Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’

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Global asteroseismic properties of solar-like oscillations observed by Kepler : A comparison of complementary analysis methods

We present the asteroseismic analysis of 1948 F-, G- and K-type main-sequence and subgiant stars observed by the NASA {\em Kepler Mission}. We detect and characterise solar-like oscillations in 642 of these stars. This represents the largest cohort of main-sequence and subgiant solar-like oscillators observed to date. The photometric observations are analysed using the methods developed by nine independent research teams. The results are combined to validate the determined global asteroseismic parameters and calculate the relative precision by which the parameters can be obtained. We correlate the relative number of detected solar-like oscillators with stellar parameters from the {\em Kepler Input Catalog} and find a deficiency for stars with effective temperatures in the range $5300 \lesssim T_\mathrm{eff} \lesssim 5700$\,K and a drop-off in detected oscillations in stars approaching the red edge of the classical instability strip. We compare the power-law relationships between the frequency of peak power, $\nu_\mathrm{max}$, the mean large frequency separation, $\Delta\nu$, and the maximum mode amplitude, $A_\mathrm{max}$, and show that there are significant method-dependent differences in the results obtained. This illustrates the need for multiple complementary analysis methods to be used to assess the robustness and reproducibility of results derived from global asteroseismic parameters.Comment: 14 pages, 9 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

Cancer and systemic inflammation: treat the tumour and treat the host

Determinants of cancer progression and survival are multifactorial and host responses are increasingly appreciated to have a major role. Indeed, the development and maintenance of a systemic inflammatory response has been consistently observed to confer poorer outcome, in both early and advanced stage disease. For patients, cancer-associated symptoms are of particular importance resulting in a marked impact on day-to-day quality of life and are also associated with poorer outcome. These symptoms are now recognised to cluster with one another with anorexia, weight loss and physical function forming a recognised cluster whereas fatigue, pain and depression forming another. Importantly, it has become apparent that these symptom clusters are associated with presence of a systemic inflammatory response in the patient with cancer. Given the understanding of the above, there is now a need to intervene to moderate systemic inflammatory responses, where present. In this context the rationale for therapeutic intervention using nonselective anti-inflammatory agents is clear and compelling and likely to become a part of routine clinical practice in the near future. The published literature on therapeutic intervention using anti-inflammatory agents for cancer-associated symptoms was reviewed. There are important parallels with the development of useful treatments for the systemic inflammatory response in patients with rheumatological disease and cardiovascular disease

A multidimensional examination of marital conflict and subjective health over 16 years

Guided by stress process perspectives, this study conceptualizes marital conflict as a multidimensional stressor to assess how three aspects of conflict—frequency of disagreements, breadth of disagreements, and cumulative disagreements—impact subjective health. Longitudinal data of married couples spanning 16 years (n = 373 couples) were analyzed using multilevel modeling. For husbands, more frequent disagreements than usual within a given year were associated with poorer subjective health. For wives, the greater cumulative effects of disagreements over 16 years were harmful for subjective health. We discuss how gendered self‐representations and relationship power issues help explain the findings. This research demonstrated the importance of examining multiple aspects of marital conflict to reveal that their subjective health consequences function differently for wives and husbands.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151831/1/pere12292_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151831/2/pere12292.pd

Verification of the Kepler Input Catalog from Asteroseismology of Solar-type Stars

We calculate precise stellar radii and surface gravities from the asteroseismic analysis of over 500 solar-type pulsating stars observed by the Kepler space telescope. These physical stellar properties are compared with those given in the Kepler Input Catalog (KIC), determined from ground-based multi-color photometry. For the stars in our sample, we find general agreement but we detect an average overestimation bias of 0.23 dex in the KIC determination of log (g) for stars with log (g)_KIC > 4.0 dex, and a resultant underestimation bias of up to 50% in the KIC radii estimates for stars with R_KIC < 2 R sun. Part of the difference may arise from selection bias in the asteroseismic sample; nevertheless, this result implies there may be fewer stars characterized in the KIC with R ~ 1 R sun than is suggested by the physical properties in the KIC. Furthermore, if the radius estimates are taken from the KIC for these affected stars and then used to calculate the size of transiting planets, a similar underestimation bias may be applied to the planetary radii.Comment: Published in The Astrophysical Journal Letter

Solar-like oscillations in cluster stars

We present a brief overview of the history of attempts to obtain a clear detection of solar-like oscillations in cluster stars, and discuss the results on the first clear detection, which was made by the Kepler Asteroseismic Science Consortium (KASC) Working Group 2.Comment: 4 pages, 7 figures, accepted by Astronomische Nachrichte

