13 research outputs found
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inková Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga María José Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-Lévi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- Bjørgo Kathrine
- Bjørnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
- Bonelli Raphael
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borowsky B.
- Bos Reineke
- Bos Reineke
- Bosca Maria E.
- Bosredon Cecile
- Bost Marie
- Boukbiza Ouhaid Lagha
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bürk Katrin
- C Jan Frich
- Caldentey Juan Garcia
- Callaghan J.
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Campbell C.
- Campbell C.
- Campbell M.
- Campos Anabel
- Capellari Sabina
- Capetian Philipp
- Carette Maryline Cabaret Anne-Sophie
- Carrillo Fátima
- Carruesco Gemma Tome
- Cash D. M.
- Castaldo Anna
- Catena Judit López
- Chu Carol
- Chu Carol
- Chu Carol
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman A.
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Hermoso Eva Pacheco
- Cortelli Pietro
- Coulthard Elizabeth
- Courtin Françoise
- Craufurd D.
- Craufurd David
- Crawford H.
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- Cáceres María Teresa
- D'Alessio Barbara
- da Silva Wildson Vieira
- Damas Fatima
- Davies Rhys
- De Bruycker Christelle
- De Michele Giuseppe
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- de Yébenes Justo García
- de Yébenes Justo García
- Debruxelles Sabrina
- Dec Malgorzata
- Decolongon J.
- Defebvre Eric Decorte Luc
- Dekker M.
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Descals Asunción Martínez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Maio Luigi
- Di Pietro Anna
- di Poggio Monica Bandettini
- Di Renzo Martina
- Diercks Gabriele
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas E. M.
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen
- Dupuit Michel
- Durr Alexandra
- Duru Cécile
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madeleine
- Fasquel Véronique
- Favellato Mariagrazia
- Fenollar María
- Ferrandes Giovanna
- Ferreira Joaquim
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fox N. C.
- Foy Kevin
- Frajman E.
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frontali Marina
- Frost C.
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Gago Miguel
- Galassi Roberto
- Gallantrae Deena
- Gallentrae Deena
- Ganos Christos
- Garcia Patrocinio Moreno
- García Rocío García-Ramos
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Gerrans Emily
- Gethin Louise
- Ghelli Elena
- Gibbard C.
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Godefroy Olivier
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gonzenbach Roman
- González González Sonia
- Goodman Anna
- Gorospe Aranzazú
- Gorzkowska Agnieszka
- Gorzolla Heike
- Grant Janet
- Griguoli Annamaria
- Gross Diana
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guerra Maria Rosália
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Gustafsson Lena
- Guzman Natalie Valle
- Guérid Marie-Anne
- Gørvell Per F.
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia
- Handley Olivia
- Handley Olivia J.
- Harding Alison
- Hare Marianne
- Harrison David
- Hauer Maria
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Moss Davina J.
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Durán
- Herrmann Lennard
- Hicks S.
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Ho Carrie
- Hobbs N.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hotter Anna
- Howard Liz
- Hughes Max
- Hughes Teresa
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago Jesús Miguel Ruiz
- Illmann Torsten
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Jasinska-Myga Barbara
- Johns Nicola
- Johnson H.
- Johnson Liz
- Jones Lesley
- Jones Lesley
- Jones Mary
- Jones R.
- Jones Una
- Julié Celine
- Jung Hans H.
- Jurgens C.
- Justo D.
- Kaelin Alain
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Keenan S.
- Kennard C.
- Kershaw Ann
- Kesse Andrea
- Khalil Hanan
- Klempír Jirí
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klöppel Stefan
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kotz Peter
- Kraus Alison
- Kraus Alison
- Kraus Alison
- Kraus P.
- Krawczyk Malgorzata
- Kremer B.
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Labuschagne I.
- Lafoucrière Danielle
- Lahiri N.
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer B.
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lang Christina
- Langbehn Douglas
- Lange Herwig
- Lange Herwig
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- Laurà Matilde
- Laver Fiona
- Leavitt Blair R.
- Lee S.
- Leenders K. L.
- Lehericy S.
- Lemaire Marie-Hélène
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewis Monica
- Lewis Monica
- Leythäuser Gabriele
- Lezius Franziska
- Liessens Dirk
- Lilek Sabine
- Linnsand Petra
- Lo Kitty
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Mónica Rodriguez
- Lorentzen Eirin
- Loutfi Ghada
- Lucena Carolina Mendez
- Löhle Matthias
- Maass Antonia
- Magnet Markus
- Maiwald Robert
- Majerová Veronika
- Malone I.
- Man A. Hoff
- Mandich Paola
- Manouvrier Sylvie
- Mantaux Béatrice
- Manzanares Salvadora
- Marchese Roberta
- Marcinkowski Jerzy
- Marelli C.
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Horta Saül
- Martinez-Jaurrieta Maria Dolores
- Martín Esther Suaréz San
- Martínez-Descals Asunción
- Mason Sarah
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- Mazzante Irene
- McGill Marie
- McKenzie Sue
- Mead Simon
- Mechi Claudia
- Mendes Tiago
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milchman C.
- Milkereit Eva
- Minet Cécile
- Minster Sara
- Minster Sara
- Mir Pablo
- Monaco W.
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Jose Manuel Garcia
- Moreno José Luis López-Sendón
- Mundler Laura
- Murch Ann
- Murphy Helen
- Musgrave Hannah
- Möller Jens Carsten
- Mühlau Mark
- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Mütze Lisanne
- Nanetti Lorenzo
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen Jørgen
- Nielsen Jørgen E.
- Niess Anke
- Nigaud K.
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Regan A.
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Ordidge R.
- Ortega Paloma
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Owen G.
- Owen Michael
- Padieu Hélène
- Paganini Marco
- Painold Annamaria
- Pardiñas Antonio F.
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel A.
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Pepple T.
