Presence of Waddlia chondrophila in hot water systems from non-domestic buildings in France

Postprint (author's final draft

SODA-IIoT4Energy: Blockchain-based Access Control to manage smart meter credentials & access rights for Smart Grids

International audienceCo-designed with Engie and Gemalto, SODA-IIoT4Energy offers an access control paradigm whereby access rights are granted to smart meters through the use of security policies stored inside a blockchain.The demonstrator is specific in that it mostly relies on entities deployed at Engie customer premises (the smart meters), which gain uplink connectivity through concentrators, each serving an entire cluster. The smart meters use highly robust, low throughput, wide-range communications to exchange data with the concentrator. For example, LoRaWAN, Sigfox, NB-IoT,... , 6LoWPAN over power-line communication, and/or WiFi mesh can be used to form clusters and transmit various data including consumption reports, alarms (uplink), software updates or reconfiguration commands (downlink)

Substitutions in PBP2b from β-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity

Pneumococcus resists β-lactams by expressing variants of its target enzymes, the penicillin-binding proteins (PBPs), with many amino acid substitutions. Up to 10% of the sequence can be modified. These altered PBPs have a much reduced reactivity with the drugs but retain their physiological activity of cross-linking the peptidoglycan, the major constituent of the bacterial cell wall. However, as β-lactams are chemical and structural mimics of the natural substrate, resistance mediated by altered PBPs raises the following paradox: how PBPs that react poorly with the drugs maintain a sufficient level of activity with the physiological substrate? This question is addressed for the first time in this study, which compares the peptidoglycan cross-linking activity of PBP2b from susceptible and resistant strains with their inhibition by different β-lactams. Unexpectedly, the enzymatic activity of the variants did not correlate with their antibiotic reactivity. This finding indicates that some of the numerous amino acid substitutions were selected to restore a viable level of enzymatic activity by a compensatory molecular mechanism

Territorial assemblages simulation for territorial intelligence

International audienceThe following article is based on the theory of assemblage ontology seen as a framework to formalize new projects territories in a perspective of territorial intelligence. The area of research is PARIS-SACLAY Campus, which views the development of a world science cluster. The assemblages are simulating by means of simplicial complexes. Its objective is to offer new decision-making tools to territorial community

Bimodality, prion aggregates infectivity and prediction of strain phenomenon

21 pagesWe consider a model for the polymerization (fragmentation) process involved in infectious prion self-replication and study both its dynamics and non-zero steady state. We address several issues. Firstly, we give conditions leading to size repartitions of PrPsc aggregates that exhibit bimodal distributions, as indicated by recent experimental studies of prion aggregates distribution. Secondly, we show stability results for this steady state for general coefficients where reduction to a system of differential equations is not possible. We use a duality method based on recent ideas developed for population models. These results underline the potential influence of the amyloid precursor production rate in promoting amyloidogenic diseases. Finally, we numerically investigate the influence of different parameters of the model on PrPsc accumulation kinetics, in the aim to study specific features of prion strains

Broadband twin tail fins antenna on HR SOI silicon substrate for 60GHz applications

International audienceThis paper presents a broadband antenna on HR SOI CMOS technology for co-integration with power amplifier (PA) or low noise amplifier (LNA). In a system on Chip (SoC) approach, the co-design of the antenna and Integrated Circuits (ICs) on a same silicon substrate is a convenient solution to suppress lossy matching networks and to reduce the radio front-end cost. The proposed antenna presents a simulated gain greater than 5 dBi and a simulated |S11|dB below -10 dB over a 30 GHz frequency band [53-80 GHz]. This concept has been validated on Alumina substrate with a good agreement between measurement and simulation

Moldable multispectral glasses in GeS2–Ga2S3–CsCl system transparent from the visible up to the thermal infrared regions

International audienceThis work is based on the development of glasses with extremely wide optical transmission range for multispectral imaging (visible + thermal imaging for example) with the same optical system. Glass compns. based on the GeS2-​Ga2S3-​CsCl system have been selected in order to obtain glasses transparent from the visible up to the 8-​12 μm region. An increase of CsCl content can greatly improve the visible transmission of the glasses which however will be more sensitive to ambient moisture. Two glasses with different chromatic dispersion, necessary for the design of an optical system, are developed and characterized. Molding tests on aspheric surfaces demonstrate clearly the ability of these two glasses to be molded into complex optics without crystn. and with excellent roughness. In order to test the ability of an anti-​reflective coating to protect these glasses against the atm. aggression, a ZnS coating has been applied to these glasses. An effective protection can be achieved with a ZnS coating of less than 1 μm of thickness. These results allow considering the use of compns. with higher CsCl content if still more transparency in the visible region is desired

Docking Analysis and Resistance Evaluation of Clinically Relevant Mutations Associated with the HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors Nevirapine, Efavirenz and Etravirine

n/