Tratamiento farmacológico de la emergencia Hipertensiva

Se presenta la emergencia hipertensiva desde varios puntos de vista. Se define la entidad, se abordaron las diferentes formas de presentación así como las causas que la producen. Se exponeel tratamiento de elección para cada complicación, con dosis, vía de administración y efectos adversos

Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature

This is an Author's Accepted Manuscript of an article published in Ronaldo E. Mello, Alessia Fontana, Antonio Mulet, Jefferson Luiz, G. Correa & Juan A. Cárcel (2020) Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature, Drying Technology, 38:1-2, 259-267, DOI: 10.1080/07373937.2019.1645685 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/10.1080/07373937.2019.1645685[EN] Atmospheric freeze-drying (AFD) at -10 degrees C and moderate temperature convective drying (MTD) at 50 degrees C without and with ultrasound application (20.5 kW/m(3)) were carried out. Alcohol insoluble residue (AIR) and its swelling capacity (SC), water retention capacity (WRC) and fat retention capacity (FRC) were measured in the dried product. Ultrasound significantly shortened the drying time in both processes, the intensification effect being more significant in atmospheric freeze-drying (57% and 27% reduction in atmospheric freeze-drying and convective drying, respectively). As regards AIR and WRC, no effect was observed of either the drying temperature or ultrasound application. On the contrary, SC was significantly lower in AFD samples. The FRC of MTD samples was similar to that of the fresh ones and higher than the values obtained for atmospheric freeze-dried samples. Therefore, convective drying at moderate temperature preserved the AIR properties better than atmospheric freeze-drying.The authors acknowledge the financial support of INIA-ERDF through project RTA2015-00060-C04-02. We are also grateful for the economic support of the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (Capes)- Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG).Mello, RE.; Fontana, A.; Mulet Pons, A.; Correa, J.; Carcel, JA. (2020). Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature. Drying Technology. 38(1-2):259-267. https://doi.org/10.1080/07373937.2019.1645685S259267381-2Freire, F. B., Atxutegi, A., Freire, F. B., Freire, J. T., Aguado, R., & Olazar, M. (2016). An adaptive lumped parameter cascade model for orange juice solid waste drying in spouted bed. Drying Technology, 35(5), 577-584. doi:10.1080/07373937.2016.1190937Tasirin, S. M., Puspasari, I., Sahalan, A. Z., Mokhtar, M., Ghani, M. K. A., & Yaakob, Z. (2014). Drying ofCitrus sinensisPeels in an Inert Fluidized Bed: Kinetics, Microbiological Activity, Vitamin C, and Limonene Determination. Drying Technology, 32(5), 497-508. doi:10.1080/07373937.2013.838782Zielinska, M., Sadowski, P., & Błaszczak, W. (2015). Combined hot air convective drying and microwave-vacuum drying of blueberries (Vaccinium corymbosumL.): Drying kinetics and quality characteristics. Drying Technology, 34(6), 665-684. doi:10.1080/07373937.2015.1070358Moreno, C., Brines, C., Mulet, A., Rosselló, C., & Cárcel, J. A. (2017). Antioxidant potential of atmospheric freeze-dried apples as affected by ultrasound application and sample surface. Drying Technology, 35(8), 957-968. doi:10.1080/07373937.2016.1256890Garcia-Perez, J. V., Ortuño, C., Puig, A., Carcel, J. A., & Perez-Munuera, I. (2011). Enhancement of Water Transport and Microstructural Changes Induced by High-Intensity