as the investigative method of choice as it quickly provides resources for the determination of the correct therapeutic response, however, the effectiveness of the technique in canines remains understudied in veterinary medicine. This study aims at evaluating the degree of correlation with immunohistochemical marking for cytokeratin 5 (CK5), oestrogen and progesterone receptors (ER and PR) between the cytoinclusion and the histopathology technique in mammary carcinomas. Twenty-five samples of mammary carcinoma, both for the cytoinclusion and histopathological techniques were submitted for histological processing; microscope slides were created for hematoxylin-eosin (HE) staining and the immunohistochemical technique (IHC) was assessed for the ER, PR and CK5 receptors. Through the HE staining, we reached a concordance rate of 100% between the cytoinclusion and the histopathological analysis in the diagnosis of carcinomas. The immunohistochemical assay presented sensitivity of 85.71%, 95.45% and 100% and Cohen’s kappa of 0.78, 0.84 and 0.95 for ER, PR and CK5, respectively, as well as 100% specificity and P<0.01 for all three markers. Therefore, cytoinclusion represents an accessible, fast and low-cost method, offering high sensitivity for the cytomorphological and immunohistochemical diagnosis of mammary carcinoma in female canines

Las interfaces entre apoyo social, calidad de vida y depresión en usuarios elegibles para cuidados paliativos

Objective: Analyzing the relationship between social support, quality of life and depression in patients eligible for palliative care at Primary Health Care of a municipality in the interior of Minas Gerais, Brazil. Method: A correlational cross-sectional study carried out with patients treated in six primary health care units. Data were submitted to descriptive statistical analysis, tests for differences between averages and medians, and correlation tests. The significance level was 0.05. Results: The sample consisted of 115 participants, and it was identified that the higher the social support, the better the global quality of life (p<0.001) and functional quality of life (p=0.035); the greater the presence of physical symptoms, the lower the level of social support (p=0.012) and the higher the level of depression (p<0.001); the higher the symptoms of depression, the worse the global quality of life (p<0.001), functional quality of life (p<0.001) and the lower the levels of social support (p<0.001). Conclusion: Levels of quality of life, social support and depression of patients eligible for palliative care are influenced by socioeconomic factors such as marital status, gender, age, income, education and presence of a caregiver.Objetivo: Analisar a relação entre apoio social, qualidade de vida e depressão em pacientes elegíveis para cuidados paliativos atendidos na Atenção Primária à Saúde de um município no interior de Minas Gerais, Brasil. Método: Estudo transversal correlacional, realizado com pacientes atendidos em seis unidades da atenção primária à saúde. Os dados foram submetidos à análise estatística descritiva, testes de diferenças entre médias e medianas e testes de correlação. O nível de significância adotado foi 0,05. Resultados: A amostra foi composta por 115 participantes, e identificou-se que quanto maior o apoio social, melhor é a qualidade de vida global (p<0,001) e funcional (p=0,035); quanto maior a presença de sintomas físicos, menor o nível de apoio social (p=0,012) e maior o nível de depressão (p<0,001); quanto maiores os sintomas de depressão, pior é a qualidade de vida global (p<0,001), funcional (p<0,001) e menores os níveis de apoio social (p<0,001). Conclusão: Os níveis de qualidade de vida, apoio social e depressão de pacientes elegíveis para cuidados paliativos são influenciados por fatores socioeconômicos, tais como estado conjugal, sexo, idade, renda, escolaridade e presença de cuidador.Objetivo: Analizar la relación entre apoyo social, calidad de vida y depresión en pacientes elegibles para cuidados paliativos atendidos en la Atención Primaria a la Salud de un municipio en el interior de Minas Gerais, Brasil. Método: Estudio transversal correlacional, realizado con pacientes atendidos en seis unidades de atención primaria a la salud. Los datos fueron sometidos al análisis estadístico descriptivo, pruebas de diferencias entre medias y medianas y pruebas de correlación. El nivel de significancia adoptado fue 0,05. Resultados: La muestra fue compuesta por 115 participantes, y se identificó que cuanto mayor el apoyo social, mejor es la calidad de vida global (p<0,001) y funcional (p=0,035); cuanto mayor sea la presencia de síntomas físicos, menor el nivel de apoyo social (p=0,012) y mayor el nivel de depresión (p<0,001); cuanto mayores los síntomas de depresión, peor es la calidad de vida global (p<0,001), funcional (p<0,001) y menores los niveles de apoyo social (p<0,001). Conclusión: Los niveles de calidad de vida, apoyo social y depresión de pacientes elegibles para cuidados paliativos son influenciados por factores socioeconómicos, tales como estado conyugal, sexo, edad, renta, escolaridad y presencia de cuidador

