Mid Infrared Photometry of Mass-Losing AGB Stars

We present ground-based mid-infrared imaging for 27 M-, S- and C-type Asymptotic Giant Branch (AGB) stars. The data are compared with those of the database available thanks to the IRAS, ISO, MSX and 2MASS catalogues. Our goal is to establish relations between the IR colors, the effective temperature $T_{eff}$, the luminosity $L$ and the mass loss rate $\dot M$, for improving the effectiveness of AGB modelling. Bolometric (absolute) magnitudes are obtained through distance compilations, and by applying previously-derived bolometric corrections; the variability is also studied, using data accumulated since the IRAS epoch. The main results are: i) Values of $L$ and $\dot M$ for C stars fit relations previously established by us, with Miras being on average more evolved and mass losing than Semiregulars. ii) Moderate IR excesses (as compared to evolutionary tracks) are found for S and M stars in our sample: they are confirmed to originate from the dusty circumstellar environment. iii) A larger reddening characterizes C-rich Miras and post-AGBs. In this case, part of the excess is due to AGB models overestimating $T_{eff}$ for C-stars, as a consequence of the lack of suitable molecular opacities. This has a large effect on the colors of C-rich sources and sometimes disentangling the photospheric and circumstellar contributions is difficult; better model atmospheres should be used in stellar evolutionary codes for C stars. iv) The presence of a long-term variability at mid-IR wavelengths seems to be limited to sources with maximum emission in the 8 -- 20 $\mu$m region, usually Mira variables (1/3 of our sample). Most Semiregular and post-AGB stars studied here remained remarkably constant in mid-IR over the last twenty years.Comment: Accepted for publication in the Astronomical Journal - 35 pages (in preprint), 9 figures, 5 table

Stellar Models and Yields of Asymptotic Giant Branch Stars

We present stellar yields calculated from detailed models of low and intermediate-mass asymptotic giant branch (AGB) stars. We evolve models with a range of mass from 1 to 6Msun, and initial metallicities from solar to 1/200th of the solar metallicity. Each model was evolved from the zero age main sequence to near the end of the thermally-pulsing AGB phase, and through all intermediate phases including the core He-flash for stars initially less massive than 2.5Msun. For each mass and metallicity, we provide tables containing structural details of the stellar models during the TP-AGB phase, and tables of the stellar yields for 74 species from hydrogen through to sulphur, and for a small number of iron-group nuclei. All tables are available for download. Our results have many applications including use in population synthesis studies and the chemical evolution of galaxies and stellar systems, and for comparison to the composition of AGB and post-AGB stars and planetary nebulae.Comment: 26 pages; to appear in Publications of the Astronomical Society of Australia (PASA); typos fixed in the text and in Tables 4 and

Breast milk butyrate as protective factor against food allergy

Conflicting evidences suggest a role for breast milk as pro- tective factor against food allergy. The major short chain fatty acids, butyrate produced by gut microbiota exerts positive effect on immune system. We aimed to see whether butyrate concen- tration in human milk is able to prevent food allergy in an animal model of cow milk allergy. Mature breast milk butyrate concentration from 40 healthy women (aged 21–42 yrs) was assessed by gas chromatography. 4- Week-old female C3H/HeOuJ mice were sensitized by oral route with -lactoglobulin (BLG, 20 mg) plus cholera toxin (CT, 10 g) as an adjuvant in the presence or absence of butyrate. Acute aller- gic skin response,anaphylactic symptom score, body temperature, intestinal permeability, anti-BLG IgE, IL-4 and IL-10 production were assessed soon after oral challenge. Mean butyrate concen- tration in breast milk was 0.75 mM (SD ± 0.15). Based on this concentration a daily dose of 30 mg/kg body weight was calculated. The same butyrate concentration was able to significantly prevent acute allergic skin response, anaphylactic symptom score, body temperature decrease, intestinal permeability increase, anti-BLG IgE, IL-4 and IL-10 production in CMA animal model (p < .05). Our data suggest a pivotal role for butyrate as an effective human milk component in food allergy prevention

