4 research outputs found
Supporting Search-As-You-Type Using SQL in Databases
- Publication venue
- Publication date
- 24/04/2020
- Field of study
ABSTRACT : A search-as-you-type system determines answers while a user types a keyword query character by character. We study the search-as-you-type on data which is residing in a relational DBMS. We focus on native database language, SQL as how to support this type of search. A main challenge is how to make full use of existing database functionalities to meet the high-performance to achieve an interactive speed. Further we study how to use auxiliary indexes stored in the tables to increase the search performance. We present solutions for both multi keyword queries and singlekeyword queries, and develop novel techniques for the fuzzy search using SQL by allowing the mismatches between query keywords and answers. Since the volume of data increases day to day the real world, the searching process has become unvaried. The good search technique must be render the requested data in a stipulated time based on the user requested query. Using the native query language, i.e SQL to implement search-as-you-type reduces programming effort. Here we are providing user requested result based on the user previous search
Creation of a long-acting rilpivirine prodrug nanoformulation
- Author
- Adam Szlachetka
- Adams
- Aderem
- Aditya N. Bade
- Baert
- Bahar
- Barrett
- Benjamin G. Lamberty
- Benson J. Edagwa
- Berry
- Bhagya Laxmi Dyavar Shetty
- Bishara
- Brady Sillman
- C. Antiretroviral Therapy Cohort
- Darville
- Dash
- Edagwa
- Flexner
- Foley
- Gandhi
- Gendelman
- Gendelman
- Gulick
- Gunawardana
- Haberer
- Howard E. Gendelman
- Howard S. Fox
- Huttunen
- James R. Hilaire
- JoEllyn M. McMillan
- Jonathan Herskovitz
- Kalter
- Kerrigan
- Kharsany
- Klooster
- Kovarova
- Lavis
- Lin
- Lorenzo-Redondo
- Margolis
- May
- Melinda S. Wojtkiewicz
- Murray
- Nagsen Gautam
- Nair
- Nowacek
- Nowacek
- Osterberg
- Penrose
- Prasanta K. Dash
- Rattan
- Rautio
- Shubber
- Sillman
- Singh
- Spreen
- Spreen
- Sruthi Sravanam
- Taylor
- Turncliff
- Verloes
- Wang
- Williams
- Williams
- Winner
- Wong
- Yazen Alnouti
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Exposure to Short Photoperiod Regime Restores Spatial Cognition in Ventral Subicular Lesioned Rats: Potential Role of Hippocampal Plasticity, Glucocorticoid Receptors, and Neurogenesis
- Author
- A Dhanushkodi
- A Khodadad
- AK Barnes
- AL Vivinetto
- AN Coogan
- AN Coogan
- B Bindu
- B Bindu
- BC Trainor
- BR Hoover
- BS Shankaranarayana Rao
- C Anacker
- C Gao
- C Kopp
- C Meyer
- CB Alme
- CJP Oswald
- CM Bye
- D Dulcis
- D Subhadeep
- D Subhadeep
- E Gould
- E Yilmaz-Rastoder
- EY Sterner
- F Faul
- G Paxinos
- G Vandewalle
- GM Cónsole
- H Odaka
- HA Kenny
- J Eller
- J Gil-Mohapel
- J Grønli
- J Rekha
- J Rekha
- J Rogers
- JA Evans
- JC Walton
- JC Walton
- JC Walton
- JC Walton
- JC Walton
- JF Guzowski
- JL Workman
- JP Herman
- JP Herman
- JR Whitlock
- JS Taube
- JW Kenney
- K Mahati
- L Devi
- L Jacobson
- L Trujillo-Estrada
- L Yan
- LA Smith
- LM Pyter
- M Ben-Hamo
- M Stazi
- N Hanford
- NK Mueller
- P Tahsili-Fahadan
- PD Heideman
- R Cohen
- R Mariné-Casadó
- RGM Morris
- RJ Nelson
- RJ Salaka
- RM Sapolsky
- S Seedat
- S Sosniyenko
- SL Chellappa
- SM O’Mara
- T Goodman
- T Miyashita
- T Steckler
- TA Bedrosian
- TR Laxmi
- V Kapgal
- VR Bhagya
- WW Anderson
- Y Takai
- YE Rybak
- YW Pan
- Z Dong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akçay Özlem
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Aşkar Ahmet
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia Fernández
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baños Pedro Antonio Parra
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel Sánchez
- Bayhan Zülfü
- Bayo José Manuel Muros
- Bayón Raquel Álvaro
- Bánky Balázs
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
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- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
