291 research outputs found
Observation of the Dependence of Scintillation from Nuclear Recoils in Liquid Argon on Drift Field
We have exposed a dual-phase Liquid Argon Time Projection Chamber (LAr-TPC)
to a low energy pulsed narrowband neutron beam, produced at the Notre Dame
Institute for Structure and Nuclear Astrophysics to study the scintillation
light yield of recoiling nuclei in a LAr-TPC. A liquid scintillation counter
was arranged to detect and identify neutrons scattered in the LAr-TPC target
and to select the energy of the recoiling nuclei.
We report the observation of a significant dependence on drift field of
liquid argon scintillation from nuclear recoils of 11 keV. This observation is
important because, to date, estimates of the sensitivity of noble liquid TPC
dark matter searches are based on the assumption that electric field has only a
small effect on the light yield from nuclear recoils.Comment: v3 updated to reflect published version, including a set of plots for
49.9 keV dat
The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal in the regulation of skeletal myogenesis. Using a mouse model of skeletal muscle regeneration after injury and several cellular strategies, we explored the potential use of obestatin as a therapeutic agent for the treatment of trauma-induced muscle injuries. Our results evidenced that the overexpression of the preproghrelin, and thus obestatin, and GPR39 in skeletal muscle increased regeneration after muscle injury. More importantly, the intramuscular injection of
obestatin significantly enhanced muscle regeneration by simulating satellite stem cell expansion as well as myofiber hypertrophy through a kinase hierarchy. Added to the myogenic action, the obestatin administration resulted in an increased expression of VEGF/VEGFR2 and the consequent microvascularization, with no effect on collagen deposition in skeletal muscle. Furthermore, the potential inhibition of myostatin during obestatin treatment might contribute to its myogenic action improving muscle growth and regeneration. Taken together, our data demonstrate successful improvement of muscle regeneration, indicating obestatin is a potential therapeutic agent for skeletal muscle injury and would
benefit other myopathies related to muscle regeneration
Measurement of Scintillation and Ionization Yield and Scintillation Pulse Shape from Nuclear Recoils in Liquid Argon
We have measured the scintillation and ionization yield of recoiling nuclei
in liquid argon as a function of applied electric field by exposing a
dual-phase liquid argon time projection chamber (LAr-TPC) to a low energy
pulsed narrow band neutron beam produced at the Notre Dame Institute for
Structure and Nuclear Astrophysics. Liquid scintillation counters were arranged
to detect and identify neutrons scattered in the TPC and to select the energy
of the recoiling nuclei. We report measurements of the scintillation yields for
nuclear recoils with energies from 10.3 to 57.3 keV and for median applied
electric fields from 0 to 970 V/cm. For the ionization yields, we report
measurements from 16.9 to 57.3 keV and for electric fields from 96.4 to 486
V/cm. We also report the observation of an anticorrelation between
scintillation and ionization from nuclear recoils, which is similar to the
anticorrelation between scintillation and ionization from electron recoils.
Assuming that the energy loss partitions into excitons and ion pairs from
Kr internal conversion electrons is comparable to that from Bi
conversion electrons, we obtained the numbers of excitons () and ion
pairs () and their ratio () produced by nuclear recoils from
16.9 to 57.3 keV. Motivated by arguments suggesting direction sensitivity in
LAr-TPC signals due to columnar recombination, a comparison of the light and
charge yield of recoils parallel and perpendicular to the applied electric
field is presented for the first time.Comment: v2 to reflect published versio
Measurement of the Two-Neutrino Double Beta Decay Half-life of Te with the CUORE-0 Experiment
We report on the measurement of the two-neutrino double beta decay half-life
of Te with the CUORE-0 detector. From an exposure of 33.4 kgy of
TeO, the half-life is determined to be = [8.2 0.2
(stat.) 0.6 (syst.)] 10y. This result is obtained after a
detailed reconstruction of the sources responsible for the CUORE-0 counting
rate, with a specific study of those contributing to the Te
neutrinoless double beta decay region of interest.Comment: Corrected typo in section 9: 3.43E5 Bq/kg should have read 3.43E-5
Bq/k
Analysis Techniques for the Evaluation of the Neutrinoless Double-Beta Decay Lifetime in Te with CUORE-0
We describe in detail the methods used to obtain the lower bound on the
lifetime of neutrinoless double-beta () decay in Te and
the associated limit on the effective Majorana mass of the neutrino using the
CUORE-0 detector. CUORE-0 is a bolometric detector array located at the
Laboratori Nazionali del Gran Sasso that was designed to validate the
background reduction techniques developed for CUORE, a next-generation
experiment scheduled to come online in 2016. CUORE-0 is also a competitive
decay search in its own right and functions as a platform to
further develop the analysis tools and procedures to be used in CUORE. These
include data collection, event selection and processing, as well as an
evaluation of signal efficiency. In particular, we describe the amplitude
evaluation, thermal gain stabilization, energy calibration methods, and the
analysis event selection used to create our final decay search
spectrum. We define our high level analysis procedures, with emphasis on the
new insights gained and challenges encountered. We outline in detail our
fitting methods near the hypothesized decay peak and catalog
the main sources of systematic uncertainty. Finally, we derive the
decay half-life limits previously reported for CUORE-0,
yr, and in combination with the Cuoricino
limit, yr.Comment: 18 pages, 18 figures. (Version 3 reflects only minor changes to the
text. Few additional details, no major content changes.
