Planeamiento estratégico de tecnologías de la información para medianas y pequeñas empresas del sector minero

Actualmente las pequeñas y medianas empresas mineras, vienen trabajando con un mercado comercial altamente competitivo en los últimos 15 años, con respecto a las grandes empresas mineras formalmente constituidas. La presente tesis tiene como objetivo mostrar el panorama actual y futuro de las empresas mineras pequeñas, medianas e informales, para quienes propongo una metodología para que puedan utilizarla en la transición de una mina tradicional a una mina inteligente, pasando por mina moderna, la misma que se describe mediante la alineación de un Plan Estratégico Empresarial alineado con el Plan Estratégico en Tecnologías de Información PETI. El propósito es que las empresas mineras pequeñas y medianas que están experimentando un gran crecimiento en sus operaciones, logren administrar su empresa de una manera más eficiente y eficaz; por su rubro estas se ven regidas por el ambiente global en el que se desempeñan, el cual es altamente competitivo y exige una constante toma de decisiones estratégicas si buscan permanecer en el mercado de manera exitosa

Configuración e interconexión entre sí de cada uno de los dispositivos que forman parte de la empresa que posee tres sucursales distribuidas en las Ciudades de Bogotá, Medellín y Bucaramanga.

link con la practica en packet tracer https://drive.google.com/file/d/1wIw7m015un0G3IsBhR066CmZSZtuGsI9/view?usp=sharingConfiguración e interconexión entre sí de cada uno de los dispositivos que forman parte una empresa que posee tres sucursales distribuidas en las ciudades de Bogotá, Medellín y Bucaramanga.Configuration and interconnection between each of the devices that are part of a company that has three branches distributed in the cities of Bogotá, Medellín and Bucaramanga

Five pillars for stakeholder analyses in sustainability transformations: The global case of phosphorus.

Phosphorus is a critical agricultural nutrient and a major pollutant in waterbodies due to inefficient use. In the form of rock phosphate it is a finite global commodity vulnerable to price shocks and sourcing challenges. Transforming toward sustainable phosphorus management involves local to global stakeholders. Conventional readings of stakeholders may not reflect system complexity leaving it difficult to see stakeholder roles in transformations. We attempt to remedy this issue with a novel stakeholder analysis method based on five qualitative pillars: stakeholder agency, system roles, power and influence, alignment to the problem, and transformational potential. We argue that our approach suits case studies of individual stakeholders, stakeholder groups, and organisations with relationships to sustainability challenges

Effects of bone morphogenic protein 4 (BMP4) and its inhibitor, Noggin, on in vitro maturation and culture of bovine preimplantation embryos

<p>Abstract</p> <p>Background</p> <p>BMP4 is a member of the transforming growth factor beta (TGFbeta) superfamily and Noggin is a potent BMP inhibitor that exerts its function by binding to BMPs preventing interactions with its receptors. The aim of this work was to investigate the role of BMP4 and Noggin, on oocytes <it>in vitro </it>maturation (m experiments) and embryos <it>in vitro </it>development (c experiments) of bovine.</p> <p>Methods</p> <p>For m experiments, COCs were collected from slaughterhouse ovaries and <it>in vitro </it>matured in TCM with 100 ng/ml of either BMP4 or Noggin. After 24 h, the nuclear stage of the oocytes was determined by staining with Hoechst 33342. In addition, RT-qPCR was performed on MII oocytes to study the relative concentration of <it>ZAR1, GDF9, BAX, MATER </it>and <it>HSP70 </it>transcripts. Treated oocytes were submitted to parthenogenic activation (PA) or <it>in vitro </it>fertilization (IVF) and cultured in CR2. For c experiments, non-treated matured oocytes were submitted to PA or IVF to generate embryos that were exposed to 100 ng/ml of BMP4 or Noggin in CR2 until day nine of culture. Cleavage, blastocyst and hatching rates, expression pattern of the transcription factor Oct-4 in blastocysts and embryo cell number at day two and nine post-activation or fertilization were evaluated.</p> <p>Results</p> <p>We found that Noggin, as BMP4, did not affect oocyte nuclear maturation. Noggin supplementation up-regulated the expression of <it>HSP70 and MATER </it>genes in matured oocytes. Moreover, BMP4 during maturation increased the proportion of Oct-4 positive cells in parthenogenic embryos. On the other hand, when Noggin was added to embryo culture medium, developmental rates of parthenogenic and <it>in vitro </it>fertilized embryos were reduced. However, BMP4 addition decreases the development only for <it>in vitro </it>fertilized embryos. BMP4 and Noggin during culture reduced the proportion of Oct-4-expressing cells.</p> <p>Conclusions</p> <p>Our results show that BMP4 is implicated in bovine oocytes maturation and embryo development. Moreover, our findings demonstrate, for the first time, that a correct balance of BMP signaling is needed for proper pre-implantation development of bovine embryos.</p