- Perea María Fuensanta Noguera
- Peter Mireille
- Petersen Jens
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Pica Emmanul
- Piedad John
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pourchot C.
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Probst Daniela
- Prundean Adriana
- Prüß Harald
- Päivärinta Markku
- Quarrell Oliver
- Queller S.
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria A.
- Ramos-Arroyo Maria A.
- Raymond Lucy
- Read J.
- Redondo Luis
- Reetz Kathrin
- REGISTRY investigators
- Reilmann R.
- Reilmann Ralf
- Reinante Gema
- Reisinger Karin
- Ret C. Jauff
- Retterstøl Lars
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo García
- Ribaï Pascale
- Ribbat Michael
- Richter Przemyslaw
- Rickards Hugh
- Rissling Ida
- Rivadeneyra Perez Jessica
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Rodríguez María José Torres
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos Raymund
- Roos Raymund A. C.
- Roos Raymund A. C.
- Rosas H. D.
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ruíz Pedro J. García
- Ryglewicz Danuta
- Røren Niini
- Sablonnière Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santhouse Alastair
- Santos R. Dar
- Sass Christian
- Say M.
- Scaglione Cesa
- Scahill R.
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián A. Rojo
- Sebastián Ana Rojo
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila A.
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Stattin Eva-Lena
- Stebler Yanik
- Stepniak Iwona
- Stokke Bodil
- Stompel Daniel
- Stopford C.
- Stopford Cheryl
- Storch Alexander
- Stout J.
- Stubbe Lars
- Sturrock A.
- Stárková Irena
- Städtler Michael
- Suarez María José Lama
- Sulek Anna
- Summers Fiona
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Sánchez Vicenta
- Süßmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres María Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- Valabrègue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-González Laura
- Vaughan Vivien
- Ventura Marta Fatás
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen Peiró
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
Dopamine Transporter, Depression and Anxiety Differences Between Tremor-Predominant and Non-Tremulous PD are Already Evident Within 2 Years of PD Diagnosis
- Publication venue
- PDXScholar
- Publication date
- 20/06/2016
- Field of study
Objective: PD patients can be partitioned into two groups, denoted Tremor Dominant (PD-TD) and non-tremor-dominant (PD-NTD) based on their MDS-UPDRS III subscores. Is this distinction correlated with the outcomes of cognitive tests, biomarkers, and dopaminergic imaging within 2 years of the PD diagnosis?
Background: The classification of Parkinson’s disease (PD) patients into tremor-dominant (PD-TD) and non-tremor-dominant (PD-NTD) is commonly used clinically. The distinction is based on the relative difficulty the patient has with tremor vs akinetic or rigid aspects of PD, as reflected in scores on specific questions in the MDS-UPDRS III. The Parkinson’s Progression Markers Initiative (PPMI) cohort is a large observational clinical study aimed at verifying progression markers of Parkinson’s disease. This cohort provides us with the data for answering this question. Indeed, it contains 400 patients with a diagnosis of PD within 2 years of the baseline visit and an exhaustive collection of assessments.
Methods: We have studied a comprehensive collection of PPMI measurements, including neurological and psychological tests, biofluid-based biomarkers, and dopamine transporter Imaging acquired at the baseline visit. In each case, we conducted a Wilcoxon test for the difference of the median within the two groups PD-TD and PD-NTD and corrected for multiple testing.
Results: PD-NTD patients were clinically more severe in regards to their motor and non-motor symptoms of PD, as measured with the MDS-UPDRS I and II, as well as more likely to have depression and anxiety symptomatology. In addition, there were very significant dopamine transporter imaging (DaTscan) differences between the PD subtypes: PD-TD patients had less of a reduction in uptake in the striatum, caudate, and putamen compared to PD-NTD.
Conclusions: The distinction between PD-TD and PD-NTD is well established using neurological exams. However, we have shown that the depression, anxiety and DaTscan measurements are also significantly different between these 2 groups at the earliest stages of the disease
A computational neurodegenerative disease progression score: Method and results with the Alzheimer's disease neuroimaging initiative cohort
- Author
- Andrew Lang
- Ashford
- Bennett
- Berg
- Bo Liu
- Bradley T. Wyman
- Brian Caffo
- Brooks
- Brooks
- Bruno M. Jedynak
- C. Pierre Jedynak
- Caroli
- Carroll
- David Raunig
- Duara
- Dubois
- Elyse Katz
- Folstein
- Fonteijn
- Hampel
- Hardle
- Hayden
- Hinrichs
- Hughes
- Jack
- Jack
- Jerry L. Prince
- Jicha
- Labbe
- Levenberg
- Martin
- Mitnitski
- Mosconi
- Mungas
- Qiu
- Richards
- Rizk-Jackson
- Sabuncu
- Shaw
- Sperling
- Stern
- Turner
- Turner
- Ververidis
- Walhovd
- Yang
- Yang
- Yanwei Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- 't Hart Ep
- Aanonsen No
- Aaserud O
- Acera Gil Ma
- Akhtar S
- Allain P
- Almagro Ca
- Almeida M
- Alonso Frech F
- Andrew A
- Andrews T
- Anjum U
- Anna Bryl Ja
- Antczak J
- Antequera Torres Mm
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud Lévi Ac
- Bachoud Lévi Ac
- Badei F
- Banaszkiewicz K
- Bandmann O
- Barbera Ma
- Barnett L
- Barral Vm
- Barth K
- Barth K
- Bartoli C
- Bas J
- Bascuñana M
- Bechtel N
- Beckmann H
- Bek J
- Bentivoglio Ar
- Berglund P
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- Bertrand M
