Usability and Feasibility Study of a Remote Cognitive Behavioral Therapy System with Long-Term Unemployed Women

We present the results of the use of a cognitive behavioral therapeutic intervention tool to improve the mental, physical, and social health of a group of long-term unemployed women in Spain. Method: We sent automated text messages (SMS) to the mobile phones of long-term unemployed women selected at random from public social services. During a 28-day intervention period, women received four daily automated text messages on her mobile phone on a predetermined hourly schedule. We measured depression symptoms at the start and end of the intervention and we analyzed qualitative data to determine the acceptability of a remote SMS program. Results: Depression symptoms using the Personal Health Questionnaire-9 (PHQ-9), went from an average of 13.8 at baseline to 4.9 at the end of 28 days (p = 0.89). One hundred percent of the women reported that they liked receiving the text messages and most found them helpful

Histone Mutants Separate R Loop Formation from Genome Instability Induction

R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability. R loops containing single-stranded DNA (ssDNA), versus RNA-DNA hybrids alone, were demonstrated using ssDNA-specific human AID and bisulfite. Notably, they are similar size regardless of whether or not they induce genome instability. Contrary to mutants causing R loop-mediated instability, these histone mutants do not accumulate H3 serine-10 phosphate (H3S10-P). We propose a two-step mechanism in which, first, an altered chromatin facilitates R loops, and second, chromatin is modified, including H3S10-P, as a requisite for compromising genome integrity. Consistently, these histone mutations suppress the high H3S10 phosphorylation and genomic instability of hpr1 and sen1 mutants. Therefore, contrary to what was previously believed, R loops do not cause genome instability by themselves.European Research Council ERC2014 AdG669898Ministerio de Economía y Competitividad BFU2013-42918-P, BFU2016-75058-

Descripción de los parámetros fonético-acústico y autopercepción vocal de telefonistas en la región Metropolitana de Chile

Tesis (Fonoaudiología)Los callcenters son un espacio laboral que se ha desarrollado ampliamente en el presente siglo y con ello el rubro de los telefonistas se encuentra en aumento. Sin embargo, la rapidez con que éstos se han instaurado dentro de nuestra sociedad, no ha permitido una valoración adecuada de las posibles consecuencias que tiene el uso de la voz durante las horas que comprende una jornada laboral. El presente estudio, consistió en describir y establecer una relación de los parámetros fonético-acústicos (frecuencia fundamental, Jitter, Shimmer y relación ruido/armónico) y autopercepción vocal en telefonistas de la Región Metropolitana de Chile, utilizando los instrumentos Multidimensional Voice Program (MDVP) e Índice de Incapacidad Vocal (VHI). La muestra de este estudio estuvo compuesta por 56 sujetos, de los cuales 14 eran hombres y las 42 restantes, mujeres, que se desempeñan al año 2013 como telefonistas dentro de uno de los cuatro callcenters seleccionados y que pertenecen a la Región Metropolitana de Chile. En cuanto a los resultados del MDVP, se pudo evidenciar que la utilización de esta herramienta fue eficiente en la entrega de los resultados. Respecto de las diferencias encontradas entre el MDVP y VHI como instrumentos de evaluación simultáneos, se demuestran que todavía ningún parámetro objetivo puede considerarse como factor pronóstico definitivo en la evaluación de los pacientes y que las sensaciones acerca de su problema vocal no pueden valorarse mediante medidas objetivas.Se evidencia la alteración vocal objetiva presente en el 41 % de la muestra y se observa una tendencia a presentar primordialmente solo un parámetro alterado, siendo principalmente Jitter o FO, lo que se registra en un 30% aproximadamente. Respecto a la autopercepción vocal, se obtuvo que el 89% de ellos distinguen una alteración leve en su voz y tan solo un 10% alude a un daño moderado. No se evidenció correlación significativa entre los parámetros fonéticoacústicos y la autopercepción vocal de los telefonistas de la Región Metropolitana.The callcenters are a working place with a significant development during the present century and with it, the function of the telephone operators is growing. However, the fast introduction of them into our society, hasn't allow a proper appreciation of the impact that have the use of the voice during the hours of a working day. The present study consist in the description and stablish a relationship between the phonetic-acoustic parameters (fundamental frequency, Jitter, Shimmer and the relationship noise/harmonic) and the vocal self-perception on telephone operators of Chile's RegiónMetropolitana, using the Multidimensional Voice Program (MDVP) and the Vocal Handicap lndex (VHI) instruments. The sampling of this study was composed by 56 subjects, of which 14 were men and the 42 remaining were women, who work at the year 2013 as telephone operators inside tour selected callcenters of Chile's RegiónMetropolitana. As soon as the results of the MDVP, it was evidenced that the utilization of this tool was efficient at the results development. Respect the differences found between the MDVP and the VHI as evaluation instruments, evidence that no objective parameter can be considerad as an optimal prognostic factor on the patient evaluations and their feelings about own vocal problems can't be assessed by objective measures. Is Evidenced the objective vocal disturbance present in the 41 % of the sample and is observad a tendency to present primarily only one altered parameter, being mainly Jitter or FO, which is registered by a 30%, approximately. Respect the vocal self perception, was obtained that the 89% of them distinguishes a slight alteration on their voice and only the 10% a moderated harm. lt not was evidenced a significativa correlation between the phonetic-acoustic parameters and the vocal self-perception of telephone operators of the RegiónMetropolitana

