634 research outputs found
ZMYM2 inhibits NANOG-mediated reprogramming [version 1; peer review: 2 approved, 1 approved with reservations]
A Space-Time Orbifold: A Toy Model for a Cosmological Singularity
We explore bosonic strings and Type II superstrings in the simplest time
dependent backgrounds, namely orbifolds of Minkowski space by time reversal and
some spatial reflections. We show that there are no negative norm physical
excitations. However, the contributions of negative norm virtual states to
quantum loops do not cancel, showing that a ghost-free gauge cannot be chosen.
The spectrum includes a twisted sector, with strings confined to a ``conical''
singularity which is localized in time. Since these localized strings are not
visible to asymptotic observers, interesting issues arise regarding unitarity
of the S-matrix for scattering of propagating states. The partition function of
our model is modular invariant, and for the superstring, the zero momentum
dilaton tadpole vanishes. Many of the issues we study will be generic to
time-dependent cosmological backgrounds with singularities localized in time,
and we derive some general lessons about quantizing strings on such spaces.Comment: 21 pages, 2 figure
Natural Theories of Ultra-Low Mass PNGB's: Axions and Quintessence
We consider the Wilson Line PNGB which arises in a U(1)^N gauge theory,
abstracted from a latticized, periodically compactified extra dimension U(1).
Planck scale breaking of the PNGB's global symmetry is suppressed, providing
natural candidates for the axion and quintessence. We construct an explicit
model in which the axion may be viewed as the 5th component of the U(1)_Y gauge
field in a 1+4 latticized periodically compactified extra dimension. We also
construct a quintessence PNGB model where the ultra-low mass arises from
Planck-scale suppressed physics itself.Comment: 20 pages, fixed typo and reference
Morphological and microstructural characterization of laser-glazedplasma-sprayed thermal barrier coatings
Laser glazing has been revealing a high potential for the improvement of plasma-sprayed (PS) thermal barrier coatings (TBCs) by
reducing surface roughness, eliminating open porosity on the surface and generating a controlled segmented crack network, although the
relationship of the processing parameters with the resultant properties has not yet been completely established. In this investigation, TBCs
consisting of atmospheric plasma-sprayed (APS) ZrO2–8wt.%Y2O3 were subjected to a CO2 continuous wave laser-glazing process in
order to seal its surface porosity, generating an external dense layer. For that purpose, different amounts of radiation resulting from different
scanning speeds were applied to the specimens as well as different track overlapping. Results have shown a significant decrease of the
surface roughness after the laser treatment. All specimens presented a fully dense and porous free external layer with a polyfaceted
columnar microstructure highly adherent to the plasma-sprayed coating. Controlled surface crack networks, extremely dependent on the
laser scanning speed and track overlapping, were achieved for each set of processing parameters. The cracks were found to have a
tendency to be oriented in two perpendicular directions, one in the direction of the laser-beam travel direction, the other perpendicular to it.
Moreover, the cracks parallel to the beam travel direction are found to be on the overlapping zone, coinciding with the edge of the
subsequent track. The cracks are perpendicular to the surface along the densified layer and tend to branch and deviate from the vertical
direction below it, within the porous PS coating. XRD results revealed mainly tV nontransformable tetragonal zirconia with a small
percentage of residual monoclinic zirconia for the as-sprayed coating. All glazed coatings presented only tV nontransformable tetragonal
zirconia with some variations on preferable crystal orientation. Grain sizes varied from 26 to 52 nm, increasing with an increase of laserirradiated
energy; microstrain behaved inversely.Fundação para a Ciência e a Tecnologia (FCT) - Project POCTI/CTM/44590/2002.União Europeia (UE). Fundo Europeu de Desenvolvimento Regional (FEDER)
Boundary States for D-branes with Traveling Waves
We construct boundary states for D-branes which carry traveling waves in the
covariant formalism. We compute their vacuum amplitudes to investigate their
interactions. In non-compact space, the vacuum amplitudes become trivial as is
common in plane wave geometries. However, we found that if they are
compactified in the traveling direction, then the amplitudes are affected by
non-trivial time dependent effects. The interaction between D-branes with waves
traveling in the opposite directions (`pulse-antipulse scattering') are also
computed. Furthermore, we apply these ideas to open string tachyon condensation
with traveling waves.Comment: 30 pages. 1 figure, Latex, minor corrections, references adde
New hadrons as ultra-high energy cosmic rays
Ultra-high energy cosmic ray (UHECR) protons produced by uniformly
distributed astrophysical sources contradict the energy spectrum measured by
both the AGASA and HiRes experiments, assuming the small scale clustering of
UHECR observed by AGASA is caused by point-like sources. In that case, the
small number of sources leads to a sharp exponential cutoff at the energy
E<10^{20} eV in the UHECR spectrum. New hadrons with mass 1.5-3 GeV can solve
