127 research outputs found
Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors
An anti-Hebbian form of LTP is observed at excitatory synapses made with some hippocampal interneurons. LTP induction is facilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through Ca(2+)-permeable glutamate receptors is enhanced. The contribution of modulatory transmitters to anti-Hebbian LTP induction remains to be established. Activation of group I metabotropic receptors (mGluRs) is required for anti-Hebbian LTP induction in interneurons with cell bodies in the CA1 stratum oriens. This region receives a strong cholinergic innervation from the septum, and muscarinic acetylcholine receptors (mAChRs) share some signaling pathways and cooperate with mGluRs in the control of neuronal excitability.We therefore examined possible interactions between group I mGluRs and mAChRs in anti-Hebbian LTP at synapses which excite oriens interneurons in rat brain slices. We found that blockade of either group I mGluRs or M1 mAChRs prevented the induction of anti-Hebbian LTP by pairing presynaptic activity with postsynaptic hyperpolarization. Blocking either receptor also suppressed long-term effects of activation of the other G-protein coupled receptor on interneuron membrane potential. However, no crossed blockade was detected for mGluR or mAchR effects on interneuron after-burst potentials or on the frequency of miniature EPSPs. Paired recordings between pyramidal neurons and oriens interneurons were obtained to determine whether LTP could be induced without concurrent stimulation of cholinergic axons. Exogenous activation of mAChRs led to LTP, with changes in EPSP amplitude distributions consistent with a presynaptic locus of expression. LTP, however, required noninvasive presynaptic and postsynaptic recordings
New infrared star clusters in the Northern and Equatorial Milky Way with 2MASS
We carried out a survey of infrared star clusters and stellar groups on the
2MASS J, H and K_s all-sky release Atlas in the Northern and Equatorial Milky
Way (350 < l < 360, 0 < l < 230). The search in this zone complements that in
the Southern Milky Way (Dutra et al. 2003a). The method concentrates efforts on
the directions of known optical and radio nebulae. The present study provides
167 new infrared clusters, stellar groups and candidates. Combining the two
studies for the whole Milky Way, 346 infrared clusters, stellar groups and
candidates were discovered, whereas 315 objects were previously known. They
constitute an important new sample for future detailed studies.Comment: Accepted to Astronomy and Astrophysic
SPI observations of the diffuse 60Fe emission in the Galaxy
Gamma-ray line emission from radioactive decay of 60Fe provides constraints
on nucleosynthesis in massive stars and supernovae. The spectrometer SPI on
board INTEGRAL has accumulated nearly three years of data on gamma-ray emission
from the Galactic plane. We have analyzed these data with suitable
instrumental-background models and sky distributions to produce high-resolution
spectra of Galactic emission. We detect the gamma-ray lines from 60Fe decay at
1173 and 1333 keV, obtaining an improvement over our earlier measurement of
both lines with now 4.9 sigma significance for the combination of the two
lines. The average flux per line is (4.4 \pm 0.9) \times 10^{-5} ph cm^{-2}
s^{-1} rad^{-1} for the inner Galaxy region. Deriving the Galactic 26Al
gamma-ray line flux with using the same set of observations and analysis
method, we determine the flux ratio of 60Fe/26Al gamma-rays as 0.148 \pm 0.06.
The current theoretical predictions are still consistent with our result.Comment: 10 pages, 7 figures, 2 tables, A&A in pres
The Scientific Performance of the Microchannel X-ray Telescope on board the SVOM Mission
The Microchannel X-ray Telescope (MXT) will be the first focusing X-ray
telescope based on a "Lobster-Eye" optical design to be flown on Sino-French
mission SVOM. SVOM will be dedicated to the study of Gamma-Ray Bursts and more
generally time-domain astrophysics. The MXT telescope is a compact (focal
length ~ 1.15 m) and light (< 42 kg) instrument, sensitive in the 0.2--10 keV
energy range. It is composed of an optical system, based on micro-pore optics
(MPOs) of 40 micron pore size, coupled to a low-noise pnCDD X-ray detector. In
this paper we describe the expected scientific performance of the MXT
telescope, based on the End-to-End calibration campaign performed in fall 2021,
before the integration of the SVOM payload on the satellite.Comment: 22 pages, 12 figures, accepted for publication in Experimental
Astronom
Power-to-Hydrogen and Hydrogen-to-X pathways: opportunities for next generation energy systems
Energy systems are evolving rapidly around the world, driven mainly by CO2-e reduction targets. This has led to opportunities for integrated low carbon electricity-and-fuel systems founded on large scale βPower-to-Hydrogen, Hydrogen-to-Xβ (PtH-HtX). Power-to-Hydrogen (PtH) refers to large scale electrolysis. Hydrogen-to-X (HtX) refers to a range of high value products and services. If these pathways start with low-carbon electricity, then the fuel consumed at the downstream end also low-carbon. Use of intermittently low valued power lowers all production costs. This paper specifically identifies the main pathways and interconnections in a way that overcomes the ambiguities inherent in the term βPower-to-Gasβ. In turn, this provides solid and easier to understand foundations for building legal and regulatory frameworks for new business opportunities along the lengths of the numerous pathways from supply to consumption.<br/
New infrared star clusters in the southern Milky Way with 2MASS
We carried out a 2MASS J, H and K_s survey of infrared star clusters in the
Milky Way sector 230 350. This zone was the
least studied in the literature, previously including only 12 infrared clusters
