Análisis de la evolución de los precios y del consumo en España y en Castilla y León

El Indice de Precios de Consumo (IPC) es una medida estadística de la evolución de los precios de los bienes y servicios que consume la población en viviendas familiares en España. El conjunto de bienes y servicios, que conforman la cesta de la compra, se obtiene básicamente del consumo de las familias y la importancia de cada uno de ellos en el cálculo del IPC está determinado por dicho consumo. Este consumo lo obtenemos en la Encuesta de Presupuestos Familiares (EPF). Esta actividad suministra información anual sobre la naturaleza y destino de los gastos de consumo, así como sobre diversas características relativas a las condiciones de vida de los hogares. Con todo esto se va a realizar un estudio del consumo en España y en Castilla y León.Grado en Estadístic

Importance of Tetrahydroiso α-acids to the microbiological stability of beer

Producción CientíficaWhile beer provides a very stable microbiological environment, a few niche microorganisms are capable of growth in malt, wort, and beer. The production of off-flavors and development of turbidity in the packaged product are due to the growth and metabolic activity of wild yeast, certain lactic acid bacteria (LAB) and anaerobic Gram-negative bacteria. Beer also contains bitter hop compounds, which are toxic to Gram-positive and Gram-negative bacteria, and contribute to preventing the spoilage of this beverage. In the boiling process, the hop -acids (humulones) are isomerized into iso -acids. These products are responsible for the bitter taste of beer, but they also play an essential role in enhancing foam stability. Antibacterial activity of iso -acids and their hydrogenated derivates (rhoiso -acids and tetrahydroiso -acids) in MRS broth and beer have been evaluated against different LAB (Lactobacillus and Pediococcus) for the determination of their beer-stabilizing capabilities. Besides this, we have determined the minimum inhibitory concentration and the bacteriostatic effect of each compound against Pediococcus. We found that tetrahydroiso-acids (added directly to beer during production processes) are the compounds that present the greatest antibacterial activity against the main agents implicated in beer spoilage

DETERMINANTES FINANCIEROS QUE HACEN QUE UNA EMPRESA COTICE EN FORMA EXITOSA EN LA BOLSA MEXICANA DE VALORES.

Cabe destacar que, las empresas que cotizan en la BMV se caracterizan por ser económicamente estables, generan gran número de empleos, poseen gran capacidad de expansión y crecimiento, y la información financiera de éstas está disponible. Por lo anterior, una de las necesidades más apremiantes de este trabajo de investigación es estudiar y analizar los determinantes financieros que hacen que las empresas coticen en forma exitosa en la BMV. Entendiendo como éxito financiero a “aquellas empresas que crean valor teniendo crecimiento consecutivo por tres años en: utilidades netas, el precio de mercado y la generación económica operativa” (García, 2014: II). Luego entonces, resulta trascendente, medir el desempeño financiero de las empresas ya que este impacta de manera directa en otras variables de la economía nacional, puesto que el fracaso o éxito empresarial implica el deterioro o mejoramiento de una sociedad en general, pues impacta en el crecimiento del PIB, en su fuerza laboral, en la inversión y la distribución del ingreso. Adicionalmente, se generan de manera prácticamente automática pérdidas o ganancias al sector industrial al que ésta pertenezca, lo cual desencadena en la escasez o no de los bienes o productos que la empresas ponen a disposición de los mercados. Asimismo, el entorno actual de incertidumbre económica obliga a las empresas a estudiar y controlar de forma constante su riesgo de crédito y liquidez. De allí que los investigadores, analistas financieros, entre otros agentes económicos y sociales, estén 4 interesados en identificar las variables que determinen una posible situación de fracaso empresarial, dando prioridad a la detección y prevención de estas situaciones

Systematic review of population-based bladder cancer registries : How criteria heterogeneity affects the comparison of incidences

The population-based registry of bladder cancer (BC) raises specific problems intrinsic to the tumor, as the inclusion of noninfiltrating, potentially malignant and multiple tumors. We performed a systematic review (PRISMA guidelines) of population-based BC registries to obtain information on their geographic areas involved, last dates of real incidence of BC, and rules coding used in BC for uncertain behavior, in situ and multiple tumors. Using MEDLINE and Google Scholar, we identified scientific publications of in the last 10 years in English or Spanish, whether they were related to a national or international cancer registry, provided information on registry rules, and provided data on the incidence of BC. After the first screening, a total of 194 references were obtained. After a second analysis, three registries were selected: International Agency for Research on Cancer (IARC) is a world registry providing real incidence of BC in the period 2008-2012. Surveillance, Epidemiology, and End Results (SEER) Program registered incidence until 2017 in more than 90% of the US population. Spanish Network of Cancer Registries (REDECAN) unifies 14 Spanish registries (27.4% of the population) with real incidence data from 2010 to 2015. The coding and inclusion rules have been modified, but currently, most registries include BC in situ and uncertain behavior tumors. Whenever a new case occurs 36 months after a previous diagnosis, SEER registers those as multiple incident cancers in the same location, while IARC and REDECAN only allow one cancer per location during the lifespan of the patient. Comparison of the incidence of BC among different population-based cancer registries is prone to bias due to the methodological differences regarding the inclusion of carcinomas in situ, indeterminate, and multiple tumors. A good cancer registry could provide better surveillance strategies for BC patients. The bladder cancer registry is complex due to the peculiarities of urothelial tumors. The heterogeneity in the rules to define carcinomas in situ, indeterminate and multiple tumors interfere with the comparability of incidence of bladder cancer