Postoperative self-efficacy and psychological morbidity in radical prostatectomy

Objective: evaluate the general and perceived self-efficacy, psychological morbidity, and knowledge about postoperative care of patients submitted to radical prostatectomy. Identify the relationships between the variables and know the predictors of self-efficacy. Method: descriptive, cross-sectional study, conducted with 76 hospitalized men. The scales used were the General and Perceived Self-efficacy Scale and the Hospital Anxiety and Depression Scale, in addition to sociodemographic, clinical and knowledge questionnaires. Results: a negative relationship was found for self-efficacy in relation to anxiety and depression. Psychological morbidity was a significant predictor variable for self-efficacy. An active professional situation and the waiting time for surgery also proved to be relevant variables for anxiety and knowledge, respectively. Conclusion: participants had a good level of general and perceived self-efficacy and small percentage of depression. With these findings, it is possible to produce the profile of patients about their psychological needs after radical prostatectomy and, thus, allow the nursing professionals to act holistically, considering not only the need for care of physical nature, but also of psychosocial nature.Paper extracted from doctoral dissertation "Effectiveness of a teaching program for home care of patients undergoing to radical prostatectomy: randomized clinical trial", presented to Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, PAHO/WHO Collaborating Centre for Nursing Research Development, Ribeirao Preto, SP, Brazil. Supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil, process # 141377/2010-0

Intellectual capital of Technology-Based Incubators

The objective of this work is to evaluate the associations between the intellectual capital of technology-based incubators in the sustainability of incubated companies located in Portugal. For this purpose, the methodological strategy employed was the survey, and to test the hypotheses the Partial Least Squares Structural Equation Modeling PLS-SEM method was applied from a sample of 82 incubated company managers. The results show that the intellectual capital of the incubator company has a direct and positive relationship with the innovative capacity, satisfaction, and sustainability of the incubated company. In turn, the incubated company’s innovative capacity has a direct and positive impact on sustainability itself. In addition, both the sustainability of the incubated company and its levels of satisfaction with the incubated company has a positive and direct impact on its competitive success. The management implications include the perception that the greater the effort to improve the human capital, structural capital, and relational capital of the incubated companies, the better will be the results achieved in supporting companies, helping start-ups develop sustainably and competitively in the market.info:eu-repo/semantics/publishedVersio

Producción científica de la enfermería en relación con el cáncer de próstata : revisión integradora

Objetivo: analisar a produção científica da enfermagem brasileira sobre câncer de próstata. Método: revisão integrativa a partir da questão norteadora: qual o conhecimento científico produzido pela enfermagem sobre câncer de próstata nos periódicos brasileiros? Com busca na Biblioteca Virtual da Saúde e consulta às bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e na coleção Scientific Eletronic Library Online (SciELO). Foram elegíveis 11 estudos. Resultados: identificou-se que a discussão desta temática na enfermagem é algo recente e ela concentra-se, em maior parte, na região sudeste. De acordo com a abordagem temática, os assuntos mais discutidos foram: conhecimento da população masculina sobre o câncer de próstata e as barreiras de adesão aos exames de rastreamento. Conclusão: a produção científica da Enfermagem sobre a temática está em recente desenvolvimento, portanto, deve ganhar mais notoriedade em publicações nacionais, a fim de contribuir para a produção de conhecimento como subsídio para a melhoria da assistência.Objective: to analyze the scientific production of Brazilian nursing about prostate cancer. Method: integrative review from the question: “what is the scientific knowledge produced by nursing on prostate cancer in Brazilian journals?” By means a searching in the Virtual Health Library, and consultations in the database of LILACS and SciELO. Eleven studies were eligible, then categorized and analyzed with basis on the instrument elaborated; they were grouped, summarized and integrated to the discussion of review. Results: it was found that the discussion of this thematic in nursing is a recent fact and it is concentrated, mostly, in the Southeast of Brazil. According to the thematic approach, the most discussed topics were: knowledge of the male population about the prostate cancer and the barriers of adherence to screening examinations. Conclusion: the scientific production of the Nursing about prostate cancer is in recent development, therefore, should gain more prominence in national publications, in order to contribute to the production of knowledge as a support for the improvement of care.Objetivo: analizar la producción científica de la enfermería brasileña sobre el cáncer de próstata. Método: revisión integradora de la literatura, a partir de la cuestión: “¿que el conocimiento científico producido por la enfermería en el cáncer de próstata en los periódicos brasileños?”, en la Biblioteca Virtual en Salud con consulta a la base de datos LILACS y colección SciELO. Resultados: se encontró que la discusión de este tema en la enfermería es una reciente y se concentra principalmente en el sureste. De acuerdo con el enfoque temático, los temas más discutidos fueron: el conocimiento de la población masculina en el cáncer de próstata y las barreras de la adherencia a las pruebas de detección. Conclusión: La producción científica de enfermería sobre el cáncer de próstata es un fenómeno reciente, por lo tanto, debe ganar más notoriedad en publicaciones nacionales con el fin de contribuir para la producción de conocimiento con base para la mejora del cuidado

