676 research outputs found
Whole Genome Association Analysis of Idiopathic Eosinophilic Enteritis in Brown Egg Layers
Idiopathic Eosinophilic Enteritis (IEE) is an intestine disease that affects absorption of nutrients and performance. Hens of a commercial breeding layer line and its two reciprocal crosses with another line were recorded for IEE related traits and genotyped for over 40,000 genetic markers across the genome. Whole genome association analysis was performed on 288 daughters from high and low incidence sire families. Single marker association analyses of IEE incidence in separate lines showed consistent significant regions on chromosomes 4 and 5 (p\u3c0.001). Simultaneous analyses of all SNPs in all 3 lines using Bayesian whole genome selection methods indicated evidence of associations on chromosomes 1, 2 and 4 for additive effects and on chromosome 5 for dominance effects. Line specific regions also appeared on chromosome Z. With further investigation, these results can be used to develop genetic markers to select against this disease and to understand its genetic basis
Dynamic Critical Behavior of the Chayes-Machta Algorithm for the Random-Cluster Model. I. Two Dimensions
We study, via Monte Carlo simulation, the dynamic critical behavior of the
Chayes-Machta dynamics for the Fortuin-Kasteleyn random-cluster model, which
generalizes the Swendsen-Wang dynamics for the q-state Potts ferromagnet to
non-integer q \ge 1. We consider spatial dimension d=2 and 1.25 \le q \le 4 in
steps of 0.25, on lattices up to 1024^2, and obtain estimates for the dynamic
critical exponent z_{CM}. We present evidence that when 1 \le q \lesssim 1.95
the Ossola-Sokal conjecture z_{CM} \ge \beta/\nu is violated, though we also
present plausible fits compatible with this conjecture. We show that the
Li-Sokal bound z_{CM} \ge \alpha/\nu is close to being sharp over the entire
range 1 \le q \le 4, but is probably non-sharp by a power. As a byproduct of
our work, we also obtain evidence concerning the corrections to scaling in
static observables.Comment: LaTeX2e, 75 pages including 26 Postscript figure
Pulsar Timing and its Application for Navigation and Gravitational Wave Detection
Pulsars are natural cosmic clocks. On long timescales they rival the
precision of terrestrial atomic clocks. Using a technique called pulsar timing,
the exact measurement of pulse arrival times allows a number of applications,
ranging from testing theories of gravity to detecting gravitational waves. Also
an external reference system suitable for autonomous space navigation can be
defined by pulsars, using them as natural navigation beacons, not unlike the
use of GPS satellites for navigation on Earth. By comparing pulse arrival times
measured on-board a spacecraft with predicted pulse arrivals at a reference
location (e.g. the solar system barycenter), the spacecraft position can be
determined autonomously and with high accuracy everywhere in the solar system
and beyond. We describe the unique properties of pulsars that suggest that such
a navigation system will certainly have its application in future astronautics.
We also describe the on-going experiments to use the clock-like nature of
pulsars to "construct" a galactic-sized gravitational wave detector for
low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the
current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks,
Springer Space Science Review
Approximating a Behavioural Pseudometric without Discount for<br> Probabilistic Systems
Desharnais, Gupta, Jagadeesan and Panangaden introduced a family of
behavioural pseudometrics for probabilistic transition systems. These
pseudometrics are a quantitative analogue of probabilistic bisimilarity.