this cutoff problem. For the first time we discuss the production of such
hadrons in proton collisions with infrared/optical photons in astrophysical
sources. This production mechanism, in contrast to proton-proton collisions,
requires the acceleration of protons only to energies E<10^{21} eV. The diffuse
gamma-ray and neutrino fluxes in this model obey all existing experimental
limits. We predict large UHE neutrino fluxes well above the sensitivity of the
next generation of high-energy neutrino experiments. As an example we study
hadrons containing a light bottom squark. These models can be tested by
accelerator experiments, UHECR observatories and neutrino telescopes.Comment: 17 pages, revtex style; v2: shortened, as to appear in PR
Making maps from Planck LFI 30 GHz data with asymmetric beams and cooler noise
The Planck satellite will observe the full sky at nine frequencies from 30 to 857 GHz. Temperature and polarization frequency maps made from these observations are prime deliverables of the Planck mission. The goal of this paper is to examine the effects of four realistic instrument systematics in the 30 GHz frequency maps: non-axially-symmetric beams, sample integration, sorption cooler noise, and pointing errors. We simulated one-year long observations of four 30 GHz detectors. The simulated timestreams contained cosmic microwave background (CMB) signal, foreground components ( both galactic and extra-galactic), instrument noise ( correlated and white), and the four instrument systematic effects. We made maps from the timelines and examined the magnitudes of the systematics effects in the maps and their angular power spectra. We also compared the maps of different mapmaking codes to see how they performed. We used five mapmaking codes ( two destripers and three optimal codes). None of our mapmaking codes makes any attempt to deconvolve the beam from its output map. Therefore all our maps had similar smoothing due to beams and sample integration. This is a complicated smoothing, because each map pixel has its own effective beam. Temperature to polarization cross-coupling due to beam mismatch causes a detectable bias in the TE spectrum of the CMB map. The effects of cooler noise and pointing errors did not appear to be major concerns for the 30 GHz channel. The only essential difference found so far between mapmaking codes that affects accuracy ( in terms of residual root-mean-square) is baseline length. All optimal codes give essentially indistinguishable results. A destriper gives the same result as the optimal codes when the baseline is set short enough ( Madam). For longer baselines destripers (Springtide and Madam) require less computing resources but deliver a noisier map.The Planck satellite will observe the full sky at nine frequencies from 30 to 857 GHz. Temperature and polarization frequency maps made from these observations are prime deliverables of the Planck mission. The goal of this paper is to examine the effects of four realistic instrument systematics in the 30 GHz frequency maps: non-axially-symmetric beams, sample integration, sorption cooler noise, and pointing errors. We simulated one-year long observations of four 30 GHz detectors. The simulated timestreams contained cosmic microwave background (CMB) signal, foreground components ( both galactic and extra-galactic), instrument noise ( correlated and white), and the four instrument systematic effects. We made maps from the timelines and examined the magnitudes of the systematics effects in the maps and their angular power spectra. We also compared the maps of different mapmaking codes to see how they performed. We used five mapmaking codes ( two destripers and three optimal codes). None of our mapmaking codes makes any attempt to deconvolve the beam from its output map. Therefore all our maps had similar smoothing due to beams and sample integration. This is a complicated smoothing, because each map pixel has its own effective beam. Temperature to polarization cross-coupling due to beam mismatch causes a detectable bias in the TE spectrum of the CMB map. The effects of cooler noise and pointing errors did not appear to be major concerns for the 30 GHz channel. The only essential difference found so far between mapmaking codes that affects accuracy ( in terms of residual root-mean-square) is baseline length. All optimal codes give essentially indistinguishable results. A destriper gives the same result as the optimal codes when the baseline is set short enough ( Madam). For longer baselines destripers (Springtide and Madam) require less computing resources but deliver a noisier map.The Planck satellite will observe the full sky at nine frequencies from 30 to 857 GHz. Temperature and polarization frequency maps made from these observations are prime deliverables of the Planck mission. The goal of this paper is to examine the effects of four realistic instrument systematics in the 30 GHz frequency maps: non-axially-symmetric beams, sample integration, sorption cooler noise, and pointing errors. We simulated one-year long observations of four 30 GHz detectors. The simulated timestreams contained cosmic microwave background (CMB) signal, foreground components ( both galactic and extra-galactic), instrument noise ( correlated and white), and the four instrument systematic effects. We made maps from the timelines and examined the magnitudes of the systematics effects in the maps and their angular