Extracellular Matrix-Derived Hydrogels to Augment Dermal Wound Healing:A Systematic Review

Chronic, non-healing, dermal wounds form a worldwide medical problem with limited and inadequate treatment options and high societal burden and costs. With the advent of regenerative therapies exploiting extracellular matrix (ECM) components, its efficacy to augment wound healing is to be explored. This systematic review was performed to assess and compare the current therapeutic efficacy of ECM hydrogels on dermal wound healing. The electronic databases of Embase, Medline Ovid, and Cochrane Central were searched for in vivo and clinical studies on the therapeutic effect of ECM-composed hydrogels on dermal wound healing (April 13, 2021). Two reviewers selected studies independently. Studies were assessed based on ECM content, ECM hydrogel composition, additives, and wound healing outcomes, such as wound size, angiogenesis, and complications. Of the 2102 publications, 9 rodent-based studies were included while clinical studies were not published at the time of the search. Procedures to decellularize tissue or cultured cells and subsequently generate hydrogels were highly variable and in demand of standardization. ECM hydrogels with or without additives reduced wound size and also seem to enhance angiogenesis. Serious complications were not reported. To date, preclinical studies preclude to draw firm conclusions on the efficacy and working mechanism of ECM-derived hydrogels on dermal wound healing. The use of ECM hydrogels can be considered safe. Standardization of decellularization protocols and implementation of quality and cytotoxicity controls will enable obtaining a generic and comparable ECM product. Impact statementExtracellular matrix (ECM)-based hydrogels are biocompatible and harbor growth factors that can instruct tissue healing. Their application is a novelty in (pre)clinical wound healing treatment. This systematic review provides an overview of the current evidence for ECM hydrogels in enhancing wound healing and an extensive overview of the decellularization procedures used. Lastly, challenges and future directions to standardize decellularization procedures and implement quality controls are proposed

Estudio Relacional del Pensamiento Creativo Motriz respecto al Desempeño Académico y Desarrollo Motor en los estudiantes de ciclo I, II Y IV del Colegio IED Vista Bella.

El interés del estudio se centra en establecer las posibles relaciones que se dan entre tres eventos de estudio: la creatividad motriz en relación a el concepto de rendimiento escolar definido según Chain y Ramírez como el grado de conocimientos que a través de la escuela reconoce el sistema educativo que posee un individuo,y desarrollo motor definido cómo el proceso de cambios en el tiempo por los cuales un individuo adquiere las capacidades esenciales para la vida humana como son lenguaje, motricidad, y pensamiento, que permiten la comunicación, movimiento y en general adaptación al medioambiente, en una muestra representativa estudiantes de grupos de ciclos I, II, IV DEL I.E.D Vista Bella

Laser-induced fluorescence of organic matter from a Brazilian oxisol under sewage sludge applications.

A aplicação do lodo de esgoto é utilizada como alternativa de conservação e manutenção da fertilidade dos solos sem prejudicar o ecossistema. O objetivo do presente trabalho foi avaliar a influência da aplicação de lodo de esgoto sobre a matéria orgânica (MO) de um Latossolo vermelho amarelo brasileiro, através da fluorescência induzida por laser (LIF). A LIF foi utilizada para analisar a fluorescência do solo intacto e suas frações químicas e físicas. Houve grande contribuição da fração humina à fluorescência do solo intacto, remarcando a importância de estudar a matéria orgânica (MO) associada à matriz mineral do solo. Para cada fração granulométrica foram obtidos espectros com diferentes perfis, indicando diferenças nos compostos orgânicos a elas ligados. A fração 2-20 ?m, que apresentou maior conteúdo de carbono (~5%), representa somente 10% do solo mas acumula 34-39 % do conteúdo total de carbono do mesmo e mostrou a maior intensidade de fluorescência. O espectro desta fração mostra sua heterogeneidade e alta concentração de compostos cuja fluorescência é centrada nos 510 nm, o que indica alta concentração de sistemas com ligações insaturadas, com alto grau de ressonância e maior conjugação do sistema de eletrons, indicando maior aromaticidade quando comparado as outras frações. Não foram observadas diferenças significativas entre os tratamentos de lodo de esgoto. A LIF é uma técnica promissora para caraterizar a MO de solos intactos, permitindo estudar sua distribuição na matriz mineral do solo, inclusive nos Latossolos