Distance zero captures probabilistic bisimilarity. Each pseudometric has a
discount factor, a real number in the interval (0, 1]. The smaller the discount
factor, the more the future is discounted. If the discount factor is one, then
the future is not discounted at all. Desharnais et al. showed that the
behavioural distances can be calculated up to any desired degree of accuracy if
the discount factor is smaller than one. In this paper, we show that the
distances can also be approximated if the future is not discounted. A key
ingredient of our algorithm is Tarski's decision procedure for the first order
theory over real closed fields. By exploiting the Kantorovich-Rubinstein
duality theorem we can restrict to the existential fragment for which more
efficient decision procedures exist
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
Colossal dielectric constants in transition-metal oxides
Many transition-metal oxides show very large ("colossal") magnitudes of the
dielectric constant and thus have immense potential for applications in modern
microelectronics and for the development of new capacitance-based
energy-storage devices. In the present work, we thoroughly discuss the
mechanisms that can lead to colossal values of the dielectric constant,
especially emphasising effects generated by external and internal interfaces,
including electronic phase separation. In addition, we provide a detailed
overview and discussion of the dielectric properties of CaCu3Ti4O12 and related
systems, which is today's most investigated material with colossal dielectric
constant. Also a variety of further transition-metal oxides with large
dielectric constants are treated in detail, among them the system La2-xSrxNiO4
where electronic phase separation may play a role in the generation of a
colossal dielectric constant.Comment: 31 pages, 18 figures, submitted to Eur. Phys. J. for publication in
the Special Topics volume "Cooperative Phenomena in Solids: Metal-Insulator
Transitions and Ordering of Microscopic Degrees of Freedom
Cluster Monte Carlo and dynamical scaling for long-range interactions
Many spin systems affected by critical slowing down can be efficiently
simulated using cluster algorithms. Where such systems have long-range
interactions, suitable formulations can additionally bring down the
computational effort for each update from O() to O() or even
O(), thus promising an even more dramatic computational speed-up. Here, we
review the available algorithms and propose a new and particularly efficient
single-cluster variant. The efficiency and dynamical scaling of the available
algorithms are investigated for the Ising model with power-law decaying
interactions.Comment: submitted to Eur. Phys. J Spec. Topic
A bacteriophage detection tool for viability assessment of Salmonella cells
Available online 7 September 2013Salmonellosis, one of the most common food and water-borne diseases, has a major global health and economic impact. Salmonella cells present high infection rates, persistence over inauspicious conditions and the potential to preserve virulence in dormant states when cells are viable but non-culturable (VBNC). These facts are challenging for current detection methods. Culture methods lack the capacity to detect VBNC cells, while biomolecular methods (e.g. DNA- or protein-based) hardly distinguish between dead innocuous cells and their viable lethal counterparts. This work presents and validates a novel bacteriophage (phage)-based microbial detection tool to detect and assess Salmonella viability. Salmonella Enteritidis cells in a VBNC physiological state were evaluated by cell culture, flow-cytometry and epifluorescence microscopy, and further assayed with a biosensor platform. Free PVP-SE1 phages in solution showed the ability to recognize VBNC cells, with no lysis induction, in contrast to the minor recognition of heat-killed cells. This ability was confirmed for immobilized phages on gold surfaces, where the phage detection signal follows the same trend of the concentration of viable plus VBNC cells in the sample. The phage probe was then tested in a magnetoresistive biosensor platform allowing the quantitative detection and discrimination of viable and VBNC cells from dead cells, with high sensitivity. Signals arising from 3 to 4 cells per sensor were recorded. In comparison to a polyclonal antibody that does not distinguish viable from dead cells, the phage selectivity in cell recognition minimizes false-negative and false-positive results often associated with most detection methods
Fully dynamic recognition of proper circular-arc graphs
We present a fully dynamic algorithm for the recognition of proper
circular-arc (PCA) graphs. The allowed operations on the graph involve the
insertion and removal of vertices (together with its incident edges) or edges.
Edge operations cost O(log n) time, where n is the number of vertices of the
graph, while vertex operations cost O(log n + d) time, where d is the degree of
the modified vertex. We also show incremental and decremental algorithms that
work in O(1) time per inserted or removed edge. As part of our algorithm, fully
dynamic connectivity and co-connectivity algorithms that work in O(log n) time
per operation are obtained. Also, an O(\Delta) time algorithm for determining
if a PCA representation corresponds to a co-bipartite graph is provided, where
\Delta\ is the maximum among the degrees of the vertices. When the graph is
co-bipartite, a co-bipartition of each of its co-components is obtained within
the same amount of time.Comment: 60 pages, 15 figure
Physics of Solar Prominences: II - Magnetic Structure and Dynamics
Observations and models of solar prominences are reviewed. We focus on
non-eruptive prominences, and describe recent progress in four areas of
prominence research: (1) magnetic structure deduced from observations and
models, (2) the dynamics of prominence plasmas (formation and flows), (3)
Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and
large-scale patterns of the filament channels in which prominences are located.
Finally, several outstanding issues in prominence research are discussed, along
with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape
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