150 research outputs found
Sondrestrom Overview
This overview of the Sondrestrom radar provides background material to help understand the early scientific results discussed in the following series of papers. It describes the geophysical region probed by the radar, the data acquisition procedure, and the extensive set of physical parameters derived
Maximum Entropy for Gravitational Wave Data Analysis: Inferring the Physical Parameters of Core-Collapse Supernovae
The gravitational wave signal arising from the collapsing iron core of a Type
II supernova progenitor star carries with it the imprint of the progenitor's
mass, rotation rate, degree of differential rotation, and the bounce depth.
Here, we show how to infer the gravitational radiation waveform of a core
collapse event from noisy observations in a network of two or more LIGO-like
gravitational wave detectors and, from the recovered signal, constrain these
source properties. Using these techniques, predictions from recent core
collapse modeling efforts, and the LIGO performance during its S4 science run,
we also show that gravitational wave observations by LIGO might have been
sufficient to provide reasonable estimates of the progenitor mass, angular
momentum and differential angular momentum, and depth of the core at bounce,
for a rotating core collapse event at a distance of a few kpc.Comment: 44 pages, 12 figures; accepted version scheduled to appear in Ap J 1
April 200
Network Infrastructure Configuration
The nine papers in this special issue focus on network infrastructure configuration and some of the problems encountered in the areas of specification, diagnosis, repair, synthesis, and anonymization
Bi-Objective Community Detection (BOCD) in Networks using Genetic Algorithm
A lot of research effort has been put into community detection from all
corners of academic interest such as physics, mathematics and computer science.
In this paper I have proposed a Bi-Objective Genetic Algorithm for community
detection which maximizes modularity and community score. Then the results
obtained for both benchmark and real life data sets are compared with other
algorithms using the modularity and MNI performance metrics. The results show
that the BOCD algorithm is capable of successfully detecting community
structure in both real life and synthetic datasets, as well as improving upon
the performance of previous techniques.Comment: 11 pages, 3 Figures, 3 Tables. arXiv admin note: substantial text
overlap with arXiv:0906.061
Integrated high voltage power supply utilizing burst mode control and its performance impact on dielectric electro active polymer actuators
Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study.
Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors. Past research has determined that stress experienced in adulthood is associated with shorter telomere length, but is limited to mostly cross-sectional reports. We test whether repeated reports of chronic psychosocial and financial burden is associated with telomere length change over a 5-year period (years 15 and 20) from 969 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal, population-based cohort, ages 18-30 at time of recruitment in 1985. We further examine whether multisystem resiliency, comprised of social connections, health-maintaining behaviors, and psychological resources, mitigates the effects of repeated burden on telomere attrition over 5 years. Our results indicate that adults with high chronic burden do not show decreased telomere length over the 5-year period. However, these effects do vary by level of resiliency, as regression results revealed a significant interaction between chronic burden and multisystem resiliency. For individuals with high repeated chronic burden and low multisystem resiliency (1 SD below the mean), there was a significant 5-year shortening in telomere length, whereas no significant relationships between chronic burden and attrition were evident for those at moderate and higher levels of resiliency. These effects apply similarly across the three components of resiliency. Results imply that interventions should focus on establishing strong social connections, psychological resources, and health-maintaining behaviors when attempting to ameliorate stress-related decline in telomere length among at-risk individuals
Telomeres and the natural lifespan limit in humans
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink
Telomere Length as a Biomarker for Adiposity Changes after a Multidisciplinary Intervention in Overweight/Obese Adolescents: The EVASYON Study
[Context]
Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents.
[Objective]
To evaluate the association between telomere length (TL) and adiposity markers in overweight/obese adolescents after an intensive program. We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment.
Design, Setting, Patients and Intervention
The EVASYON is a multidisciplinary treatment program for adolescents with overweight and obesity that is aimed at applying the intervention to all possibly involved areas of the individual, such as dietary habits, physical activity and cognitive and psychological profiles. Seventy-four participants (36 males, 38 females, 12–16 yr) were enrolled in the intervention program: 2 months of an energy-restricted diet and a follow-up period (6 months).
[Main Outcome]
TL was measured by quantitative real-time polymerase chain reaction at baseline and after 2 months; meanwhile, anthropometric variables were also assessed after 6 months of follow-up.
[Results]
TL lengthened in participants during the intensive period (+1.9±1.0, p<0.001) being greater in overweight/obese adolescents with the shortest telomeres at baseline (r = −0.962, p<0.001). Multivariable linear regression analysis showed that higher baseline TL significantly predicted a higher decrease in body weight (B = −1.53, p = 0.005; B = −2.25, p = 0.047) and in standard deviation score for body mass index (BMI-SDS) (B = −0.22, p = 0.010; B = −0.47, p = 0.005) after the intensive and extensive period treatment respectively, in boys.
[Conclusion]
Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight/obese adolescents. Moreover, we suggest that initial longer TL could be a potential predictor for a better weight loss response.Research relating to this work was funded by grants from the Health Research Fund from the Carlos III Health Institute from Ministry of Health and Consumption, Fondo de Investigación Sanitaria (FIS; PI051579, PI051080) for the EVASYON project; LÃnea Especial, Nutrición y Obesidad (University of Navarra); Spanish Ministry of Science and Innovation (MICINN) [SAF2010-20367]; Carlos III Health Institute [Centro de Investigación Biomédica en Red (CIBER) project, CB06/03/1017], and RETICS network. The scholarship to S. GarcÃa-Calzón from the FPU ‘Formación de Profesorado Universitario’ from the Spanish Ministry is fully acknowledged
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