Intermittent SBAS (ISBAS) InSAR with COSMO-SkyMed X-band high resolution SAR data for landslide inventory mapping in Piana degli Albanesi (Italy)

In the context of recent advances in InSAR processing techniques to retrieve higher persistent scatterer and coherent target densities over unfavourable land cover classes, this study tests the Intermittent Small Baseline Subset (ISBAS) approach to update the landslide inventory around the town of Piana degli Albanesi (Italy), an area where only 2% of the land appears suitable to generate radar scatterers based on a pre-survey feasibility assessment. ISBAS processing of 38 ascending mode and 36 descending mode COSMO-SkyMed StripMap HIMAGE SAR scenes at 3m resolution allows identification of ~726,000 and ~893,000 coherent and intermittently coherent pixels for the ascending and descending data stacks respectively. Observed improvements in the number of ISBAS solutions for the ascending mode are greater than 40 times compared to the conventional SBAS approach, not only for urban and rocky terrains, but also rural and vegetated land covers. Line of sight ground motion rates range between -6.4 and +5.5 mm/yr in 2008-2011, although the majority of the processed area shows general stability, with average rates of -0.6 mm/yr in the ascending and -0.1 mm/yr in the descending mode results. Interpretation of the ISBAS deformation rates, integrated with targeted field surveys and aerial photo-interpretation, provides a new and more complete picture of landslide distribution, state of activity and intensity in the test area, and allows depiction of very slow and extremely slow landslide processes even in areas difficult to access, with unprecedented coverage of results. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Post-failure evolution analysis of a rainfall-triggered landslide by multi-temporal interferometry SAR approaches integrated with geotechnical analysis

Persistent Scatterers Interferometry (PSI) represents one of the most powerful techniques for Earth's surface deformation processes' monitoring, especially for long-term evolution phenomena. In this work, a dataset of 34 TerraSAR-X StripMap images (October 2013–October 2014) has been processed by two PSI techniques - Coherent Pixel Technique-Temporal Sublook Coherence (CPT-TSC) and Small Baseline Subset (SBAS) - in order to study the evolution of a slow-moving landslide which occurred on February 23, 2012 in the Papanice hamlet (Crotone municipality, southern Italy) and induced by a significant rainfall event (185 mm in three days). The mass movement caused structural damage (buildings' collapse), and destruction of utility lines (gas, water and electricity) and roads. The results showed analogous displacement rates (30–40 mm/yr along the Line of Sight – LOS-of the satellite) with respect to the pre-failure phase (2008–2010) analyzed in previous works. Both approaches allowed detect the landslide-affected area, however the higher density of targets identified by means of CPT-TSC enabled to analyze in detail the slope behavior in order to design possible mitigation interventions. For this aim, a slope stability analysis has been carried out, considering the comparison between groundwater oscillations and time-series of displacement. Hence, the crucial role of the interaction between rainfall and groundwater level has been inferred for the landslide triggering. In conclusion, we showed that the integration of geotechnical and remote sensing approaches can be seen as the best practice to support stakeholders to design remedial works.Peer ReviewedPostprint (author's final draft

Verification of the electromagnetic deep-penetration effect in the real world

The deep penetration of electromagnetic waves into lossy media can be obtained by properly generating inhomogeneous waves. In this work, for the very first time, we demonstrate the physical implementation and the practical relevance of this phenomenon. A thorough numerical investigation of the deep-penetration effects has been performed by designing and comparing three distinct practical radiators, emitting either homogeneous or inhomogeneous waves. As concerns the latter kind, a typical Menzel microstrip antenna is first used to radiate improper leaky waves. Then, a completely new approach based on an optimized 3-D horn TEM antenna applied to a lossy prism is described, which may find applications even at optical frequencies. The effectiveness of the proposed radiators is measured using different algorithms to consider distinct aspects of the propagation in lossy media. We finally demonstrate that the deep penetration is possible, by extending the ideal and theoretical evidence to practical relevance, and discuss both achievements and limits obtained through numerical simulations on the designed antennas

Monitoring of remedial works performance on landslide-affected areas through ground- and satellite-based techniques

