Patogenia de la inflamación: discurso para los ejercicios del grado de Doctor de Santiago Ramón y Cajal

Tesis de doctorado leída en la Universidad Central el 26 de junio de 1877También disponible la reproducción digitalManuscrito firmadoTesis Doctorales históricasTesis Complutenses históricasmanuscritoFacultad de MedicinaFacultad de Medicinatruepu

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways

Intercellular communication is essential for the development of specialized cells, tissues, and organs and is critical in a variety of diseases including cancer. Current knowledge states that different cell types communicate by ligand–receptor interactions: hormones, growth factors, and cytokines are released into the extracellular space and act on receptors, which are often expressed in a cell-type-specific manner. Non-coding RNAs (ncRNAs) are emerging as newly identified communicating factors in both physiological and pathological states. This class of RNA encompasses microRNAs (miRNAs, well-studied post-transcriptional regulators of gene expression), long non-coding RNAs (lncRNAs) and other ncRNAs. lncRNAs are diverse in length, sequence, and structure (linear or circular), and their functions are described as transcriptional regulation, induction of epigenetic changes and even direct regulation of protein activity. They have also been reported to act as miRNA sponges, interacting with miRNA and modulating its availability to endogenous mRNA targets. Importantly, lncRNAs may have a cell-type-specific expression pattern. In this paper, we propose that lncRNA–miRNA interactions, analogous to receptor–ligand interactions, are responsible for cell-type-specific outcomes. Specific binding of miRNAs to lncRNAs may drive cell-type-specific signaling cascades and modulate biochemical feedback loops that ultimately determine cell identity and response to stress factors

Inducciones fisiológicas de la morfología y conexiones de las neuronas

Se recordará que Golgi, en sus trabajos sobre la fina anatomia de los centros, habia defendido la idea de que la conducción nerviosa a través de la sustancia gris, se efectúa exclusivamente por los cilindros-ejes, las colaterales nerviosas y la red nerviosa intersticial; las expansiones protoplasmáticas desempeñarían un oficio meramente nutritivo y, para mejor satisfacerlo, pensaba el sabio italiano que todas ellas se dirigen hacia las células de neuroglia perivasculares ó hacia los vasos mismos, con los cuales entrarian algunas veces en contacto. Lo que indujo a Goigi a sostener estos asertos, fue una observación incompleta, a saber: que las expansiones dendriticas se reúnen precisamente donde faltan las fibrillas nerviosas (capas moleculares del cerebro, cerebelo y hasta de Ammon), concentrándose de preferencia, en las zonas limitantes de sustancia gris ricas en corpúsculos de araña.Facultad de Ciencias Jurídicas y Sociale

La Psicología de Don Quijote de la Mancha y el Quijotismo

«Universalmente admirada es la soberbia figura moral del hidalgo manchego. D. Alonso Quijano el bueno, convertido en andante caballero por la sugestión de los disparatados libros de caballería, representa, según se ha dicho mil veces, el más perfecto símbolo del honor y del altruismo. Jamás el genio anglo-sajón, tan dado á imaginar caracteres enérgicos y originales, creó personificación mas exquisita del individualismo indómito y de la abnegación sublime. Pero puntualicemos brevemente los rasgos psicológicos sobresalientes del protagonista de la novela inmortal.

Corrigendum : Pío del Río-Hortega: A Visionary in the Pathology of Central Nervous System Tumors

Fondo de Investigaciones Sanitarias (11/00185), Redes Temáticas de Investigación Cooperativa en Salud (Ref. RD06/0020/1020

Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors.

Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2(Mnk1/2) play a pivotal role in regulating the capdependent translation through phosphorylation ofeIF4E transcription factor. Thus, Mnk1/2 targeting have been proposed as a novel therapeutic strategy that would minimize side-effects in contrast to other therapies. For this reason, there is a growing interestin designing in silico new Mnk1/2 inhibitors which demands from reliable structural models. Interestingly,the catalytic domain of Mnk proteins are characterized by a DFD motif instead of the characteristicDFG motif of other kinases. However, Mnk2 structural models described in literature are DFG mutated and do not contain the activation loop. Molecular design techniques have been applied to obtain a structural model of the full wild type Mnk2 protein including the activation loop. The effect of the loop on the interaction mechanism of well-known ligands has been evaluated. Obtained results suggest that the presence of the activation loop is determinant for the correct prediction of the active site and it is essential for the design of new inhibitors

On thalamic and tectal nuclei and fiber paths in the brain of the American alligator

No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49895/1/900400107_ftp.pd

Intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid

OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis. RESULTS: Of the 3590 deliveries included, 503 (14%) had MSAF. The incidence of MSAF rises with gestational age at delivery, reaching 20.7% in gestations above 41 weeks compared to 4.3% below 37 weeks. As the amniotic fluid staining progresses we found a higher proportion of intrapartum fevers (p  0.05). We have observed a similar distribution of umbilical artery pH ranges in all groups (p > 0.05). CONCLUSIONS: MSAF was associated with an increase in the rate of pathological fetal heart rate patterns, intrapartum fevers, operative vaginal and cesarean section deliveries, need for neonatal resuscitation, low Apgar scores and higher fetal-neonatal mortality. Moreover, we found that the risks increase as the staining and consistency of the amniotic fluid evolves so it should alert the obstetrician and paediatrician to the potential adverse outcomes