Considering a war with Iran

The paper is a strategic studies analyis of the war-fronts, weapon systems and political-military tactics of a U.S.-Iranian war, including the U.S. use of nuclear weapons

Reconciling Hierarchy and Democracy: The Value of Management Learning.

Pluralistic organizations are often argued to have become an indisputable reality for senior managers. In consequence, the role of hierarchy has come under close scrutiny. How can organizations balance the need for congruence, provided through hierarchy, with the need for greater organizational democracy? As yet, the potential for management education and learning to impact on this debate, at either an organizational or a societal level, has been largely unfulfilled. This article argues that the aspirational values of liberal adult educationalists have a significant contribution to make to the management of contemporary organizations. It positions these values alongside the business requisites that shape organizations and examine the motivations of senior managers to apply these ideas in practice. The concept of voluntarism, derived from the field of political philosophy, is proposed as an alternative organizational binding mechanism that alters the rationale for the role of hierarchy. The implications for senior executives and management educationalists are considered

Saving the Planet by Cutting Corporate Taxes: A Comparative Case Study Analysis

This Article examines corporate tax trends in the context of the press¬ing global issue of climate change. Multinational corporations play a huge role in the global economy. We argue that the role of for-profit corporations should not be limited to making short-term profits for their shareholders. If corporations benefit from corporate tax reduc¬tions, some of that benefit should be shared with society. This Article explores the connection between climate change and corporate activity through a new lens: corporate tax policy. It expands the current inquiry about the impact of taxes on corporations by connecting that discussion to the impact of multinational corporate activity on the global environment. To date, while research has been done on the interaction between corporate tax avoidance and corporate social responsibility, no research has examined the connection between the global trend of corporate tax rate cuts and the increasingly important influence of corporate environmental social responsibility. This Article begins to fill that gap by making a qualitative inquiry into the interac¬tion between effective corporate tax rates, corporate tax cuts, and cor¬porate social responsibility

cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG.

Identifying genes that are differentially expressed by Mycobacterium bovis BCG after phagocytosis by macrophages will facilitate the understanding of the molecular mechanisms of host cell-intracellular pathogen interactions. To identify such genes a cDNA-total RNA subtractive hybridization strategy has been used that circumvents the problems both of limited availability of bacterial RNA from models of infection and the high rRNA backgrounds in total bacterial RNA. The subtraction products were used to screen a high-density gridded Mycobacterium tuberculosis genomic library. Sequence data were obtained from 19 differential clones, five of which contained overlapping sequences for the gene encoding mycocerosic acid synthase (mas). Mas is an enzyme involved in the synthesis of multi-methylated long-chain fatty acids that are part of phthiocerol dimycocerosate, a major component of the complex mycobacterial cell wall. Northern blotting and primer extension data confirmed up-regulation of mas in intracellular mycobacteria and also revealed a putative extended -10 promoter structure and a long untranslated upstream region 5' of the mas transcripts, containing predicted double-stranded structures. Furthermore, clones containing overlapping sequences for furB, groEL-2, rplE and fadD28 were identified and the up-regulation of these genes was confirmed by Northern blot analysis. The cDNA-RNA subtractive hybridization enrichment and high density gridded library screening, combined with selective extraction of bacterial mRNA represents a valuable approach to the identification of genes expressed during intra-macrophage residence for bacteria such as M. bovis BCG and the pathogenic mycobacterium, M. tuberculosis

Linear response functions for a vibrational configuration interaction state

Linear response functions are implemented for a vibrational configuration interaction state allowing accurate analytical calculations of pure vibrational contributions to dynamical polarizabilities. Sample calculations are presented for the pure vibrational contributions to the polarizabilities of water and formaldehyde. We discuss the convergence of the results with respect to various details of the vibrational wave function description as well as the potential and property surfaces. We also analyze the frequency dependence of the linear response function and the effect of accounting phenomenologically for the finite lifetime of the excited vibrational states. Finally, we compare the analytical response approach to a sum-over-states approac

The role of voluntarism in stimulating organization democracy

This thesis represents a body of work developed over 10 years in the areas of management learning, organizational politics, and change and organization democracy. It focuses on the role of hierarchy in balancing the need for strategic coherence with the ever burgeoning plurality of organizational life. In recent years, there has been a variety of academic discourses that have illuminated this debate. Often coming from different epistemological traditions, each makes a helpful contribution to the debate. However, I argue that none provides, nor in some cases is intended to provide, senior managers with robust and practical methods of re-conceptualising the role of hierarchy in organization. Based on this analysis, four key requirements for the development of theory in the area are suggested. Using these principles as a starting point, this thesis makes a contribution to knowledge in three interrelated areas. Firstly, by developing the concept of voluntarism, derived from the field of political philosophy, as an alternative organizational binding mechanism that alters the rationale for the role of hierarchy. Secondly, this concept is operationalised as a form of ‘representative’ leadership. Research data are provided which explore the behavioural dimensions and cognitive antecedents of this approach to leadership. The findings are suggestive of a democratic orientation toward leading and organizing, and on this basis, the third contribution focuses on how such leadership principles may be more widely adopted through the vehicle of management learning.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions

Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials enhanced their survival. We identified a transcriptional regulator, RaaS (for regulator of antimicrobial-assisted survival), encoded by bcg1279 (rv1219c) as being responsible for the observed phenomenon. Induction of this transcriptional regulator resulted in reduced expression of specific ATP-dependent efflux pumps and promoted long-term survival of mycobacteria, while its deletion accelerated bacterial death under nonpermissive growth conditions in vitro and during macrophage or mouse infection. These findings have implications for the design of antimicrobial drug combination therapies for persistent infectious diseases, such as tuberculosis

TSIL: a program for the calculation of two-loop self-energy integrals

TSIL is a library of utilities for the numerical calculation of dimensionally regularized two-loop self-energy integrals. A convenient basis for these functions is given by the integrals obtained at the end of O.V. Tarasov's recurrence relation algorithm. The program computes the values of all of these basis functions, for arbitrary input masses and external momentum. When analytical expressions in terms of polylogarithms are available, they are used. Otherwise, the evaluation proceeds by a Runge-Kutta integration of the coupled first-order differential equations for the basis integrals, using the external momentum invariant as the independent variable. The starting point of the integration is provided by known analytic expressions at (or near) zero external momentum. The code is written in C, and may be linked from C, C++, or Fortran. A Fortran interface is provided. We describe the structure and usage of the program, and provide a simple example application. We also compute two new cases analytically, and compare all of our notations and conventions for the two-loop self-energy integrals to those used by several other groups.Comment: 31 pages. Updated to reflect new functionality through v1.4 May 2016 and new information about use with C++. Source code and documentation are available at http://www.niu.edu/spmartin/TSIL or http://faculty.otterbein.edu/DRobertson/tsil

Galaxies undergoing ram-pressure stripping: the influence of the bulge on morphology and star formation rate

We investigate the influence of stellar bulges on the star formation and morphology of disc galaxies that suffer from ram pressure. Several tree-SPH (smoothed particle hydrodynamics) simulations have been carried out to study the dependence of the star formation rate on the mass and size of a stellar bulge. In addition, different strengths of ram pressure and different alignments of the disc with respect to the intra-cluster medium (ICM) are applied. As claimed in previous works, when ram pressure is acting on a galaxy, the star formation rate (SFR) is enhanced and rises up to four times with increasing ICM density compared to galaxies that evolve in isolation. However, a bulge suppresses the SFR when the same ram pressure is applied. Consequently, fewer new stars are formed because the SFR can be lowered by up to 2 M_sun/yr. Furthermore, the denser the surrounding gas, the more inter-stellar medium (ISM) is stripped. While at an ICM density of 10^-28 g/cm^3 about 30% of the ISM is stripped, the galaxy is almost completely (more than 90%) stripped when an ICM density of 10^-27 g/cm^3 is applied. But again, a bulge prevents the stripping of the ISM and reduces the amount being stripped by up to 10%. Thereby, fewer stars are formed in the wake if the galaxy contains a bulge. The dependence of the SFR on the disc tilt angle is not very pronounced. Hereby a slight trend of decreasing star formation with increasing inclination angle can be determined. Furthermore, with increasing disc tilt angles, less gas is stripped and therefore fewer stars are formed in the wake. Reducing the disc gas mass fraction results in a lower SFR when the galaxies evolve in vacuum. On the other hand, the enhancement of the SFR in case of acting ram pressure is less pronounced with increasing gas mass fraction. Moreover, the fractional amount of stripped gas does not depend on the gas mass fraction.Comment: 11 pages, 18 figure

Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with Chlamydia trachomatis.

Background: The low population-prevalence of trachomatous trichiasis and high prevalence of trachomatous inflammation-follicular (TF) provide contradictory estimates of the magnitude of the public health threat from trachoma in the Solomon Islands. Improved characterisation of the biology of trachoma in the region may support policy makers as they decide what interventions are required. Here, age-specific profiles of anti-Pgp3 antibodies and conjunctival scarring were examined to determine whether there is evidence of ongoing transmission and pathology from ocularChlamydia trachomatis (Ct)infection.Methods:A total of 1511 individuals aged ≥1 year were enrolled from randomly selected households in 13 villages in which >10% of children aged 1-9 years had TF prior to a single round of azithromycin mass drug administration undertaken six months previously. Blood was collected to be screened for antibodies to theCtantigen Pgp3. Tarsal conjunctival photographs were collected for analysis of scarring severity.Results:Anti-Pgp3 seropositivity was 18% in 1-9 year olds, sharply increasing around the age of sexual debut to reach 69% in those over 25 years. Anti-Pgp3 seropositivity did not increase significantly between the ages of 1-9 years and was not associated with TF (p=0.581) or scarring in children (p=0.472). Conjunctival scars were visible in 13.1% of photographs. Mild (p<0.0001) but not severe (p=0.149) scars increased in prevalence with age.Conclusions:Neither conjunctival scars nor lymphoid follicles were associated with antibodies toCt,suggesting that they are unlikely to be a direct result of ocularCtinfection.Clinical signs of trachoma were prevalent in this population but were not indicative of the underlying rates ofCtinfection. The current World Health Organization guidelines for trachoma elimination indicated that this population should receive intervention with mass distribution of antibiotics, but the data presented here suggest that this may not have been appropriate