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- Binetti Margherita
- Bintintan Vasile
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- Biondo Santino Antonio
- Bisgin Tayfun
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- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel Ríos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- Budrikienė Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- Bælum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga Estíbaliz Gutiérrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
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- Caltea Mihaela
- Calvo Almudena Castro
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- Cappiello Antonio
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- Cardoso Diogo
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- Chmielewski Gaspard
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- Chornet Marta Roselló
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Colás-Ruiz Enrique
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
- Coppolino Francesco
- Coratti Francesco
- Cordeiro Lisbete
- Correia Angela
- Correia Débora
- Cortes Bruno Giusti Werneck
- Cortés Guillermo Felipe Valderas
- Coskun Nurcan
- Costa Breno Xaia Martins
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- Costa Susana
- Cour Kenn La
- Crabtree Nicholas
- Creavin Ben
- Cremonini Camilla
- Crescentini Giacomo
- Cricrì Michele
- Crisan Dana
- Cristian Daniel
- Croce Gianni Di
- Cruz Isabela
- Cucinotta Eugenio
- Cuichan Marco Vinicio Yugsi
- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
- Curcio Silvia
- Currà Maria Cristina
- Currás Rosana Pérez
- Curro Giuseppe
- Custódio Pedro
- Cutellè Clelia
- Czarnecki Roman
- Ćoza Ivo
- D'Angelo Salvatore
- D'Ugo Stefano
- da Luz Magda
- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
- Damieta Marta Pascual
- Danassi Despoina
- Danelli Piergiorgio
- Danial Aghyad Kudra
- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
- Daryanani Deepu
- Dassanayake Vihara
- Daugėla Edvardas
- Dauri Mario
- Davidovskaja Larisa
- Davies Emma
- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
- de Franciscis Silvia
- de Kort Chantal
- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
- de Lebrusant Fernández Sara
- de León Rendón Jorge Luis
- de Luca Michele
- de Lucia Chiara
- de Miranda Silvestre Simone Chaves
- de Oliveira Góes Igor Arantes
- de Oliveira Flávia Gomes
- de Oliveira João Carlos Costa
- de Palma Giovanni Domenico
- de Paoli Massimo
- de Queiroz Fábio Lopes
- de San Pío Carvajal Eduardo
- de Silva Dulantha
- de Simone Giuseppe
- de Souza Artioli Luana Maria
- de Souza Pires Bruno Lucena
- de Stefano Mauro
- de Zoysa Ishan
- Deac Vasile
- Debono Marianne
- Dedeu-Bastardas Imma
- Degiuli Maurizio
- Del Carmen Casas García Maria
- Del Castillo Vanesa Crespo Garcia
- Del Olmo Maria Inmaculada Ureña
- Del Pueblo Cristina Sanchez
- Del-Rio-Lafuente Francisco-Javier
- Delgado Eduardo
- Delgado Marina
- Delibegovic Samir
- Delimpalta Christina
- Delrio Paolo
- Demir Mehmet
- Demirel Emel
- Demirgan Serdar
- Dempsy Charlotte
- Deniz Nuri
- Depalma Norma
- Desai Neha
- Deus Ana Cláudia
- Devesa Helena
- Dhali Arkadeep
- Dhali Gopal Krishna
- Dhar Puneet
- Diaconescu Cati
- Diego Alejandro Romero-De
- Diez-Alonso Manuel
- Diéguez Beatriz
- Dijan Emilio
- Dilawar Maha
- Dimitriou Nikoletta
- Dimitrov Dobromir
- Dimitrova Slavina
- Dimofte Mihail-Gabriel
- Dindelegan George
- Dindri Franco
- Dinkci Mustafa Deniz
- Díez Miguel Cuende
- Djumabayev Khasan
- Dobkowski Grzegorz
- Dodhy Afia Arshed
- Dolhai Erika
- Domanskiy Andrei
- Domingos Hugo
- Dominguez Fabiana
- Dominguez Sara Hernández
- Dominioni Tommaso
- Donatiello Valerio
- Doniquian Alejandro Marcelo
- Doree Nicholas
- Dorovinis Panagiotis
- Dos Santos José Mauro
- Dos Santos Marco Antônio Miranda
- Dos Santos Maria Beatriz Alves
- Douba Zain
- Drissi Farouk
- Drozdov Evgeniy
- Duarte Maria José
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- Dudric Vlad