Differential Interferometric Synthetic Aperture Radar (DInSAR) techniques have repeatedly proved to be an effective tool for built environments monitoring in areas affected by geological hazards. This paper describes how the Coherent Pixel Technique (CPT) approach has been successfully applied to assess the response of an unstable slope to the different phases of remedial works following a landslide event. The CPT technique was performed on 59 COSMO-SkyMed images obtained between May 2011 and August 2016 and centred on the Quercianella settlement (a small hamlet of Livorno municipality, Tuscany, Italy), where the reactivation of a dormant shallow slide had occurred in March 2011 and, hereafter, a geotechnical intervention, designed with the aim of mitigating the risks, has been conducted from August 2013, lasting thirteen months. The time series of CPT results show a deformation pattern with sudden accelerations (up to 21 mm in few months) corresponding to the beginning of the interventions, during which the area has been excavated to install a drainage well, followed by mild decelerations resulting from the stabilization of the area after the conclusion of the works. In particular, the integration of ground-based subsurface monitoring (inclinometers and piezometers) and DInSAR superficial data has provided consistent results for landslide characterization and helped defining the state of activity and the areal distribution of the sliding surface. Moreover, the performance of remedial works in the landslide-affected area has been observed, showing stabilization in the upper part of the hamlet and the ongoing movement in the lower part. The combined monitoring system also led the geotechnical company in charge of remedial works to design further stabilization works in order to preserve buildings and roads in the moving area. Therefore, the integration of remote sensing techniques and in situ instruments represents a timely and cost-efficient solution for intervention works monitoring, opening new perspectives on designing engineering solutions for the stabilization of unstable slopes

An untargeted lipidomic analysis reveals depletion of several phospholipid classes in patients with familial hypercholesterolemia on treatment with Evolocumab

Familial hypercholesterolemia (FH) is caused by mutations in genes involved in low-density lipoprotein cholesterol (LDL-C) metabolism, including those for pro-protein convertase subtilisin/kexin type 9 (PCSK-9). The effect of PCSK-9 inhibition on the plasma lipidome has been poorly explored. Objective: Using an ultra-high-performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry method, the plasma lipidome of FH subjects before and at different time intervals during treatment with the PCSK-9 inhibitor Evolocumab was explored. Methods and Results: In 25 FH subjects, heterozygotes or compound heterozygotes for different LDL receptor mutations, untargeted lipidomic revealed significant reductions in 26 lipid classes belonging to phosphatidylcholine (PC), sphingomyelin (SM), ceramide (CER), cholesteryl ester (CE), triacylglycerol (TG) and phosphatidylinositol (PI). Lipid changes were graded between baseline and 4- and 12-week treatment. At 12-week treatment, five polyunsaturated diacyl PC, accounting for 38.6 to 49.2% of total PC at baseline; two ether/vinyl ether forms; seven SM; five CER and glucosyl/galactosyl-ceramide (HEX-CER) were reduced, as was the unsaturation index of HEX-CER and lactosyl—CER (LAC-CER). Although non quantitative modifications were observed in phosphatidylethanolamine (PE) during treatment with Evolocumab, shorter and more saturated fatty acyl chains were documented. Conclusions: Depletion of several phospholipid classes occurs in plasma of FH patients during treatment with the PCSK-9 inhibitor Evolocumab. The mechanism underlying these changes likely involves the de novo synthesis of SM and CER through the activation of the key enzyme sphingomyelin synthase by oxidized LDL and argues for a multifaceted system leading to vascular improvement in users of PCSK-9 inhibitor

Numerical Evaluation of Electromagnetic-wave Penetration at Normal Incidence through an Inhomogeneous-wave Approach, Journal of Telecommunications and Information Technology, 2018, nr 2

This paper presents numerical scenarios concerning penetration in a lossy medium that can be obtained by radiating inhomogeneous electromagnetic waves. Former papers approached this problem, both analytically and numerically, finding requirements and limits of the so-called “deeppenetration” condition, which consists of a wave transmitted in a lossy medium having an attenuation vector whose direction forms the angle of ninety degrees with the normal to the separation surface. The deep-penetration condition always requires an oblique incidence, therefore is not practical in many applications. For this reason, we are interested here in finding whether an inhomogeneous wave guarantees larger penetration than the one obtainable with homogeneous waves, even when the incident wave is normal to the separation surface between two media, i.e. when the deep-penetration condition is not satisfied. We are also interested in verifying numerically whether the lossy-prism structure may achieve larger penetration than the one obtainable through traditional leakywave antennas, and we also wish to propose a lossy-prism design more realistic than the one previously presented in the literature

