Public health training in Europe. Development of European masters degrees in public health.

BACKGROUND: Changing political and economic relations in Europe mean that there are new challenges for public health and public health training. There have been several attempts to develop training at the master's level in public health which is focused on meeting the new needs. These have failed due to being too inflexible to allow participation by schools of public health. METHODS: A project funded by the European Union involving public health trainers has developed a new approach which allows participating schools to retain their national differences and work within local rules and traditions, but which aims to introduce the European dimension into public health training. This paper reports the conclusions of this project. CONCLUSIONS: A network of schools wishing to develop European Master's degrees is being established and other schools offering good quality programmes will be able to join

A framework for use in modelling the modal choice decision making process in North West England’s Atlantic Gateway

The task of producing a generic model of the modal choice decision making process is a challenging one. Modal choice is strongly influenced by the infrastructure limitations and geographical constraints of the area in which the decision is being made. With this in mind, addressing modal choice on an individual basis for each region may be the optimal solution. This is the approach adopted in this paper. The creation of a modal choice model is a multistage process of which this paper addresses the first stage, the production a framework of the decision making process. Firstly, a number of criteria that are commonly used in modal choice models are identified. Then a number of gaps in the criteria utilized in previous papers are established. Subsequently, the method used to produce a framework of the decision making process within North West England’s Atlantic Gateway is outlined. Through consultation with transport industry experts in North West England, an initial list of sixty eight papers was reduced to thirty six that were considered to be of specific relevance to modern day freight transportation within their region. The criteria used in each of these papers were then, along with further industry input, used to create the foundation on which a modal choice framework specific to the Atlantic Gateway could be built. A greater understanding of what influences modal choice within this region will allow informed decisions to be made by policy makers on how to more efficiently utilize the available modes of freight transport. Having established this, future work can then go on to build upon these findings. This paper recommends that future work is performed to establish the weights of each criteria and sub-criteria within the framework. This should then be followed by establishing industry’s perceptions of the best and worst alternatives for moving freight within the Atlantic Gateway

Expression of an Activation Antigen, Mo3e, Associated With the Cellular Response to Migration Inhibitory Factor by HL‐60 Promyelocytes Undergoing Monocyte‐Macrophage Differentiation

HL‐60 promyelocytic cells acquire the surface expression of the Mo3e antigenic determinant after exposure to PMA or compounds that raise intracellular concentrations of cyclic AMP (dibutyryl cyclic AMP or a combination of cholera toxin and IBMX). The expression of Mo3e by these stimulated HL‐60 cells coincides with the development of features of monocyte‐macrophage differentiation (characteristic morphology, nonspecific esterase activity, and respiratory burst activity). During in vitro monocyte‐macrophage differentiation, HL‐60 cells become responsive to migration inhibitory factor (MIF); the MIF responsiveness of differentiated HL‐60 cells is blocked by anti‐Mo3e monoclonal antibody. These findings further support the relationship between the expression of Mo3e and the cellular response to MIF.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141671/1/jlb0492.pd

Chapter Genetics of Familial Amyotrophic Lateral Sclerosis

Electronics engineerin

Genetics of Familial Amyotrophic Lateral Sclerosis

Electronics engineerin

Insights Arising from Gene Expression Profiling in Amyotrophic Lateral Sclerosis

Public health & preventive medicin

Clinical Pharmacokinetics of Triazoles in Pediatric Patients

Triazoles represent an important class of antifungal drugs in the prophylaxis and treatment of invasive fungal disease in pediatric patients. Understanding the pharmacokinetics of triazoles in children is crucial to providing optimal care for this vulnerable population. While the pharmacokinetics is extensively studied in adult populations, knowledge on pharmacokinetics of triazoles in children is limited. New data are still emerging despite drugs already going off patent. This review aims to provide readers with the most current knowledge on the pharmacokinetics of the triazoles: fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. In addition, factors that have to be taken into account to select the optimal dose are summarized and knowledge gaps are identified that require further research. We hope it will provide clinicians guidance to optimally deploy these drugs in the setting of a life-threatening disease in pediatric patients

'A light in a very dark place' : The role of a voluntary organisation providing support for those affected by encephalitis

Voluntary organisations are seen as contributing to the ‘democratisation’ of health and social care. Little, however, is written about their role and this paper, by focusing on the work of The Encephalitis Society, provides insights into the challenges facing voluntary organisations as they manage twin roles as service providers and advocates, of people with neurological disorders. Two studies are presented: a review conducted by the Society, focusing on patient’s experiences of neurological services; and an external evaluation of the Society’s current provision. The first, based on a postal survey of its members affected by encephalitis (n = 339), illustrates the Society’s advocacy role. The survey provided support for the Association of British Neurologists’ recommendation for nationally agreed standards of care. The second study, a postal survey of recent contacts (n = 76) and in-depth telephone interviews (n = 22), illustrates the Society’s value role as a service provider and supports its role in helping rehabilitate affected individuals and their families. These studies provided the Society with information for policy and service development. Importantly, providing the basis of informed action and partnership with stakeholders and informing the organisation’s sense of purpose, in the changing context of welfare provision in the UK

Rotator cuff disorders: A survey of current (2018) Italian physiotherapy practice

© 2020-IOS Press and the authors. All rights reserved. BACKGROUND: Shoulder pain is a common musculoskeletal complaint and disorders of the rotator cuff (RC) are widely regarded as the most common cause. Where clinical care is required, physiotherapists play an integral role. Previous studies have reported physiotherapy practice across other countries as a means of determining current practice and understanding whether practice changes over time in response to emerging research evidence. AIM: To investigate the practice of Italian physiotherapists, in order to determine current practice for the assessment and management of RC disorders. METHODS: A cross sectional online survey. A 20-item questionnaire based on one clinical vignette was developed using Survey Monkey Software. Data were analyzed descriptively and difference in proportions between those with no specific education compared to those with a specific education (i.e. 'Master's Degree,' '1-2 days Training Course' or 'Other) were analysed using the chi-squared test. RESULTS: A total of 805 participants accessed the survey with a total of 436 completed responses (54%). Fifty-five percent of respondents were male (239/436). Seventy-one percent of respondents (309/436) reported having specific education with regards to RC disorders. The methods of diagnosing RC disorders were variable across the respondents as well as the requests for imaging (184/436, 42%), the adoption of manual therapy techniques (251/436, 58%), the duration of treatment (231/436, 53% visit the patient six times at least) and the administration of physical examination tests (175/436, 40%). Advice (279/436, 64%) and some form of exercise therapy (268/436, 62%) were the most popular choices of treatment. DISCUSSION AND CONCLUSION: This current study is the first to describe Italian physiotherapy practice for RC disorders. Italian physiotherapy practice is in line with other European countries. Italian physiotherapy practice also aligns with current recommendations with regards to minimal use of imaging and prescription of therapeutic exercise. However, there is heterogeneity across the responses particularly with regards the use of manual therapy, physical examination tests, and duration of treatment. Furthermore this study is a platform for future research to explore whether Italian physiotherapy practice changes over time