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- Betz S
- Biunno I
- Bjørgo K
- Boczarska Jedynak M
- Boelmans K
- Bohlen S
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- Bojarsky Jk
- Bonelli Rm
- Borgerød N
- Bos R
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- Bosca M
- Boudali L
- Bourdet C
- Boćwińska D
- Bradbury A
- Brockie P
- Brown S
- Brugada Carmen Peiró Vilaplana Fc
- Bruno S
- Buck A
- Burguera Ja
- Burgunder Jm
- Burgunder Jm
- Busquets N
- Busse M
- Butcher C
- Bárcenas Ah
- Błaszczyk M
- Calado A
- Caldentey Jg
- Caldentey Jg
- Caldentey Jg
- Callaghan J
- Callaghan J
- Callaghan J
- Calopa M
- Calvas F
- Calzado N
- Campolongo A
- Cannella M
- Capodarca S
- Carruesco Gt
- Cass G
- Catena Jl
- Chabot C
- Charpentier S
- Cheriet S
- Chu E
- Ciach Wysocka E
- Ciesielska A
- Classen Sj
- Clayton C
- Clenaghan C
- Cléret L
- Coarelli G
- Codella V
- Coebergh J
- Coelho M
- Come A
- Connemann J
- Constantinescu R
- Cormio C
- Corrales Kb
- Cortegana Ep
- Cosgrove J
- Couette M
- Coulthard E
- Craufurd D
- Crooks J
- Cubillo Pt
- Cubillo Pt
- Cubo E
- Curtis A
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- Davison J
- De Gregorio F
- De Michele G
- De Nicola A
- de Souza J
- de Tommaso M
- Debruxelles S
- Dec M
- Dedichá Nr
- Delfini M
- Dellomonaco Ar
- Descals Am
- Di Maio L
- Di Renzo M
- Diago Eb
- Dias M
- Diercks G
- Difruscolo O
- Dipple H
- Dixon K
- Doherty K
- Donovan Jo
- Dose M
- Downie L
- Dramstad E
- Dressler D
- Duché C
- Dumas Em
- Dunnett S
- Dunnett Sb
- Dziadkiewicz A
- Ecker D
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- Eddy C
- Edwards R
- Eklund P
- Elifani F
- Ellrichmann G
- Esposito C
- Eusebio A
- Fairtlough H
- Fannemel M
- Feliz Cf
- Fenollar Mdel M
- Fernandez de Bobadilla R
- Fernandez Jdel V
- Fernandez Cm
- Ferraldeschi M
- Ferreira Jj
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- FIGORILLI MICHELA
- Fillingham K
- Finisterra Am
- Finisterra Am
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- Foustanos I
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- Fuller K
- Fullerton N
- Gallantree D
- Ganos C
- García de Yébenes J
- García Moreno Jm
- García Ramos García R
- García A
- Garde Mb
- Garreau C
- Gaston I
- Gayde Stephan S
- Geitner C
- Genoves C
- Gethin L
- Ghelli E
- Ghenam A
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- Gilling M
- Ginestroni A
- Goerendt I
- Gogol A
- Gohier B
- Goizet C
- Golding C
- Gomez Esteban Jc
- González A
- González S
- Gorospe A
- Gorzkowska A
- Gorzolla H
- Gowers L
- Grabska N
- Grosjean H
- Guedes Lc
- Guedes Lc
- Guia Db
- Guisasola Lm
- Gundersen H
- Guérid Ma
- Göpfert N
- Gørvell P
- Haggag K
- Haider S
- Hallam C
- Hamer S
- Handley Oj
- Handley Oj
- Hare M
- Harrison D
- Hayward B
- Heiberg A
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- Heinicke W
- Held C
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- Hensman D
- Hermoso Fd
- Hernanz Lc
- Herrera Cd
- Herrmann L
- Hidding U
- Hiivola H
- Hjermind L
- Hobson E
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- Illmann T
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- José Sainz Artiga M
- Júlio F
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- Klimberg A
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- Konkel A
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- Lafoucrière D
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- Mestre T
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- Townhill J
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- VACCA MELISA IRIS SABINA
- Valadas A
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- van Hout Ms
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- van Walsem M
- van Walsem Mr
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- Zielonka D
- Zielonka D
- Zielonka E
- Zinzi P
- Zinzi P
- Ziora Jakutowicz K
- Zittel S
- Šašinková P
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen No
- Aaserud O
- Abbruzzese G
- Acera Gil Ma
- Ackermann O
- Adarmes A
- Agarwal V
- Agosti C
- Akhtar S
- Alaerts N
- Alarcón Md
- Albanese A
- Allain P
- Almagro Ca
- Almeida M
- Alonso-Frech F
- Alusi S
- Anderson M
- Andersson C
- Andrade C
- Andrew A
- Andrews T
- Andrews T
- Andrich J
- Anheim M
- Anjum U
- Anna Bryl Ja
- Annic A
- Antczak J
- Antequera Torres Mm
- Antonova V
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Armstrong R
- Arntsen V
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud-Lévi Ac
- Bachoud-Lévi Ac
- Badei F
- Bailey W
- Banaszkiewicz K
- Bandettini di Poggio M
- Bandmann O
- Barbera Ma
- Barker Ra
- Barlati S
- Barral Vm
- Barrero F
- Barrett W
- Barth K
- Barth K
- Barthélémy R
- Bartoli C
- Barun N
- Bas J
- Bascuñana M
- Becanovic K
- Bechtel N
- Beckmann H
- Bek J
- Bellonet M
- Benaich S
- Benaminov S
- Benito Dm
- Bentivoglio Ar
- Bentivoglio Ar
- Berglund M
- Berglund M
- Berglund P
- Bergmann U
- Bernal-Escudero M
- Bernard T
- Bertini E
- Bethwaite P
- Betz S
- Beuth M
- Bezdíček O
- Bijlsma Emilia K
- Bioux S
- Biunno I
- Björnsson E
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- Bjørnevoll I
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- Bliaux E
- Blin S
- Blinkenberg Eø
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- Boelmans K
- Bohlen S
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- Buratti L
- Burguera Ja
- Burgunder Jm
- Burgunder Jm
- Burgunder Jm
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- Burrows L
- Busquets N
- Busse M
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- Böringer R
- Bürk K
- Błaszczyk M
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- Calvas F
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- Campolongo A
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- Carruesco Gt
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- Castagliuolo S
- Castaldo A
- Catalli C
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- Coarelli G
- Codella V
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- Coelho M
- Coleman C
- Come A
- Compostella S
- Connemann J
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- Cormio C
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- Cosgrove J
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- Craufurd D
- Craven J
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- Crooks J
- Cubillo Pt
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- Dipple H
- Dixon K
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- Dunnett S
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- Ecker D
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- Eddy C
- Edwards M
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- El-Nimr G
- Elifani F
- Ellrichmann G
- Esmaeilzadeh M
- Esposito C
- Esposito F
- Eusebio A
- Evans C
- Ewenczyk C
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- Fannemel M
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- Figorilli M
- Figuerola Bj
- Fillingham K
- Finisterra Am
- Fisher K
- Flamez A
- Fletcher A
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- Fortuna L
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- Foustanos I
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- Frontali M
- Frontali M
- Frost J
- Fullam R
- Fullam R
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- Gago M
- Gallantree D
- Gallassi R
- Gallentree D
- Ganos C
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- Garcia-Amigot F
- García de Yébenes J
- García Moreno Jm
- García Ruíz Pj
- García A
- García-Ramos García R
- Garde Mb
- Garrett C
- Gaston I
- Gayde-Stephan S
- Geitner C
- Gelderblom H
- Gellera C
- Genitrini S
- Genoves C
- Germain V
- Gerrans E
- Gerrtiz Nee Di Pietro A
- Gethin L
- Ghelli E
- Gill P
- Gillardin Af
- Gilling M
- Ginestroni A
- Girard C
- Giuliano J
- Goerendt I
- Gogol Formerly Kalbarczyk A
- Gohier B
- Goizet C
- Golding C
- Golding C
- Gomez Esteban Jc
- González A
- González S
- Gonçalves A
- Good Jm
- Goodman A
- Gorzkowska A
- Gorzolla H
- Gosling Nee Brown S
- Goudie D
- Gowers L
- Grabska N
- Guedes Lc
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- Guenam A
- Guia Db
- Guidubaldi A
- Guimarães J
- Guisasola Lm
- Gunner K
- Guyant-Maréchal L
- Guzman Nv
- Guérid Ma
- Göller Ml
- Göpfert N
- Gørvell Pf
- Haggag K
- Haider S
- Haig-Brown D
- Haig-Brown D
- Hallam C
- Hamer S
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- Hametner Em
- Handley Oj
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- Hannequin D
- Hannier V
- Harding A
- Hare M
- Hare M
- Harris K
- Harrison D
- Harrison K
- Harrower T
- Harrower T
- Hartikainen P
- Haug Mg
- Hauge E
- Hayward B
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- Hecht K
- Heiberg A
- Heiberg A
- Heinicke W
- Held C
- Held C
- Hensman D
- Hepperger C
- Hermoso Fd
- Hernanz Lc
- Herranhof B
- Herrera Cd
- Herrmann L
- Heywood M
- Hidding U
- Hiivola H
- Hill S
- Hjermind L
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- Horta A
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- Hotter A
- Howard L
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- Januário C
- Jaramillo Ja
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30\u201350 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of 6435 or a UHDRS motor score of 645 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, 120.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients
ALICE Technical Design Report on Forward Detectors : FMD, T0 and V0
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- Abrahantes Quintana A.
- Adamova D.
- Adler C.
- Aggarwal M.M.
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- Publication venue
- HAL CCSD
- Publication date
- 01/01/2005
- Field of study
ALICE PHASE EI SEP ACC S2
ALICE Technical Design Report of the Computing
- Author
- Abrahantes Quintana A.
- Adamova D.
- Adler C.
- Aggarwal M.M.
- Ahammed Z.
- Ahmad N.
- Ahmad S.
- Ahmad T.
- Aiftimiei C.
- Akichine P.G.
- Akindinov A.N.
- Aleksandrov D.
- Alessandro B.
- Alfaro Molina J.R.
- Alici A.
- Alme J.
- Andronic A.
- Anelli G.
- Anfreville M.
- Angelov V.
- Anticic T.
- Antinori F.
- Antinori S.
- Antonczyk D.
- Antonenko V.
- Antonioli P.
- Aphecetche Laurent
- Arcelli S.
- Areev V.A.
- Arnaldi R.
- Atanassov I.
- Atayan M.
- Augustin I.
- Augustinus A.
- Awes T.
- Ayala A.
- Aysto J.
- Baatar Ts.
- Bablok S.
- Badala A.
- Badura E.
- Badyal S.K.
- Baechler J.
- Bailhache R.
- Baldisseri A.
- Baldit A.
- Ban J.
- Barbera R.
- Barbet J.M.
- Bari G.
- Bari W.
- Barret V.
- Bartke J.
- Basciu S.
- Basile M.
- Basmanov V.
- Bastid N.
- Batigne Guillaume
- Batiounia B.V.
- Baudot J.
- Baumann Cédric
- Bearden I.
- Becker Bern,
- Beitlerova A.
- Beliaev S.
- Belikov J.A.
- Bellagamba L.
- Belmont Moreno E.
- Belogianni A.
- Beole S.
- Berdermann E.
- Berdnikov Ya.
- Berger J.
- Betev L.
- Bhardwaj S.
- Bhasin A.
- Bhaskar P.
- Bhati A.K.
- Bhattacharya P.
- Bielcikova J.
- Billmeier A.
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- Blank T.
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- Karavichev O.V.
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- Karpechev E.V.
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- Kataria V.
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- Kaurova L.
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- Khaoustov G.V.
- Kharadze G.
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- Khlebnikov A.
- Khurelbaatar B.
