274 research outputs found
PEY10 COST-EFFECTIVENESS OF TWO TREATMENT SEQUENCES IN GLAUCOMA TREATMENT: XALATAN®-XALACOM® VERSUS TRAVATAN®-DUOTRAV®
PAE13 COST-EFFECTIVENESS ANALYSIS OF TIMOLOL LATANOPROST AND TRAVOPROST IN 3 EUROPEAN COUNTRIES: THE UK, GERMANY AND FRANCE
PEE7: THE BURDEN OF AGE-RELATED MACULAR DEGENERATION—RESULTS OF A COHORT STUDY IN TWO FRENCH REFERRAL CARE CENTERS
PEY14 IMPACT OF VISUAL ACUITY ON MEDICAL AND NON-MEDICAL COSTS IN PATIENTS SUFFERING FROM WET AGE-RELATED MACULAR DEGEN-ERATION IN FRANCE, GERMANY AND ITALY
PSS25 COST-EFFECTIVENESS OF ETANERCEPT AND EFALIZUMAB IN THE MANAGEMENT OF MODERATE AND SEVERE PLAQUE PSORIASIS
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The VIRMOS deep imaging survey: I. overview and survey strategy
This paper presents the CFH12K-VIRMOS survey: a deep B, V, R and I imaging
survey in four fields totalling more than 17 deg^2, conducted with the 30x40
arcmin^2 field CFH-12K camera. The survey is intended to be a multi-purpose
survey used for a variety of science goals, including surveys of very high
redshift galaxies and weak lensing studies.
Four high galactic latitude fields, each 2x2 deg^2, have been selected along
the celestial equator: 0226-04, 1003+01, 1400+05, and 2217+00. The 16 deg^2 of
the "wide" survey are covered with exposure times of 2h, 1.5h, 1h, 1h, while
the 1.3x1 deg^2 area of the "deep" survey at the center of the 0226-04 field is
covered with exposure times of 7h, 4.5h, 3h, 3h, in B,V,R and I respectively.
The data is pipeline processed at the Terapix facility at the Institut
d'Astrophysique de Paris to produce large mosaic images. The catalogs produced
contain the positions, shape, total and aperture magnitudes for the 2.175
million objects. The depth measured (3sigma in a 3 arc-second aperture) is
I_{AB}=24.8 in the ``Wide'' areas, and I_{AB}=25.3 in the deep area. Careful
quality control has been applied on the data as described in joint papers.
These catalogs are used to select targets for the VIRMOS-VLT Deep Survey, a
large spectroscopic survey of the distant universe (Le F\`evre et al., 2003).
First results from the CFH12K-VIRMOS survey have been published on weak lensing
(e.g. van Waerbeke & Mellier 2003).
Catalogs and images are available through the VIRMOS database environment
under Oracle ({\tt http://www.oamp.fr/virmos}). They will be open for general
use on July 1st, 2003.Comment: 17 pages including 9 figures, submitted to A&
pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737
Although Bcl-2 family members control caspase activity by regulating mitochondrial permeability, caspases can, in turn, amplify the apoptotic process upstream of mitochondria by ill-characterized mechanisms. We herein show that treatment with a potent inhibitor of Bcl-2 and Bcl-xL, ABT-737, triggers caspase-dependent induction of the BH3-only protein, Mcl-1 inhibitor, Noxa. RNA interference experiments reveal that induction of Noxa, and subsequent cell death, rely not only on the transcription factor E2F-1 but also on its regulator pRb. In response to ABT-737, pRb is cleaved by caspases into a p68Rb form that still interacts with E2F-1. Moreover, pRb occupies the noxa promoter together with E2F-1, in a caspase-dependent manner upon ABT-737 treatment. Thus, caspases contribute to trigger the mitochondrial apoptotic pathway by coupling Bcl-2/Bcl-xL inhibition to that of Mcl-1, via the pRb/E2F-1-dependent induction of Noxa
Cosmic Shear Statistics and Cosmology
We report a measurement of cosmic shear correlations using an effective area
of 6.5 sq. deg. of the VIRMOS deep imaging survey in progress at the
Canada-France-Hawaii Telescope. We measured various shear correlation
functions, the aperture mass statistic and the top-hat smoothed variance of the
shear with a detection significance exceeding 12 sigma for each of them. We
present results on angular scales from 3 arc-seconds to half a degree. The
consistency of different statistical measures is demonstrated and confirms the
lensing origin of the signal through tests that rely on the scalar nature of
the gravitational potential. For Cold Dark Matter models we find at the 95% confidence level. The
measurement over almost three decades of scale allows to discuss the effect of
the shape of the power spectrum on the cosmological parameter estimation. The
degeneracy on sigma_8-Omega_0 can be broken if priors on the shape of the
linear power spectrum (that can be parameterized by Gamma) are assumed. For
instance, with Gamma=0.21 and at the 95% confidence level, we obtain
0.60.65 and
Omega_0<0.4 for flat (Lambda-CDM) models. From the tangential/radial modes
decomposition we can set an upper limit on the intrinsic shape alignment, which
was recently suggested as a possible contribution to the lensing signal. Within
the error bars, there is no detection of intrinsic shape alignment for scales
larger than 1'.Comment: 13 pages, submitted to A&
Cosmic Shear Analysis with CFHTLS Deep data
We present the first cosmic shear measurements obtained from the T0001
release of the Canada-France-Hawaii Telescope Legacy Survey. The data set
covers three uncorrelated patches (D1, D3 and D4) of one square degree each
observed in u*, g', r', i' and z' bands, out to i'=25.5. The depth and the
multicolored observations done in deep fields enable several data quality
controls. The lensing signal is detected in both r' and i' bands and shows
similar amplitude and slope in both filters. B-modes are found to be
statistically zero at all scales. Using multi-color information, we derived a
photometric redshift for each galaxy and separate the sample into medium and
high-z galaxies. A stronger shear signal is detected from the high-z subsample
than from the low-z subsample, as expected from weak lensing tomography. While
further work is needed to model the effects of errors in the photometric
redshifts, this results suggests that it will be possible to obtain constraints
on the growth of dark matter fluctuations with lensing wide field surveys. The
various quality tests and analysis discussed in this work demonstrate that
MegaPrime/Megacam instrument produces excellent quality data. The combined Deep
and Wide surveys give sigma_8= 0.89 pm 0.06 assuming the Peacock & Dodds
non-linear scheme and sigma_8=0.86 pm 0.05 for the halo fitting model and
Omega_m=0.3. We assumed a Cold Dark Matter model with flat geometry.
Systematics, Hubble constant and redshift uncertainties have been marginalized
over. Using only data from the Deep survey, the 1 sigma upper bound for w_0,
the constant equation of state parameter is w_0 < -0.8.Comment: 14 pages, 16 figures, accepted A&
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