The diffusion-induced nova scenario. CK Vul and PB 8 as possible observational counterparts

We propose a scenario for the formation of DA white dwarfs with very thin helium buffers. For these stars we explore the possible occurrence of diffusion-induced CNO- flashes, during their early cooling stage. In order to obtain very thin helium buffers, we simulate the formation of low mass remnants through an AGB final/late thermal pulse (AFTP/LTP scenario). Then we calculate the consequent white dwarf cooling evolution by means of a consistent treatment of element diffusion and nuclear burning. Based on physically sounding white dwarf models, we find that the range of helium buffer masses for these diffusion-induced novas to occur is significantly smaller than that predicted by the only previous study of this scenario. As a matter of fact, we find that these flashes do occur only in some low-mass (M < 0.6M) and low metallicity (Z_ZAMS <0.001) remnants about 10^6 - 10^7 yr after departing from the AGB. For these objects, we expect the luminosity to increase by about 4 orders of magnitude in less than a decade. We also show that diffusion-induced novas should display a very typical eruption lightcurve, with an increase of about a few magnitudes per year before reaching a maximum of M_V ~ -5 to -6. Our simulations show that surface abundances after the outburst are characterized by logNH/NHe ~ -0.15...0.6 and N>C>O by mass fractions. Contrary to previous speculations we show that these events are not recurrent and do not change substantially the final H-content of the cool (DA) white dwarf. (Abridged)Comment: 16 pages, 8 figures, 3 tables. Replaced to match the final version published by MNRAS. The definitive version is available at http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291365-296

CSF parvalbumin levels reflect interneuron loss linked with cortical pathology in multiple sclerosis

INTRODUCTION AND METHODS: In order to verify whether parvalbumin (PVALB), a protein specifically expressed by GABAergic interneurons, could be a MS-specific marker of grey matter neurodegeneration, we performed neuropathology/molecular analysis of PVALB expression in motor cortex of 40 post-mortem progressive MS cases, with/without meningeal inflammation, and 10 control cases, in combination with cerebrospinal fluid (CSF) assessment. Analysis of CSF PVALB and neurofilaments (Nf-L) levels combined with physical/cognitive/3TMRI assessment was performed in 110 naïve MS patients and in 32 controls at time of diagnosis. RESULTS: PVALB gene expression was downregulated in MS (fold change = 3.7 ± 1.2, P < 0.001 compared to controls) reflecting the significant reduction of PVALB+ cell density in cortical lesions, to a greater extent in MS patients with high meningeal inflammation (51.8, P < 0.001). Likewise, post-mortem CSF-PVALB levels were higher in MS compared to controls (fold change = 196 ± 36, P < 0.001) and correlated with decreased PVALB+ cell density (r = -0.64, P < 0.001) and increased MHC-II+ microglia density (r = 0.74, P < 0.01), as well as with early age of onset (r = -0.69, P < 0.05), shorter time to wheelchair (r = -0.49, P < 0.05) and early age of death (r = -0.65, P < 0.01). Increased CSF-PVALB levels were detected in MS patients at diagnosis compared to controls (P = 0.002). Significant correlation was found between CSF-PVALB levels and cortical lesion number on MRI (R = 0.28, P = 0.006) and global cortical thickness (R = -0.46, P < 0.001), better than Nf-L levels. CSF-PVALB levels increased in MS patients with severe cognitive impairment (mean ± SEM:25.2 ± 7.5 ng/mL) compared to both cognitively normal (10.9 ± 2.4, P = 0.049) and mild cognitive impaired (10.1 ± 2.9, P = 0.024) patients. CONCLUSIONS: CSF-PVALB levels reflect loss of cortical interneurons in MS patients with more severe disease course and might represent an early, new MS-specific biomarker of cortical neurodegeneration, atrophy, and cognitive decline

