Phytoplankton across Tropical and Subtropical Regions of the Atlantic, Indian and Pacific Oceans

Postprint4,411

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Pressure control in vacuum towers

The increase in severity of visbreaking relates to an increase in olefin concentration in the visbreaking pitches. To conditions of the recovery of gas oils in the vacuum distillation tower, these olefins undergo oligomerization reactions, which produce sludge/polymers. The oligomerization reactions are favored by high temperatures, increment in the times of residence, free radicals and metals that can act as catalysts. The polymers are deposited in the Glitsch meshes and they become traps for the asphalt that are carried by the vapor currents. As a consequence of this process, the free area of the meshes is decreased and the linear rates of the vapors are increased. In time, an increment is registered in the pressure drops of the meshes as well as a growing contamination of the gas oils. The experimentation demonstrated high solubility of the components that cause this contamination. As a result of the study, a methodology for online tower clearing was put into practice and the problem indicated was controlled.Se implementa una nueva metodología para lavar el empaque de la torre de vacío de una planta viscorreductora evitando su ensuciamiento. El incremento de la severidad en la viscorreducción conlleva a un aumento en la concentración de olefinas en las breas viscorreducidas. A condiciones de la recuperación de gasóleos en la torre de destilación al vacío, estas olefinas se oligomerizan produciendo gomas. La reacción de oligomerización se favorece por las altas temperaturas, incremento en los tiempos de residencia, presencia de radicales libres o de trazas de metales que pueden actuar como catalizadores. Las gomas se depositan en las mallas Glitsch y se convierten en trampas para los asfaltenos arrastrados por las corrientes gaseosas. Como consecuencia de este proceso, se va reduciendo el área libre de las mallas y se incrementan las velocidades lineales de los vapores. En el tiempo se va registrando un incremento en las caídas de presión de las mallas y una creciente contaminación en los gasóleos. La experimentación demostró una alta solubilidad de los componentes causantes de este ensuciamiento. Como resultado del estudio se puso en práctica una metodología de lavado en línea de la torre y se controló el problema enunciado

Repertorio Americano. Edición del 21-ABRIL-1924

Gabriel Alomar, Wilson, 65* A. Masferrer, El sermón de Juan, 65* Ramón Vinyes, Dietario en Zig-Zag, 67* Rafael Estrada, Noticia de libros, 68* Sin autor, El corazón de Voltaire, 69* Juana de Ibarbourou, Página lírica, 70* Sin autor, Leyendo a Wilson, 72* Sin autor, El demonio harto de carne... de cañones, se mete a fraile pacifista, 72* Arturo Torres Rioseco, Voltaire y la religión, 73* Hubbert, Voltaire, 73* Luis de Zulueta, Otra lección de Wilson, 74* Flor de Luna, La oración en el huerto, 75* Sin autor, Si usted desea un libro instructivo, al alcance de los niños busque De la vida de las plantas, 76* Eduardo Barrios, ¿Juana de Ibarbourou se entristece?, 76* Sin autor, De la vida de las plantas, 76* Sin autor, La justicia de los tiranos, 78* Sin autor, La nota de Washington al gobierno de Honduras, 78* Efrain Sáenz C., La parábola de Jesús en el templo, 79* Sin autor, Obras de Alfonso Reyes, 79* Sin autor, Lector si quiere usted proteger eficazmente al Repertorio Americano, suscríbase, 79* Sin autor, Dr Constantino Herdocia, 80* Sin autor, Dr Eduardo Montealegre, 80* Sin autor, Dr. Alejandro Montero S.,80* Sin autor, Dr. Odio de Granda, 80* Sin autor, Repertorio Americano, 80* Sin autor, Cervecería Traube, 80* Sin Autor, Pegaso, 80* Sin autor, Botica Española, 80* Sin autor, Revista de Filosofía, 80* Sin autor, Talco El japonesito, 80

Hidrología Experimental como Fuente de Información para el Manejo Integral del Agua en Cuencas Hidrológicas

International audienc

The extrapituitary prolactin promoter polymorphism is associated with rheumatoid arthritis and anti-CCP antibodies in Mexican population

