Inhibidores de la neuraminidasa y nuevas estrategias terapéuticas frente al virus de la gripe

Inhibidores de la neuraminidasa y nuevas estrategias terapéuticas frente al virus de la gripe

Modelling and simulation of heat and mass transfer for liquid type foods under high pressure processes

High Pressure (HP) Processing has turned out to be very effective in order to prolong the shelf life of some foods. This paper deals with the modelling and simulation of the effect of the combination of high pressure with thermal treatments on food. The behaviour and stability of this model are checked by various numerical examples. Furthermore, a simplified version of the model is presented and compared with the full model in terms of accuracy and computational time. The models developed provide a useful tool to design suitable industrial equipments and optimize the processes

Identificación de la conductividad de un material cuando depende de la presión a la que está sometido

Depto. de Análisis Matemático y Matemática AplicadaInstituto de Matemática Interdisciplinar (IMI)Fac. de Ciencias MatemáticasTRUEpu

Modelling and simulation of high pressure processes in food engineering

Depto. de Análisis Matemático y Matemática AplicadaInstituto de Matemática Interdisciplinar (IMI)Fac. de Ciencias MatemáticasTRUEpu

Simultaneous concentration of nutrients from anaerobically digested sludge centrate and pre-treatment of industrial effluents by forward osmosis

[EN] In the last years, forward osmosis (FO) has gained increasing prominence, new membranes are being developed and new applications are being considered. In this study, the recovery of nitrogen and phosphorus of the anaerobically digested sludge centrate was studied by FO using two industrial effluents characterized by high osmotic pressure (residual stream from an absorption process for ammonia elimination and brine from a seawater desalination facility) as draw solutions. The experiments were carried out in a laboratory plant testing two FO membranes (CTA-NW and Aquaporin Inside membrane). Results showed that nitrogen concentration was achieved with both membranes and both draw solutions. The use of the effluent from ammonia absorption enhanced of the nitrogen concentration in the feed stream to the FO membrane. The reached concentration factor in the laboratory tests was 1.61 when Aquaporin membrane was used. Phosphorus could not be concentrated because of its precipitation as calcium phosphate (confirmed by EDX analysis) as a consequence of the high calcium concentration of the municipal wastewater.This study was supported by the Spanish Ministry of Economy and Competitiveness through the project RTC-2015-3582-5-AR.Soler Cabezas, JL.; Mendoza Roca, JA.; Vincent Vela, MC.; Lujan Facundo, MJ.; Pastor Alcañiz, L. (2018). Simultaneous concentration of nutrients from anaerobically digested sludge centrate and pre-treatment of industrial effluents by forward osmosis. Separation and Purification Technology. 193:289-296. https://doi.org/10.1016/j.seppur.2017.10.058S28929619

A comparative study of the influence of salt concentration on the performance of an osmotic membrane bioreactor and a sequencing batch reactor

[EN] BACKGROUNDAn osmotic membrane bioreactor (OMBR) is a wastewater treatment technique that presents low energy requirements, low membrane fouling and high removal of nutrients and organic matter. However, reverse salt flux is the main disadvantage because it causes conductivity increase in the bioreactor. This study compares the performance of a sequencing batch reactor (SBR) and an OMBR in terms of chemical oxygen demand (COD) removal, soluble microbial products (SMP) and extracellular polymeric substances (EPS) production. For that, the influent conductivity in the SBR was increased as this increases conductivity in the osmotic membrane bioreactor. RESULTSComparing the results obtained at two mixed liquor suspended solids (MLSS) concentrations in terms of membrane fouling, a concentration of 5 g L-1 of MLSS was chosen for the comparison with the SBR. The SBR achieved slightly higher COD removal efficiencies than the OMBR is spite of the accumulation of cellular debris in the membrane bioreactor. The accumulation of SMP and EPS in the OMBR was also higher than in the SBR due to the cellular debris and organic matter accumulation. In both reactors the microbial activity measured in terms of standard oxygen uptake rate decreased due to the increase of salt concentration in the bioreactor. CONCLUSIONSAs a conclusion, OMBR will be especially feasible when the draw solution is a residual stream of the same industry, like tannery wastewater or table olive processing. (c) 2017 Society of Chemical IndustryThis study was supported by the Spanish Ministry of Economy and Competitiveness through the project RTC-2015-3582-5-AR.Soler Cabezas, JL.; Lujan Facundo, MJ.; Mendoza Roca, JA.; Vincent Vela, MC.; Pastor Alcañiz, L. (2018). A comparative study of the influence of salt concentration on the performance of an osmotic membrane bioreactor and a sequencing batch reactor. Journal of Chemical Technology & Biotechnology. 93(1):72-79. https://doi.org/10.1002/jctb.5321S727993