- Dulskas Audrius
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- Dushimova Zaure
- Duzgun Ozgul
- Dychko Aleksander
- Dzharov Georgi
- Dzhumabekov Berik
- Dziakova Jana
- Earley Helen
- Ebdewi Hamdi
- Ebrahem Aamal
- Edington John
- Egwuonwu Ochonma Amobi
- Ejiofor Gloria
- Ekepil Anna
- Ekwesianya Andrew
- Ekwunife Okechukwu
- El Ahmadi Brahim
- El Jamali Faek
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- El Sorogy Mohamed
- El-Hussuna Alaa
- El-Wafa Yahya Abou
- Elbahrawy Khaled
- Eldakroury Israa
- Eldin Sami Jalal
- Elena Fanti
- Elfallal Ahmed
- Elfeki Hossam
- Elhadi Muhammed
- Elisiario Luisa
- Ellebæk Mark Bremholm
- Elmore Ugo
- Elrefai Mohamad
- Elshami Mohamedraed
- Emar Mohammed
- Emegoakor Chiemelu
- Emhareb Abdalla
- Emile Sameh
- en Siew Bei
- Ene-Cocis Mihaela-Valentina
- Eng Stanley Chee Ren
- Eraslan Huseyin
- Erdmann Thomas Rolf
- Erginöz Ergin
- Ergün Sefa
- Eriksen Niels Damgaard
- Erturk Candeniz
- Espin-Basany Eloy
- Espinha Daniela Roncoletta
- Espino Julieta
- Espino Pablo Calvo
- Espí-Macías Alejandro
- Esposito Giuseppe
- Esposito Rosario
- Estevão Pedro
- Estudillo Marta Copano
- Etelka Santo
- Evans Jonathan
- Ewah Richard
- Ewedah Moataz
- Fabbri Nicolò
- Fagan Paul
- Fagarasan Vlad
- Fakhradiyev Ildar
- Fakoya Adegbolahan
- Falenius Ville
- Farah José Francisco
- Farkašová Martina
- Farrés Laia Pagés
- Fathi Nik Qisti
- Fatudimu Samuel
- Faustino Ana
- Favacho Bernard Costa
- Feiss Anna
- Felix Michael Shalzim
- Feo Carlo V
- Ferlengez Aysegul
- Fermani Claudio
- Fernandes Andre
- Fernandes Vania
- Fernandez Eugenia
- Fernandez Laura
- Fernández Begoña Fadrique
- Fernández Ignacio Ortega
- Fernández-Arias Sebastian
- Fernández-Hevia Maria
- Fernández-Martínez Daniel
- Ferrario Luca
- Ferraz Teresa
- Ferreira Andreia
- Ferreira Cátia
- Ferro Ezequiel
- Ferroni Andrea Felice
- Fidelis Flávia
- Fiedziuk Agnieszka
- Filardo Matteo
- Filho Antônio Lacerda
- Filipová Lenka
- Filippou Jana
- Finch David
- Fiorenza Juan Maria
- Fiori Enrico
- Fiorito Pablo
- Fiume Diego
- Flandoli Claudia
- Fleres Francesco
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- Flores Natalia
- Flynn Collette
- Foppa Caterina
- Forero-Torres Alexander
- Fortuna Laura
- Fortunato Crescenza
- Fraj Victoria
- Franceschill Marzia
- Frasson Matteo
- Freitas Antonio Hilário
- Freitas António
- Frolova Yulia
- Frongia Federica
- Frontali Alice
- Fuenmayor-Valera Maria Luisa
- Futaba Kaori
- Fuzari Jamile
- Fütterer Carsten
- Galetti Ken
- Galimberti Andrea
- Gallardo Alfredo
- Galliamov Eduard
- Gallo Gaetano
- Galmes Carla
- Galván-Pérez Armando
- Galvez Sandra Torres
- Garau Alessandra Grazia Giuseppina
- Garay Lorena
- Garcia-Flórez Luis Joaquin
- García-Botello Stephanie
- García-Conde María
- García-Señoráns Marta Paniagua
- García-Ureña Miguel Ángel
- Garg Lalit
- Garmanova Tatiana
- Garoufalia Zoe
- Garrido Pilar Garcia
- Garritano Stefano
- Garzali Ibrahim Umar
- Gascon Isabel
- Gaspa Ilaria
- Gata Vlad Alexandru
- Gates Zoe
- Gava Guilherme
- Gbadegesin Peter
- Gemes Geza
- George Gejoe
- Gerald Seitinger
- Gerber Marlus Tavares
- Gezahegn Habtamu
- Gezer Turna
- Gharbi Akram
- Ghose Tapas
- Ghosh Anil
- Ghosh Dhruv
- Ghouali Amine Khayreddine
- Giacomini Giovanni
- Giakoustidis Dimitris
- Giannaraki Styliani
- Gili Simona
- Gill Aun Jamal
- Gillissen Freek
- Giuffrida Maria Carmela
- Giulino Giuseppina
- Giuseppina Forte
- Gklavas Antonios
- Glasbey James C
- Golub József
- Gomendio Maria Dolores Picardo
- Gomes Carina
- Gomes Diogo Carrola
- Gomes Gabriel
- Gomez-Rosado Juan-Carlos
- Gomila-Sanso Joan Andreu
- Gonçalves Vera
- Gonçalvez Sandra Alonso
- Gondal Khalid Masud
- Gonullu Emre
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- null null
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- Yalkin Ömer
- Yanishev Alexey
- Yao Hongwei
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- Yew Chor Kuan
- Yiğit Direnç
- Yılmaz Gülseren
- Yilmazlar Tuncay
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)