Ultrasound Application on Orange Peel Drying. Food and Bioprocess Technology, 5(6), 2256-2265. doi:10.1007/s11947-011-0645-0Do Nascimento, E. M. G. C., Mulet, A., Ascheri, J. L. R., de Carvalho, C. W. P., & Cárcel, J. A. (2016). Effects of high-intensity ultrasound on drying kinetics and antioxidant properties of passion fruit peel. Journal of Food Engineering, 170, 108-118. doi:10.1016/j.jfoodeng.2015.09.015Martins, M. P., Cortés, E. J., Eim, V., Mulet, A., & Cárcel, J. A. (2018). Stabilization of apple peel by drying. Influence of temperature and ultrasound application on drying kinetics and product quality. Drying Technology, 37(5), 559-568. doi:10.1080/07373937.2018.1474476García-Pérez, J. V., Cárcel, J. A., Riera, E., & Mulet, A. (2009). Influence of the Applied Acoustic Energy on the Drying of Carrots and Lemon Peel. Drying Technology, 27(2), 281-287. doi:10.1080/07373930802606428Blasco, M., García-Pérez, J. V., Bon, J., Carreres, J. E., & Mulet, A. (2006). Effect of Blanching and Air Flow Rate on Turmeric Drying. Food Science and Technology International, 12(4), 315-323. doi:10.1177/1082013206067352Garau, M. C., Simal, S., Femenia, A., & Rosselló, C. (2006). Drying of orange skin: drying kinetics modelling and functional properties. Journal of Food Engineering, 75(2), 288-295. doi:10.1016/j.jfoodeng.2005.04.017Garau, M. C., Simal, S., Rosselló, C., & Femenia, A. (2007). Effect of air-drying temperature on physico-chemical properties of dietary fibre and antioxidant capacity of orange (Citrus aurantium v. Canoneta) by-products. Food Chemistry, 104(3), 1014-1024. doi:10.1016/j.foodchem.2007.01.009Beigi, M. (2015). Hot air drying of apple slices: dehydration characteristics and quality assessment. Heat and Mass Transfer, 52(8), 1435-1442. doi:10.1007/s00231-015-1646-8Santos, P. H. S., & Silva, M. A. (2008). Retention of Vitamin C in Drying Processes of Fruits and Vegetables—A Review. Drying Technology, 26(12), 1421-1437. doi:10.1080/07373930802458911Gallego-Juárez, J. A., Riera, E., de la Fuente Blanco, S., Rodríguez-Corral, G., Acosta-Aparicio, V. M., & Blanco, A. (2007). Application of High-Power Ultrasound for Dehydration of Vegetables: Processes and Devices. Drying Technology, 25(11), 1893-1901. doi:10.1080/07373930701677371Santacatalina, J. V., Ahmad-Qasem, M. H., Barrajón-Catalán, E., Micol, V., García-Pérez, J. V., & Cárcel, J. A. (2014). Use of Novel Drying Technologies to Improve the Retention of Infused Olive Leaf Polyphenols. Drying Technology, 33(9), 1051-1060. doi:10.1080/07373937.2014.982251Silva, V. M., & Viotto, L. A. (2010). Drying of sicilian lemon residue: influence of process variables on the evaluation of the dietary fiber produced. Ciência e Tecnologia de Alimentos, 30(2), 421-428. doi:10.1590/s0101-20612010000200020Garcia-Amezquita, L. E., Tejada-Ortigoza, V., Campanella, O. H., & Welti-Chanes, J. (2018). Influence of Drying Method on the Composition, Physicochemical Properties, and Prebiotic Potential of Dietary Fibre Concentrates from Fruit Peels. Journal of Food Quality, 2018, 1-11. doi:10.1155/2018/9105237Abou-Arab, E. A., Mahmoud, M. H., & Abu-Salem, F. M. (2017). Functional Properties of Citrus Peel as Affected by Drying Methods. American Journal of Food Technology, 12(3), 193-200. doi:10.3923/ajft.2017.193.200Ghanem Romdhane, N., Bonazzi, C., Kechaou, N., & Mihoubi, N. B. (2015). Effect of Air-Drying Temperature on Kinetics of Quality Attributes of Lemon (Citrus limoncv. lunari) Peels. Drying Technology, 33(13), 1581-1589. doi:10.1080/07373937.2015.101226

Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults

Background: Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases, such as cardiovascular disease (CVD), metabolic syndrome, and breast and colon cancers, and shortens life expectancy. We aimed to determine the effects of moderate (MCT)- versus high-intensity interval training (HIT) on vascular function parameters in physically inactive adults. We hypothesized that individualized HIT prescription would improve the vascular function parameters more than the MCT in a greater proportion of individuals. Methods: Twenty-one inactive adults were randomly allocated to receive either MCT group (60-75% of their heart rate reserve, [HRR] or HIT group (4 min at 85-95% of peak HRR), 3 days a week for 12 weeks. Vascular function (brachial artery flow-mediated dilation, FMD [%], normalized brachial artery flow-mediated dilation, FMDn [%], aortic pulse wave velocity, PWV [m·s - 1 ], AIx, augmentation index: aortic and brachial [%]), were measured at baseline and over 12 weeks of training. In order for a participant to be considered a responder to improvements in vascular function parameters (FMDn and PWV), the typical error was calculated in a favorable direction. Results: FMD changed by - 1.0% (SE 2.1, d = 0.388) in the MCT group, and + 1.8% (SE 1.8, d = 0.699) in the HIT group (no significant difference between groups: 2.9% [95% CI, - 3.0 to 8.8]. PWV changed by + 0.1 m·s - 1 (SE 0.2, d = 0.087) in the MCT group but decreased by - 0.4 m·s - 1 in the HIT group (SE 0.2, d = 0.497), with significant difference between groups: - 0.4 [95% CI, - 0.2 to - 0.7]. There was not a significant difference in the prevalence of no-responder for FMD (%) between the MCT and HIT groups (66% versus 36%, P = 0.157). Regarding PWV (m·s - 1 ), an analysis showed that the prevalence of no-responder was 77% (7 cases) in the MCT group and 45% (5 cases) in the HIT group (P = 0.114). Conclusions: Under the conditions of the present study, both groups experienced changed in vascular function parameters. Compared to MCT group, HIT is more efficacious for improving FMD and decreasing PWV, in physically inactive adults. Trial registration: ClinicalTrials.gov NCT02738385 registered on 23 March 2016. © 2019 The Author(s)

Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study

Patients with acute myocardial infarction (AMI) and respiratory impairment may be treated with either invasive or non-invasive mechanical ventilation (MV). However, there has been little testing of non-invasive MV in the setting of AMI. Our objective was to evaluate the incidence and associated clinical outcomes of patients with AMI who were treated with non-invasive or invasive MV

Improving physical activity behaviors, physical fitness, cardiometabolic and mental health in adolescents - ActTeens program : a protocol for a randomized controlled trial

This trial aims to investigate the effects of the ActTeens physical activity program, on adolescents' physical activity level, health-related fitness, cardiometabolic and mental health. The trial will aim to recruit ∼140 adolescents (aged 13-14 years). Participants will be randomized into either intervention or control groups. The intervention will be guided by social cognitive theory and self-determination theory and implemented over one school term (24- weeks). The ActTeens Program will include: (1) structured physical activity sessions delivered within physical education, including movement-based games and dynamic stretching warm-ups; resistance training skill development; high-intensity training workouts; and cooldowns; (2) self-monitoring plus goal setting for physical activity by pedometer-smart wearable; and (3) healthy lifestyle guidance (social support) by WhatsApp® messages about healthy eating and regular physical activity for the intervention and parents groups. Study outcomes will be assessed at baseline, 24-weeks from baseline, and 12-months from baseline. Physical activity (accelerometer) is the primary outcome. Secondary outcomes include muscular and cardiorespiratory fitness, cardiometabolic profile, and mental health. A process evaluation will be conducted (i.e., recruitment, retention, attendance, and program satisfaction). This project will have the potential to address many questions and debates regarding the implementation of physical activity interventions in low-and- middle-income countries

Efecto de la adición de clorhidrato de zilpaterol genérico en el perfil bioquímico y hematológico de ovinos de pelo engordados en corral