The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

Background: The intracellular bacteria Anaplasma phagocytophilum are emerging zoonotic pathogens affecting human and animal health, and a good model for the study of tick-host-pathogen interactions. This tick-borne pathogen is transmitted by Ixodes scapularis in the United States where it causes human granulocytic anaplasmosis. Tick midguts and salivary glands play a major role during tick feeding and development, and in pathogen acquisition, multiplication and transmission. Vertebrate host proteins are found in tick midguts after feeding and have been described in the salivary glands of fed and unfed ticks, suggesting a role for these proteins during tick feeding and development. Furthermore, recent results suggested the hypothesis that pathogen infection affects tick metabolic processes to modify host protein digestion and persistence in the tick with possible implications for tick physiology and pathogen life-cycle. Methods: To address this hypothesis, herein we used I. scapularis female ticks fed on uninfected and A. phagocytophilum-infected sheep to characterize host protein content in midguts and salivary glands by proteomic analysis of tick tissues. Results: The results evidenced a clear difference in the host protein content between tick midguts and salivary glands in response to infection suggesting that A. phagocytophilum selectively manipulates the levels of vertebrate host proteins in ticks in a tissue-specific manner to facilitate pathogen infection, multiplication and transmission while preserving tick feeding and development. The mechanisms by which A. phagocytophilum manipulates the levels of vertebrate host proteins are not known, but the results obtained here suggested that it might include the modification of proteolytic pathways. Conclusions: The results of this study provided evidence to support that A. phagocytophilum affect tick proteolytic pathways to selectively manipulate the levels of vertebrate host proteins in a tissue-specific manner to increase tick vector capacity. Investigating the biological relevance of host proteins in tick biology and pathogen infection and the mechanisms used by A. phagocytophilum to manipulate host protein content is essential to advance our knowledge of tick-host-pathogen molecular interactions. These results have implications for the identification of new targets for the development of vaccines for the control of tick-borne diseases.This research was supported by the Ministerio de Economia y Competitividad (Spain) grant BFU2011-23896 and the European Union (EU) Seventh Framework Programme (FP7) ANTIGONE project number 278976. NA was funded by Ministerio de Economia y Competitividad, Spain. MV was supported by the Research Plan of the University of Castilla - La Mancha, Spain. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.S

Inverse problems in high pressure processes and food engineering

Depto. de Análisis Matemático y Matemática AplicadaInstituto de Matemática Interdisciplinar (IMI)Fac. de Ciencias MatemáticasTRUEpu

Generation and Applications of Extreme-Ultraviolet Vortices

Vortex light beams are structures of the electromagnetic field with a spiral phase ramp around a point-phase singularity. These vortices have many applications in the optical regime, ranging from optical trapping and quantum information to spectroscopy and microscopy. The extension of vortices into the extreme-ultraviolet (XUV)/X-ray regime constitutes a significant step forward to bring those applications to the nanometer or even atomic scale. The recent development of a new generation of X-ray sources, and the refinement of other techniques, such as harmonic generation, have boosted the interest of producing vortex beams at short wavelengths. In this manuscript, we review the recent studies in the subject, and we collect the major prospects of this emerging field. We also focus on the unique and promising applications of ultrashort XUV/X-ray vortex pulsesA.P. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 702565. C.H.-G. acknowledges support from the Marie Curie International Outgoing Fellowship within the EU Seventh Framework Programme for Research and Technological Development (2007-2013), under REA grant Agreement No 328334. We acknowledge support and from Junta de Castilla y León (Project SA046U16) and MINECO (FIS2013-44174-P, FIS2015-71933-REDT, FIS2016-75652-P)

Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome

OBJECTIVES: PTEN hamartoma tumor syndrome (PHTS) is a hereditary disorder caused by germline inactivating mutations of the PTEN gene. PHTS includes Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. We describe how the peculiar pathologic and immunohistochemical thyroid features lead pathologists to suggest PHTS. METHODS: A 28-year-old white Spanish woman had a multinodular goiter. Total thyroidectomy was performed after fine-needle aspiration biopsy. Microscopic, immunohistochemical, and molecular analyses of the thyroid lesions were realized. RESULTS: The thyroid was multinodular, showing one papillary microcarcinoma, five follicular adenomas, three adenolipomas, 46 tiny adenomatous nodules (microadenomas), scattered foci of adipose tissue, and lymphocytic thyroiditis. Tumors were positive for thyroglobulin, thyroperoxidase, pendrin, cyclin D1, and p27 but negative for calcitonin and PTEN. A germline heterozygous deletion of one adenine at nucleotide 827 in exon 8 of the PTEN gene was confirmed. No BRAF, NRAS, or KRAS somatic mutations were detected in the papillary microcarcinoma, follicular adenoma, adenolipomas, or microadenomas. Negativity for PTEN was also found in the colonic tubulovillous adenoma and the storiform collagenoma. CONCLUSIONS: Pathologists play a crucial role in recognizing pathologic thyroid findings associated with PHTS for selecting patients for genetic testing