Variability and power enhancement of current controlled resistive switching devices

Producción CientíficaIn this work, the unipolar resistive switching behaviour of Ni/HfO2/Si(n+) devices is studied. The structures are characterized using both current and voltage sweeps, with the device resistance and its cycle-to-cycle variability being analysed in each case. Experimental measurements indicate a clear improvement on resistance states stability when using current sweeps to induce both set and reset processes. Moreover, it has been found that using current to induce these transitions is more efficient than using voltage sweeps, as seen when analysing the device power consumption. The same results are obtained for devices with a Ni top electrode and a bilayer or pentalayer of HfO2/Al2O3 as dielectric. Finally, kinetic Monte Carlo and compact modelling simulation studies are performed to shed light on the experimental results.Junta de Andalucía - FEDER (B-TIC-624-UGR20)Consejo Superior de Investigaciones Científicas (CSIC) (project 20225AT012)Ramón y Cajal (grant RYC2020-030150-I

Modelado de Procesos de Neurorrehabilitación

La Neurorrehabilitación es un proceso clínico que se centra en el abordaje de la alteración del sistema nervioso. Existe una enorme variabilidad tanto en la tipología como en el grado de las lesiones neurológicas, lo que la convierte en un proceso extremadamente complejo de analizar y comprender. El presente trabajo se centra en el modelado de las principales actividades que se llevan a cabo en el contexto de la Neurorrehabilitación actual con el objetivo de detectar aquellos puntos en que puedan ser mejoradas, tanto a nivel organizativo como a nivel de ejecución. Por otra parte, se trata de comprenderlas en profundidad para tratar de transformarlas posteriormente en nuevas actividades automatizadas y monitorizadas que se ajusten al nuevo paradigma de rehabilitación ubicua, personalizada y basada en la evidencia

alpha-particle production in the scattering of 6He by 208Pb at energies around the Coulomb barrier

New experimental data from the scattering of 6He+208Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of $\alpha$ particles. The energy and angular distributions of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the $\alpha$ particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakly bound states of the final nucleus.Comment: 20 pages, 5 figures. Nuclear Physics A792 (2007) 2-1

Superficial radiotherapy as haemostatic treatment in breast cancer

Poster Session [EP-1661] Purpose or Objective Breast cancer is a common pathology in which o = 25% in tumor size and absence of bleeding was observed. Conclusion Surface radiotherapy is a treatment modality that should be taken into account in patients with breast cancer who present bleeding as a consequence of local tumor growth, given that this is a treatment comfortable for the patient, non invasive and increases the quality of patient’s life

¿Cuáles son los avances empíricos en el estudio de la satisfacción laboral?