Archiving multi-epoch data and the discovery of variables in the near infrared

We present a description of the design and usage of a new synoptic pipeline and database model for time series photometry in the VISTA Data Flow System (VDFS). All UKIRT-WFCAM data and most of the VISTA main survey data will be processed and archived by the VDFS. Much of these data are multi-epoch, useful for finding moving and variable objects. Our new database design allows the users to easily find rare objects of these types amongst the huge volume of data being produced by modern survey telescopes. Its effectiveness is demonstrated through examples using Data Release 5 of the UKIDSS Deep Extragalactic Survey (DXS) and the WFCAM standard star data. The synoptic pipeline provides additional quality control and calibration to these data in the process of generating accurate light-curves. We find that 0.6+-0.1% of stars and 2.3+-0.6% of galaxies in the UKIDSS-DXS with K<15 mag are variable with amplitudes \Delta K>0.015 magComment: 30 pages, 31 figures, MNRAS, in press Minor changes from previous version due to refereeing and proof-readin

The combined use of surgical debulking and diode laser photocoagulation for limbal melanoma treatment: a retrospective study of 21 dogs

Objective To evaluate effectiveness and safety of debulking and diode laser photocoagulation (DPC) for the treatment of limbal melanoma (LM). Procedure Retrospective multi-institutional case series. Medical records of animals diagnosed with LM at the Centro Veterinario Specialistico (CVS) and at the Long Island Veterinary Specialists from 1994 to 2014 were retrieved. Signalment, location, extent of tumors, recurrence rate, and early and late complications were reported. Patient follow-up information was obtained from veterinary ophthalmologists, primary care veterinarians, and where appropriate, owners. Results Twenty-one eyes of 21 dogs (13 females and 8 males) were included in this study. The dogs' average age was 6 years (range: 7 months-11 years). The follow-up period ranged from 1-108 months (median 48 months) after the last DPC procedure. Long-term follow-up was obtained by telephone interviews in 6 of 20 cases and by clinical re-evaluations in 14 of 20 cases. The most common early complications were a moderate anterior uveitis and peripheral corneal edema (21/21 eyes). Late complications included corneal fibrosis and/or pigmentation (20/21). In one case, a severe bullous keratopathy associated with extensive corneal fibrosis was observed (1/21). One case was blind due to concurrent Sudden Acquired Retinal Degeneration (SARD). However, after surgery 2 of 20 eyes lost vision and one of these was enucleated. Conclusions Debulking, in addition to diode laser photocoagulation, was technically straightforward to perform, minimally invasive, well tolerated, and highly successful in this case series

The evolutionary state of Miras with changing pulsation periods

Context: Miras are long-period variables thought to be in the asymptotic giant branch (AGB) phase of evolution. In about one percent of known Miras, the pulsation period is changing. It has been speculated that this changing period is the consequence of a recent thermal pulse in these stars. Aims: We aim to clarify the evolutionary state of these stars, and to determine in particular whether or not they are in the thermally-pulsing (TP-)AGB phase. Methods: One important piece of information that has been neglected so far when determining the evolutionary state is the presence of the radio-active s-process element technetium (Tc). We obtained high-resolution, high signal-to-noise-ratio optical spectra of a dozen prominent Mira variables with changing pulsation period to search for this indicator of TPs and dredge-up. We also use the spectra to measure lithium (Li) abundances. Furthermore, we establish the evolutionary states of our sample stars by means of their present-day periods and luminosities. Results: Among the twelve sample stars observed in this programme, five were found to show absorption lines of Tc. BH Cru is found to be a carbon-star, its period increase in the past decades possibly having stopped by now. We report a possible switch in the pulsation mode of T UMi from Mira-like to semi-regular variability in the past two years. R Nor, on the other hand, is probably a fairly massive AGB star, which could be true for all meandering Miras. Finally, we assign RU Vul to the metal-poor thick disk with properties very similar to the short-period, metal-poor Miras. Conclusions: We conclude that there is no clear correlation between period change class and Tc presence. The stars that are most likely to have experienced a recent TP are BH Cru and R Hya, although their rates of period change are quite different.Comment: 11 pages, 7 figures, 2 tables; accepted for publication in A&