Pregnancy-Related Lumbopelvic Pain: Listening to Australian Women

To investigate the prevalence and nature of lumbo-pelvic pain (LPP), that is experienced by women in the lumbar and/or sacro-iliac area and/or symphysis pubis during pregnancy. Cross-sectional, descriptive study. An Australian public hospital antenatal clinic. Women in their third trimester of pregnancy. Method. Women were recruited to the study as they presented for their antenatal appointment. A survey collected demographic data and was used to self report LPP. A pain diagram differentiated low back, pelvic girdle or combined pain. Closed and open ended questions explored the experiences of the women.Main OutcomeMeasures. The Visual Analogue Scale and the Oswestry Disability Index (Version 2.1a). Results. There was a high prevalence of self reported LPP during the pregnancy (71%). An association was found between the reporting of LPP, multiparity, and a previous history of LPP. The mean intensity score for usual pain was 6/10 and four out of five women reported disability associated with the condition.Most women (71%) had reported their symptoms to their maternity carer however only a small proportion of these women received intervention. Conclusion. LPP is a potentially significant health issue during pregnancy

Prevalence and predictors of video game addiction: a study based on a national representative sample of gamers

Video gaming has become a popular leisure activity in many parts of the world, and an increasing number of empirical studies examine the small minority that appears to develop problems as a result of excessive gaming. This study investigated prevalence rates and predictors of video game addiction in a sample of gamers, randomly selected from the National Population Registry of Norway (N =3389). Results showed there were 1.4 % addicted gamers, 7.3 % problem gamers, 3.9 % engaged gamers, and 87.4 % normal gamers. Gender (being male) and age group (being young) were positively associated with addicted-, problem-, and engaged gamers. Place of birth (Africa, Asia, South- and Middle America) were positively associated with addicted- and problem gamers. Video game addiction was negatively associated with conscientiousness and positively associated with neuroticism. Poor psychosomatic health was positively associated with problem- and engaged gaming. These factors provide insight into the field of video game addiction, and may help to provide guidance as to how individuals that are at risk of becoming addicted gamers can be identified

POWERFUL, ROTATING DISK WINDS from STELLAR-MASS BLACK HOLES

We present an analysis of ionized X-ray disk winds observed in the Fe K band of four stellar-mass black holes observed with Chandra, including 4U 1630-47, GRO J1655-40, H 1743-322, and GRS 1915+105. High-resolution photoionization grids were generated in order to model the data. Third-order gratings spectra were used to resolve complex absorption profiles into atomic effects and multiple velocity components. The Fe XXV line is found to be shaped by contributions from the intercombination line (in absorption), and the Fe XXVI line is detected as a spin-orbit doublet. The data require 2-3 absorption zones, depending on the source. The fastest components have velocities approaching or exceeding 0.01c, increasing mass outflow rates and wind kinetic power by orders of magnitude over prior single-zone models. The first-order spectra require re-emission from the wind, broadened by a degree that is loosely consistent with Keplerian orbital velocities at the photoionization radius. This suggests that disk winds are rotating with the orbital velocity of the underlying disk, and provides a new means of estimating launching radii -- crucial to understanding wind driving mechanisms. Some aspects of the wind velocities and radii correspond well to the broad-line region (BLR) in active galactic nuclei, suggesting a physical connection. We discuss these results in terms of prevalent models for disk wind production and disk accretion itself, and implications for massive black holes in active galactic nuclei

A realistic pattern of fermion masses from a five-dimensional SO(10) model

We provide a unified description of fermion masses and mixing angles in the framework of a supersymmetric grand unified SO(10) model with anarchic Yukawa couplings of order unity. The space-time is five dimensional and the extra flat spatial dimension is compactified on the orbifold $S^1/(Z_2 \times Z_2')$, leading to Pati-Salam gauge symmetry on the boundary where Yukawa interactions are localised. The gauge symmetry breaking is completed by means of a rather economic scalar sector, avoiding the doublet-triplet splitting problem. The matter fields live in the bulk and their massless modes get exponential profiles, which naturally explain the mass hierarchy of the different fermion generations. Quarks and leptons properties are naturally reproduced by a mechanism, first proposed by Kitano and Li, that lifts the SO(10) degeneracy of bulk masses in terms of a single parameter. The model provides a realistic pattern of fermion masses and mixing angles for large values of $\tan\beta$. It favours normally ordered neutrino mass spectrum with the lightest neutrino mass below 0.01 eV and no preference for leptonic CP violating phases. The right handed neutrino mass spectrum is very hierarchical and does not allow for thermal leptogenesis. We analyse several variants of the basic framework and find that the results concerning the fermion spectrum are remarkably stable.Comment: 30 pages, 7 figures, 4 table