Eventos térmicos y pluviométricos máximos extremos en la isla de El Hierro

Ponencia presentada en: XII Congreso de la Asociación Española de Climatología celebrado en Santiago de Compostela entre el 19 y el 21 de octubre de 2022.[ES]El Panel Intergubernamental del Cambio Climático (IPCC) evidencia un incremento en la frecuencia e intensidad de extremos climáticos y meteorológicos. El presente trabajo tiene como objetivo principal analizar los eventos térmicos y pluviométricos máximos extremos acontecidos en El Hierro, así como comprobar si estos han presentado algún tipo de tendencia. El método empleado ha consistido en el uso de percentiles, aplicación del test de Mann-Kendall, estimación de la intensidad máxima de precipitación horaria y el cálculo de SPI, índice de precipitación estandarizado para diversos periodos.[EN]The Intergovernmental Panel on Climate Change (IPCC) evidences an increase in the frequency and intensity of climatic and meteorological extremes. The main purpose of this paper is to analyze the extreme maximum thermal and rainfall phenomena in El Hierro, as well as checking if there has been any climatic trend. The methodology has been the use of the percentiles, the use of the Mann Kendall test, the estimation of the maximum intensity of hourly precipitation, and the SPI, standardized precipitation index has been calculated for various periods.Este proyecto se inscribre dentro de los objetivos del programa Junitur (CSO2011-24425, 2012-2015) y Junitur+ (CSO2015-68500- R, 2016-2019) de la Secretaría de Investigación, Desarrollo e innovación del Ministerio de Economía y Competitividad

The Effectiveness of Additional Core Stability Exercises in Improving Dynamic Sitting Balance, Gait and Functional Rehabilitation for Subacute Stroke Patients (CORE-Trial) : Study Protocol for a Randomized Controlled Trial

Background: Trunk impairment produces disorders of motor control, balance and gait. Core stability exercises (CSE) are a good strategy to improve local strength of trunk, balance and gait. Methods and analysis: This is a single-blind multicenter randomized controlled trial. Two parallel groups are compared, and both perform the same type of therapy. A control group (CG) (n = 110) performs conventional physiotherapy (CP) (1 h per session) focused on improving balance. An experimental group (EG) (n = 110) performs CSE (30 min) in addition to CP (30 min) (1 h/session in total). EG is divided in two subgroups, in which only half of patients (n = 55) perform CSE plus transcutaneous electrical nerve stimulation (TENS). Primary outcome measures are dynamic sitting, assessed by a Spanish version of Trunk Impairment Scale and stepping, assessed by Brunel Balance Assessment. Secondary outcomes are postural control, assessed by Postural Assessment Scale for Stroke patients; standing balance and risk of fall assessed by Berg Balance Scale; gait speed by BTS G-Walk (accelerometer); rate of falls, lower-limb spasticity by Modified Ashworth Scale; activities of daily living by Barthel Index; and quality of life by EQ-5D-5L. These are evaluated at baseline (T0), at three weeks (T1), at five weeks (end of the intervention) (T2), at 17 weeks (T3) and at 29 weeks (T4). Study duration per patient is 29 weeks (a five-week intervention, followed by a 24-week post-intervention)

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain

Neoplasias de la vejiga; Contaminantes atmosféricos; Exposición ambientalUrinary bladder neoplasms; Air pollutants; Environmental exposureCàncer de bufeta; Contaminants atmosfèrics; Exposició ambientalBackground: Bladder cancer (BC) is the most common of those affecting the urinary tract, and a significant proportion of the cases are attributable to tobacco use as well as occupational and environmental factors. Objective: The aim of this study is to estimate the current incidence of BC in an industrialized area in northeastern Spain and to analyze its time trends over three decades from an ecological perspective. Methods: Patients diagnosed with histologically confirmed primary BC, during 2018-2019, in an area in northeastern Spain (430,883 inhabitants) were included. Crude and age-standardized incidence rates were estimated per 100,000 person-years based on the number of individuals getting their first diagnosis. An exploratory time trend analysis was carried out to describe the evolution in tobacco use and occupational or environmental risk factors and the incidence of BC in the same area from the 1990s. Results: 295 patients were included (age 72.5 ± 10.3 years; 89.8% men). The crude rate was 62.6 (95% CI: 51.9-73.2) for men and 6.8 (95% CI: 3.4-10.3) for women. The annual rate adjusted to the European Standard Population was 85.3 (95% CI:75.0-95.5) for men and 7.0 (95% CI:4.5-9.5) for women. From 1994 to 2018, the prevalence of smokers decreased in men (42.3% to 30.9%) as well as in the active population working in the industry (44.36% to 22.59%). Nevertheless, the car fleet, especially diesel, has increased considerably. The annual mean concentrations of air (PM10, PM2.5, O3, and NO2) and water (nitrates, arsenic, trihalomethanes) pollutants were within the regulatory limit values, but not the maximum levels. Conclusions: The incidence of BC is one of the highest in men but not in women, despite the decrease in tobacco use and industrial activity (perhaps related to high latency after carcinogen exposure cessation) and despite the control of environmental pollution (the maximum regulatory limit probably needs to be lowered). Finally, a similar exposure to the carcinogen would result in a gender-specific differential incidence

miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.

Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma, which routinely excludes most xenobiotic therapeutics compounds. The BBB is a multicellular complex that structurally forms the neurovascular unit (NVU) and is organized by neuro-endothelial and glial cells. BBB breakdown and dysfunction from the cerebrovascular cells lead to leakages of systemic components from the blood into the CNS, contributing to neurological deficits. Understanding the molecular mechanisms that regulate BBB permeability and disruption is essential for establishing future therapeutic strategies to restore permeability and improve cerebrovascular health. MicroRNAs (miRNAs), a type of small noncoding RNAs, are emerging as an important regulator of BBB integrity by modulating gene expression by targeting mRNA transcripts. miRNAs is implicated in the development and progression of various illnesses. Conversely, nanoparticle carriers offer unprecedented opportunities for cell-specific controlled delivery of miRNAs for therapeutic purposes. In this sense, we present in this graphical review critical evidence in the regulation of cell junction expression mediated by miRNAs induced by hypoxia and for the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of BBB permeability

Perceived Motivational Climate Determines Self-Confidence and Precompetitive Anxiety in Young Soccer Players: Analysis by Gender

The main objective of this study was to analyze whether the perception of the motivational climate in young soccer players determines the level of competitive anxiety and self-confidence. In addition, the results were explored according to gender, in order to observe if there were differences between the female and male categories. A total of 113 cadet and youth soccer players from six soccer teams in the provinces of Malaga and Granada, aged between 14 and 19 years, who competed in regional leagues, participated in the study. Of these, 50 were female and 63 were male. The Competitive Sport Anxiety (CSAI-2), Perceived Motivational Climate in Sport Questionnaire-2 (PMCSQ-2), and Self-Confidence in Sport Competition Questionnaire (CACD) were used to collect the information. Correlation, linear regression and cluster analyses were performed. The data analyses carried out affirmed the relationship between the study variables, observing that the perception of ego climate was positively related to cognitive anxiety (p < 0.05) and insecurity (p < 0.01), and inversely to self-confidence (p < 0.05). By gender, boys showed a higher perception of an ego-oriented (p < 0.001) and lower perception of a task-oriented climate (p < 0.05) than girls. However, girls showed a greater intensity in the relationships related to ego climate and lower scores in self-confidence (p < 0.01), as well as higher scores in insecurity (p < 0.001). The results have shown positive relationships between self-confidence and a task-oriented climate, as well as negative ones with an ego-oriented climate. It is also observed that ego orientation generates more insecurity and anxiety, which is more evident in girls.Partial funding for open access charge: Universidad de Mála

COVID-19 Infection among Nursing Students in Spain: The Risk Perception, Perceived Risk Factors, Coping Style, Preventive Knowledge of the Disease and Sense of Coherence as Psychological Predictor Variables: A Cross Sectional Survey

The exploration of patterns of health beliefs about COVID-19 among nursing students may be beneficial to identify behaviors, attitudes and knowledge about contagion risk. We sought to analyze the variables of risk perception, perceived risk factors, coping style, sense of coherence and knowledge of preventive measures as possible predictors of having suffered from COVID-19. Participants were nursing students from 13 universities in Spain. Sociodemographic and health variables were collected. To test the independent variables, the Perception Risk Coping Knowledge (PRCK-COVID-19) scale was created and validated because there was no specific survey for young people adapted to the pandemic situation of COVID-19. It was validated with adequate psychometric properties. A total of 1562 students (87.5% female, mean age 21.5 ± 5.7 years) responded. The high perception of the risk of contagion, the high level of knowledge and a coping style focused on the situation were notable. Significant differences by gender were found in the coping styles, problem-focused, avoidance and knowledge scales, with women scoring higher in all categories. The multiple regression analysis was significant (F = 3.68; p &lt; 0.001). The predictor variables were the coping styles subscale search for support and the intrinsic and extrinsic perceived risk factors. Our model predicts that nursing students with a social support-based coping style are at a higher risk of becoming infected with COVID-19, based on their own health belief model.Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Acknowledgments: We are grateful to all participating institutions and students