Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease

Objectives. This open-label study assessed the efficacy and safety of exclusive night-time administration of transdermal rotigotine in patients with nocturnal and early morning PD symptoms. Methods. Patients with PD and nocturnal and early morning symptoms received transdermal rotigotine patches (2–16 mg/24 h) applied in the evening and removed in the morning for 3 months. Sleep disturbance was assessed with modified Parkinson’s Disease Sleep Scale (PDSS-2). Other outcomes included a pain visual analogue scale (VAS) and short-form Parkinson’s Disease Questionnaire (PDQ-8) for quality of life. Results. 74 patients completed treatment in this study. At the end of treatment, PDSS-2 total score had improved by mean 10.9 points from baseline (p < 0.001). All three PDSS-2 domain scores (sleep disturbances, nocturnal motor symptoms, and nocturnal symptoms) were also significantly improved by 41%, 56%, and 48%, respectively (p < 0.001). VAS-pain score decreased from 3.2 to 2.3 (p < 0.001). PDQ-8 score decreased from 23.8 to 18.1 (p < 0.001). The most frequently reported adverse events included nausea (9%), anxiety (4%), and dizziness (4%). Conclusions. Night-time administration of transdermal rotigotine is an effective and well tolerated treatment for nocturnal symptoms in patients with PD

Equitat en salut: el cas del biaix de genere

Equitat en salut; Equity in Health; Equidad en saludL’equitat en salut ens ha de preocupar si considerem que tots els éssers humans són moralment iguals i que, per tant, mereixen el mateix respecte a la seva vida i dignitat. Però també és rellevant des d’una visió més utilitarista, atès que uns nivells pitjors de salut dels individus comprometen el benestar social i econòmic global de les comunitats. Així, doncs, l’aspiració a l’equitat no és només una qüestió d’altruisme o de bones intencions, sinó una obligació moral i una qüestió de dret

Serum haptoglobin dynamics in pigs vaccinated or not vaccinated against porcine circovirus type 2

The present work describes the serum haptoglobin (Hp) dynamics in piglets vaccinated and non-vaccinated with a commercial porcine circovirus type 2 (PCV2) vaccine at 3 weeks of age, and its relationship with the average daily weight gain (ADWG). The field study was carried out on two farms (A and B) with a previous clinical history of PCV2-systemic disease (PCV2-SD). The aim of the study was to assess whether Hp could be used as a surrogate marker of PCV2 vaccine efficacy. PCV2 infection was confirmed by quantitative real time PCR (qPCR) in pigs from both farms, but PCV2-SD was only diagnosed in farm A. No statistically significant relation was found between serum Hp concentration and the percentage of qPCR positive animals and the treatment applied (PCV2 vaccination) in both farms. On the other hand, using linear regression analysis, a significant negative correlation between the area under the curve of Hp (AUC) and ADWG was observed for farm A (p < 0.00001) and B (p = 0.01). Based on the obtained determination coefficient (R 2) values, AUC explained 20.0 and 11.6% of the observed ADWG for farms A and B, respectively. The present study supports that the measurement of acute phase proteins may be an indicator of ADWG in pig farms, but it was not apparently feasible to use the serum Hp concentration as a surrogate marker of PCV2 vaccine efficacy

Library Exhibition: documentary collection of Dr. Antonio Martínez-Cob donated to the Library of the EEAD-CSIC

