117 research outputs found
Genetic footprints of iberian cattle in America 500 years after the arrival of Columbus.
American Creole cattle presumably descend from animals imported from the Iberian Peninsula during the period of colonization and settlement, through different migration routes, andmay have also suffered the influence of cattle directly imported from Africa. The introduction of European cattle, which began in the 18th century, and later of Zebu from India, has threatened the survival of Creole populations, some of which have nearly disappeared or were admixed with exotic breeds. Assessment of the genetic status of Creole cattle is essential for the establishment of conservation programs of these historical resources. Methodology/Principal Findings: We sampled 27 Creole populations, 39 Iberian, 9 European and 6 Zebu breeds. We used microsatellite markers to assess the origins of Creole cattle, and to investigate the influence of different breeds on their genetic make-up. The major ancestral contributions are from breeds of southern Spain and Portugal, in agreement with the historical ports of departure of ships sailing towards the Western Hemisphere. This Iberian contribution to Creoles may also include some African influence, given the influential role that African cattle have had in the development of Iberian breeds, but the possibility of a direct influence on Creoles of African cattle imported to America can not be discarded. In addition to the Iberian influence, the admixture with other European breeds was minor. The Creoles from tropical areas, especially those from the Caribbean, show clear signs of admixture with Zebu. Conclusions/Significance: Nearly five centuries since cattle were first brought to the Americas, Creoles still show a strong and predominant signature of their Iberian ancestors. Creole breeds differ widely from each other, both in genetic structure and influences from other breeds. Efforts are needed to avoid their extinction or further genetic erosion, which would compromise centuries of selective adaptation to a wide range of environmental conditions
Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controlled trial.
Background: Pertussis immunization during pregnancy is recommended in many countries. Data from
large randomized controlled trials are needed to assess the immunogenicity, reactogenicity and safety
of this approach.
Methods: This phase IV, observer-blind, randomized, placebo-controlled, multicenter trial assessed
immunogenicity, transplacental transfer of maternal pertussis antibodies, reactogenicity and safety of
a reduced-antigen-content diphtheria-tetanus-three-component acellular pertussis vaccine (Tdap) during
pregnancy. Women received Tdap or placebo at 27–36 weeks’ gestation with crossover 72-hourpostpartum
immunization. Immune responses were assessed before the pregnancy dose and 1 month
after, and from the umbilical cord at delivery. Superiority (primary objective) was reached if the lower
limits of the 95% confidence intervals (CIs) of the pertussis geometric mean concentration (GMC) ratios
(Tdap/control) in cord blood were 1.5. Solicited and unsolicited adverse events (AEs) and pregnancy-/
neonate-related AEs of interest were recorded.
Results: 687 pregnant women were vaccinated (Tdap: N = 341 control: N = 346). Superiority of the pertussis
immune response (maternally transferred pertussis antibodies in cord blood) was demonstrated
by the GMC ratios (Tdap/control): 16.1 (95% CI: 13.5–19.2) for anti-filamentous hemagglutinin, 20.7
(15.9–26.9) for anti-pertactin and 8.5 (7.0–10.2) for anti-pertussis toxoid. Rates of pregnancy-/
neonate-related AEs of interest, solicited general and unsolicited AEs were similar between groups.
None of the serious AEs reported throughout the study were considered related to maternal Tdap vaccination.
Conclusions: Tdap vaccination during pregnancy resulted in high levels of pertussis antibodies in cord
blood, was well tolerated and had an acceptable safety profile. This supports the recommendation of
Tdap vaccination during pregnancy to prevent early-infant pertussis disease.post-print502 K
Observation of direct-photon collective flow in sqrt(s_NN)=200 GeV Au+Au collisions
The second Fourier component v_2 of the azimuthal anisotropy with respect to
the reaction plane was measured for direct photons at midrapidity and
transverse momentum (p_T) of 1--13 GeV/c in Au+Au collisions at sqr(s_NN)=200
GeV. Previous measurements of this quantity for hadrons with p_T < 6 GeV/c
indicate that the medium behaves like a nearly perfect fluid, while for p_T > 6
GeV/c a reduced anisotropy is interpreted in terms of a path-length dependence
for parton energy loss. In this measurement with the PHENIX detector at the
Relativistic Heavy Ion Collider we find that for p_T > 4 GeV/c the anisotropy
for direct photons is consistent with zero, as expected if the dominant source
of direct photons is initial hard scattering. However, in the p_T < 4 GeV/c
region dominated by thermal photons, we find a substantial direct photon v_2
comparable to that of hadrons, whereas model calculations for thermal photons
in this kinematic region significantly underpredict the observed v_2.Comment: 384 authors, 6 pages, 3 figures, and 1 table. Submitted to Phys. Rev.