This study aimed to evaluate zilpaterol hydrochloride (ZH, generic) supplementation on fattening hair sheep, using hematological and biochemical variables as health status indicators. A total of 32 hair lambs (Dorper x Pelibuey) were grouped by initial weight and randomly assigned into four treatments: T1= basal diet (control group), T2= basal diet supplemented with ZH at 0.10 mg·kg-1 of LW d-1 (Grofactor®, Virbac México, Guadalajara, Mexico), T3= basal diet supplemented with ZH at 0.20 mg·kg-1 of LW d-1, and T4= basal diet supplemented with ZH at 0.30 mg·kg-1 of LW d-1. Blood samples were collected on days 1, 15, and 30 of the study. The hematological profile was determined in fresh blood samples; metabolites, electrolytes, and hormones were determined in serum samples. The study followed a randomized complete block experimental design, using an orthogonal polynomial analysis to determine the trend of the responses at the different concentrations of ZH. Cholesterol and urea levels were higher (P<0.05) in T3 than in T2. Furthermore, the mean corpuscular hemoglobin concentration was higher (P<0.05) in T1 than in T3; the red blood cell distribution width was higher (P<0.05) in T2 and T3 than in T4. The Na levels and the number of platelets showed a linear trend (P <0.05) to decrease and increase, respectively, as ZH levels increased. A quadratic trend was observed (P<0.05) in mean corpuscular hemoglobin concentration and red blood cell distribution width with increasing dose of ZH (generic). The remaining variables did not show significant trends at ZH levels (generic). The values of the biochemical and hematological profiles were within the reference range, which suggests that the addition of ZH did not alter the health status of fattening lambs. El objetivo fue evaluar la adición de clorhidrato de zilpaterol (CZ, genérico) en la dieta de ovinos de pelo de engorda, sobre variables hematológicas y bioquímicas como indicadores del estado de salud. Treinta y dos (32) corderos de pelo cruzados (Dorper x Pelibuey) se bloquearon por peso inicial y cuatro tratamientos y se asignaron aleatoriamente dentro de cada bloque: T1= dieta basal (grupo testigo), T2= dieta basal más 0.10 mg·kg-1 de PV d-1 de CZ (Grofactor®, Virbac México, Guadalajara, México), T3= dieta basal más 0.20 mg·kg-1 de PV d-1 de CZ y T4= dieta basal más 0.30 mg·kg-1 de PV d-1 de CZ. Se tomaron muestras de sangre los días 1, 15 y 30 del estudio. El perfil hematológico se estimó en muestras de sangre fresca, mientras que metabolitos, electrolitos y hormonas en muestras de suero. El diseño experimental fue bloques completos al azar y se efectuó análisis de polinomios ortogonales para determinar la tendencia de las respuestas a los niveles de CZ. Los niveles de colesterol y urea fueron mayores (P<0.05) en T3 que en T2; asimismo, el nivel de concentración corpuscular medio de hemoglobina fue mayor (P<0.05) en T1 que en T3, mientras que el ancho de distribución de eritrocitos fue mayor (P<0.05) en T2 y T3 que en T4. Los niveles de Na y el número de plaquetas mostraron tendencia lineal (P<0.05) a disminuir y aumentar, respectivamente, conforme los niveles de CZ aumentaron. Se observó tendencia cuadrática (P<0.05) en la concentración corpuscular media de hemoglobina y ancho de distribución de eritrocitos al aumentar la dosis de CZ (genérico). Las variables restantes no mostraron tendencias significativas a los niveles de CZ (genérico). Los valores de los perfiles bioquímico y hematológico se encontraron dentro del rango de referencia, lo que sugiere que la adición de CZ no alteró el estado de salud de corderos en engorda

C7a, a Biphosphinic Cyclopalladated Compound, Efficiently Controls the Development of a Patient-Derived Xenograft Model of Adult T Cell Leukemia/Lymphoma

Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor prognosis because the leukemic cells are resistant to conventional chemotherapy. We have investigated the therapeutic efficacy of a biphosphinic cyclopalladated complex {Pd2 [S(−)C2, N-dmpa]2 (μ-dppe)Cl2}, termed C7a, in a patient-derived xenograft model of ATLL, and investigated the mechanism of C7a action in HTLV-1-positive and negative transformed T cell lines in vitro. In vivo survival studies in immunocompromised mice inoculated with human RV-ATL cells and intraperitoneally treated with C7a led to significantly increased survival of the treated mice. We investigated the mechanism of C7a activity in vitro and found that it induced mitochondrial release of cytochrome c, caspase activation, nuclear condensation and DNA degradation. These results suggest that C7a triggers apoptotic cell death in both HTLV-1 infected and uninfected human transformed T-cell lines. Significantly, C7a was not cytotoxic to peripheral blood mononuclear cells (PBMC) from healthy donors and HTLV-1-infected individuals. C7a inhibited more than 60% of the ex vivo spontaneous proliferation of PBMC from HTLV-1-infected individuals. These results support a potential therapeutic role for C7a in both ATLL and HTLV-1-negative T-cell lymphomas