Depleted argon from underground sources
Abstract Argon is a powerful scintillator and an excellent medium for detection of ionization. Its high discrimination power against minimum ionization tracks, in favor of selection of nuclear recoils, makes it an attractive medium for direct detection of WIMP dark matter. However, cosmogenic 39 Ar contamination in atmospheric argon limits the size of liquid argon dark matter detectors due to pile-up. The cosmic ray shielding by the earth means that Argon from deep underground is depleted in 39 Ar. In Cortez Colorado a CO 2 well has been discovered to contain approximately 500ppm of argon as a contamination in the CO 2 . In order to produce argon for dark matter detectors we first concentrate the argon locally to 3-5% in an Ar, N 2 , and He mixture, from the CO 2 through chromatographic gas separation. The N 2 and He will be removed by continuous cryogenic distillation in the Cryogenic Distillation Column recently built at Fermilab. In this talk we will discuss the entire extraction and purification process; with emphasis on the recent commissioning and initial performance of the cryogenic distillation column purification
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Search for Solar Axions Produced in Reaction with Borexino Detector
A search for 5.5-MeV solar axions produced in the reaction was performed using the Borexino detector. The Compton
conversion of axions to photons, ; the
axio-electric effect, ; the decay of axions into
two photons, ; and inverse Primakoff conversion on
nuclei, , are considered. Model independent
limits on axion-electron (), axion-photon (), and
isovector axion-nucleon () couplings are obtained: and at 1 MeV (90% c.l.). These limits are
2-4 orders of magnitude stronger than those obtained in previous
laboratory-based experiments using nuclear reactors and accelerators.Comment: 11 pages, 7 figures, submitted to Phys.Rev.
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Measurement of geo-neutrinos from 1353 days of Borexino
We present a measurement of the geo--neutrino signal obtained from 1353 days
of data with the Borexino detector at Laboratori Nazionali del Gran Sasso in
Italy. With a fiducial exposure of (3.69 0.16) proton
year after all selection cuts and background subtraction, we detected
(14.3 4.4) geo-neutrino events assuming a fixed chondritic mass Th/U
ratio of 3.9. This corresponds to a geo-neutrino signal = (38.8
12.0) TNU with just a 6 probability for a null geo-neutrino
measurement. With U and Th left as free parameters in the fit, the relative
signals are = (10.6 12.7) TNU and =
(26.5 19.5) TNU. Borexino data alone are compatible with a mantle
geo--neutrino signal of (15.4 12.3) TNU, while a combined analysis with
the KamLAND data allows to extract a mantle signal of (14.1 8.1) TNU. Our
measurement of a reactor anti--neutrino signal =
84.5 TNU is in agreement with expectations in the presence of
neutrino oscillations.Comment: 9 pages, 6 figure
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Solar neutrino with Borexino: results and perspectives
Borexino is a unique detector able to perform measurement of solar neutrinos
fluxes in the energy region around 1 MeV or below due to its low level of
radioactive background. It was constructed at the LNGS underground laboratory
with a goal of solar Be neutrino flux measurement with 5\% precision. The
goal has been successfully achieved marking the end of the first stage of the
experiment. A number of other important measurements of solar neutrino fluxes
have been performed during the first stage. Recently the collaboration
conducted successful liquid scintillator repurification campaign aiming to
reduce main contaminants in the sub-MeV energy range. With the new levels of
radiopurity Borexino can improve existing and challenge a number of new
measurements including: improvement of the results on the Solar and terrestrial
neutrino fluxes measurements; measurement of pp and CNO solar neutrino fluxes;
search for non-standard interactions of neutrino; study of the neutrino
oscillations on the short baseline with an artificial neutrino source (search
for sterile neutrino) in context of SOX project.Comment: 15 pages, 4 figure
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