Temporal trends in mode, site and stage of presentation with the introduction of colorectal cancer screening: a decade of experience from the West of Scotland

background:  Population colorectal cancer screening programmes have been introduced to reduce cancer-specific mortality through the detection of early-stage disease. The present study aimed to examine the impact of screening introduction in the West of Scotland. methods:  Data on all patients with a diagnosis of colorectal cancer between January 2003 and December 2012 were extracted from a prospectively maintained regional audit database. Changes in mode, site and stage of presentation before, during and after screening introduction were examined. results:  In a population of 2.4 million, over a 10-year period, 14 487 incident cases of colorectal cancer were noted. Of these, 7827 (54%) were males and 7727 (53%) were socioeconomically deprived. In the postscreening era, 18% were diagnosed via the screening programme. There was a reduction in both emergency presentation (20% prescreening vs 13% postscreening, P0.001) and the proportion of rectal cancers (34% prescreening vs 31% pos-screening, P0.001) over the timeframe. Within non-metastatic disease, an increase in the proportion of stage I tumours at diagnosis was noted (17% prescreening vs 28% postscreening, P0.001). conclusions:  Within non-metastatic disease, a shift towards earlier stage at diagnosis has accompanied the introduction of a national screening programme. Such a change should lead to improved outcomes in patients with colorectal cancer

The solar-like CoRoT target HD 170987: spectroscopic and seismic observations

The CoRoT mission is in its third year of observation and the data from the second long run in the galactic centre direction are being analysed. The solar-like oscillating stars that have been observed up to now have given some interesting results, specially concerning the amplitudes that are lower than predicted. We present here the results from the analysis of the star HD 170987.The goal of this research work is to characterise the global parameters of HD 170987. We look for global seismic parameters such as the mean large separation, maximum amplitude of the modes, and surface rotation because the signal-to-noise ratio in the observations do not allow us to measure individual modes. We also want to retrieve the stellar parameters of the star and its chemical composition.We have studied the chemical composition of the star using ground-based observations performed with the NARVAL spectrograph. We have used several methods to calculate the global parameters from the acoustic oscillations based on CoRoT data. The light curve of the star has been interpolated using inpainting algorithms to reduce the effect of data gaps. We find power excess related to p modes in the range [400 - 1200]muHz with a mean large separation of 55.2+-0.8muHz with a probability above 95% that increases to 55.9 +-0.2muHz in a higher frequency range [500 - 1250] muHz and a rejection level of 1%. A hint of the variation of this quantity with frequency is also found. The rotation period of the star is estimated to be around 4.3 days with an inclination axis of i=50 deg +20/-13. We measure a bolometric amplitude per radial mode in a range [2.4 - 2.9] ppm around 1000 muHz. Finally, using a grid of models, we estimate the stellar mass, M=1.43+-0.05 Msun, the radius, R=1.96+-0.046 Rsun, and the age ~2.4 Gyr.Comment: 12 pages, 15 figures, accepted for publication in A&

Prospects for asteroseismology

The observational basis for asteroseismology is being dramatically strengthened, through more than two years of data from the CoRoT satellite, the flood of data coming from the Kepler mission and, in the slightly longer term, from dedicated ground-based facilities. Our ability to utilize these data depends on further development of techniques for basic data analysis, as well as on an improved understanding of the relation between the observed frequencies and the underlying properties of the stars. Also, stellar modelling must be further developed, to match the increasing diagnostic potential of the data. Here we discuss some aspects of data interpretation and modelling, focussing on the important case of stars with solar-like oscillations.Comment: Proc. HELAS Workshop on 'Synergies between solar and stellar modelling', eds M. Marconi, D. Cardini & M. P. Di Mauro, Astrophys. Space Sci., in the press Revision: correcting abscissa labels on Figs 1 and

Asteroseismology of solar-type stars with K2

We present the first detections by the NASA K2 Mission of oscillations in solar-type stars, using short-cadence data collected during K2 Campaign\,1 (C1). We understand the asteroseismic detection thresholds for C1-like levels of photometric performance, and we can detect oscillations in subgiants having dominant oscillation frequencies around $1000\,\rm \mu Hz$. Changes to the operation of the fine-guidance sensors are expected to give significant improvements in the high-frequency performance from C3 onwards. A reduction in the excess high-frequency noise by a factor of two-and-a-half in amplitude would bring main-sequence stars with dominant oscillation frequencies as high as ${\simeq 2500}\,\rm \mu Hz$ into play as potential asteroseismic targets for K2.Comment: Accepted for publication in PASP; 16 pages, 2 figure