Heat Treatment Improvement of Dairy Products via Ohmic Heating Processes : Thermal and Hyrodynamic Effect on Fouling

Fouling and consequently cleaning of heat exchangers in the dairy industry are nowadays a significant issue still not solved for the processing of quite a large variety of products. Ohmic heating processes for food products a priori are well known to minimize the fouling phenomenon due to a totally different way of heating food by admitting the current directly in the product. Such a technology could be a good alternative to counter both fouling and cleaning aspects when pasteurizing or sterilizing dairy desserts known to generate large amounts of soil on heated surfaces. The aim of this experimental study was to investigate the respective roles of both the hydrodynamic parameters and surface electrode temperatures on the fouling phenomenon when heating a simple dairy mix designed to mimic dairy product behaviors

Improved climatological precipitation characteristics over West Africa at convection-permitting scales

The West African climate is unique and challenging to reproduce using standard resolution climate models as a large proportion of precipitation comes from organised deep convection. For the first time, a regional 4.5 km convection permitting simulation was performed on a pan-African domain for a period of 10 years (1997–2006). The 4.5 km simulation (CP4A) is compared with a 25 × 40 km convection-parameterised model (R25) over West Africa. CP4A shows increased mean precipitation, which results in improvements in the mature phase of the West African monsoon but deterioration in the early and late phases. The distribution of precipitation rates is improved due to more short lasting intense rainfall events linked with mesoscale convective systems. Consequently, the CP4A model shows a better representation of wet and dry spells both at the daily and sub-daily time-scales. The diurnal cycle of rainfall is improved, which impacts the diurnal cycle of monsoon winds and increases moisture convergence in the Sahel. Although shortcomings were identified, with implications for model development, this convection-permitting model provides a much more reliable precipitation distribution than its convection-parameterised counterpart at both daily and sub-daily time-scales. Convection-permitting scales will therefore be useful to address the crucial question of how the precipitation distribution will change in the future

The benefits of global high-resolution for climate simulation: process-understanding and the enabling of stakeholder decisions at the regional scale

A perspective on current and future capabilities in global high-resolution climate simulation for assessing climate risks over next few decades, including advances in process representation and analysis, justifying the emergence of dedicated, coordinated experimental protocols. The timescales of the Paris Climate Agreement indicate urgent action is required on climate policies over the next few decades, in order to avoid the worst risks posed by climate change. On these relatively short timescales the combined effect of climate variability and change are both key drivers of extreme events, with decadal timescales also important for infrastructure planning. Hence, in order to assess climate risk on such timescales, we require climate models to be able to represent key aspects of both internally driven climate variability, as well as the response to changing forcings. In this paper we argue that we now have the modelling capability to address these requirements - specifically with global models having horizontal resolutions considerably enhanced from those typically used in previous IPCC and CMIP exercises. The improved representation of weather and climate processes in such models underpins our enhanced confidence in predictions and projections, as well as providing improved forcing to regional models, which are better able to represent local-scale extremes (such as convective precipitation). We choose the global water cycle as an illustrative example, because it is governed by a chain of processes for which there is growing evidence of the benefits of higher resolution. At the same time it comprises key processes involved in many of the expected future climate extremes (e.g. flooding, drought, tropical and mid-latitude storms)

Global pressures, specific responses: effects of nutrient enrichment in streams from different biomes

Fil: Artigas, Joan. Clermont Université. Université Blaise Pascal. Laboratoire Microorganismes: Génome et Environnement; FranceFil: García-Berthou, Emili. Institute of Aquatic Ecology. University of Girona. Girona; SpainFil: Bauer, Delia Elena. Instituto de Limnología Dr. Raúl A. Ringuelet (ILPLA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Castro, Maria I.. Department of Biology. National University of Colombia. Bogotá DC; ColombiaFil: Cochero, Joaquín. Instituto de Limnología Dr. Raúl A. Ringuelet (ILPLA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Colautti, Darío César. Instituto de Limnología Dr. Raúl A. Ringuelet (ILPLA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Cortelezzi, Agustina. Instituto de Limnología Dr. Raúl A. Ringuelet (ILPLA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La PlataFil: Donato, John C.. Department of Biology. National University of Colombia. Bogotá DC; ColombiaFil: Elosegi, Arturo. Faculty of Science and Technology. The University of the Basque Country. Bilbao; SpainFil: Feijoó, Claudia S.. INEDES. Department of Basic Sciences. National University of Luján. Luján; ArgentinaFil: Giorgi, Adonis. INEDES. Department of Basic Sciences. National University of Luján. Luján; ArgentinaFil: Gómez, Nora. Institute of Aquatic Ecology. University of Girona. Girona; SpainFil: Leggieri, Leonardo. Institute of Aquatic Ecology. University of Girona. Girona; SpainFil: Muñoz, Isabel. Department of Ecology. University of Barcelona. Barcelona; SpainFil: Rodrigues Capítulo, Alberto. Instituto de Limnología Dr. Raúl A. Ringuelet (ILPLA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Romaní, Anna M.. Institute of Aquatic Ecology. University of Girona. Girona; SpainFil: Sabater, Sergi. Catalan Institute for Water Research (ICRA). Scientific and Technological Park of the University of Girona. Girona; Spai

Outcome of Ph negative myeloproliferative neoplasms transforming to accelerated or leukemic phase

Myeloproliferative neoplasms (MPN) are chronic disorders that can sometimes evolve into accelerated or leukemic phases. We retrospectively identified 122 patients with such blastic phases. The overall median survival was four months: 10.2 months for patients treated with intensive treatments compared to three months for best supportive care (p = .005). Azacytidine, intensive chemotherapies, or allogeneic stem cell transplantation gave the highest median survivals with 9, 10.2, and 19.4 months, respectively. Accelerated phases (AP) had a longer median survival compared to acute leukemia (4.8 months vs. 3.1 months; p = .02). In this retrospective and observational study, we observe that the longest survivals are seen in patients eligible for intensive treatments. Azacytidine shows interesting results in patients non-fit for intensive chemotherapy. Supportive care should probably be restricted to elderly patients and those with unfavorable karyotype. An early diagnosis of AP could also result in a better survival rate

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice

We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical analysis and stringent selection criteria (2-fold change, 0% false discovery rate) identified 267 significantly changed genes involved in several molecular pathways. The fenofibrate-treated group did not have significantly altered levels of hepatic human APOA-I mRNA and plasma ApoA-I compared with the control group. However, the treatment increased cholesterol levels to 1.95-fold mainly due to the increase in high-density lipoprotein (HDL) cholesterol. The observed changes in HDL are associated with the upregulation of genes involved in phospholipid biosynthesis and lipid hydrolysis, as well as phospholipid transfer protein. Significant upregulation was observed in genes involved in fatty acid transport and β-oxidation, but not in those of fatty acid and cholesterol biosynthesis, Krebs cycle and gluconeogenesis. Fenofibrate changed significantly the expression of seven transcription factors. The estrogen receptor-related gamma gene was upregulated 2.36-fold and had a significant positive correlation with genes of lipid and lipoprotein metabolism and mitochondrial functions, indicating an important role of this orphan receptor in mediating the fenofibrate-induced activation of a specific subset of its target genes.National Institutes of Health (HL48739 and HL68216); European Union (LSHM-CT-2006-0376331, LSHG-CT-2006-037277); the Biomedical Research Foundation of the Academy of Athens; the Hellenic Cardiological Society; the John F Kostopoulos Foundatio