Automated detection of merging galaxies at z = 0.25 − 1.0 in the CLAUDS+HSC survey using random forests

x, 190 leaves : colour illustrations ; 29 cmIncludes abstract and appendix.Includes bibliographical references (leaves 135-142).Using a sample of galaxies (M⋆ ≥ 1010.5M⊙) covering an effective area of ∼ 20 deg2 in the CLAUDS+HSC survey, we apply a Random Forest Classifier to automatically identify merger candidates in deep r-band images. We identify a largely pure, ∼ 90% complete sample of mergers which we use to derive the evolution in the merger fraction from 0.25 ≤ zphot ≤ 1.0. We parameterize the merger fraction evolution with a power law of the form fm = f0(1+z)m . Simulating the effects of increasing redshift on the detectability of mergers, we correct our merger fractions for incompleteness to obtain a local merger fraction of f0 = 1.0%±0.2% and power-law index of m = 2.3±0.4, which is inconsistent with the mild or non-evolving merger scenario (m < 1.5) with 96.6% confidence. Finally, we estimate 0.3 merging events to occur per massive galaxy since z = 1

Assessment on experimental bacterial biofilms and in clinical practice of the efficacy of sampling solutions for microbiological testing of endoscopes

International audienceOpinions differ on the value of microbiological testing of endoscopes, which varies according to the technique used. We compared the efficacy on bacterial biofilms of sampling solutions used for the surveillance of the contamination of endoscope channels. To compare efficacy, we used an experimental model of a 48-h Pseudomonas biofilm grown on endoscope internal tubing. Sampling of this experimental biofilm was performed with a Tween 80-lecithin-based solution, saline, and sterile water. We also performed a randomized prospective study during routine clinical practice in our hospital sampling randomly with two different solutions the endoscopes after reprocessing. Biofilm recovery expressed as a logarithmic ratio of bacteria recovered on bacteria initially present in biofilm was significantly more effective with the Tween 80-lecithin-based solution than with saline solution (P = 0.002) and sterile water (P = 0.002). There was no significant difference between saline and sterile water. In the randomized clinical study, the rates of endoscopes that were contaminated with the Tween 80-lecithin-based sampling solution and the saline were 8/25 and 1/25, respectively (P = 0.02), and the mean numbers of bacteria recovered were 281 and 19 CFU/100 ml (P = 0.001), respectively. In conclusion, the efficiency and therefore the value of the monitoring of endoscope reprocessing by microbiological cultures is dependent on the sampling solutions used. A sampling solution with a tensioactive action is more efficient than saline in detecting biofilm contamination of endoscopes

Monitoring Progress Toward Fulfilling Rights in Early Childhood Under the Convention on the Rights of the Child to Improve Outcomes for Children and Families

Can the United Nations Convention on the Rights of the Child (UN-CRC), to which 193 countries are signatory, be used as a tool to support developmental health in the early years? Improving early childhood development (ECD) requires finding ways for social determinants and child rights approaches to work together, which, to date, has not occurred. However, in 2005, the UN-CRC Monitoring Committee issued General Comment 7: Implementing Rights in Early Childhood (GC7) in response to the observation that children under the age of 8 were often overlooked in countries' reporting of progress toward implementing UN-CRC. This chapter shows how a commitment from the UN-CRC Monitoring Committee and key relevant international agencies (WHO, UNICEF) to a long-term program of monitoring compliance with GC7, in conjunction with monitoring of ECD developmental outcomes in all signatory countries, could help move global society toward equity in developmental health from the start of life. © Oxford University Press, 2014

Common climatic signal from glaciers in the European Alps over the last 50 years

Conventional glacier-wide mass balances are commonly used to study the effect of climate forcing on glacier melt. Unfortunately, the glacier-wide mass balances are also influenced by the glacier's dynamic response. Investigations on the effects of climate forcing on glaciers can be largely improved by analyzing point mass balances. Using a statistical model, we have found that 52% of the year-to-year deviations in the point mass balances of six glaciers distributed across the entire European Alps can be attributed to a common variability. Point mass balance changes reveal remarkable regional consistencies reaching 80% for glaciers less than 10 km apart. Compared to the steady state conditions of the 1962–1982 period, the surface mass balance changes are −0.85 m water equivalent (w.e.) a⁻¹ for 1983–2002 and −1.63 m w.e. a⁻¹ for 2003–2013. This indicates a clear and regionally consistent acceleration of mass loss over recent decades over the entire European Alps