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- Lebedev V.
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- Lehmann Th.
- Leistam L.
- Lenti V.
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- Li Q.
- Li Xiaojian
- Lietava R.
- Linares M.
- Lindenstruth V.
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- Zhitnik A.
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- Zinovjev G.
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2005
- Field of study
ALICE, EI PHASE SE
Suicidal ideation in a European Huntington's disease population.
- Author
- 't Hart Ellen P
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- Albanese Alberto
- Alberti Silvia
- Alegre Javier
- Allain Philippe
- Alonso-Frech Fernando
- Amico Enrico
- Ammendola Sarah
- Andrade Carlos
- Andrews Thomasin
- Andrich Jürgen
- Antczak Jakub
- Armstrong Richard
- Arques Penelope Navas
- Arran Natalie
- Artiga María José Saiz
- Avarvarei Luminita Dinca
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-Lévi A-C
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A
- Barrero Francisco
- Barth Katrin
- Bas Jordi
- Bascuñana Mónica
- Bastida Antonio Martín
- Bek Judith
- Bellonet Marcellin
- Bentivoglio A R
- Bentivoglio Anna Rita
- Bernhard Landwehrmeyer G
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Bisson Jonathan
- Biunno I
- Bjørgo Kathrine
- Blaszcyk Magdalena
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J J W
- Bonelli R M
- Bonelli Raphael M
- Boogaerts Andrea
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Casterá
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder J-M
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Bürk Kathrin
- Cabaret Maryline
- Caldentey Juan Garcia
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Capellari Sabina
- Capetian Philipp
- Carette Anne-Sophie
- Carrillo Fátima
- Carruesco Gemma Tome
- Casado Ana González
- Catalli Claudio
- Catena Judit López
- Cavaco Sara
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia-Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Courtin Françoise
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- Càrdenas Regina Ponsi
- Cáceres María Teresa
- da Silva Wildson Vieira
- Damásio Joana
- Davidson Jill
- De Bruycker Christelle
- De Michele Giuseppe
- de Raedt Sylvie
- Debruxelles Sabrina
- Dec Małgorzata
- Decorte Eric
- Defebvre Luc
- Dekker M
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Descals Asunción Martínez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Pardo Alba
- Di Pietro Anna
- di Poggio Monica Bandettini
- Diercks Gabriele
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas Eve M
- Dunnett S B
- Dunnett Stephen
- Duru Cécile
- Dziadkiewicz Artur
- Démonet Jean-François
- Díez-AjaLópez Cristóbal
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Elorza Marina Dalmau
- Eschenbach Carolin
- Esmaeilzadeh Mona
- Eusebio Alexandre
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel Véronique
- Fenollar María
- Ferrandes Giovanna
- Ferreira J J
- Ferreira Joaquim J
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Fluchère Frédér- ique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frontali Marina
- Fullam Ruth
- Gago Miguel
- Gallantrae Deena
- Gallassi Roberto
- Ganos Christos
- Garcia Anabel Campos
- Garcia Patrocinio Moreno
- García Ruíz Pedro J
- García Rocío García-Ramos
- García Socorro Soriano
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Ghelli Elena
- Gill Paul
- Giltay Erik J
- Ginestroni Andrea
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- González Mónica
- González Sonia González
- Gorospe Aranzazú
- Gorzkowska Agnieszka
- Gorzolla Heike
- Griguoli Annamaria
- Guerra Maria Rosália
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Guzman [Unknown]
- Guérid Marie-Anne
- Göller Marie-Louise
- Gørvell Per
- Haider Salman
- Hamer Stephanie
- Hametner Eva-Maria
- Handley O J
- Handley Olivia
- Harding Alison
- Hare Marianne
- Harrison David
- Hartikainen Päivi
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg A
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Durán
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Horta Saul Martinez
- Hotter Anna
- Howard Liz
- Hubers Anna A M
- Hughes Alis
- Hughes Max
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Höglund Arja
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago Jesús Miguel Ruiz
- ielewska Anna Was
- Ignatius Jaakko
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Januário Cristina
- Jaremek Kamila Bojakowska
- Jasinska-Myga Barbara
- Johansson Anders
- Johns Nicola
- Johnson Liz
- Johnstone Catherine
- Jones Lesley
- Jones Mary
- Jones Una
- Júlio Filipa
- Kaelin Alain
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Khalil Hanan
- Klempíř Jiří
- Klimberg Aneta
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kraus Alison
- Krawczyk Malgorzata
- Kremer H P H
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Kärppä Mikko
- Kłodowska-Duda Gabriela
- Ladurner Gunther
- Lafoucrière Danielle
- Lahiri Nayana
- Laing Hana
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G B
- Lange Herwig
- Lashwood Alison
- Laurà Matilde
- Laver Fiona
- Leenders K L
- Legarda Inés
- Lemaire Marie-Hélène
- Levey J
- Lewerenz Jan
- Lewis Monica
- Leythaeuser Gabriele
- Lezius Franziska
- lhagen Sven E P
- Lilek Sabine
- Lilek Stefan
- Lima Joana
- Llesoy Joan Roig
- llmann T I
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lorentzen Eirin
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- López-Sendón Moreno José Luis
- Maass Antonia
- Magalhães Marina
- Maglione Vittorio
- Magnet Markus
- Majerová Veronika
- Mandich Paola
- Manouvrier Sylvie
- Mantaux Béatrice
- Manuel Jose
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Martirio María
- Martínez Isabel Haro
- Martínez Laura Martinez
- Martínez-Descals Asunción
- Mason Sarah
- Massano João
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- McGill Marie
- McKenzie Sue
- Mechi Claudia
- Meireles Joana
- Mendes Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Milkereit Eva
- Miller Joanne
- Minster Sara
- Mir Pablo
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Garcia
- Morez V
- Morgan Karen
- Mundler Laura
- Murphy Helen
- Musgrave Hannah
- Mustonen Aki
- Möller Jens Carsten
- Mühlau Mark
- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Mütze Lisanne
- Nanetti Lorenzo
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nielsen J E
- Nielsen Mette Gilling
- Niess Anke
- Noguera Perea María Fuensanta
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Orth Michael
- Otti Daniela
- Oughton Emma
- Overland Torborg
- Owen Michael
- Padieu Helene
- Paganini Marco
- Painold Annamaria
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Pearson Pauline
- Peinemann Alexander
- Peppa Nadia
- Perez Maria Rabasa
- Peter Mireille
- Peterson Maria
- Petersén Asa
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Porteous Mary
- Pradella Silvia
- Price Kathleen
- Priller Josef
- Probst Daniela
- ProKoivisto S
- Prundean Adriana
- Prüß Harald
- Päivärinta M
- Pålhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Quiroga Purificacion Pin
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramos-Arroyo Maria A
- Recio Maria Fernández
- Reetz Kathrin
- Reilmann Ralf
- Reimer Jan
- Reinante Gema
- Reisinger Karin
- Retterstøl Lars
- Reza- Soltani Tina Walldén
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo García
- Richter Przemyslaw
- Rickards Hugh
- Rinaldi Carlo
- Rissling Ida
- Ritchie Stuart
- Rivera Susana Vázquez
- Riza-Soltani Tina Waldèn
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Roedig Verena
- Rogers Dawn
- Rojo Sebastián A
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos R A C
- Roos Raymund A C
- Rose Linda Ellison
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Rossi Fabiana
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzińska Monika
- Russo Cinzia Valeria
- Ruíz Belén Garzón
- Ryglewicz Danuta
- Røren Niini
- Sablonnière Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- San Martín Esther Suaréz
- Sando Botne
- Sandström Britta
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Scherer- Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenk Daniela
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián Ana Rojo
- Seliverstov Yury
- Sempołowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila
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- Zimmermann Marie- Agathe
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Åman Jaana
- Økland Ellen
- Šašinková Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2013
- Field of study
Optimization of adsorptive removal of α-toluic acid by CaO2 nanoparticles using response surface methodology
- Author
- 't Hart Ellen P.
- Aaserud Olaf
- Abbruzzese Giovanni
- Aguilar Barbera Miquel
- Albanese Alberto
- Allain Philippe
- Alonso-Frech Fernando
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Antczak Jakub
- Antequera Torres María Martirio
- Arran Natalie
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-Lévi A. C.
- Badenes Guia Dolors
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barker Roger A.
- Barnes Kathy
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Bas Jordi
- Bascuñana Garde Mónica
- Bascuñana Garde Mónica
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- Bate Louise
- Bechtel Natalie
- Beckmann Heike
- Beister Antonie
- Bellonet Marcellin
- Bentivoglio A. R.
- Bentivoglio Anna Rita
- Bertini Elisabetta
- Bisson Jonathan
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- Blinkenberg Ellen Økland
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J. J. W.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
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- Bryl Anna
- Buck Andrea
- Buongiorno Maria Teresa
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- Burguera Juan Andrés
- Burgunder J. M.
- Burgunder Jean-Marc
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- Busse Monica
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- Callaghan Jenny
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- Cannella Milena
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- Codella Valentina
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- Coleman Caroline
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- Constantinescu Radu
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- Correia Guedes Leonor
- Correia Guedes Leonor
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- Curtis Adrienne
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- Dalmau Elorza Marina
- Damásio Joana
- de Bruycker Christelle
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- de Michele Giuseppe
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- de Weert A. Marit
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- Decorte Eric
- Dekker M.
- Delliaux Marie
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- di Bella Daniela
- di Donato Stefano
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- di Maio Luigi
- di Maria Emilio
- di Pietro Anna
- Diercks Gabriele
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- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dujardin Kathy
- Dumas Eve M.
- Dunnett S. B.
- Dunnett Stephen B.
- Duru Cécile
- Durán Herrera Carmen
- Durán-Sindreu Terol Santiago
- Démonet Jean-Francois
- Díez-Aja López Cristóbal
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Ellison-Rose Lynda
- Eschenbach Carolin
- Esmaeilzadeh Mona
- European Huntington's Disease Network
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madelein
- Fasano Alfonso
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- Fenollar María
- Fernández Recio Maria
- Ferrandes Giovanna
- Ferreira J. J.
- Ferreira Joaquim J.
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- Handley Olivia J.
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- Handley Olivia J.
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- Illmann T.
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- Lange Herwig
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- Schepers Sigrun
- Scherer-Gagou Clarisse* Gagou, Clarisse Scherer-
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenke C.
- Schwenke Carsten
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián A. R.
- Selimbegovic-Turkovic Amina
- Sempolowicz Justyna
- Senkárová Zuzana
- Seppi Klaus
- Serpino Claudia
- Sieradzan Kasia
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- Simpson Sheila
- Sinadinosa Daniela
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- Snowden Julie
- Soleti Francesco
- Solis Pilar
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- Spadaro Maria
- Spruth Eike Jakob
- Squitieri Ferdinando
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- Stattin Eva-Lena
- Stebler Yanik
- Steiner Tanja
- Steinmetz Gisèle
- Stokholm Jette
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- Suaréz San Martín Esther
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- Sánchez Sánchez Violeta
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- Tabrizi S. J.
- Tabrizi Sarah
- Tabrizi Sarah
- Taylor Rachel
- Tedroff Joakim
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Thomson Jenny
- Tidswell Katherine
- Timóteo Angela
- Tomasello Chiara
- Tome Carruesco Gemma
- Torres Rodríguez María José
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- Tranchant Christine
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- Trigo Cubillo Patricia
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- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Uhrova T.
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Vale José
- van den Bogaard Simon J. A.
- van Hout Monique S.
- van Kammen D.
- van Oostrom J. C. H.
