Quality of life in hidradenitis suppurativa : Validation of the hsqol-24

Altres ajuts: reports grants, personal fees, non-financial support and other from Abbvie, Almirall, Amgen, Boehringer, Celgene, Janssen-Cilag, Leo Pharma, Lilly, MSD-Schering-Plough, Novartis, Pfizer and UCB, outside the submitted work. TGC reports personal fees from Lilly and Novartis, outside the submitted work. LP reports grants and personal fees from AbbVie, Almirall, Amgen, Boehringer Ingelheim, Celgene, Janssen, Leo-Pharma, Lilly, Novartis, Pfizer, Regeneron, Roche, Sanofi, and UCB, personal fees from Baxalta, Biogen, Fresenius-Kabi, JS Biocad, Mylan, Sandoz, Samsung-Bioepis, and Bristol Myers Squibb, outside the submitted work. The other authors have no conflicts of interest to declare.To date, there are no disease-specific instruments in Spanish to assess quality of life of patients with hidra-denitis suppurativa. A multicentre study was pre-viously carried out in Spain between 2016 and 2017 to develop the Hidradenitis Suppurativa Quality of Life-24 (HSQoL-24), a disease-specific questionnaire to assess quality of life in patients with hidradenitis suppurativa. The objectives of this study are to revali-date the HSQoL-24 in Spanish with a larger sample of patients, and to present the English version. In this multi centre study in Spain, patients with hidradenitis suppurativa completed the HSQoL-24, the Dermatology Life Quality Index and the Skindex-29. The Hurley staging system was used to assess the severity of the disease. Validation of the questionnaire was carried out in 130 patients, of whom 75 (57.7%) were women. This study demonstrates adequate values of reliability and validity of the HSQoL-24, confirming the previous test re-test validation and making this questionnaire one of wide clinical validity in terms of results perceiv-ed by patients

An ancient reservoir of volatiles in the Moon sampled by lunar meteorite Northwest Africa 10989

Northwest Africa (NWA) 10989 is a recently found lunar meteorite we used to elucidate the history of volatiles (H and Cl) in the Moon through analysis of its phosphates. The petrology, bulk geochemistry and mineralogy of NWA 10989 are consistent with it being a lunar meteorite with intermediate-iron bulk composition, composed of 40% of mare basaltic material and ~ 60% non-mare material, but with no obvious KREEP-rich basaltic components. It is probable that the source region for this meteorite resides near a mare–highlands boundary, possibly on the farside of the Moon. Analyses of chlorine and hydrogen abundances and isotopic composition in apatite and merrillite grains from NWA 10989 indicate sampling of at least two distinct reservoirs of volatiles, one being similar to those for known mare basalts from the Apollo collections, while the other potentially represents a yet unrecognized reservoir. In situ Th-U-Pb dating of phosphates reveal two distinct age clusters with one ranging from 3.98 ± 0.04 to 4.20 ± 0.02 Ga, similar to the ages of cryptomare material, and the other ranging from 3.32 ± 0.01 to 3.96 ± 0.03 Ga, closer to the ages of mare basalts known from the Apollo collections. This lunar breccia features mixing of material, among which a basaltic D-poor volatile reservoir which doesn’t appear to have been recorded by Apollo samples

Multiple reservoirs of volatiles in the Moon revealed by the isotopic composition of chlorine in lunar basalts

The isotopes of chlorine (37Cl and 35Cl) are highly fractionated in lunar samples compared to most other Solar System materials. Recently, the chlorine isotope signatures of lunar rocks have been attributed to large-scale degassing processes that occurred during the existence of a magma ocean. In this study we investigated how well a suite of lunar basalts, most of which have not previously been analyzed, conform to previous models. The Cl isotope compositions (δ37Cl (‰) = [(37Cl/35Clsample/37Cl/35ClSMOC)-1]×1000, where SMOC refers to standard mean ocean chloride) recorded range from ∼+7 to +14 ‰ (Apollo 15), +10 to +19 ‰ (Apollo 12), +9 to +15 ‰ (70017), +4 to +8 ‰ (MIL 05035), and +15 to +22 ‰ (Kalahari 009). The Cl isotopic data from the present study support the mixing trends previously reported by Boyce et al., 2015, Barnes et al., 2016, as the Cl isotopic composition of apatites are positively correlated with bulk-rock incompatible trace element abundances in the low-Ti basalts, inclusive of low-Ti and KREEP basalts. This trend has been interpreted as evidence that incompatible trace elements, including Cl, were concentrated in the urKREEP residual liquid of the lunar magma ocean, rather than the mantle cumulates, and that urKREEP Cl had a highly fractionated isotopic composition. The source regions for the basalts were thus created by variable mixing between the mantle (Cl-poor and relatively unfractionated) and urKREEP. The high-Ti basalts show much more variability in measured Cl isotope ratios and scatter around the trend formed by the low-Ti basalts. Most of the data for lunar meteorites also fits the mixing of volatiles in their sources, but Kalahari 009, which is highly depleted in incompatible trace elements, contains apatites with heavily fractionated Cl isotopic compositions. Given that Kalahari 009 is one of the oldest lunar basalts and ought to have been derived from very early-formed mantle cumulates, a heavy Cl isotopic signature is likely not related to its mantle source, but more likely to magmatic or secondary alteration processes, perhaps via impact-driven vapor metasomatism of the lunar crust

Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians

The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of the CCR5 coding region alleles in South Brazil and noticed a high CCR5*D32 frequency in the Euro-Brazilian population of the Paraná State (9.3%), which is the highest thus far reported for Latin America. The D32 frequency is even higher among the Euro-Brazilian Mennonites (14.2%). This allele is uncommon in Afro-Brazilians (2.0%), rare in the Guarani Amerindians (0.4%) and absent in the Kaingang Amerindians and the Oriental-Brazilians. R223Q is common in the Oriental-Brazilians (7.7%) and R60S in the Afro-Brazilians (5.0%). A29S and L55Q present an impaired response to β-chemokines and occurred in Afro- and Euro-Brazilians with cumulative frequencies of 4.4% and 2.7%, respectively. Two new non-synonymous alleles were found in Amerindians: C323F (g.3729G > T) in Guarani (1.4%) and Y68C (g.2964A > G) in Kaingang (10.3%). The functional characteristics of these alleles should be defined and considered in epidemiological investigations about HIV-1 infection and AIDS incidence in Amerindian populations

Electric characterization of grain boundaries in ionic conductors by impedance spectroscopy measurements in a bicrystal

En este trabajo se presentan resultados de medidas de espectroscopia de impedancias realizadas en un bicristal del conductor iónico zirconia estabilizada con itria (YSZ). Utilizando electrodos de tamaño micrométrico se ha podido medir el transporte iónico a través, perpendicularmente, de una única frontera de grano, caracterizando eléctricamente las propiedades de dicha frontera. De este modo se han obtenido los parámetros microscópicos que determinan la distribución de carga en la frontera y por lo tanto el transporte iónico a través de ella, como son la barrera de potencial en la frontera DF = 0.35±0.01 V a 275 ºC, y el espesor de la zona de carga espacial l* = 5±1 Å. Estos valores son significativamente diferentes a los obtenidos anteriormente en muestras cerámicas policristalinas del mismo material, y muestran mejor acuerdo con los valores que predice el modelo de Mott-Schottky para la distribución de carga y el transporte iónico a través de la frontera de grano.Here we show impedance spectroscopy measurements on a bicrystal of the ionically conducting yttria stabilized zirconia (YSZ). By using micrometer sized electrodes it is possible to measure ionic transport perpendicular to a single grain boundary, and characterize its electrical properties. We are thus able to obtain the microscopic parameters that determine the charge distribution at the grain boundary and the ionic transport through it, as the potential energy barrier DF = 0.35±0.01 V at 275 ºC, and the space charge layer thickness l* = 5±1 Å. These values are significantly different from those previously obtained in polycrystalline ceramic samples of the same material, and show much better agreement with the values predicted by the Mott-Schottky model for the charge distribution and ionic transport through the grain boundaryFil: Frechero, Marisa Alejandra. Universidad Complutense de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Rocci, M.. Universidad Complutense de Madrid; EspañaFil: Schmidt, R.. Universidad Complutense de Madrid; EspañaFil: Diaz Guillen, M.. Universidad Complutense de Madrid; EspañaFil: Dura, O.. Universidad Complutense de Madrid; EspañaFil: Rivera Calzada, A.. Universidad Complutense de Madrid; EspañaFil: Santamaria, J.. Universidad Complutense de Madrid; EspañaFil: Leon,C.. Universidad Complutense de Madrid; Españ

Paving the way to nanoionics: atomic origin of barriers for ionic transport through interfaces

The blocking of ion transport at interfaces strongly limits the performance of electrochemical nanodevices for energy applications. The barrier is believed to arise from space-charge regions generated by mobile ions by analogy to semiconductor junctions. Here we show that something different is at play by studying ion transport in a bicrystal of yttria (9% mol) stabilized zirconia (YSZ), an emblematic oxide ion conductor. Aberration-corrected scanning transmission electron microscopy (STEM) provides structure and composition at atomic resolution, with the sensitivity to directly reveal the oxygen ion profile. We find that Y segregates to the grain boundary at Zr sites, together with a depletion of oxygen that is confined to a small length scale of around 0.5 nm. Contrary to the main thesis of the space-charge model, there exists no evidence of a long-range O vacancy depletion layer. Combining ion transport measurements across a single grain boundary by nanoscale electrochemical strain microscopy (ESM), broadband dielectric spectroscopy measurements, and density functional calculations, we show that grain-boundary-induced electronic states act as acceptors, resulting in a negatively charged core. Besides the possible effect of the modified chemical bonding, this negative charge gives rise to an additional barrier for ion transport at the grainboundary.Fil: Frechero, Marisa Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Complutense de Madrid; EspañaFil: Rocci, M.. Universidad Complutense de Madrid; EspañaFil: Sanchez Santolino, G.. Universidad Complutense de Madrid; EspañaFil: Kumar, Amit. Oak Ridge National Laboratory. Center for Nanophase Materials Sciences; Estados UnidosFil: Salafranca, Juan. Universidad Complutense de Madrid; EspañaFil: Schmidt, Rainer. Universidad Complutense de Madrid; EspañaFil: Diaz Guillen, M.R.. Universidad Complutense de Madrid; EspañaFil: Durá, O. J.. Universidad Complutense de Madrid; EspañaFil: RiveraCalzada, A.. Universidad Complutense de Madrid; EspañaFil: Mishra, R.. Vanderbilt University; Estados UnidosFil: Jesse, Stephen. Oak Ridge National Laboratory. Center for Nanophase Materials Sciences; Estados UnidosFil: Pantelides, S.T.. Vanderbilt University; Estados UnidosFil: Kalinin, Sergei. Oak Ridge National Laboratory. Center for Nanophase Materials Sciences; Estados UnidosFil: Varela, M.. Universidad Complutense de Madrid; EspañaFil: Pennycook, Steve. University Of Tennessee; Estados UnidosFil: Santamaria, J.. Universidad Complutense de Madrid; EspañaFil: Leon, C.. Universidad Complutense de Madrid; Españ