Cross-Química: a Química através das palavras cruzadas

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Efectividad de un programa de enseñanza para cuidado domiciliario de pacientes prostatectomizados: ensayo clínico controlado randomizado

Objective: To evaluate the effectiveness of a teaching program for hospital discharge of patients submitted to radical prostatectomy based on the self-efficacy construct of the Cognitive Social Theory. Method: A controlled clinical trial carried out on a 2-month follow-up of 68 prostatectomized men randomized into intervention group (n = 34) and control (n = 34). The intervention group received routine guidance from the service plus the teaching program. The control group only received routine guidance from the service. The data collection instruments were: sociodemographic and clinical questionnaire, self-efficacy scale, hospital depression and anxiety scale, household care knowledge questionnaire, and an item on satisfaction with a score of 1 to 5. Results: There was a significant difference between the intragroups for satisfaction (p<0.001) and knowledge (p<0.001) of the pre-test to the post-test. In the intervention group, there were significant changes between the times for anxiety (p=0.011) and knowledge (p<0.001). Conclusion: The teaching program with a combination of oral guidance, written instruction and telephone follow-up was effective in improving knowledge about home care and personal satisfactionObjetivo: Evaluar la efectividad de un programa de enseñanza para alta hospitalaria de pacientes sometidos a la prostatectomía radical, pautado en el constructo de la autoeficacia de la Teoría Social Cognitiva. Método: Ensayo clínico controlado, realizado en seguimiento de dos meses, con 68 hombres prostatectomizados, aleatorizados en grupo de intervención (n=34) y de control (n=34). El grupo de intervención recibió orientaciones de rutina del servicio más el programa de enseñanza. El grupo de control recibió solo orientaciones de rutina del servicio. Los instrumentos de recolección de datos fueron: cuestionario sociodemográfico y clínico, escala de autoeficacia, escala de ansiedad y depresión hospitalaria, cuestionario de conocimiento sobre cuidados domiciliarios y un ítem sobre satisfacción con puntaje de 1 a 5. Resultados: Hubo diferencia significativa entre e intra grupos para satisfacción (p<0,001) y conocimiento (p<0,001) de la pre prueba a la post prueba. En el grupo intervención, hubo cambios significativos entre los tiempos para ansiedad (p=0,011) y conocimiento (p<0,001). Conclusión: El programa de enseñanza con combinación de orientación oral, escrita y seguimiento telefónico se mostró efectivo en la mejoría del conocimiento en cuanto a los cuidados domiciliarios y satisfacción de los individuos. Registro Brasileño de Ensayos Clínicos: RBR-5n95rmObjetivo: Avaliar a efetividade de um programa de ensino para alta hospitalar de pacientes submetidos à prostatectomia radical, pautado no construto da autoeficácia da Teoria Social Cognitiva. Método: Ensaio clínico controlado, realizado em seguimento de 2 meses, com 68 homens prostatectomizados, randomizados em grupo-intervenção (n=34) e controle (n=34). O grupo-intervenção recebeu orientações de rotina do serviço mais o programa de ensino. O grupo-controle recebeu apenas orientações de rotina do serviço. Os instrumentos de coleta de dados foram: questionário sociodemográfico e clínico, escala de autoeficácia, escala de ansiedade e depressão hospitalar, questionário de conhecimento sobre cuidados domiciliares e um item sobre satisfação com pontuação de 1 a 5. Resultados: Houve diferença significativa entre e intragrupos para satisfação (p<0,001) e conhecimento (p<0,001) do pré-teste para o pós-teste. No grupo-intervenção, houve mudanças significativas entre os tempos para ansiedade (p=0,011) e conhecimento (p<0,001). Conclusão: O programa de ensino com combinação de orientação oral, escrita e acompanhamento telefônico mostrou-se efetivo na melhoria do conhecimento quanto aos cuidados em domicílio e satisfação dos indivíduos. Registro Brasileiro de Ensaios Clínicos: RBR-5n95rm.Financial support Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq