Evaluating Delayed Write in a Multilevel Caching File System

Delayed write in a multilevel file system cache hierarchy offers a way to improve performance in diverse client/server scenarios, such as integrating mass store into a distributed file system or providing distributed file system access over low-speed links. Using file system traces and cache simulations, we explore extensions and modifications to the traditional client caching model employed in such file systems as AFS, Sprite, and DFS. High cache hit rates at an intermediate cache server—a machine logically interposed between clients and servers that provides cached file service to the clients—combined with high client cache hit rates lend practicality to an integrated mass storage file system. In such a system, magnetic tape or optical-based mass storage devices may be used as a first-class data repository, fronted by disk and RAM caches to offer acceptable access times to the large, but slow, mass storage system. Similarly, a high cache hit rate is necessary for users accessing file systems via low-speed links, where a delayed write intermediate caching server can mediate traffic to make better use of available bandwidth. In an example taken from mobile computing, an intermediate server might be used as a docking station at a user's home. This arrangement would be convenient for users of mobile computers who upload large amounts of data generated while operating in disconnected mode. Simulations of delayed write caching strategies are applicable to both the mass storage and low-speed link scenarios.http://deepblue.lib.umich.edu/bitstream/2027.42/107940/1/citi-tr-95-9.pd

A Technique for the Nondestructive Detection of Voids and Composition Anomalies in Metal Matrix Composite Wires Using X or γ Rays

An initial study of a technique proposed for the nondestructive testing of metal matrix composites is the subject of this paper. These composites are manufactured in the form of approximately 1/2-mm-diameter “precursor” wires. Larger structures are fabricated by diffusion bonding of lay-ups. Reliable nondestructive quality control indicators of wire integrity have not yet been developed although a number of possibilities are being examined.1 Testing of the precursor wires is difficult because current manufacturing processes produce wires that may be entirely satisfactory but that vary in cross-sectional geometry, in surface properties, and sometimes in the amount of matrix material that is present. Techniques based on observations of wire resistance, surface emissivity, and sound emission signatures are difficult to interpret because of these characteristics. Wire imaging using x-ray or neutron techniques is also difficult because large lengths of wire must be examined with a resolution in the plane of the wire exceeding 50 line pairs per millimeter

Development of ultra-light pixelated ladders for an ILC vertex detector

The development of ultra-light pixelated ladders is motivated by the requirements of the ILD vertex detector at ILC. This paper summarizes three projects related to system integration. The PLUME project tackles the issue of assembling double-sided ladders. The SERWIETE project deals with a more innovative concept and consists in making single-sided unsupported ladders embedded in an extra thin plastic enveloppe. AIDA, the last project, aims at building a framework reproducing the experimental running conditions where sets of ladders could be tested

Medium Effects on Binary Collisions with the Delta Resonance

To facilitate the relativistic heavy-ion calculations based on transport equations, the binary collisions involving a $\Delta$ resonance in either the entrance channel or the exit channel are investigated within a Hamiltonian formulation of $\pi NN$ interactions. An averaging procedure is developed to define a quasi-particle $\Delta^*$ and to express the experimentally measured $NN\rightarrow \pi NN$ cross section in terms of an effective $NN\rightarrow N\Delta^\ast$ cross section. In contrast to previous works, the main feature of the present approach is that the mass and the momentum of the produced $\Delta^*$'s are calculated dynamically from the bare $\Delta \leftrightarrow \pi N$ vertex interaction of the model Hamiltonian and are constrained by the unitarity condition. The procedure is then extended to define the effective cross sections for the experimentally inaccessible $N\Delta^\ast \rightarrow NN$ and $N\Delta^\ast \rightarrow N\Delta^\ast$ reactions. The predicted cross sections are significantly different from what are commonly assumed in relativistic heavy-ion calculations. The $\Delta$ potential in nuclear matter has been calculated by using a Bruckner-Hartree-Fock approximation. By including the mean-field effects on the $\Delta$ propagation, the effective cross sections of the $NN\rightarrow N\Delta^\ast$, $N\Delta^\ast \rightarrow NN$ and $N\Delta^\ast \rightarrow N\Delta^\ast$ reactions in nuclear matter are predicted. It is demonstrated that the density dependence is most dramatic in the energy region close to the pion production threshold.Comment: 20 pages, RevTe

Diverse mechanisms in proton knockout reactions from the Borromean nucleus 17Ne

Nucleon knockout experiments using beryllium or carbon targets reveal a strong dependence of the quenching factors, i.e., the ratio (R s) of theoretical to the experimental spectroscopic factors (C 2S), on the proton-neutron asymmetry in the nucleus under study. However, this dependence is greatly reduced when a hydrogen target is used. To understand this phenomenon, exclusive 1H (17Ne , 2p16F) and inclusive 12C(17Ne,2p16F)X , 12C (17Ne , 16F) X as well as 1H (17Ne , 16F) X (X-denotes undetected reaction products) reactions with 16F in the ground and excited states were analysed. The longitudinal momentum distribution of 16F and the correlations between the detached protons were studied. In the case of the carbon target, there is a significant deviation from the predictions of the eikonal model. The eikonal approximation was used to extract spectroscopic factor values C 2S . The experimental C 2S value obtained with C target is markedly lower than that for H target. This is interpreted as rescattering due to simultaneous nucleon knockout from both reaction partners, 17Ne and 12C

Alteration of the embryo transcriptome of hexaploid winter wheat (Triticum aestivum cv. Mercia) during maturation and germination

Grain dormancy and germination are areas of biology that are of considerable interest to the cereal community. We have used a 9,155-feature wheat unigene cDNA microarray resource to investigate changes in the wheat embryo transcriptome during late grain development and maturation and during the first 48 h of postimbibition germination. In the embryo 392 mRNAs accumulated by twofold or greater over the time course from 21 days postanthesis (dpa) to 40 dpa and on through 1 and 2 days postgermination. These included mRNAs encoding proteins involved in amino acid biosynthesis and metabolism, cell division and subsequent cell development, signal transduction, lipid metabolism, energy production, protein turnover, respiration, initiation of transcription, initiation of translation and ribosomal composition. A number of mRNAs encoding proteins of unknown function also accumulated over the time course. Conversely 163 sequences showed decreases of twofold or greater over the time course. A small number of mRNAs also showed rapid accumulation specifically during the first 48 h of germination. We also examined alterations in the accumulation of transcripts encoding proteins involved in abscisic acid signalling. Thus, we describe changes in the level of transcripts encoding wheat Viviparous 1 (Vp1) and other interacting proteins. Interestingly, the transcript encoding wheat Viviparous-interacting protein 1 showed a pattern of accumulation that correlates inversely with germination. Our data suggests that the majority of the transcripts required for germination accumulate in the embryo prior to germination and we discuss the implications of these findings with regard to manipulation of germination in wheat

Coulomb breakup of 17Ne from the viewpoint of nuclear astrophysics

By the Coulomb breakup of 17Ne, the time-reversed reaction 15O(2p,γ)17Ne has been studied. This reaction might play an important role in the rp process, as a break-out reaction of the hot CNO cycle. The secondary 17Ne ion beam with an energy of 500 MeV/nucleon has been dissociated in a Pb target. The reaction products have been detected with the LAND-R3B experimental setup at GSI. The preliminary differential and integral Coulomb dissociation cross section sCoul has been determined, which then will be converted into a photo-absorption cross section sphoto, and a two-proton radiative capture cross section σcap. Additionally, information about the structure of the 17Ne, a potential two-proton halo nucleus, will be received. The analysis is in progress. \ua9 Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence

Modulation of phosphofructokinase (PFK) from Setaria cervi, a bovine filarial parasite, by different effectors and its interaction with some antifilarials

<p>Abstract</p> <p>Background</p> <p>Phosphofructokinase (ATP: D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11, PFK) is of primary importance in the regulation of glycolytic flux. This enzyme has been extensively studied from mammalian sources but relatively less attention has been paid towards its characterization from filarial parasites. Furthermore, the information about the response of filarial PFK towards the anthelmintics/antifilarial compounds is lacking. In view of these facts, PFK from <it>Setaria cervi</it>, a bovine filarial parasite having similarity with that of human filarial worms, was isolated, purified and characterized.</p> <p>Results</p> <p>The <it>S. cervi </it>PFK was cytosolic in nature. The adult parasites (both female and male) contained more enzyme activity than the microfilarial (Mf) stage of <it>S. cervi</it>, which exhibited only 20% of total activity. The <it>S. cervi </it>PFK could be modulated by different nucleotides and the response of enzyme to these nucleotides was dependent on the concentrations of substrates (F-6-P and ATP). The enzyme possessed wide specificity towards utilization of the nucleotides as phosphate group donors. <it>S. cervi </it>PFK showed the presence of thiol group(s) at the active site of the enzyme, which could be protected from inhibitory action of para-chloromercuribenzoate (p-CMB) up to about 76% by pretreatment with cysteine or β-ME. The sensitivity of PFK from <it>S. cervi </it>towards antifilarials/anthelmintics was comparatively higher than that of mammalian PFK. With suramin, the Ki value for rat liver PFK was 40 times higher than PFK from <it>S. cervi</it>.</p> <p>Conclusions</p> <p>The results indicate that the activity of filarial PFK may be modified by different effectors (such as nucleotides, thiol group reactants and anthelmintics) in filarial worms depending on the presence of varying concentrations of substrates (F-6-P and ATP) in the cellular milieu. It may possess thiol group at its active site responsible for catalysis. Relatively, 40 times higher sensitivity of filarial PFK towards suramin as compared to the analogous enzyme from the mammalian system indicates that this enzyme could be exploited as a potential chemotherapeutic target against filariasis.</p