or stellar groups with 10, according to the recent catalogue
by Bica et al. (2003). We concentrated efforts on embedded clusters, which are
those expected in the areas of known radio and optical nebulae. The present
study provides 179 new infrared clusters and stellar groups, which are
interesting targets for detailed future infrared studies. The sample of
catalogued infrared clusters and stellar groups in the Galaxy is now increased
by 63%.Comment: 8 pages, 10 figures, accepted to A&A. Tables 3 and 4 available in
eletronic form at CD
DNA Adenine Methylation Is Required to Replicate Both Vibrio cholerae Chromosomes Once per Cell Cycle
DNA adenine methylation is widely used to control many DNA transactions, including replication. In Escherichia coli, methylation serves to silence newly synthesized (hemimethylated) sister origins. SeqA, a protein that binds to hemimethylated DNA, mediates the silencing, and this is necessary to restrict replication to once per cell cycle. The methylation, however, is not essential for replication initiation per se but appeared so when the origins (oriI and oriII) of the two Vibrio cholerae chromosomes were used to drive plasmid replication in E. coli. Here we show that, as in the case of E. coli, methylation is not essential for oriI when it drives chromosomal replication and is needed for once-per-cell-cycle replication in a SeqA-dependent fashion. We found that oriII also needs SeqA for once-per-cell-cycle replication and, additionally, full methylation for efficient initiator binding. The requirement for initiator binding might suffice to make methylation an essential function in V. cholerae. The structure of oriII suggests that it originated from a plasmid, but unlike plasmids, oriII makes use of methylation for once-per-cell-cycle replication, the norm for chromosomal but not plasmid replication
Simulation of Postsynaptic Glutamate Receptors Reveals Critical Features of Glutamatergic Transmission
Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic calcium concentration at hippocampal synapses, resulting in various types of changes in synaptic strength. Thus, while activation of NMDA receptors has been shown to be critical for long-term potentiation (LTP) and long term depression (LTD) of synaptic transmission, activation of metabotropic glutamate receptors (mGluRs) has been linked to either LTP or LTD. While it is generally admitted that dynamic changes in postsynaptic calcium concentration represent the critical elements to determine the direction and amplitude of the changes in synaptic strength, it has been difficult to quantitatively estimate the relative contribution of the different types of glutamate receptors to these changes under different experimental conditions. Here we present a detailed model of a postsynaptic glutamatergic synapse that incorporates ionotropic and mGluR type I receptors, and we use this model to determine the role of the different receptors to the dynamics of postsynaptic calcium with different patterns of presynaptic activation. Our modeling framework includes glutamate vesicular release and diffusion in the cleft and a glutamate transporter that modulates extracellular glutamate concentration. Our results indicate that the contribution of mGluRs to changes in postsynaptic calcium concentration is minimal under basal stimulation conditions and becomes apparent only at high frequency of stimulation. Furthermore, the location of mGluRs in the postsynaptic membrane is also a critical factor, as activation of distant receptors contributes significantly less to calcium dynamics than more centrally located ones. These results confirm the important role of glutamate transporters and of the localization of mGluRs in postsynaptic sites in their signaling properties, and further strengthen the notion that mGluR activation significantly contributes to postsynaptic calcium dynamics only following high-frequency stimulation. They also provide a new tool to analyze the interactions between metabotropic and ionotropic glutamate receptors
Cluster Density and the IMF
Observed variations in the IMF are reviewed with an emphasis on environmental
density. The remote field IMF studied in the LMC by several authors is clearly
steeper than most cluster IMFs, which have slopes close to the Salpeter value.
Local field regions of star formation, like Taurus, may have relatively steep
IMFs too. Very dense and massive clusters, like super star clusters, could have
flatter IMFs, or inner-truncated IMFs. We propose that these variations are the
result of three distinct processes during star formation that affect the mass
function in different ways depending on mass range. At solar to intermediate
stellar masses, gas processes involving thermal pressure and supersonic
turbulence determine the basic scale for stellar mass, starting with the
observed pre-stellar condensations, and they define the mass function from
several tenths to several solar masses. Brown dwarfs require extraordinarily
high pressures for fragmentation from the gas, and presumably form inside the
pre-stellar condensations during mutual collisions, secondary fragmentations,
or in disks. High mass stars form in excess of the numbers expected from pure
turbulent fragmentation as pre-stellar condensations coalesce and accrete with
an enhanced gravitational cross section. Variations in the interaction rate,
interaction strength, and accretion rate among the primary fragments formed by
turbulence lead to variations in the relative proportions of brown dwarfs,
solar to intermediate mass stars, and high mass stars.Comment: 14 pages, 3 figures, to be published in ``IMF@50: A Fest-Colloquium
in honor of Edwin E. Salpeter,'' held at Abbazia di Spineto, Siena, Italy,
May 16-20, 2004. Kluwer Academic Publishers; edited by E. Corbelli, F. Palla,
and H. Zinnecke
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