- van Reijen Dimphna
- van Vugt Jeroen P.
- van Walsem Marleen R.
- van Walsem Marlene R.
- Vandenberghe Wim
- Vandenberghe Wim
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Verstraelen Nichola
- Villa Riballo Antonio
- Villanueva Clara
- Vivancos Moreau Laura
- Vives Barbara
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- Wagner Caroline
- Wahlström J.
- Wahlström Jan
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- Wallner M.
- Wannepain Sandrine
- Warner Thomas
- Weber Zaugg Sabine
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius Johannes
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hakan
- Wiedemann Alexandra
- Wiklund Leif
- Wikström Birgitta
- Wild E. J.
- Wild Edward
- Wild Sue
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wolf Elisabeth
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- Zangerl Anja
- Zaremba J.
- Zaremba Jacek
- Zdzienicka Elzbieta
- Zeman Adam
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Åman Jaana
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
The present work addresses the optimization of process parameters for adsorptive removal of α-toluic acid by calcium peroxide (CaO2) nanoparticles using response surface methodology (RSM). CaO2 nanoparticles were synthesized by chemical precipitation method and confirmed by Transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) analysis which shows the CaO2 nanoparticles size range of 5–15 nm. A series of batch adsorption experiments were performed using CaO2 nanoparticles to remove α-toluic acid from the aqueous solution. Further, an experimental based central composite design (CCD) was developed to study the interactive effect of CaO2 adsorbent dosage, initial concentration of α-toluic acid, and contact time on α-toluic acid removal efficiency (response) and optimization of the process. Analysis of variance (ANOVA) was performed to determine the significance of the individual and the interactive effects of variables on the response. The model predicted response showed a good agreement with the experimental response, and the coefficient of determination, (R2) was 0.92. Among the variables, the interactive effect of adsorbent dosage and the initial α-toluic acid concentration was found to have more influence on the response than the contact time. Numerical optimization of process by RSM showed the optimal adsorbent dosage, initial concentration of α-toluic acid, and contact time as 0.03 g, 7.06 g/L, and 34 min respectively. The predicted removal efficiency was 99.50%. The experiments performed under these conditions showed α-toluic acid removal efficiency up to 98.05%, which confirmed the adequacy of the model prediction
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
- B\ue1rcenas Antonio Herranz
- B\uf6ringer Regina
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-L\ue9vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Ver\uf3nica Ma\uf1anes
- Barrero Francisco
- Barth Katrin
- Barth\ue9l\ue9my Recka
- Bas Jordi
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Berglund Maria
- Berglund Peter
- Bergmann Ulrike
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bj\uf6rnsson Elisabeth
- Bj\uf8rgo Kathrine
- Bj\uf8rnevoll Inga
- Blaszczyk Magdalena
- Bliaux Evangeline
- Blin St\ue9phanie
- Blinkenberg Ellen 8kland
- Blondeau Leily
- Bo\u107wi\u144ska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boiss\ue9 Marie-Fran\ue7oise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Borge\uf8d Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boudali Lotfi
- Bove Francesco
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno Mar\ueda Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets N\ufaria
- Busse Monica
- Butcher Cynthia
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan Garc\ueda
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carri\ue8re Nicolas
- Carrillo F\ue1tima
- Carruesco Gemma Tome
- Casado Roc\uedo Villagr\ue1n
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit L\uf3pez
- Chabot Christelle
- Charles Perrine
- Charpentier S\ue9bastien
- Cheriet Samia
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaum\ue1
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortegana Eva Mar\ueda Pacheco
- Cortelli Pietro
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Courtin Fran\ue7oise
- Couttier Julien
- Craufurd David
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D\ucdaz-Zorita Juan Pablo Tartari
- Da Silva Wildson Vieira
- Das Purkayastha Debasish
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Bruycker Christelle
- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Roc\uedo Malo
- De Nicola Annunziata
- De Souza Keylock Jenny
- De Tommaso Marina
- De Weert A. Marit
- De Y\ue9benes Justo Garc\ueda
- Debilly B\ue9reng\ue8re
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dedich\ue1 Nadia Rodr\uedguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar Mar\ueda
- Del Valle Loarte Mar\ueda
- Delabaere Hel\ue8ne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-Fran\ue7ois
- Depelchin Aliz\ue9
- Destee Alain
- Dewulf-Pasz Nelly
- DI Bella Daniela
- DI Donato Stefano
- DI Giacopo Raffaella
- DI Maio Luigi
- DI Maria Emilio
- DI Pietro Anna Gerrtiz
- DI Poggio Monica Bandettini
- DI Renzo Martina
- DI\ue9guez Esther
- DIas Margarida
- DIercks Gabriele
- DIfruscolo Olimpia
- DIpple Heather
- Doherty Karen
- Dondaine Thibaut
- Donovan John O
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler DIrk
- Duch\ue9 Charlotte
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru C\ue9cile
- Dziadkiewicz Artur
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Federica
- Esteban Juan Carlos Gomez
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Farewell Daniel
- Fasano Alfonso
- Fasquel V\ue9ronique
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
- Figuerola Bego\uf1a Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament M\ue9lanie
- Fletcher Amy
- Fluchere Fr\ue9d\ue9rique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Bel\ue9n
- Francis Flverly
- Francisque H\ue9l\ue8ne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan C.
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fuller Kathleen
- G\uf6ller Marie-Lousie
- G\uf6pfert Nicole
- G\uf8rvell Per F.