Effect of Dietary Components on Larval Life History Characteristics in the Medfly (Ceratitis capitata: Diptera, Tephritidae)

Background: The ability to respond to heterogenous nutritional resources is an important factor in the adaptive radiation of insects such as the highly polyphagous Medfly. Here we examined the breadth of the Medfly’s capacity to respond to different developmental conditions, by experimentally altering diet components as a proxy for host quality and novelty. Methodology/Principal Findings: We tested responses of larval life history to diets containing protein and carbohydrate components found in and outside the natural host range of this species. A 40% reduction in the quantity of protein caused a significant increase in egg to adult mortality by 26.5%±6% in comparison to the standard baseline diet. Proteins and carbohydrates had differential effects on larval versus pupal development and survival. Addition of a novel protein source, casein (i.e. milk protein), to the diet increased larval mortality by 19.4%±3% and also lengthened the duration of larval development by 1.93±0.5 days in comparison to the standard diet. Alteration of dietary carbohydrate, by replacing the baseline starch with simple sugars, increased mortality specifically within the pupal stage (by 28.2%±8% and 26.2%±9% for glucose and maltose diets, respectively). Development in the presence of the novel carbohydrate lactose (milk sugar) was successful, though on this diet there was a decrease of 29.8±1.6 µg in mean pupal weight in comparison to pupae reared on the baseline diet. Conclusions: The results confirm that laboratory reared Medfly retain the ability to survive development through a wide range of fluctuations in the nutritional environment. We highlight new facets of the responses of different stages of holometabolous life histories to key dietary components. The results are relevant to colonisation scenarios and key to the biology of this highly invasive species

Genotyping concordance in DNA extracted from formalin‐fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135708/1/mol22015991868.pd

The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing

The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV solar telescope on board ESA's Project for Onboard Autonomy 2 (PROBA2) mission launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm and provides images of the low solar corona over a 54x54 arcmin field-of-view with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is designed to monitor all space-weather-relevant events and features in the low solar corona. Given the limited resources of the PROBA2 microsatellite, the SWAP telescope is designed with various innovative technologies, including an off-axis optical design and a CMOS-APS detector. This article provides reference documentation for users of the SWAP image data.Comment: 26 pages, 9 figures, 1 movi

Efficient Identification of Critical Residues Based Only on Protein Structure by Network Analysis

Despite the increasing number of published protein structures, and the fact that each protein's function relies on its three-dimensional structure, there is limited access to automatic programs used for the identification of critical residues from the protein structure, compared with those based on protein sequence. Here we present a new algorithm based on network analysis applied exclusively on protein structures to identify critical residues. Our results show that this method identifies critical residues for protein function with high reliability and improves automatic sequence-based approaches and previous network-based approaches. The reliability of the method depends on the conformational diversity screened for the protein of interest. We have designed a web site to give access to this software at http://bis.ifc.unam.mx/jamming/. In summary, a new method is presented that relates critical residues for protein function with the most traversed residues in networks derived from protein structures. A unique feature of the method is the inclusion of the conformational diversity of proteins in the prediction, thus reproducing a basic feature of the structure/function relationship of proteins

PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery

We have developed PVS (Protein Variability Server), a web-based tool that uses several variability metrics to compute the absolute site variability in multiple protein-sequence alignments (MSAs). The variability is then assigned to a user-selected reference sequence consisting of either the first sequence in the alignment or a consensus sequence. Subsequently, PVS performs tasks that are relevant for structure-function studies, such as plotting and visualizing the variability in a relevant 3D-structure. Neatly, PVS also implements some other tasks that are thought to facilitate the design of epitope discovery-driven vaccines against pathogens where sequence variability largely contributes to immune evasion. Thus, PVS can return the conserved fragments in the MSA—as defined by a user-provided variability threshold—and locate them in a relevant 3D-structure. Furthermore, PVS can return a variability-masked sequence, which can be directly submitted to the RANKPEP server for the prediction of conserved T-cell epitopes. PVS is freely available at: http://imed.med.ucm.es/PVS/