Investigations on the subject of job satisfaction, for the most part, have been made under the explanatory or quantitative approach. These studies show the degree of job satisfaction of workers and their determinants with other variables, both personal and business. However, there is a need to carry out studies under the comprehensive approach, in order to provide useful data enabling to advance the field of knowledge of job satisfaction, which will allow us to know the point of view of workers, or posture emic, of people living daily satisfaction or labor dissatisfaction in their places of work. Why he was raised as a topic of PhD thesis, know the theoretical construction occupational health physicians have been made about job satisfaction. Objective: To show the State of the art of job satisfaction, from both perspectives, through documentary inquiry on the subject. Conclusions: the results of qualitative studies of job satisfaction differ from explaining cut, because by providing workers emic vision, they not only labelled as satisfactory work or not, but give a holistic view of the same and offer further prospects of greater depth.Las investigaciones sobre el tema de la satisfacción laboral, en su mayor parte, han sido realizadas bajo el enfoque explicativo o cuantitativo. Dichos estudios muestran el grado de satisfacción laboral de los trabajadores y sus determinantes con otras variables, tanto personales como laborales. Sin embargo, existe la necesidad de realizar estudios bajo el enfoque comprensivo, en aras de aportar datos útiles que permitan avanzar en el campo del conocimiento de la satisfacción laboral, que nos permitan conocer el punto de vista de los trabajadores, o postura emic, de las personas que viven diariamente la satisfacción o la insatisfacción laboral en sus centros de trabajo. De ahí que se planteó como tema de tesis doctoral, conocer la construcción teórica que los médicos de salud ocupacional han realizado sobre la satisfacción laboral. Objetivo: Mostrar el estado del arte de la satisfacción laboral, desde las perspectivas etic y emic, a través de la indagación documental sobre el tema. Conclusiones: los resultados de los estudios cualitativos de satisfacción laboral difieren de los de corte explicativo, pues al aportar la visión emic de los trabajadores, no solo etiquetan al trabajo como satisfactorio o no, sino que dan una visión integral del mismo y ofrecen otras perspectivas de mayor profundidad

ANGPTL-4 is associated with obesity and lipid profile in children and adolescents

Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile

Personal Construct Therapy vs Cognitive Behavioral Therapy in the Treatment of Depression in Women with Fibromyalgia: Study Protocol for a Multicenter Randomized Controlled Trial

Background: Fibromyalgia (FM) is a debilitating syndrome, more prevalent in women, which is aggravated by the presence of depressive symptoms. In the last decade, cognitive behavioral therapy (CBT) has demonstrated to reduce such depressive symptoms and pain in these patients, but there are still a considerable number of them who do not respond to interventions. The complexity of the disorder requires the consideration of the unique psychological characteristics of each patient to attain good outcomes. One approach that could accomplish this goal might be personal construct therapy (PCT), an idiographic approach that considers identity features and interpersonal meanings as their main target of intervention. Then, the aim of the study is to test the efficacy of PCT as compared to a well-established treatment in the reduction of depressive symptoms in women with fibromyalgia. Methods and Analysis: This is a multicenter randomized controlled trial. In each condition participants will attend up to eighteen 1-hr weekly therapy sessions and up to three 1-hr booster sessions during the following 3- 5 months after the end of treatment. The depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) will be the primary outcome measure and it will be assessed at baseline, at the end of therapy, and at 6-month follow-up. Other secondary measures will be applied following the same schedule. Participants will be 18- to 70-years-old women with a diagnosis of FM, presenting depressive symptoms evinced by scores above seven in depression items of the HADS-D. Intention-to-treat and complete case analyses will be performed for the main statistical tests. Linear mixed models will be used to analyze and to compare the treatment effects of both conditions