Matrix factorizations for quantum complete intersections

We introduce twisted matrix factorizations for quantum complete intersections of codimension two. For such an algebra, we show that in a given dimension, almost all the indecomposable modules with bounded minimal projective resolutions correspond to such matrix factorizations.Comment: 13 page

Optimal path shape for range-only underwater target localization using a Wave Glider

Underwater localization using acoustic signals is one of the main components in a navigation system for an autonomous underwater vehicle (AUV) as a more accurate alternative to dead-reckoning techniques. Although different methods based on the idea of multiple beacons have been studied, other approaches use only one beacon, which reduces the system’s costs and deployment complexity. The inverse approach for single-beacon navigation is to use this method for target localization by an underwater or surface vehicle. In this paper, a method of range-only target localization using a Wave Glider is presented, for which simulations and sea tests have been conducted to determine optimal parameters to minimize acoustic energy use and search time, and to maximize location accuracy and precision. Finally, a field mission is presented, where a Benthic Rover (an autonomous seafloor vehicle) is localized and tracked using minimal human intervention. This mission shows, as an example, the power of using autonomous vehicles in collaboration for oceanographic research.Peer ReviewedPostprint (author's final draft

Diseño de una guía de prácticas de laboratorio de acuerdo con las orientaciones del EEES

La adaptación de la docencia universitaria al Espacio Europeo de Educación Superior (EEES) supone un cambio en los sistemas de enseñanza actual. En este sentido el desarrollo de guías de laboratorio capaces de informar al alumnado, y normalizar la confección y presentación de las prácticas de laboratorio, asegurando una mejor calidad de la docencia y coordinación entre grupos, viene a cumplir con algunos de los objetivos pretendidos en el contexto de la Convergencia Europea. La Guía que se presenta, destinada a su empleo en la docencia práctica de una asignatura troncal de la licenciatura en Farmacia en la Universidad de Granada, recoge las indicaciones necesarias para llevar a cabo un trabajo seguro y eficiente en los laboratorios

Evaluation of anti-inflammatory and immunoregulatory activities of Stimunex® and Stimunex D3® in human monocytes/macrophages stimulated with LPS or IL-4/IL-13

Macrophages exert an important role in maintaining and/or ameliorating the inflammatory response. They are involved in the activation of an immune response to pathogens, with a balance between the immunomodulatory role and tissue integrity maintenance, however, excessive macrophage activity promotes tissue injury and chronic disease pathogenesis. There is a high interest in evaluating the anti-inflammatory properties of new botanical preparations. Stimunex® and Stimunex D3® are two food supplements formulated as syrups, containing the extract of elderflower (Sambucus nigra, Caprifoliaceae), standardized in polyphenol (6%) and anthocyanins (4%), associated with wellmune WGP® β-glucan, with the addiction of vitamin D3 (in Stimunex D3® formulation). The aim of the work was the evaluation of Stimunex® and Stimunex D3® activity in human polarized-macrophages, in order to support their use as supplement for preventing and reducing the inflammatory processes. In primary human stimulated macrophages, both syrups were able to revert LPS- and IL-4/IL-13-mediated response, reducing the release of several pro-inflammatory cytokines. Results support that these standardized botanical preparations fortified with β-glucan, may have a potential use in the prevention and coadjuvant management of inflammatory process as respiratory recurrent infections and other similar conditions. Moreover, the addition of vitamin D3 revealed to be an advantage in Stimunex D3® for its important role in maintaining and enhancing the innate immune response

Iniciativas implementadas y Liberación de Software Libre en la Municipalidad de Rosario, Argentina

Exposición de las principales iniciativas exitosas en software libre implementadas en la Municipalidad de Rosario y la liberación a la comunidad del Sistema Integral de Administración Tributaria, desarrollo en software libre con foco en el ciudadano y autogestión via internet, a fin de que otros municipios con similares necesidades que Rosario puedan adoptarlo, promoviendo las buenas prácticas desarrolladas y multiplicando sus beneficios.Sociedad Argentina de Informática e Investigación Operativ

Intracellular targets of RGDS peptide in melanoma cells

<p>Abstract</p> <p>Background</p> <p>RGD-motif acts as a specific integrins-ligand and regulates a variety of cell-functions via extracellular action affecting cell-adhesion properties. However, increasing evidence identifies additional RGDS-functions at intracellular level. Previous reports show RGDS-internalization in endothelial cells, cardiomyocytes and lymphocytes, indicating intracellular targets such as caspase-8 and caspase-9, and suggest RGDS specific activity at cytoplasmic level. Given the role RGDS-peptides play in controlling proliferation and apoptosis in several cell types, investigating intracellular targets of RGDS in melanoma cells may un-reveal novel molecular targets and key pathways, potentially useful for a more effective approach to melanoma treatment.</p> <p>Results</p> <p>In the present study we show for the first time that RGDS-peptide is internalized in melanoma cells in a time-dependent way and exerts strong anti-proliferative and pro-apoptotic effects independently from its extracellular anti-adhesive action. RGES control-peptide did not show biological effects, as expected; nevertheless it is internalized, although with slower kinetics. Survivin, a known cell-cycle and survival-regulator is highly expressed in melanoma cells. Co-immunoprecipitation assays in cell lysates and overlay assays with the purified proteins showed that RGDS interacts with survivin, as well as with procaspase-3, -8 and -9. RGDS-peptide binding to survivin was found to be specific, at high affinity (Kd 27.5 μM) and located at the survivin C-terminus. RGDS-survivin interaction appeared to play a key role, since RGDS lost its anti-mitogenic effect in survivin-deprived cells with a specific siRNA.</p> <p>Conclusions</p> <p>RGDS inhibits melanoma growth with an adhesion-independent mechanism; it is internalized in melanoma cells and specifically interacts with survivin. The present data may indicate a novel role of RGDS-containing peptides physiologically released from the extracellular matrix and may suggest a possible novel anti-proliferation strategy in melanoma.</p