Prolactin (PRL) is a hormone-cytokine that has been involved in autoimmunity due to its immunoregulatory and lymphoproliferative effects. It is produced by various extrapituitary sites including immune cells, under control of a superdistal promoter that contains a single nucleotide polymorphism - 1149 G/T previously associated with rheumatoid arthritis (RA) susceptibility in European population. The aim of this study was to investigate the association of the extrapituitary PRL - 1149 G/T promoter polymorphism with clinical parameters, clinical activity and disability indices in RA patients from Western Mexico and to analyze the PRL mRNA expression according to the PRL - 1149 G/T promoter polymorphism in total leucocytes from RA patients and controls. We conducted a case-control study that included 258 RA patients and 333 control subjects (CS). The DNA samples were genotyped using the PCR-RFLP method and the PRL mRNA expression was determined by quantitative real time PCR. PRL serum levels and antibodies to cyclic citrullinated peptides (anti-CCP) were measured with ELISA. We found significant differences in the genotype (p = 0.022) and allelic (p = 0.046) distribution of the polymorphism between RA patients and control subjects. According to the dominant genetic model, there is an association between the T allele (GT. +. TT genotypes) and decreased RA susceptibility in comparison to the G allele carriers (GG genotype) (OR 0.64, 95% CI 0.45-0.92; p = 0.011). The T allele carriers (GT. +. TT genotypes) had lower titers of anti-CCP antibodies in comparison to the G allele carriers (GG genotype) (median, 66. U/mL vs. 125. U/mL; p = 0.03). Furthermore, the GG homozygotes had higher PRL mRNA expression in comparison to the GT heterozygotes, and this latter with respect to the TT homozygotes, in both groups (RA: 1 > 0.72 > 0.19; CS: 1 > 0.54. > 0.28). However, PRL serum levels were similar in both groups. Our results suggest that the PRL - 1149 T allele is a genetic marker for decreased RA susceptibility and is associated with lower titers of anti-CCP antibodies in Mexican population. We also suggest influence of genotype upon PRL mRNA expression. © 2013 Elsevier B.V

The effects of non-uniformities and frequency dependence of line parameters on electromagnetic surge propagation

Prolactin (PRL) is a hormone-cytokine that has been involved in autoimmunity due to its immunoregulatory and lymphoproliferative effects. It is produced by various extrapituitary sites including immune cells, under control of a superdistal promoter that contains a single nucleotide polymorphism - 1149 G/T previously associated with rheumatoid arthritis (RA) susceptibility in European population. The aim of this study was to investigate the association of the extrapituitary PRL - 1149 G/T promoter polymorphism with clinical parameters, clinical activity and disability indices in RA patients from Western Mexico and to analyze the PRL mRNA expression according to the PRL - 1149 G/T promoter polymorphism in total leucocytes from RA patients and controls. We conducted a case-control study that included 258 RA patients and 333 control subjects (CS). The DNA samples were genotyped using the PCR-RFLP method and the PRL mRNA expression was determined by quantitative real time PCR. PRL serum levels and antibodies to cyclic citrullinated peptides (anti-CCP) were measured with ELISA. We found significant differences in the genotype (p = 0.022) and allelic (p = 0.046) distribution of the polymorphism between RA patients and control subjects. According to the dominant genetic model, there is an association between the T allele (GT. +. TT genotypes) and decreased RA susceptibility in comparison to the G allele carriers (GG genotype) (OR 0.64, 95% CI 0.45-0.92; p = 0.011). The T allele carriers (GT. +. TT genotypes) had lower titers of anti-CCP antibodies in comparison to the G allele carriers (GG genotype) (median, 66. U/mL vs. 125. U/mL; p = 0.03). Furthermore, the GG homozygotes had higher PRL mRNA expression in comparison to the GT heterozygotes, and this latter with respect to the TT homozygotes, in both groups (RA: 1 > 0.72 > 0.19; CS: 1 > 0.54. > 0.28). However, PRL serum levels were similar in both groups. Our results suggest that the PRL - 1149 T allele is a genetic marker for decreased RA susceptibility and is associated with lower titers of anti-CCP antibodies in Mexican population. We also suggest influence of genotype upon PRL mRNA expression. " 2013 Elsevier B.V.",,,,,,"10.1016/j.gene.2013.04.068",,,"http://hdl.handle.net/20.500.12104/45120","http://www.scopus.com/inward/record.url?eid=2-s2.0-84878820569&partnerID=40&md5=0f26d513181a244052a6b4d93763ea3