Portal Hypertension in Childhood Bilateral Wilms' Tumor Survivor: An Excellent Indication for TIPS

Introduction. Increased pressure in portal venous system is relatively a rare complication after chemoradiotherapy for Wilms' tumor (WT). In paediatric population, feasibility and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in portal hypertension nonresponsive to medical or endoscopic treatment have been recently advocated. We report a case of TIPS positioning in a 15-year-old girl with portal hypertension as a long-term sequel of multimodality therapy in bilateral WT. Case Report. Two-year-old girl was diagnosed for bilateral WT. Right nephrectomy with left heminephrectomy and chemoradiotherapy were performed. At 7 years of age, the first gastrointestinal bleeding appeared, followed by another episode two years later, both were treated successfully with beta-blockers. At 15 years of age, severe unresponsive life-threatening gastroesophageal bleeding without hepatosplenomegaly was managed by TIPS. Reduction of the portosystemic pressure gradient was obtained. Conclusion. TIPS positioning for portal hypertension in long-term tumors' sequel is feasible and could be considered as an additional indication in paediatric patients

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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Self-perceived physical level and fitness performance in children and adolescents with inflammatory bowel disease

Background: Inflammatory bowel disease (IBD) patients show a higher risk of developing metabolic and cardiovascular diseases due to the presence of systemic low-grade chronic inflammation. Exercise can improve cardiovascular fitness and modulate the inflammatory processes. We evaluated the physical activity (PA) level and the fitness performance of children and adolescents with IBD. Patients and methods: We considered 54 pediatric patients with IBD (14.6 ± 2.2; 22 M), including CD (n = 27) UC (n = 24) and IBD unclassified (n = 3), and 70 healthy children. In all children, the Physical Activity Questionnaire (PAQ-C) and the International Fitness Enjoyment Scale were self-reported and recorded. Results: PAQ-C showed significant difference in PA levels in patients with IBD compared to controls (p < 0.001). A decrease in general fitness (p = 0.003), cardiorespiratory fitness (p = 0.002), strength (p = 0.01), speed agility (p = 0.003), and flexibility (p = 0.01) were also detected between patients and controls. Speed agility was related to age (p = 0.02) and BMI z-score (p = 0.01), and flexibility to BMI z-score (p = 0.05). We noted a correlation between PA levels and physician global assessment (p = 0.021) and activity disease severity (p = 0.025). Conclusions: A poorer PA level and poor physical competence were found in patients with IBD compared to healthy children and adolescents. Monitored exercise could provide multiple benefits at both physical and psychological levels

Effects of an online supervised exercise training in children with obesity during the COVID-19 pandemic

COVID-19 restrictions have dramatically reduced the active lifestyle and physical activity (PA) levels in the whole population, a situation that can contribute to weight gain and to develop obesity. To improve physical fitness (PF) in children with obesity during COVID-19 restrictions, sport specialists started to deliver physical training through tele-exercise. For these reasons, the aim of this study was to evaluate the effects of a 12-week online supervised training program in children with obesity on different PF components and PA levels. We enrolled a total of 40 Caucasian children (9 F/31 M; aged 11 +/- 1.9 years) with obesity. The data collection consisted of a series of anthropometric measures, the PAQ-C questionnaire, and PF tests, valid and reliable tools to assess PF in children. We used a Wilcoxon's t-test and a Student's t-test, as appropriate, to assess the differences before and after the training protocol. A total of 37 patients completed the training protocol and were considered in the analysis. Our results show an improvement in all the PF tests, a reduction in the BMI z-score, the waist circumference, and in the waist-to-height ratio, and an increased PA level. In conclusion, the results of our study show that an online supervised training program is effective to promote PA, improving PF and reducing the BMI z-score in children with obesity