692 research outputs found

    PUK9 Direct and Indirect Cost of Urge Urinary Incontinence With and Without Pharmacotherapy

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    PUK21 PATIENT CHARACTERISTICS ASSOCIATED WITH INITIATION OF OVERACTIVE BLADDER (OAB) DISCUSSION WITH A PHYSICIAN

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    Series Nash Solution of Two-Person Nonzero-Sum Linear-Quadratic Differential Games

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    Coordinated Science Laboratory was formerly known as Control Systems LaboratoryJoint Services Electronics Program / DAAB-07-67-C-0199National Science Foundation / GK-3893Air Force / AFOSR 68-1579

    Real-time N-finder processing algorithms for hyperspectral imagery

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    N-finder algorithm (N-FINDR) is probably one of most popular and widely used algorithms for endmember extraction in hyperspectral imagery. When it comes to practical implementation, four major obstacles need to be overcome. One is the number of endmembers which must be known a priori. A second one is the use of random initial endmembers to initialize N-FINDR, which generally results in different sets of final extracted endmembers. Consequently, the results are inconsistent and not reproducible. A third one is requirement of dimensionality reduction (DR) where different used DR techniques produce different results. Finally yet importantly, it is the very expensive computational cost caused by an exhaustive search for endmembers all together simultaneously. This paper re-designs N-FINDR in a real time processing fashion to cope with these issues. Four versions of Real Time (RT) N-FINDR are developed, RT Iterative N-FINDR (RT IN-FINDR), RT SeQuential N-FINDR (RT SQ N-FINDR), RT Circular N-FINDR, RT SuCcessive N-FINDR (RT SC N-FINDR), each of which has its own merit for implementation. Experimental results demonstrate that real time processing algorithms perform as well as their counterparts with no real-time processing

    Polyelectrolyte interlayers with a broad processing window for high efficiency inverted organic solar cells towards mass production

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    Neutral polyelectrolyte interfacial layers in organic solar cells are well-known for their ability to tailor the work function of electrodes, improve charge carrier extraction and maximize open circuit voltage. However, they also suffer from low charge carrier conductivity, and therefore the interlayer must be kept thin, which in turn requires very precise deposition. This prerequisite significantly reduces the robustness of the fabrication process and makes such structures difficult to up-scale for roll-to-roll mass production. Herein, we find that by washing the polyelectrolyte layer with N,N-dimethylformamide (DMF) after deposition, solar cell efficiency jumps to near optimum levels, no matter what the original thickness of the polyelectrolyte layer. Subsequent characterization of the DMF-washed ZnO/PEI interlayer reveals a changed surface structure, passivated surface trap states, and thus improved transport properties and lower recombination losses. We demonstrate the general applicability of the method to other state-of-the-art material systems, namely P3HT:ICBA, PTB7:PC71BM and PTB7-Th:PC71BM. We find that the more efficient the material system, the larger the improvement in efficiency after DMF washing. Thus, this method represents a general way to relax the fabrication criteria for high efficiency organic solar cells. We anticipate that this method could be of use in other classes of devices such as OTFTs and OLEDs

    Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl

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    Background: Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don) Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results: Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion: Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens

    Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus

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    Apoptotic cells are considered to be a major source for autoantigens in autoimmune diseases such as systemic lupus erythematosus (SLE). In agreement with this, defective clearance of apoptotic cells has been shown to increase disease susceptibility. Still, little is known about how apoptotic cell–derived self-antigens activate autoreactive B cells and where this takes place. In this study, we find that apoptotic cells are taken up by specific scavenger receptors expressed on macrophages in the splenic marginal zone and that mice deficient in these receptors have a lower threshold for autoantibody responses. Furthermore, antibodies against scavenger receptors are found before the onset of clinical symptoms in SLE-prone mice, and they are also found in diagnosed SLE patients. Our findings describe a novel mechanism where autoantibodies toward scavenger receptors can alter the response to apoptotic cells, affect tolerance, and thus promote disease progression. Because the autoantibodies can be detected before onset of disease in mice, they could have predictive value as early indicators of SLE

    Some flows in shape optimization

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    Geometric flows related to shape optimization problems of Bernoulli type are investigated. The evolution law is the sum of a curvature term and a nonlocal term of Hele-Shaw type. We introduce generalized set solutions, the definition of which is widely inspired by viscosity solutions. The main result is an inclusion preservation principle for generalized solutions. As a consequence, we obtain existence, uniqueness and stability of solutions. Asymptotic behavior for the flow is discussed: we prove that the solutions converge to a generalized Bernoulli exterior free boundary problem
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