Copias .pdf de documento de donación, cartel empleado para la difusión, lista bibliográfica de títulos de ejemplares expuestos, 7 pósteres complementarios informativos. También se incluye videopresentación con fotos realizadas durante el transcurso de la exposición. La Exposición y sus contenidos también pueden ser accesibles a través de evento dedicado creado en Facebook.[ES] Se presenta a la comunidad científica especializada, para su conocimiento y uso, la colección documental personal del Dr. Antonio Martínez-Cob , donada por su familia en agosto de 2014 a la Biblioteca de la Estación Experimental de Aula Dei (EEAD) del CSIC tras su prematuro fallecimiento (21-07-2014).[EN] The documentary collection of the Dr. Antonio Martínez-Cob, donated by his family in August 2014 to the Library of the Estación Experimental de Aula Dei (EEAD) of the CSIC after his premature death (21-07-2014), is presented to the scientific specialized community for his knowledge and use.[ES] Organización de la exposición: - Se muestra todo el fondo documental personal donado a nuestra Biblioteca: 130 documentos que abarcan el período 1977 a 2012. Son libros, actas de congreso, tesis doctorales, proyectos fin de carrera, tesinas de máster, informes, manuales de software. - Paralelamente se ofrece una amplia muestra de la producción científica del Dr. Antonio Martínez-Cob llevada a cabo a lo largo de su trayectoria curricular. Destacan en esta muestra su amplio número de artículos publicados en revistas internacionales con alto índice de impacto, sus artículos divulgativos, sus tesis propias y dirigidas, sus informes técnicos, algunas comunicaciones de congresos y pósteres, presentaciones, etc. Además, se exponen en pósteres informativos complementarios: P-1. In Memoriam of Antonio Martínez-Cob; P-2. Antonio entre nosotros: algunas imágenes; P-3. Produc-ción científica de A. Martínez-Cob: visión bibliométrica ; P-4 . Producción científica de A. Martínez-Cob: visión altmétrica; P-5. Producción científica de A. Martínez-Cob: su difusión en abierto a través del repositorio Digital.CSIC; P-6. Producción científica de A. Martínez-Cob: Una publicación “top-20 “ Digital.CSIC en número de descargas.[EN] Organization of the exhibition: - In a first exhibition appears the all personal documentary collection donated to our Library: 130 documents belonging to the period 1977 2012. They are Books, Congress and Workshops, Theses, Final Projects, Reports, Software Manuals. - It's also showed a different exhibition that offers a panoramic view of the scientific production of the Dr. Antonio Martínez-Cob carried out along his curricular way. Stand out in this sample his wide number of Articles published in international Journals with high index of impact, his Divulgative Articles, his own and directed Theses, his Technical reports, some Communications and Posters in Congresses, Divulgative Presentations, etc. In addition, complementary informations are exposed in various Posters: P-1. In Memoriam of Antonio Martínez-Cob; P-2. Antonio between ourselves: some images; P-3. Scientific production of A.. Martínez-Cob: bibliometrics; P-4. Scientific production of A. Martínez-Cob: altmetrics; P-5. Scientific production of A. Martínez-Cob: his OA dissemination through the Digital.CSIC repository; P-6. Scientific production of A. Martínez-Cob: A top-20 OA publication into Digital.CSIC by number of downloads.N

Exploratory field study on the effect of Porcine circovirus 2 (PCV2) sow vaccination on serological, virological and reproductive parameters in a PCV2 subclinically infected sow herd

Abstract Background This study sought to evaluate the effect of sow vaccination against Porcine circovirus 2 (PCV2) on reproductive parameters during two consecutive reproductive cycles. The study was performed in a PCV2 subclinical infected breeding herd (PCV2 circulation but absence of major reproductive problems). Ninety-four pregnant sows were primo-immunized with a commercial PCV2 vaccine and ninety-seven were injected with phosphate-buffered saline at 6 and 3 weeks before the first studied farrowing, and then boosted at 2 weeks before the second one. Blood samples were taken throughout the study to assess PCV2 DNA load and antibodies. At farrowing, main reproductive parameters and piglet vitality index were registered. In addition, in those litters with more than three mummified or stillborn piglets, microscopic examination and PCV2 antigen detection in foetal myocardium was done. Results Vaccinated sows showed significantly higher antibody levels compared to the non-vaccinated counterparts. PCV2 DNA was only detected at farrowing in 2 (4.2%) non-vaccinated sows. Vaccinated sows had 1.3 more live-born piglets per litter at the second cycle than non-vaccinated counterparts. Piglets from vaccinated sows had significantly higher (+ 12.7%) vitality score than the ones born from non-vaccinated sows. No PCV2 compatible lesions neither PCV2 antigen were detected in the tested foetal hearts. Conclusions The present study represents a first attempt to demonstrate that PCV2 sow vaccination may have a positive influence on prolificacy and vitality of the offspring in a subclinical infected breeding herd. However, since reproductive outcomes at farm level may be affected by a number of factors, further studies would be needed to confirm this association

Evaluation of natural porcine circovirus type 2 (PCV2) subclinical infection and seroconversion dynamics in piglets vaccinated at different ages