power spectra. We also compared the maps of different mapmaking codes to see how they performed. We used five mapmaking codes ( two destripers and three optimal codes). None of our mapmaking codes makes any attempt to deconvolve the beam from its output map. Therefore all our maps had similar smoothing due to beams and sample integration. This is a complicated smoothing, because each map pixel has its own effective beam. Temperature to polarization cross-coupling due to beam mismatch causes a detectable bias in the TE spectrum of the CMB map. The effects of cooler noise and pointing errors did not appear to be major concerns for the 30 GHz channel. The only essential difference found so far between mapmaking codes that affects accuracy ( in terms of residual root-mean-square) is baseline length. All optimal codes give essentially indistinguishable results. A destriper gives the same result as the optimal codes when the baseline is set short enough ( Madam). For longer baselines destripers (Springtide and Madam) require less computing resources but deliver a noisier map.Peer reviewe
Planck intermediate results. VIII. Filaments between interacting clusters
About half of the baryons of the Universe are expected to be in the form of
filaments of hot and low density intergalactic medium. Most of these baryons
remain undetected even by the most advanced X-ray observatories which are
limited in sensitivity to the diffuse low density medium. The Planck satellite
has provided hundreds of detections of the hot gas in clusters of galaxies via
the thermal Sunyaev-Zel'dovich (tSZ) effect and is an ideal instrument for
studying extended low density media through the tSZ effect. In this paper we
use the Planck data to search for signatures of a fraction of these missing
baryons between pairs of galaxy clusters. Cluster pairs are good candidates for
searching for the hotter and denser phase of the intergalactic medium (which is
more easily observed through the SZ effect). Using an X-ray catalogue of
clusters and the Planck data, we select physical pairs of clusters as
candidates. Using the Planck data we construct a local map of the tSZ effect
centered on each pair of galaxy clusters. ROSAT data is used to construct X-ray
maps of these pairs. After having modelled and subtracted the tSZ effect and
X-ray emission for each cluster in the pair we study the residuals on both the
SZ and X-ray maps. For the merging cluster pair A399-A401 we observe a
significant tSZ effect signal in the intercluster region beyond the virial
radii of the clusters. A joint X-ray SZ analysis allows us to constrain the
temperature and density of this intercluster medium. We obtain a temperature of
kT = 7.1 +- 0.9, keV (consistent with previous estimates) and a baryon density
of (3.7 +- 0.2)x10^-4, cm^-3. The Planck satellite mission has provided the
first SZ detection of the hot and diffuse intercluster gas.Comment: Accepted by A&
Towards actionable international comparisons of health system performance: expert revision of the OECD framework and quality indicators
Objective To review and update the conceptual framework, indicator content and research priorities of the Organisation for Economic Cooperation and Development's (OECD) Health Care Quality Indicators (HCQI) project, after a decade of collaborative work. Design A structured assessment was carried out using a modified Delphi approach, followed by a consensus meeting, to assess the suite of HCQI for international comparisons, agree on revisions to the original framework and set priorities for research and development. Setting International group of countries participating to OECD projects. Participants Members of the OECD HCQI expert group. Results A reference matrix, based on a revised performance framework, was used to map and assess all seventy HCQI routinely calculated by the OECD expert group. A total of 21 indicators were agreed to be excluded, due to the following concerns: (i) relevance, (ii) international comparability, particularly where heterogeneous coding practices might induce bias, (iii) feasibility, when the number of countries able to report was limited and the added value did not justify sustained effort and (iv) actionability, for indicators that were unlikely to improve on the basis of targeted policy interventions. Conclusions The revised OECD framework for HCQI represents a new milestone of a long-standing international collaboration among a group of countries committed to building common ground for performance measurement. The expert group believes that the continuation of this work is paramount to provide decision makers with a validated toolbox to directly act on quality improvement strategie
Reye Syndrome Associated with Vaccination with Live Virus Vaccines
To determine whether vaccination with live virus vaccines may be etiologi cally related to Reye syndrome, we examined 404 cases reported to the Center for Disease Control. Fifteen of 269 children with Reye syndrome had been inoculated with live virus vaccines within 30 days before onset of illness. Although this temporal relationship may have occurred by chance, seasonal distribution and clustering of incubation periods suggests that live virus vaccines may occasionally serve as cofactors in the etiology of Reye syndrome through undefined mechanisms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66647/2/10.1177_000992287901800105.pd
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