Ocorrência do primeiro caso autóctone canino por Leishmania (Leishmania) infantum chagasi no Município de Campinas, Estado de São Paulo, Brasil

An autochthonous case of visceral leishmaniasis is reported in a dog (Canis familiaris) as an apparently natural infection in a non-endemic area. DNA obtained from spleen and liver samples produced the expected fragment in a Leishmania-specific rDNA-based nested-PCR assay. The PCR product, a 490 bp fragment, was sequenced and the nucleotide sequence was identical to that of Leishmania (Leishmania) infantum chagasi. These results are surprising since no autochthonous human or canine cases of visceral leishmaniasis have ever been reported in this municipality. This case suggests that natural transmission of this disease is occurring in this area.Caso autóctone de leishmaniose visceral é relatado em cão (Canis familiaris), aparentemente em área não endêmica. DNA obtido a partir de amostras do baço e fígado foram submetidos a nested-PCR baseada no rDNA específico de Leishmania. Os produtos das PCR foram sequenciados e os 490 pares de base foram idênticos a Leishmania (Leishmania) infantum chagasi. Esses resultados são surpreendentes, uma vez que, nenhum caso autóctone canino ou humano de leishmaniose visceral havia sido relatado neste município. Esse caso sugere que a transmissão natural da doença está ocorrendo nesta área

Fluorescência induzida por laser da matéria orgânica de um Latossolo brasileiro tratado com lodo de esgoto

A aplicação do lodo de esgoto é utilizada como alternativa de conservação e manutenção da fertilidade dos solos sem prejudicar o ecossistema. O objetivo do presente trabalho foi avaliar a influência da aplicação de lodo de esgoto sobre a matéria orgânica (MO) de um Latossolo vermelho amarelo brasileiro, através da fluorescência induzida por laser (LIF). A LIF foi utilizada para analisar a fluorescência do solo intacto e suas frações químicas e físicas. Houve grande contribuição da fração humina à fluorescência do solo intacto, remarcando a importância de estudar a matéria orgânica (MO) associada à matriz mineral do solo. Para cada fração granulométrica foram obtidos espectros com diferentes perfis, indicando diferenças nos compostos orgânicos a elas ligados. A fração 2-20 µm, que apresentou maior conteúdo de carbono (~5%), representa somente 10% do solo mas acumula 34-39 % do conteúdo total de carbono do mesmo e mostrou a maior intensidade de fluorescência. O espectro desta fração mostra sua heterogeneidade e alta concentração de compostos cuja fluorescência é centrada nos 510 nm, o que indica alta concentração de sistemas com ligações insaturadas, com alto grau de ressonância e maior conjugação do sistema de eletrons pi, indicando maior aromaticidade quando comparado as outras frações. Não foram observadas diferenças significativas entre os tratamentos de lodo de esgoto. A LIF é uma técnica promissora para caraterizar a MO de solos intatos, permitindo estudar sua distribuição na matriz mineral do solo, inclusive nos Latossolos.Sludge applications have been used to maintain fertility of agricultural soils without damaging the natural ecosystem. The aim of this study was evaluating the influence of sewage-sludge addition on the quality of organic matter (OM) of a Brazilian Oxisol by Laser Induced Fluorescence (LIF). LIF was used to analyze OM of whole soil and different soil fractions separated by chemical and physical methods. The high fluorescence contribution of humin fraction to the fluorescence of whole soils was shown, stressing the importance of studying OM associated to mineral matrix of soil. Spectra with different shapes were obtained for every particle size fraction, indicating differences in organic compounds bounded to them. The fraction with the higher carbon content was the 2-20 µm, that contains ~5% C and represents only 10% in soil, but stores 34-39 % of total C and shows the highest fluorescence intensity. The spectrum of this fraction shows its heterogeneity and a higher concentration of compounds which fluorescence is centered at 510 nm. This indicates a higher concentration of unsaturated bond systems capable of high degree of resonance, increased conjugation of the electron pi system, and higher aromaticity comparing with other fractions. No differences were detected for treatments of sewage-sludge applications. LIF spectroscopy is a promising technique for OM studies in whole soils, allowing to study spatial distribution of OM within the soil's mineral matrix, including Oxisols