Lett. v2 has minor changes to match the submission version. Plain text data
tables for the points plotted in the figures are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg126_data.htm
Azimuthal anisotropy of neutral pion production in Au+Au collisions at sqrt(s_NN) = 200 GeV: Path-length dependence of jet quenching and the role of initial geometry
We have measured the azimuthal anisotropy of pi0's for 1 < pT < 18 GeV/c for
Au+Au collisions at sqrt s_NN = 200 GeV. The observed anisotropy shows a
gradual decrease in 3 < pT < 7 - 10 GeV/c, but remains positive beyond 10
GeV/c. The magnitude of this anisotropy is under-predicted, up to at least 10
GeV/c, by current perturbative QCD (pQCD) energy-loss model calculations. An
estimate of the increase in anisotropy expected from initial-geometry
modification due to gluon saturation effects and initial-geometry fluctuations
is insufficient to account for this discrepancy. Calculations which implement a
path length dependence steeper than what is implied by current pQCD energy-loss
models, show reasonable agreement with the data.Comment: 384 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Cold Nuclear Matter Effects on J/psi Yields as a Function of Rapidity and Nuclear Geometry in Deuteron-Gold Collisions at sqrt(s_NN) = 200 GeV
We present measurements of J/psi yields in d+Au collisions at sqrt(s_NN) =
200 GeV recorded by the PHENIX experiment and compare with yields in p+p
collisions at the same energy per nucleon-nucleon collision. The measurements
cover a large kinematic range in J/psi rapidity (-2.2 < y < 2.4) with high
statistical precision and are compared with two theoretical models: one with
nuclear shadowing combined with final state breakup and one with coherent gluon
saturation effects. To remove model dependent systematic uncertainties we also
compare the data to a simple geometric model. We find that calculations where
the nuclear modification is linear or exponential in the density weighted
longitudinal thickness are difficult to reconcile with the forward rapidity
data.Comment: 449 authors from 66 institutions, 6 pages, 3 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Azimuthal anisotropy of pi^0 and eta mesons in Au+Au collisions at sqrt(s_NN)=200 GeV
The azimuthal anisotropy coefficients v_2 and v_4 of pi^0 and eta mesons are
measured in Au+Au collisions at sqrt(s_NN)=200 GeV, as a function of transverse
momentum p_T (1-14 GeV/c) and centrality. The extracted v_2 coefficients are
found to be consistent between the two meson species over the measured p_T
range. The ratio of v_4/v_2^2 for pi^0 mesons is found to be independent of p_T
for 1-9 GeV/c, implying a lack of sensitivity of the ratio to the change of
underlying physics with p_T. Furthermore, the ratio of v_4/v_2^2 is
systematically larger in central collisions, which may reflect the combined
effects of fluctuations in the initial collision geometry and finite viscosity
in the evolving medium.Comment: 384 authors, 71 institutions, 11 pages, 9 figures, and 2 tables.
Submitted to Physical Review C. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
Systematic study of charged-pion and kaon femtoscopy in AuAu collisions at =200 GeV
We present a systematic study of charged pion and kaon interferometry in
AuAu collisions at =200 GeV. The kaon mean source radii
are found to be larger than pion radii in the outward and longitudinal
directions for the same transverse mass; this difference increases for more
central collisions. The azimuthal-angle dependence of the radii was measured
with respect to the second-order event plane and similar oscillations of the
source radii were found for pions and kaons. Hydrodynamic models qualitatively
describe the similar oscillations of the mean source radii for pions and kaons,
but they do not fully describe the transverse-mass dependence of the
oscillations.Comment: 499 authors, 27 pages, 13 figures, and 11 tables. v2 is the version
accepted for publication in Phys. Rev. C. Plain text data tables for the
points plotted in figures for this and previous PHENIX publications are (or
will be) publicly available at http://www.phenix.bnl.gov/papers.htm
Upsilon (1S+2S+3S) production in d+Au and p+p collisions at sqrt(s_NN)=200 GeV and cold-nuclear matter effects
The three Upsilon states, Upsilon(1S+2S+3S), are measured in d+Au and p+p
collisions at sqrt(s_NN)=200 GeV and rapidities 1.2<|y|<2.2 by the PHENIX
experiment at the Relativistic Heavy-Ion Collider. Cross sections for the
inclusive Upsilon(1S+2S+3S) production are obtained. The inclusive yields per
binary collision for d+Au collisions relative to those in p+p collisions
(R_dAu) are found to be 0.62 +/- 0.26 (stat) +/- 0.13 (syst) in the gold-going
direction and 0.91 +/- 0.33 (stat) +/- 0.16 (syst) in the deuteron-going
direction. The measured results are compared to a nuclear-shadowing model,
EPS09 [JHEP 04, 065 (2009)], combined with a final-state breakup cross section,
sigma_br, and compared to lower energy p+A results. We also compare the results
to the PHENIX J/psi results [Phys. Rev. Lett. 107, 142301 (2011)]. The rapidity
dependence of the observed Upsilon suppression is consistent with lower energy
p+A measurements.Comment: 495 authors, 11 pages, 9 figures, 5 tables. Submitted to Phys. Rev.
C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Direct photon production in d+Au collisions at sqrt(s_NN)=200 GeV
Direct photons have been measured in sqrt(s_NN)=200 GeV d+Au collisions at
midrapidity. A wide p_T range is covered by measurements of nearly-real virtual
photons (1<p_T<6 GeV/c) and real photons (5<p_T<16 GeV/c). The invariant yield
of the direct photons in d+Au collisions over the scaled p+p cross section is
consistent with unity. Theoretical calculations assuming standard cold nuclear
matter effects describe the data well for the entire p_T range. This indicates
that the large enhancement of direct photons observed in Au+Au collisions for
1.0<p_T<2.5 GeV/c is due to a source other than the initial-state nuclear
effects.Comment: 547 authors, 7 pages, 4 figures. Submitted to Phys. Rev. Lett.. Plain
text data tables for the points plotted in figures for this and previous
PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
- …