Development of a second generation prototype reflectometer for reflectance measurement in space Final technical report

Prototype reflectometer development for reflection measurements in spac

forall x: Calgary. An Introduction to Formal Logic

forall x: Calgary is a full-featured textbook on formal logic. It covers key notions of logic such as consequence and validity of arguments, the syntax of truth-functional propositional logic TFL and truth-table semantics, the syntax of first-order (predicate) logic FOL with identity (first-order interpretations), translating (formalizing) English in TFL and FOL, and Fitch-style natural deduction proof systems for both TFL and FOL. It also deals with some advanced topics such as truth-functional completeness and modal logic. Exercises with solutions are available. It is provided in PDF (for screen reading, printing, and a special version for dyslexics) and in LaTeX source code

Groundwater reinjection and heat dissipation: lessons from the operation of a large groundwater cooling system in Central London

The performance of a large open-loop groundwater cooling scheme in a shallow alluvial aquifer at a prominent public building in Central London has been monitored closely over its first 2 years of operation. The installed system provided cooling to the site continuously for a period of 9 months between June 2012 and April 2013. During this period, c. 131300 m3 of groundwater was abstracted from a single pumping well and recharged into a single injection borehole. The amount of heat rejected in this period amounts to c. 1.37 GWh. A programme of hydraulic testing was subsequently undertaken over a 3 month period between July and October 2013 to evaluate the performance of the injection borehole. The data indicate no significant change in injection performance between commissioning trials undertaken in 2010 and the most recent period of testing, as evidenced by comparison of injection pressures for given flow rates in 2010 and 2013. Continuous temperature monitoring of the abstracted water, the discharge and a number of observation wells demonstrates the evolution of a heat plume in the aquifer in response to heat rejection and subsequent dissipation of this heat during the 18 month planned cessation

Inter-similarity between coupled networks

Recent studies have shown that a system composed from several randomly interdependent networks is extremely vulnerable to random failure. However, real interdependent networks are usually not randomly interdependent, rather a pair of dependent nodes are coupled according to some regularity which we coin inter-similarity. For example, we study a system composed from an interdependent world wide port network and a world wide airport network and show that well connected ports tend to couple with well connected airports. We introduce two quantities for measuring the level of inter-similarity between networks (i) Inter degree-degree correlation (IDDC) (ii) Inter-clustering coefficient (ICC). We then show both by simulation models and by analyzing the port-airport system that as the networks become more inter-similar the system becomes significantly more robust to random failure.Comment: 4 pages, 3 figure

On the poverty of a priorism: technology, surveillance in the workplace and employee responses

Many debates about surveillance at work are framed by a set of a priori assumptions about the nature of the employment relationship that inhibits efforts to understand the complexity of employee responses to the spread of new technology at work. In particular, the debate about the prevalence of resistance is hamstrung from the outset by the assumption that all apparently non-compliant acts, whether intentional or not, are to be counted as acts of resistance. Against this background this paper seeks to redress the balance by reviewing results from an ethnographic study of surveillance-capable technologies in a number of British workplaces. It argues for greater attention to be paid to the empirical character of the social relations at work in and through which technologies are deployed and in the context of which employee responses are played out

Separating N2O production and consumption in intact agricultural soil cores at different moisture contents and depths