THE ACCRETION DISK WIND IN THE BLACK HOLE GRS 1915+105

© 2016. The American Astronomical Society. All rights reserved. We report on a 120 ks Chandra/HETG spectrum of the black hole GRS 1915+105. The observation was made during an extended and bright soft state in 2015 June. An extremely rich disk wind absorption spectrum is detected, similar to that observed at lower sensitivity in 2007. The very high resolution of the third-order spectrum reveals four components to the disk wind in the Fe K band alone; the fastest has a blueshift of v = 0.03c. Broadened re-emission from the wind is also detected in the first-order spectrum, giving rise to clear accretion disk P Cygni profiles. Dynamical modeling of the re-emission spectrum gives wind launching radii of r ≃ 102-4 GM/c2. Wind density values of n ≃ 1013-16 cm-3 are then required by the ionization parameter formalism. The small launching radii, high density values, and inferred high mass outflow rates signal a role for magnetic driving. With simple, reasonable assumptions, the wind properties constrain the magnitude of the emergent magnetic field to be B ≃ 103-4 G if the wind is driven via magnetohydrodynamic (MHD) pressure from within the disk and B ≃ 104-5 G if the wind is driven by magnetocentrifugal acceleration. The MHD estimates are below upper limits predicted by the canonical α-disk model. We discuss these results in terms of fundamental disk physics and black hole accretion modes

Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients

BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. METHODS. Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. RESULTS AND DISCUSSION. Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). CONCLUSION. These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.National Heart, Lung, and Blood Institute (NO1-HR-96140, NO1-HR-96141-001, NO1-HR-96144, NO1-HR-96143; NO1-HR-96145; NO1-HR-96142, R01HL086936-03); The Flight Attendant Medical Research Institute; the Jo-Ann F. LeBuhn Center for Chest Diseas

DISK–WIND CONNECTION DURING THE HEARTBEATS OF GRS 1915+105

Disk and wind signatures are seen in the soft state of Galactic black holes, while the jet is seen in the hard state. Here we study the disk–wind connection in the ρ class of variability in GRS 1915+105 using a joint NuSTAR–Chandra observation. The source shows 50 s limit cycle oscillations. By including new information provided by the reflection spectrum and using phase-resolved spectroscopy, we find that the change in the inner disk inferred from the blackbody emission is not matched by reflection measurements. The latter is almost constant, independent of the continuum model. The two radii are comparable only if the disk temperature color correction factor changes, an effect that could be due to the changing opacity of the disk caused by changes in metal abundances. The disk inclination is similar to that inferred from the jet axis, and oscillates by ~10°. The simultaneous Chandra data show the presence of two wind components with velocities between 500 and 5000 km s⁻¹, and possibly two more with velocities reaching 20,000 km s⁻¹ (~0.06 c). The column densities are ~5 × 10²² cm⁻². An upper limit to the wind response time of 2 s is measured, implying a launch radius of <6 × 10¹° cm. The changes in wind velocity and absorbed flux require the geometry of the wind to change during the oscillations, constraining the wind to be launched from a distance of 290–1300 r _g from the black hole. Both data sets support fundamental model predictions in which a bulge originates in the inner disk and moves outward as the instability progresses.This work made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the National Aeronautics and Space Administration. This work is also based on observations made by the Chandra X-ray Observatory

Model counting for complex data structures

We extend recent approaches for calculating the probability of program behaviors, to allow model counting for complex data structures with numeric fields. We use symbolic execution with lazy initialization to compute the input structures leading to the occurrence of a target event, while keeping a symbolic representation of the constraints on the numeric data. Off-the-shelf model counting tools are used to count the solutions for numerical constraints and field bounds encoding data structure invariants are used to reduce the search space. The technique is implemented in the Symbolic PathFinder tool and evaluated on several complex data structures. Results show that the technique is much faster than an enumeration-based method that uses the Korat tool and also highlight the benefits of using the field bounds to speed up the analysis

Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world

[No abstract available