This study aimed to determine the porcine circovirus type 2 (PCV2) serological and virological dynamics in piglets vaccinated at different ages in a PCV2 subclinical infection (PCV2-SI) scenario. Six hundred and forty-four 2 week-old healthy piglets were selected and distributed into four treatment groups: vaccination at 3, 6 or 10 weeks of age (3W-VAC, 6W-VAC and 10W-VAC groups, respectively) and unvaccinated pigs (NON-VAC group). Blood (n = 112 pigs) and oral fluid (OF) (n = 40 pens) samples were taken throughout the study to assess PCV2 load, humoral immunity and viral genotyping. Percentage of PCV2-DNA positive sera mainly raised by 10 weeks of age, being maximum at 14 weeks of age, and then started to decrease at 18 and 25 weeks of age. Specifically, PCV2 vaccination at 3 or 6 weeks of age yielded similar results, since they produced an earlier seroconversion and reduced, at different sampling points, the proportion of viremic animals in comparison to the unvaccinated group. In contrast, PCV2 vaccination at 10 weeks of age only achieved such reduction at 25 weeks of age; in this case, vaccination coincided with the increase of the percentage of viremic pigs in the population. Both serological techniques used in sera and OF offered similar results with a high and statistically significant correlation. In contrast, a higher percentage of PCV2 DNA positivity was detected in OF in comparison with sera. In conclusion, under the present study conditions, the optimal time for PCV2 piglet vaccination was at either 3 or 6 weeks of age

Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease

Objectives. This open-label study assessed the efficacy and safety of exclusive night-time administration of transdermal rotigotine in patients with nocturnal and early morning PD symptoms. Methods. Patients with PD and nocturnal and early morning symptoms received transdermal rotigotine patches (2–16 mg/24 h) applied in the evening and removed in the morning for 3 months. Sleep disturbance was assessed with modified Parkinson’s Disease Sleep Scale (PDSS-2). Other outcomes included a pain visual analogue scale (VAS) and short-form Parkinson’s Disease Questionnaire (PDQ-8) for quality of life. Results. 74 patients completed treatment in this study. At the end of treatment, PDSS-2 total score had improved by mean 10.9 points from baseline (p < 0.001). All three PDSS-2 domain scores (sleep disturbances, nocturnal motor symptoms, and nocturnal symptoms) were also significantly improved by 41%, 56%, and 48%, respectively (p < 0.001). VAS-pain score decreased from 3.2 to 2.3 (p < 0.001). PDQ-8 score decreased from 23.8 to 18.1 (p < 0.001). The most frequently reported adverse events included nausea (9%), anxiety (4%), and dizziness (4%). Conclusions. Night-time administration of transdermal rotigotine is an effective and well tolerated treatment for nocturnal symptoms in patients with PD

Exploratory field study on the effect of Porcine circovirus 2 (PCV2) sow vaccination on serological, virological and reproductive parameters in a PCV2 subclinically infected sow herd

This study sought to evaluate the effect of sow vaccination against Porcine circovirus 2 (PCV2) on reproductive parameters during two consecutive reproductive cycles. The study was performed in a PCV2 subclinical infected breeding herd (PCV2 circulation but absence of major reproductive problems). Ninety-four pregnant sows were primo-immunized with a commercial PCV2 vaccine and ninety-seven were injected with phosphate-buffered saline at 6 and 3 weeks before the first studied farrowing, and then boosted at 2 weeks before the second one. Blood samples were taken throughout the study to assess PCV2 DNA load and antibodies. At farrowing, main reproductive parameters and piglet vitality index were registered. In addition, in those litters with more than three mummified or stillborn piglets, microscopic examination and PCV2 antigen detection in foetal myocardium was done. Vaccinated sows showed significantly higher antibody levels compared to the non-vaccinated counterparts. PCV2 DNA was only detected at farrowing in 2 (4.2%) non-vaccinated sows. Vaccinated sows had 1.3 more live-born piglets per litter at the second cycle than non-vaccinated counterparts. Piglets from vaccinated sows had significantly higher (+ 12.7%) vitality score than the ones born from non-vaccinated sows. No PCV2 compatible lesions neither PCV2 antigen were detected in the tested foetal hearts. The present study represents a first attempt to demonstrate that PCV2 sow vaccination may have a positive influence on prolificacy and vitality of the offspring in a subclinical infected breeding herd. However, since reproductive outcomes at farm level may be affected by a number of factors, further studies would be needed to confirm this association