Agricultural soils are a major source of the potent greenhouse gas and ozone depleting substance, N2O. To implement management practices that minimise microbial N2O production and maximise its consumption (i.e. complete denitrification) we must understand the interplay between simultaneously occurring biological and physical processes, especially how this changes with soil depth. Meaningfully disentangling these processes is challenging and typical N2O flux measurement techniques provide little insight into subsurface mechanisms. Additionally, denitrification studies are often conducted on sieved soil in altered O2 environments which relate poorly to in situ field conditions. Here, we use a novel dual headspace system with field-relevant O2 concentrations to incubate intact sandy clay loam textured agricultural topsoil (0-10 cm) and subsoil (50-60 cm) cores for 3-4 d at 50 and 70% water filled pore space (WFPS), respectively. 15N-N2O pool dilution and an SF6 tracer were used to determine the relative diffusivity (Ds/D0) and the net N2O emission and gross N2O emission and consumption rates. The relationship between calculated fluxes from the below- and above- soil core headspaces confirmed that the system performed well. We found no difference in Ds/D0 between soil depth fractions, which was probably because of the preservation of preferential flow pathways in intact cores. Both gross N2O emissions and uptake were not different with depth but were higher in the 50% WFPS, contrary to expectation. We attribute this to aerobic denitrification and simultaneously occurring denitrification and nitrification for the gross consumption and emission of N2O, respectively. Here, we developed a novel system that allows careful control of conditions and, with a headspace below and above a soil core, a more realistic reconstruction of in situ gas dynamics. We provide further evidence of substantial N2O consumption in drier soil and without net negative N2O emissions. The results from this study are important for the future application of the 15N-N2O pool dilution method and N budgeting and modelling, as required for improving management to minimise N2O losses

How much change is enough? Evidence from a longitudinal study on depression in UK primary care

BACKGROUND: The Patient Health Questionnaire (PHQ-9), the Beck Depression Inventory (BDI-II) and the Generalised Anxiety Disorder Assessment (GAD-7) are widely used in the evaluation of interventions for depression and anxiety. The smallest reduction in depressive symptoms that matter to patients is known as the Minimum Clinically Important Difference (MCID). Little empirical study of the MCID for these scales exists. METHODS: A prospective cohort of 400 patients in UK primary care were interviewed on four occasions, 2 weeks apart. At each time point, participants completed all three questionnaires and a 'global rating of change' scale (GRS). MCID estimation relied on estimated changes in symptoms according to reported improvement on the GRS scale, stratified by baseline severity on the Clinical Interview Schedule (CIS-R). RESULTS: For moderate baseline severity, those who reported improvement on the GRS had a reduction of 21% (95% confidence interval (CI) -26.7 to -14.9) on the PHQ-9; 23% (95% CI -27.8 to -18.0) on the BDI-II and 26.8% (95% CI -33.5 to -20.1) on the GAD-7. The corresponding threshold scores below which participants were more likely to report improvement were -1.7, -3.5 and -1.5 points on the PHQ-9, BDI-II and GAD-7, respectively. Patients with milder symptoms require much larger reductions as percentage of their baseline to endorse improvement. CONCLUSIONS: An MCID representing 20% reduction of scores in these scales, is a useful guide for patients with moderately severe symptoms. If treatment had the same effect on patients irrespective of baseline severity, those with low symptoms are unlikely to notice a benefit. FUNDING: Funding. National Institute for Health Research

Assessment of New Hub-and-spoke and Point-to-point Airline Network Configurations

This paper aims to provide new measures of airline network configuration with a view to analyse effectively the complexity of modern carriers' network design. It studies network configurations in the airline sector by taking into account both spatial and temporal dimensions. The spatial dimension is measured by using both the Gini index and the Freeman index, which originate from social science research. The temporal dimension is measured by the connectivity ratio, i.e. the share of indirect connections over the total number of connections. According to these indicators, the configuration of the largest full-service carriers and the largest low-cost carriers in Europe is investigated. The results show that the temporal dimension provides a clear distinction between full-service carriers and low-cost carriers; while the spatial dimension appears useful when identifying the peculiarities within groups

Human Remyelination Promoting Antibody Stimulates Astrocytes Proliferation Through Modulation of the Sphingolipid Rheostat in Primary Rat Mixed Glial Cultures

Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether they are directly targeting OLs, or their action is mediated by effects on other cell types. We assessed the effect of remyelination promoting antibody rHIgM22 on the proliferative response and on the ceramide/sphingosine 1-phosphate rheostat in mixed glial cell cultures (MGCs). rHIgM22 treatment caused a time-dependent increase in PDGF\u3b1R protein in MGCs. Forty-eight hours of treatment with rHIgM22 induced a dose-dependent proliferative response (evaluated as total cell number and as EdU(+) cell number) in MGCs. When the proliferation response of MGCs to rHIgM22 was analyzed as a function of the cell types, the most significant proliferative response was associated with GLAST(+) cells, i.e., astrocytes. In many cell types, the balance between different sphingolipid mediators (the "sphingolipid rheostat"), in particular ceramide and sphingosine 1-phosphate, is critical in determining the cell fate. rHIgM22 treatment in MGCs induced a moderate but significant inhibition of total acidic sphingomyelinase activity (measured in vitro on cell lysates), the main enzyme responsible for the stimulus-mediated production of ceramide, when treatment was performed in serum containing medium, but no significant differences were observed when antibody treatment was performed in the absence of serum. Moreover, rHIgM22 treatment, either in the presence or in absence of serum, had no effects on ceramide levels. On the other hand, rHIgM22 treatment for 24\ua0h induced increased production and release of sphingosine 1-phosphate in the extracellular milieu of MGC. Release of sphingosine 1-phosphate upon rHIgM22 treatment was strongly reduced by a selective inhibitor of PDGF\u3b1R. Increased sphingosine 1-phosphate production does not seem to be mediated by regulation of the biosynthetic enzymes, sphingosine kinase 1 and 2, since protein levels of these enzymes and phosphorylation of sphingosine kinase 1 were unchanged upon rHIgM22 treatment. Instead, we observed a significant reduction in the levels of sphingosine 1-phosphate lyase 1, one of the key catabolic enzymes. Remarkably, rHIgM22 treatment under the same experimental conditions did not induce changes in the production and/or release of sphingosine 1-phosphate in pure astrocyte cultures. Taken together, these data suggest that rHIgM22 indirectly influences the proliferation of astrocytes in MGCs, by affecting the ceramide/sphingosine 1-phosphate balance. The specific cell population directly targeted by rHIgM22 remains to be identified, however our study unveils another aspect of the complexity of rHIgM22-induced remyelinating effect

Seismological and geotechnical aspects of the Mw=6.3 l’Aquila earthquake in central Italy on 6 April 2009

The L’Aquila earthquake occurred on April 6 2009 at 03:32:39 local time. The earthquake (Mw=6.3) was located in the central Italy region of Abruzzo. Much of the damage occurred in the capital city of L’Aquila, a city of approximate population 73000, although many small villages in the surrounding region of the middle Aterno river valley were also significantly damaged. In the weeks following the earthquake, the Geo-Engineering Extreme Events Reconnaissance (GEER) international team, comprised of members from different European countries and the U.S., was assembled to provide post-earthquake field reconnaissance. The GEER team focused on the geological, seismological, and geotechnical engineering aspects of the event. We describe the principal seismological findings related to this earthquake including moment tensors of the main shock and two triggered events, the aftershock pattern and its variation with time, tectonic deformations associated with the main shock, surface fault rupture, and the inferred fault rupture plane. We describe damage patterns on a village-to-village scale and on a more local scale within the city of L’Aquila. In many cases the damage patterns imply site effects, as neighbouring villages on rock and soil had significantly different damage intensities (damage more pronounced on softer sediments). The April 6 mainshock was the best-recorded event to date in Italy. We present metadata related to the recording sites and then present preliminary comparisons of the data to GMPEs. Those comparisons support the notion of faster distance attenuation in Italy relative to the average for active regions as reflected in NGA GMPEs. Several incidents of ground failure are then discussed, including a number of rockfalls and minor landslides. Perhaps the most significant incidents of ground failure occurred at Lake Sinizzo, for which we describe a number of slumps and spreads around the lake perimeter. This is documented using field observations as well as LIDAR and bathymetric data