- Gago Miguel
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garc\ueda Ana
- Garc\ueda Roc\uedo Garc\ueda-Ramos
- Garcia-Amigot Fermin
- Garde M\uf3nica Bascu\uf1ana
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrans Emily
- Ghelli Elena
- Gil Acera
- Gill Paul
- Gillardin Anne-Fran\ue7oise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier B\ue9n\ue9dicte
- Goizet Cyril
- Golding Charlotte
- Gonz\ue1lez Amaia
- Gonz\ue1lez Laura Vargas
- Gonz\ue1lez Sonia
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean H\ue9l\ue8ne
- Gu\ue9rid Marie-Anne
- Guedes Leonor Correia
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimar\ue3es Joana
- Guisasola Luis Men\ue9ndez
- Gunner Kerry
- Guyant-Mar\ue9chal Lucie
- Guzman Natalie Valle
- H\uf6lzner Eva
- H\uf8sterey-Ugander Ulrika
- Haider Salman
- Haig-Brown DIane
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin DIdier
- Hannier V\ue9ronique
- Harding Alison
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrower Timothy
- Hart't Ellen P.
- Hartikainen Paivi
- Haug Marte Gj\uf8l
- Hauge Erik
- Hayward Beverley
- Hayward Elaine
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso F\ue1tima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Dur\ue1n
- Herrmann Lennard
- Heywood Melanie
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Alis
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hypp\uf6nen Hannele
- Ialongo Tamara
- Idiago Jes\ufas Miguel Ruiz
- Ignatius Jaakko
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- J\ue4\ue4skalainen Outi
- J\ufalio Filipa
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Janu\ue1rio Cristina
- Jasi\u144ska-Myga Barbara
- Jauffret C\ue9line
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain S\ue9verine
- Jung Hans H.
- Justo Damian
- K\ue4rpp\ue4 Mikko
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaiserova Michaela
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Kipps Christopher
- Klebe Stephan
- Klemp\ued\u159 Ji\u159\ued
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- L\ue9onard Marie-Claude
- L\uf3pez Rosa Guerrero
- L\uf6hle Matthias
- L\ufcsebrink Antje
- Ladurner Gunther
- Lafoucri\ue8re Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Laur\ue1 Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-H\ue9l\ue8ne
- Lemoine Laurie
- Lemos Mar\ueda Dolores Romero
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Lindquist Suzanne
- Linnsand Petra
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo S\ue1nchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- M\ue4chtel Miriam
- M\uf8ller Anette Torvin
- M\ufchlau Mark
- M\ufchlb\ue4ck Alzbeta
- M\ufcller Christoph
- M\ufcller Nicole
- M\ufcnchau Alexander
- M\ufcnkel Kristina
- M\ufctze Lisanne
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise Hasselstr\uf8m
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- Majerov\ue1 Veronika
- Malec-Litwinowicz Michalina
- Malt\ueate David
- Mandich Paola
- Mandich Paola
- Manouvrier Sylvie
- Mantaux B\ue9atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Mart\uedn Idaira
- Mart\uednez Noelia Rodr\uedguez
- Mart\uednez-Descals Asunci\uf3n
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Mason Sarah
- Massano Jo\ue3o
- Massarelli Marco
- Mata Maite Paredes
- Matheson Kirsty
- Mazzante Irene
- McDonnell Sharon
- McEntagart Meriel
- McFadyen Paula
- McGill Marie
- McKenzie Sue
- McLean Tim
- McNulty Paul
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Merino Beatriz Tijero
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Minet C\ue9cile
- Minschke Rebecca
- Minster Sara
- Mir Pablo
- Modoni Anna
- Mohammed Zeid
- Moilanen Jukka
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreno Jos\ue9 Luis L\uf3pez-Send\uf3n
- Moreno Jose Manuel Garc\ueda
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgado Joana
- Morgan Karen
- Mu\uf1oz Esteban
- Mu\uf1oz Juan Mar\uedn
- Mundler Laura
- Murphy Helen
- Musacchio Thomas
- Musgrave Hannah
- Mustonen Aki
- Mutez Eug\ue9nie
- N\uf6th Kerstin
- Nanetti Lorenzo
- Necuiniate Renata
- Neleborn-Lingefj\ue4rd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nevitt Louise
- Nielsen J\uf8rgen
- Niess Anke
- Noad Rupert
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- Nyberg Clara
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- P\ue4iv\ue4rinta Markku
- P\ue5lhagen Sven
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente J\ue9r\ue9mie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Paus Karin
- Pe\uf1a Jos\ue9 Chac\uf3n
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Peria\uf1ez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petracca Martina
- Petrollini Martina
- Phillipps Cl\ue9lie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pierre Mich\ue8le
- Pilcher Richard
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Doroth\ue9e
- Powell Kingsley
- Pr\ufc f Harald
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- Pueyo Angel Mart\uednez
- Quaranta Davide
- Quarrell Oliver
- R\uf8ren Niini
- R\uf8sby Oddveig
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramesh Raviram
- Ramirez In\ue9s Legarda
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Redondo Mar\ueda Teresa C\ue1ceres
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterst\uf8l Lars
- Riba\uef Pascale
- Ribacoba Ren\ue9
- Ribas Guillermo Garc\ueda
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ru\uedz Pedro Jos\ue9 Garc\ueda
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzi\u144ska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ryglewicz Danuta
- S\ue1nchez Vicenta
- S\ue1nchez Violeta S\ue1nchez
- S\ufcssmuth Sigurd
- Sablonni\ue8re Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Sch\uf6ggl Helmut
- Sch\ufcler B\ue9atrice
- Sch\ufcpbach Michael
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Sciruicchio Vittorio
- Sebasti\ue1n Ana Rojo
- Seliverstov Yury
- Semedo Cristina
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Cl\ue9mence
- Simpson Sheila A
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjett
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smalley Sarah
- Snowden Julie
- Sol\ueds Pilar
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- St 9pniak Iwona
- St\ue4dtler Michael
- St\uf8rseth Hanna Haugan
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gis\ue9le
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Sulek Anna
- Summers Fiona
- Sundblom Jimmy
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Tabrizi Sarah
- Tacik Pawel
- Tard C\ue9line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladz\ue9 Maya
- Thibault-Tanchou St\ue9phanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis